18
5
Significance/Impact
5.1
Short-Term Significance/Impact
This investigation contributes to the current trend to query the binding capacity of potential
modulators,
regulators, and inhibitors of nuclear receptors OUTSIDE of the known binding
pockets. This is also an ongoing trend for the AR, as summarized in Elshan et al (2018)
27
. We
expect our research to contribute to this trend and to identify novel binding sites on two domains
of a rather well-known protein. We expect that this will lead to the identification of structural
groups of organic small molecules that may be the source for the development of novel active
pharmacophores to be tested for their ability to down-regulate AR expression. Hence, the present
work will foster several experimental research avenues, including the chemical synthesis of novel
molecules and their testing in biophysical and biochemical
in vitro
assays to complement and/or
corroborate the results found herein. This in turn will warrant investigations of the effect of such
novel compounds on AR expression in cell models, notably of human prostate cancer origin. In
the long run, these results will ultimately have potential pre-clinical / clinical significance.
Dostları ilə paylaş: