English Chemist



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(1918-1998) English Chemist 

 

Derek Barton transformed the landscape of physical chemistry in one fell swoop by 



establishing conforma-tional analysis, or the notion that chemical geometry corresponds to 

molecular function. This advancement in understanding also transformed the chemical 

imagination from representing chemical reactions and structures in two dimensions, instead 

forcing chemists to visualize molecules more accurately, in their three-dimensional 

configurations. He shared the 1969 Nobel Prize in chemistry with ODD HASSEL, who had 

established the geometry of a common steroid. 

 

Derek Harold Richard Barton was born on September 8, 1918, in Gravesend, Kent, England. 



His father, William Thomas Barton, was a carpenter (like his father before him) and a 

lumberyard owner who died when Barton was 17. After helping his mother, Maude Lukes, 

run the family business for two years, Barton entered Gillingham Technical College. He 

remained there only a year before transferring to Imperial College of the University of 

London, where he graduated with first-class honors in 1940. He conducted his doctoral 

research on the synthesis of vinyl chloride (the black plastic used to make phonographic 

records) under Ian Heilbron and E. R. H. Jones to earn his Ph.D. in 1942. 

 

During World War II, Barton remained at Imperial to conduct military intelligence research 



developing secret inks. In 1944, the Albright and Wilson company in Birmingham hired him 

to work on synthesizing organic phosphorous compounds. However, he only lasted a year in 

the industry before returning to academia; he preferred a position as a junior lecturer in 

inorganic chemistry at Imperial to a corporate job. Four years later, in 1949, a position in 

organic chemistry, his actual area of specialization, opened up at Imperial College. 

 

During those four years, Barton commenced the research that led to his breakthrough 



realization. He investigated triterpenoids and steroids, recording correlations between their 

chemical structures and their molecular properties. Word of Odd Hassel’s work deciphering 

the geometry of cyclohexane (a foundational molecule for triterpenoids and steroids) reached 

him, and he extended this work to other, more complex molecules. In 1949, the prominent 

steroid chemist Louis Fieser invited Barton to Harvard University as a visiting lecturer to fill 

the position vacated by ROBERT BURNS WOODWARD, who was taking a one-year 

sabbatical. 

 

While attending a lecture by Fieser on some unsolved steroid mysteries, an epiphany visited 



Barton: He realized that the three-dimensional shapes of molecules must correspond to their 

characteristics. He immediately expounded his theory, citing experimental confirmation, in a 

four-page paper entitled “The Conformation of the Steroid Nucleus.” He published this piece 

in the Swiss journal Experientia, a relatively obscure publication that soared in circulation 

after word got out about the significance of Barton’s paper. Not only did he establish the field 

of con-formational analysis by asserting a correlation between molecular structure and 

molecular functions, but also he transformed the chemical view from a flat plane into a three-

dimensional space of complex configurations. 

 

Upon his return to England in 1950, Barton was promoted to a readership at Birkbeck College 



of the University of London, which three years later promoted him again, to a professorship. 

In 1955, the University of Glasgow named him its Regius Professor, but two years later 

Barton returned to London to take up a full professorship at Imperial College, where he 

remained for the next two decades. During the 1950s, he worked with free-radical chemistry 




to elicit reactions for chemical synthesis. He uncovered the biosynthetic process governing 

the transformation of opium poppies into morphine. He also generated photochemical 

reactions by casting ultraviolet light on samples to rupture chemical bonds into free radicals 

that he then manipulated to synthesize compounds. In 1958, he employed what became 

known as the “Barton reaction” to synthesize the steroid aldosterone, and in one experiment 

increased the world’s supply of this electrolytic hormone from a matter of milligrams to more 

than 60 grams. 

 

In 1969, the Royal Swedish Academy of Sciences honored Barton and Hassel with the Nobel 



Prize in chemistry, in recognition of Hassel’s experimental determination of the chemical 

geometry of steroids, and Barton’s “gap jumping” theory correlating this chemical geometry 

to corresponding chemical characteristics, thereby demonstrating how the two seemingly 

disparate areas of form and function actually work hand-in-hand. Three years later, Queen 

Elizabeth II knighted Barton, though he insisted on leaving the title of “Sir Derek” behind 

when he traveled outside of England. 

 

In 1978, Barton relocated to Gif-sur-Yvette, France, as the director of research for the Centre 



National de la Recherche Scientifique (CNRS) of the Institut de Chimie des Substances 

Naturelles (ICSN.) This move thrilled his second wife, Professor Christiane Cognet, who was 

French (his earlier marriage to Jeanne Kate Wilkins, which yielded one son, William Godfrey 

Luke Barton, ended in divorce.) Barton continued to invent new reactions, naming the 

components “Gif” reagents after the site of his research. 

 

In 1986, Texas A&M University named Barton a Distinguished Professor, a post he held for 



the last dozen years of his life. During this time, he received further accolades: The American 

Chemical Society granted him its 1989 Creative Work in Synthetic Chemistry Award and its 

1995 Priestley Award. His second wife died in 1994, and his third wife, Judy Cobb, survived 

him when he passed away on March 16, 1998, in College Station, Texas. 

 

 

http://pagerankstudio.com/Blog/2010/10/derek-barton-biography-life-and-career-facts-



invented/

 

 




Molecules 1998, 3, 132-134 

 

Obituary: Professor Sir Derek H. R. Barton (1918-1998) 



 

Shu-Kun Lin 

 

Molecular Diversity Preservation International (MDPI), Saengergasse 25, CH-4054 Basel, 



Switzerland 

Tel. +41 79 322 3379, Fax +41 61 302 8918, E-mail: Lin@mdpi.org 

 

Received: 19 March 1998 / Published: 20 March 1998 



 

  

Professor Sir Derek H. R. Barton 



(8 September 1918 - 16 March 1998) 

 

With great sadness I just learned that Professor Sir Derek H. R. Barton died in the evening of 



16 March 1998, at age 80. 

 

Professor Barton had been very supportive to our electronic journal, Molecules 



(http://www.mdpi.org/molecules) and served on the Editorial Board from the beginning. He 

also immediately accepted my invitation to be a member of the International Scientific 

Advisory Committee of the related conference ECSOC-1 as well as ECSOC-2(The 2nd 

International Electronic Conference on Synthetic Organic Chemistry, http://www.mdpi.org/ 

ecsoc-2.htm). He served on the editorial boards of numerous other chemistry journals also. He 

was the chairman and one of the founding editors of the famous Tetrahedron publications. 

 

Even in recent years, at high age, Professor Barton had been very active in the chemistry 



community. 

 

He had been invited to many symposia, chemistry seminars, colloquium series, and 



conference lectures, even in recent years. I have attended his lecture entitled "How to win a 

Nobel Prize" twice, the first time was at the University of Louisville, USA in 1988, and it was 

always very stimulating and full of fascinating details. 

 

He had been active in scientific research even in very recent years as we can find his frequent 



publication of research papers [1] and always ready to embrace new things such as Internet 

application in chemistry. We exchanged several e-mails recently. It is a shock that he 

suddenly passed away. 

 

Derek Harold Richard Barton [2] was born on 8 September 1918, son of William Thomas and 



Maude Henrietta Barton. He obtained his B. Sc. Hons. (1st Class) in 1940 and Ph. D. 

(Organic Chemistry) in 1942, from University of London, Imperial College. After two years 

in military intelligence and one in industry, he returned to Imperial College to teach inorganic 

and physical chemistry. He then began an academic odyssey with stops at Harvard, Birkbeck 

College, and Glasgow. 

 

In 1950, in a brief paper in Experienta entitled "The Conformation of the Steroid Nucleus", 



Professor Barton showed that organic molecules in general and steroid molecules in particular 

could be assigned a preferred conformation based upon results accumulated by chemical 




physicists, in particular by Odd Hassel. Thus he established the concept of conformational 

analysis. He returned to Imperial College as professor of organic chemistry in 1957. 

 

In 1969 he shared the Nobel Prize in Chemistry for his work on conformational analysis. 



 

Professor Barton was knighted by Queen Elizabeth II in 1972 but, by his choice, was known 

as Sir Derek only in England. 

 

In 1978 he became the Director of the Natural Products Institute at Gif-sur-Yvette in France, 



and in 1986 he became Distinguished Professor at Texas A&M and held this position for 12 

years until his death. 

 

Besides the Nobel Prize, Professor Barton won many honours. More recently, he won ACS 



Creative Work in Synthetic Chemistry Award in 1989 and ACS Priestley Award in 1995. He 

was chosen as one of several most influential chemists in the past 75 years of chemical 

research, by Chemical & Engineering News  [3]. 

 

Professor Barton has earned his place in chemical tradition the old-fashioned way, with hard 



work and by inventing reactions. Aside from fathering conformational analysis, his name is 

associated with at least five organic reactions [4]: 

 

Barton nitrite photolysis - the long range functionalization of alcohols via nitriles leading to 



gamma-hydroxy oximes; 

 

Barton deamination - free radical deamination of primary amines via isocyanides; 



 

Barton decarboxylation - decarboxylation of a mixed anhydride (thiohydroxamic-carboxylic) 

and interception of the radicals as a sulfide, selenide or bromo derivative; 

 

Barton-Kellogg olefination - olefin synthesis from hydrazones and thioketones via 1,3,4-



thiadiazolines; 

 

Barton-McCombie deoxygenation - of secondary alcohols to hydrocarbons via xanthates; 



 

His recent research interests were the invention of new chemical reactions, the 

functionalization of unactivated molecules, and the partial synthesis of natural products [4]. 

His most recent interests can be found at his Website [1]. 

 

Professor Barton was first married to Jeanne Kate Wilkins but this marriage was later 



dissolved. He married again to Professor Christiane Cognet who died in 1994. He has one 

son, W. G. L. Barton, by his first marriage. Professor Barton is survived by his third wife, 

Judy Cobb Barton; a son, William, who lives in England, and three grand children [5]. 

 

Professor Barton was not only a great scientist, he was also a very kind man, to be 



remembered by all of us. 

 

Acknowledgements: I would like to thank Dr. Matthew F. Schlecht (DuPont) for his 



communication and English correction, Professor Emile A. Schweikert (Head, Department of 

Chemistry, Texas A&M University) for allowing me to use Professor Barton's photo and 




George D. Merlin McCallion for bringing my attention to the New York Times Obituaries 

section, 19 March 1998. 

 

References and Notes: 



 

1. The website of Barton group at Department of Chemistry, Texas A&M University: 

http://www.chem.tamu.edu/brochure/new/faculty/barton/barton.html where the description of 

his research interests is: 

 

"Although organic synthesis has advanced greatly in the last few decades and is nowadays a 



multibillion dollar industry, it is still unusual to carry out a reaction with a quantitative yield. 

There is, therefore, a constant need for new reactions that are more selective and give high 

yields of single products. Our laboratory is concerned with the invention of such reactions. 

 

A family of high yielding radical reactions has been introduced. These are based on the 



radical chemistry of the thiocarbonyl group. Important applications in carbohydrate chemistry 

frequently have given the nearly quantitative yields required. A more recent development has 

associated the thiocarbonyl group with the relatively weak nitrogen-oxygen bond to provide 

an efficient system for the conversion of the carboxyl group into a radical. In this way, many 

synthetic operations can be carried out in high yields, which were not possible before. 

Applications in peptide chemistry, in steroids, in nucleosides and in other areas of natural 

products chemistry have been made. 

 

A second interest of the laboratory is in the selective substitution of saturated hydrocarbons. 



This is an excellent challenge for the present generation of chemists and for Texas. An 

interesting new approach has been invented for converting saturated hydrocarbons to ketones 

smoothly at room temperature. For a 25 percent conversion, the reaction is nearly 

quantitative. The selectivity is unusual as secondary positions are attacked more rapidly than 

tertiary centres. In steroid chemistry, a one-step synthesis of progesterone from cholestenone 

has been achieved. 

 

Recent advances have enabled the conversion of saturated hydrocarbons into a number of 



secondary derivatives, of which bromides are of significant utility." 

 

2. For the autobiography of his early part of life, visit 



http://www.nobel.se/laureates/chemistry-1969-1-bio.html Website of The Nobel Foundation. 

 

3. See the 75th Anniversary issue, Chemical & Engineering News, 12 January 1998. Website: 



http://pubs.acs.org/hotartcl/cenear/980112/crystal2.html 

 

4. This summary was kindly provided by Matthew F. Schlecht, DuPont Agricultural Products, 



Newark, DE 19714-0030, USA, tel 302-366-5760 fax 366-5738, 

Matthew.F.Schlecht@usa.dupont.com 

 

5. The New York Times Obituaries section, 19 March 1998. The URL is 



http://www.nytimes.com/yr/mo/day/news/national/obit-barton.html 

 

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©1998 MDPI. All rights reserved 




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