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Module 1: Understanding Chronic Kidney Disease (ckd)Urine albumin results are used for screening, diagnosing, and treating CKD
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səhifə | 12/18 | tarix | 25.05.2022 | ölçüsü | 2,76 Mb. | | #87833 |
| Diet Module 1 2019Urine albumin results are used for screening, diagnosing, and treating CKD - Standard of diabetes care (annual screen)
- Diagnosis
- Forty percent of people are identified with CKD on the basis of urine albumin alone.
- Prognosis
- Important prognostic marker, especially in diabetes mellitus (DM)
- Tool for patient education and self-management (such as A1C or eGFR)
Damaged kidneys allow albumin to cross the filtration barrier into the urine - Increased glomerular permeability allows albumin and other proteins to cross the glomerulus into the urine.
- Higher levels of protein within the tubule may exacerbate kidney damage.
- Level of protein may exceed the tubules’ ability to reabsorb the proteins.
Risk Factors for Albuminuria | | - Transient increases
- may be due to:
| - Diabetes
- Hypertension
- Smoking
- Obesity
| - High sodium intake
- High protein intake
- Inflammation
| - Episodic hyperglycemia
- Exercise
- Fever
- Urinary tract infection
| - References: De Jong et al. Kidney International. 2004;66:2109–2118;
- Tuttle et al. Diabetes Care; 2014: 37:2864–2883
Use urine albumin-to-creatinine ratio (UACR) for urine albumin assessment - UACR uses a spot urine sample.
- In adults, ratio of urine albumin to creatinine in a spot specimen correlates closely to albumin excretion in 24 hours.
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- UACR < 30 mg/g is generally the cutoff for normal.
- Reference: http://nkdep.nih.gov/resources/quick-reference-uacr-gfr.shtml
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