Prediction of Parkinson’s Disease Tremor Onset Using Artificial Neural Networks
Road Map Parkinson’s Disease (PD) and Treatments Deep Brain Stimulation (DBS) Treatment on PD Tremor PD Brain Data Analysis Artificial Neural Network Prediction
Parkinson’s Disease What is Parkinson's Disease (PD)? Symptoms of Parkinson’s Disease How is PD caused in theory - Substantia nigra
- Dopamine
Current PD Treatment Drugs – Various forms of Levodopa (L-dopa) - Advantage – effective for early PD patients, cheap
- Disadvantage – kyskinesias, unpredictable on-off switching and freezing, chemical side effects.
Surgical
PD Patient’s Brain Data Gathering
Road Map Parkinson’s Disease (PD) and Treatments Deep Brain Stimulation (DBS) Treatment on PD Tremor PD Brain Data Analysis Artificial Neural Networks Prediction Future Research
What is Deep Brain Stimulation? Electrode, a connecting cable and Neurostimulator Video (Dana Centre)
Research Project
Road Map Parkinson’s Disease (PD) and Treatments Deep Brain Stimulation (DBS) Treatment on PD Tremor PD Brain Data Analysis Artificial Neural Networks Prediction Future Research
PD Patients Brain Data Plot
Frequency Domain Analysis
Road Map Parkinson’s Disease (PD) and Treatments Deep Brain Stimulation (DBS) Treatment on PD Tremor PD Brain Data Analysis Artificial Neural Networks Prediction Future Research
MLP Results
Road Map Parkinson’s Disease (PD) and Treatments Deep Brain Stimulation (DBS) Treatment on PD Tremor PD Brain Data Analysis Artificial Neural Networks Prediction Comments & Future Research
Comments Aim is to accurately predict tremors and then apply stimulation in order to stop them occurring Needs research into nature of stimulation – frequency/magnitude/time prior for effect/generality with different people Doesn’t matter so much if false positive predictions Does matter if false negatives
More Comments Every PD case is a little bit different Not everyone can benefit from stimulation Probably not everyone will benefit from our prediction + stimulation (subset) Hybrid methods probably best Neural net good for nonlinearities though
Future Research More Tests on resting data – no false calls Test on a broader range of patients to assess general results with our current MLP (male, female, age difference) Test on other problems (Epilepsy/Tourette’s/Emotional) Apply feedback loop (MRC project)
Surprise Biggest shock has been the prediction time 15/20 seconds seems typical But this means we know for sure what will happen in the human brain 15/20 seconds before it happens How long could this time be? What else could we predict this way?
Other Points Developing here an AI brain within the human brain Use for other diseases – not just PD Could be used for emotional changes/control Ethical concerns: What should predictor/stimulator be used for in humans? What about responsibility/murders etc?
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