Liceo Scientifico G. Marinelli



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Dr. Milena Romanello, PhD


Education

Jul 1984: General Certificate of Education "Liceo Scientifico G. Marinelli" – Udine (UD), Italy.

Jul 1991: M.Sc. in Chemistry and Biopharmaceutical Technologies, University of Trieste, Italy. Evaluation: 110/110 cum laude.

Nov 1996: PhD in Biochemistry, University of Trieste, Italy.



Professional Experience

Jun 1989 – Jun 1991: Undergraduate trainee in Biochemistry, Department of Biochemistry, Biophysics and Macromolecular Chemistry (BBCM),University of Trieste, Italy.

Oct 1991 – Oct 1995: Pre-doctoral Fellow in Biochemistry, University of Trieste, Italy.

Nov 1995 –Nov 1996: Research fellow in Clinical Biochemistry, University of Trieste, Italy.

Dec 1996 - Dec 1998: Post-doctoral fellow in Biochemistry,University of Trieste, Italy.

Jan 1999 – Jan 2004: Research Assistant in Research Groups of Prof. L. Moro, MD, and P. D’Andrea, Ph.D., Department of Biochemistry, Biophysics and Macromolecular Chemistry,University of Trieste, Italy.

Feb 2004 – Feb 2011: Research Assistant in Molecular Biology Research Group of Prof. Gianluca Tell, PhD, Department of Biomedical Sciences and Technologies, University of Udine, Italy.

March 2011–actually: Research Assistant at the Laboratory of Regional Centre for Rare Diseases


University Hospital "Santa Maria della Misericordia"
33100 Udine, Italy.

Actually she is attending to biochemical assays useful to the laboratory diagnosis of lysosomal rare diseases. Notably, she is improving a method in tandem-mass spectrometry for the determination of biochemical markers of Niemann-Pick C disease.


Publications
She authored 46 publications in international peer reviewed journals.
Last Publications:


  1. Malini E, Zampieri S, Deganuto M, Sechi A, Romanello M, Bembi B, Dardis A. Role of LIMP-2 in the intracellular trafficking of beta glucosidase in different human cellular models. Submitted to Traffic




  1. Domenis R, Bergamin N, Gianfranceschi G, Vascotto C, Romanello M, Rigo S, Vagnarelli G, Faggiani M, Parodi P, Kelley MR, Beltrami CA, Cesselli D, Tell G, Beltrami AP. The redox function of APE1 is involved in the differentiation process of stem cells toward a neuronal cell fate. Plos One (2014), 9(2) e89232.




  1. Dardis A, Zanin I, Zampieri S, Stuani C, Pianta A, Romanello M, Baralle FE, Bembi B, Buratti E. Functional characterization of the common c.-32-13T>G mutation of GAA gene: identification . of potential therapeutic agents. Nucleic Acids Research (2014), 42(2): 1291-1302.




  1. Romanello M, Piatkowska E, Antoniali G, Cesaratto L, Vascotto C, Iozzo RV, Delneri D, Brancia FL. Osteoblastic cell secretome: A novel role for progranulin during risedronate treatment. Bone (2013), 58: 81-91.




  1. Lirussi L, Antoniali G, Vascotto C, D’Ambrosio C, Poletto M, Romanello M, Marasco D, Leone M, Quadrifoglio F, Bhakat KK, Scaloni A, and Gianluca Tell. Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells. Molecular Biology of the cell (2012), 23: 4079-4096.




  1. Bivi N, Lezcano V, Romanello M, Bellido T, and Plotkin LI. Connexin43 interacts with β-arrestin: a pre-requisite for osteoblast survival induced by parathyroid hormone. J Cell Biochem (2011), 112(10):2920-30.




  1. Bivi N, Picotti P, Mueller LN, Romanello M, Moro L, Quadrifoglio F, and Tell G. Shotgun Proteomics Analysis Reveals New Unsuspected Molecular Effectors of Nitrogen-Containing Bisphosphonates in Osteocytes. J Proteomics (2011), 74(7): 1113-22.




  1. Pianta A, Puppin C, Passon B, Franzoni A, Romanello M, Tell G, Di Loreto C, Bulotta S, Russo D, Damante G. Nucleophosmin delocalization in thyroid tumour cells. Endocr Pathol (2011), 22(1):18-23.




  1. Fantini D, Vascotto C, Marasco D, D’Ambrosio C, Romanello M, Vitagliano L, Pedone C, Poletto M, Cesaratto L, Quadrifoglio F, Scaloni A, Radicella JP, and Tell G. Critical lysine residues within the overlooked N-terminal domain of human Ape1 regulates its biological functions. Nucleic Acids Research (2010), 38(22): 8239-56.




  1. Pianta A, Fabbro D, Damiani D, Tiribelli M, Fanin R, Franzoni A, Romanello M, Tell G, Di Loreto C, and Damante G. Two novel NPM1 mutations in a therapy-responder AML patient. Hematol Oncol (2010), 28(3):151-5.




  1. Pianta A, Fabbro D, Damiani D,  Tiribelli M,  Fanin R, Franzoni A,  Romanello M, Tell G, and Damante G. Unexpected phenotype from a typical NPM1 mutant. Br J Haematol (2009) 147:760-3.




  1. Bivi N, Romanello M, Harrison R, Clarke I, Hoyle DC, Moro L, Ortolani F, Bonetti A, Quadrifoglio F, Tell G and Delneri D. Identification and characterization of new secondary targets of nitrogen-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection. Genome Biol (2009) 10:R93.


Scientific Meeting Attendance
She has attended with Posters and Oral presentations to about sixty national and international Scientific Meetings.

Teaching experiences

Oct 1996 - Feb 2000: Teaching assistant to Prof. L. Moro, M.D., Biochemistry Course, Master in Pharmaceutical Sciences, University of Trieste, Italy.

Oct 2000 - 2004: Lecturer in Chemistry, Master in Nursing Practice, University of Trieste, Italy.

June 16, 2014: National scientific qualification to function as associate professor in Biochemistry (05/E1) in Italian Universities.



From Oct 2014: Lecturer in Chemistry and Propaedeutic Biochemistry, Master in Sports Sciences, University of Udine, Italy.
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