49Tb-cm09 dose escalation study 149Tb-prrt pilot study 3

Shifts

• Shifts

• 149Tb-cm09 dose escalation study 8

• 149Tb-PRRT pilot study 3

• 152Tb/155Tb companion diagnostics incl.

• 140Nd/134Ce chelator optimization 6

• 140Nd/134Ce immuno-PET 6

• exploratory experiments (Pb, Bi,…) 3

• mass separation of 169Er/168Er 6 (offline)

• Total 26 + 6

• Available -10

• New request 16 + 6 (offline)

Therapy study with 6 mice, 70 MBq 169Er-DOTATOC per mouse

• Therapy study with 6 mice, 70 MBq 169Er-DOTATOC per mouse

• factor 2 for decay losses and labeling yield

• 850 MBq needed (1E15 atoms collected)

• LA[169Er]=5 MBq  up to 500 MBq can be handled in “class C” bat. 170

•  collect and ship two separate samples of 425 MBq each

•  ship as UN2910 (“excepted package”)

• implantation current 1 nA of 169Er for 24 h (3 shifts per sample)

• total current 1 A Er (168Er + 169Er) [cf. 7Be collections]

• ionization potential 6.11 eV > 0.5% thermal ionization efficiency

• RILIS efficiency >5%? (to be tested!)

• ship 20 GBq from ILL (2% of A2 limit > “type A” transport)

• Note: 169Er is a low-energy beta emitter, with very low emission of  rays: 0.16% 8 keV, 0.01% 110 keV

•  very low dose rate: <1 Gy/h at 1 m from unshielded 1 GBq sample.