XIV
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International Conference on Molecular Spectroscopy, Białka Tatrzańska 2017
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INVITED LECTURES
I–1 – Halina Abramczyk – Nanooncology: Raman imaging and atomic force microscopy as a
tool for proteomic, lipidomic, glycomic, epigenetic studies. The biochemical,
nanomechanical and chemometric signatures of brain, breast and colon cancers
I–2 – Tomasz Łojewski – Towards a new reference material for microfading spectrometry of
art objects
I–3 – Janusz Ryczkowski – IR photoacoustic spectroscopy – a tool for catalysts
characterization
I–4 – Francesco D’Amico – Synchrotron-based UV resonant Raman scattering experiments: a
powerful way to better investigate the structural conformation in bio-macromolecules
I–5 – Maciej Mazur – Hybrid colloidal particles
I–6 – Joanna Łojewska – Coupled AFM/Raman microscopic systems for analysis of solid
surfaces
I–7 – Agnieszka Kaczor – Raman imaging of endothelial cells – an insight into pathologies of
circulatory system in in vitro model studies
I–8 – Danuta Wróbel – Donor-acceptor systems of porphyrin-like chromophores with quantum
dot and fullerene
I–9 – Rodolphe Antoine – Fascinating linear and nonlinear optical properties of atomically
precise "molecular-like" metal nanoclusters
I–10 – Volodymyr Dzhagan – Strongly 2D-confined phonons and their overtones in colloidal
nanoplatelets
I–11 – Kouichi Nakagawa – X-band EPR imaging characterization of psoriasis vulgaris skin
I–12 – Evgeny Galuskin – New minerals as potential prototypes for advanced materials:
Raman investigation of hexagonal broken antiperovskite with a modular structure derived
from hatrurite
I–13 – Piotr Borowski – Solvent effects on the vibrational spectra of dioxane – theory vs.
experiment
I–14 – Maciej Kubicki – Different cationic forms of (-)cytisinium in the crystal structures of its
simple salts
I–15 – Zdzisław Latajka – Advanced theoretical modelling of selected model nanosystems
I–16 – Lukasz Kurpaska – Implementation of GIXRD analysis and nanoindenation technique
to study functional properties of materials – ODS case study
I–17 – Michał Malinowski – Multisite luminescence of rare earth ions doped Y4Al2O9 crystals
I–18 – Tatsuya Mori – Terahertz-band spectroscopy investigation of boson peak in glassy
glucose
I–19 – Joanna Pisarska – Rare earth-doped barium gallo-germanate glasses and their
luminescence properties
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International Conference on Molecular Spectroscopy, Białka Tatrzańska 2017
19
I–1
Nanooncology: Raman imaging and atomic force microscopy
as a tool for proteomic, lipidomic, glycomic, epigenetic studies.
The biochemical, nanomechanical and chemometric signatures of brain,
breast and colon cancers
Halina Abramczyk
1
, Monika Kopeć
1
, Beata Brożek-Płuska
1
, and Anna Imiela
1
1
Lodz University of Technology, Faculty of Chemistry, Institute of Applied Radiation Chemistry,
Laboratory of Laser Molecular Spectroscopy, Wroblewskiego 15, 93-590 Lodz, Poland,
e-mail: abramczy@mitr.p.lodz.plx
Many thousands of protein, lipid and glycan species exist and their metabolism is monitored
via numerous pathways, networks and methods. The metabolism can also change in response to
cellular environment alterations, such as development of a disease. Measuring such alterations
and understanding the pathways involved is crucial to fully understand cellular metabolism in
cancer development. Such demands have catalyzed the emergence of proteomics, lipidomics,
glycomics, epigenetics, which enables the large-scale biology studies using the principles of
analytical chemistry (Raman spectroscopy) and nanomechanics (atomic force microscopy),
largely due to their analytical power and nanomechanical information (cell and tissue stiffness,
adhesion), resolution, and rapid development of new instruments and techniques (Raman
imaging, SNOM, TERS, SERS). The biomechanical approach has been widely used in
biomedicine and greatly accelerated advances in the field.
This lecture provides an introduction to biochemical, nanomechanical and chemometric
signatures of cancers and describes some common, but important, cellular metabolic networks
that can aid our understanding of metabolic pathways. Some representative applications
performed in our laboratory for studying proteomic, lipidomic, glycomic, epigenetic alterations
in breast, brain, colon cancer are highlighted, as well as future applications for the use of Raman
microscopy and AFM in studying metabolic pathways [1–4].
Acknowledgment
This work was supported by the National Science Center of Poland (grant UMO-015/19/B/ST4/018780).
References
[1] B. Brozek-Płuska, M. Kopeć, H. Abramczyk, Anal. Methods 8(48) (2016) 8542.
[2] H. Abramczyk, J. Surmacki, M. Kopec, A.K. Olejnik, A. Kaufman-Szymczyk, K. Fabianowska-
Majewska, Analyst 141(19) (2016) 5646.
[3] H. Abramczyk, B. Brozek-Pluska, Anal. Chim. Acta 909 (2016) 91.
[4] H. Abramczyk, J. Surmacki, M. Kopeć, A. K. Olejnik, K. Lubecka-Pietruszewska, K. Fabianowska-
Majewska , Analyst 140(7) (2015) 2224.
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