Arsen mikaelyan, PhD

ARSEN MIKAELYAN, PhD
DOB: November 9, 1959 Phone: [phone]

Citizenship: Russian Fax: [phone]

E-mail: [e-mail]
Work address:

1) Center of Functional Genomics, Skolkovo Institute of Science and Technology (Skoltech), 3 Nobel Street, Skolkovo, Odintsovsky district, Moscow Region, Russia 143026

2) Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Vavilova 26, Room 303, Moscow, Russia

Education
1983 M.Sci., Biology, Yerevan State University, Armenia, USSR.

1998 Ph.D., Genetics, Koltsov Institute of Developmental Biology, Russian

Academy of Sciences, Moscow, Russia. Thesis: Structural-functional characteristics of rho-crystallin gene in frog Rana temporaria.

Advisor: Dr. R.D. Zinovieva.

Employment
2015-Present Senior Research Scientist, Center of Functional Genomics, Skoltech

2006-Present Group leader, Laboratory of Regeneration, Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia

2005-2006 Research Associate, Pulmonary/Critical Care, University of Chicago, Illinois USA

2004-2005 Research Associate, Pulmonary & Critical Care Medicine, Johns Hopkins University Baltimore, Maryland USA

2001-2004 Visiting Fellow, Cellular and Molecular Biology Section, Laboratory of Experimental Carcinogenesis, CCR, National Cancer Institute, National Institutes of Health, Bethesda, Maryland U.S.A.

1998 - 2001 Postdoctoral Associate, N.K. Koltzov, Institute of Developmental Biology, Academy of Sciences, Moscow, Russia

1995 - 1998 Post Graduate Student, Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia

1986 - 1995 Scientist, Laboratory of Molecular Genetics, Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia

1983 - 1986 Senior Technician, Medical Laboratory, Yerevan Department, All Union Center of Surgery, Armenia, USSR
Research Interests
Molecular mechanisms of liver cancer development with an ultimate goal to provide targets and means for therapeutic intervention. The role of microenvironment in HCC.
BIBLIOGRAPHY

Publications in journals indexed by Scopus/WoS

1. 
   Dolgilevich, S. M., Knyaseva, M. V., Mikaelian, A. S., and Gause, G. G.: Isolation and some characteristics of chromosome gene, coding for the frog rho crystallin. Doklady Rossiiskoi Akademii Nauk. 392: 449 452, 1988.
   
2. 
   Dolgilevich, S. M., Mikaelyan, A. S., Knyaseva, M. V., Snegovaya, I. Yu., Simirskii, V. N., Aleinikova, K. S., and Gause, G. G.: Rho crystallin of the frog lens: structure and expression. Doklady Rossiiskoi Akademii Nauk. 335: 373 377, 1994.
   
3. 
   Dolgilevch, S. M., Snegovaya, I. Yu, and Mikaelyan, A. S.: Taxon specific protein of the frog lens: phylogenetic relatedness with the family of NADPH dependent reductases. Biology Bulletin - Izvestiya Akademii Nauk. Series Biological. No. 4: 577 587, 1994.
   
4. 
   Mitashov, V. I., Lukyanov, S. A., Kasanskaya, O. V., Markitantova, Yu., V., Dolgilevich, S. M., Snegovaya, I. Yu., Znoiko, S. L., and Mikaelyan, A. S.: Molecular biological approaches to the studies of gene expression during regeneration. Biology Bulletin, Izvestiya Akademii Nauk, Series Biological, No. 3: 280 284, 1995.
   
5. 
   Kasanskaya, O. V., Markitantova, Yu. V., Snegovaya, I. Yu., Dolgilevich, S. M., Tarabykin, V., Zaraisky, A., Luk’yanov, S. A., Znoiko, S. L., Mikaelyan, A. S., and Mitashov, V. I.: Identification of new genes and analysis of their expression during lens and retina regeneration in adult newts. Biology Bulletin, Izvestiya Akademii Nauk, Series Biological, No. 3: 271-275, 1995.
   
6. 
   Mikaelyan, A. S., Znoiko, I. Yu., and Zinovieva, R. D.: Crystallins: recruitment of proteins for new functions. Ontogenez (Russian Journal of Developmental Biology) 30: 325 340, 1999.
   
7. 
   Mitashev VI, Koussoulakos S, Zinov'eva RD, Ozerniuk ND, Mikaelian AS, Shmukler EIu, Smirnova IuA. Constructive synergism of regulatory genes expressed in the course of the eye and muscle development and regeneration. Izv Akad Nauk Ser Biol. 2001, (3): 261-75. Review. Russian.
   
8. 
   Kaposi-Novak P, Lee JS, Mikaelyan A, Patel V, Thorgeirsson SS. Oligonucleotide microarray analysis of aminoallyl-labeled cDNA targets from linear RNA amplification. Biotechniques. 2004, 37(4):580, 582-6, 588.
   
9. 
   Lee JS, Chu IS, Mikaelyan A, Calvisi DF, Heo J, Reddy JK, Thorgeirsson SS. Application of comparative functional genomics to identify best-fit mouse models to study human cancer. Nat Genet. 2004, 36(12):1306-11.
   
10. 
    Lee JS, Heo J, Libbrecht L, Chu IS, Kaposi-Novak P, Calvisi DF, Mikaelyan A, Roberts LR, Demetris AJ, Sun Z, Nevens F, Roskams T, Thorgeirsson SS. A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. Nat Med. 2006, 12(4):410-6.
    
11. 
    Birukova AA, Malyukova I, Mikaelyan A, Fu P, Birukov KG. Tiam1 and betaPIX mediate Rac-dependent endothelial barrier protective response to oxidized phospholipids. J Cell Physiol. 2007, 211(3):608-17.
    
12. 
    Birukova AA, Alekseeva E, Mikaelyan A, Birukov KG. HGF attenuates thrombin-induced endothelial permeability by Tiam1-mediated activation of the Rac pathway and by Tiam1/Rac-dependent inhibition of the Rho pathway. FASEB J. 2007, 21(11):2776-86.
    
13. 
    Kozhevnikova MN, Mikaelian AS, Starostin VI. Molecular and genetic regulation of osteogenic differentiation of mesenchymal stromal cells. Izv Akad Nauk Ser Biol. 2008, (3):261-71.
    
14. 
    Kozhevnikova MN, Mikaelian AS, Paiushina OV, Starostin VI. Comparative characterization of mesenchymal bone marrow stromal cells at early and late stages of culturing. Izv Akad Nauk Ser Biol. 2008, (2):156-62. Russian.
    
15. 
    Kozhevnikova MN, Mikaelyan AS, Starostin VI. Comparative immune-phenotypic and functional characteristics of mesenchymal stromal cells from definitive and transitory hematopoietic organs. Dokl Biol Sci. 2008, 422:363-5.
    
16. 
    Kuzin BA, Modestova EA, Vorontsova IuE, Zatsepina OG, Mikaelian AS, Slezinger MV, Simonova OB. Interaction of the ss and CG5017 genes in the regulation of morphogensis of limbs in Drosophila melanogaster. Ontogenez. 2010, 41(5):364-9. Russian.
    
17. 
    Zinevich LS, Mikaelyan AS. Igf1 expression in mouse model of liver carcinogenesis. Dokl Biochem Biophys. 2012, 442:1-3.
    
18. 
    Zinevich LS, Goncharova NO, Uruvaeva IV, Delone GV, Mikaelian AS.: Igf-1 and its isoform expression in hepatic cell tumors and the surrounding tissue in mice liver carcinogenesis induced by diethylnitrozamine. Izv Akad Nauk Ser Biol. 2013, (6):673-81. Russian
    
19. 
    Ilina, I. V., Ovchinnikov, A. V., Sitnikov, D. S., Chefonov, O. V., Agranat, M. B., & Mikaelyan, A. S. (2013, June). Noncontact microsurgery of living cell membrane using femtosecond laser pulses. In European Conferences on Biomedical Optics(pp. 88030A-88030A). International Society for Optics and Photonics.
    
20. 
    Il'ina, I. V., Ovchinnikov, A. V., Sitnikov, D. S., Chefonov, O. V., & Agranat, M. B. (2014). Noncontact microsurgery and delivery of substances into stem cells by means of femtosecond laser pulses. Quantum Electronics, 44(6), 594.
    
21. 
    Kosykh, A., Ngamjariyawat, A., Vasylovska, S., Konig, N., Trolle, C., Lau, J., Mikaelyan A….. & Kozlova, E. N. (2015). Neural crest stem cells from hair follicles and boundary cap have different effects on pancreatic islets in vitro. International Journal of Neuroscience, 125(7), 547-554.
    
22. 
    Dashenkova, N., and A. Mikaelyan. "A129: Analysis of Igf axis in development of HCC." European Journal of Cancer Supplements 13.1 (2015): 11-12.
    
23. 
    Kopantseva, M. R., Usova, E., Mikaelyan, A., Kostina, M., Melekhina, O., Egorov, V., & Kopantzev, E. P. (2015). Effect of IGF1 on cancer and stromal cells of human pancreatic tumors. Cancer Research, 75(15 Supplement), 1540-1540.
    

Publications in journals not indexed by Scopus/WoS

1. 
   Kozhevnikova MN, Mikaelian AS, Starostin VI. Molecular genetic and immunophenotypic analysis of antigen profiling, osteogenic and adipogenic potentials of mesenchymal stromal cells from fetal liver and adult bone marrow in rats. Tsitologiia. 2009, 51(6):526-38. Russian.
   
2. 
   Mikaelyan, A., Lee, J-S., Conner, E. A., Factor, V. M. and Thorgeirsson, S. S.: Global gene expression analysis identifies distinct molecular pathways of HCC in mouse models of liver cancer. Proceedings of AACR, 2003, 44: 1172-1173