The Role of Antimicrobial Peptides in
Periodontal Disease
339
will be unraveled in the near future. Consequently, additional studies into new biological
activities of antimicrobial peptides are needed and will be beneficial for us to better
understand and gain deep insight into the importance of these multifunctional molecules,
particularly their essential roles in maintaining tissue homeostasis during the healthy and
diseased states of the periodontium.
Furthermore, it is still necessary to continue regulation studies, involving cellular
receptors and intracellular signaling pathways that mediate up-regulation of some inducible
antimicrobial peptides, in order to understand the mechanisms used to enhance the expression
of these peptides. In quest of new adjunctive treatment modalities against periodontitis, it is
possible that enhancement of antimicrobial peptide expression by putative components of
commensal periodontal bacteria that are not harmful to the humanbody, or by non-toxic
agents, similar to vaccination, may be of significant interest in controlling the number of
periodontopathic bacteria. Finally, we, as members of the health professions, should be
constantly aware of the clinical significance of these antimicrobial peptides in the
pathogenesis of oral infectious and
inflammatory diseases, especially periodontal disease.
Dostları ilə paylaş: