Space vehicle Years 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025
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| BION-M2: Scientific program 2 Space vehicle Years 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 «BION-M» №2 «BION-М» №3 Flight – 30 days Н=800-1000 km Н=550 km «Vozvrat-MKA» №1 Flight – 30-45 days Н=1000-200000 km - Preparation - Lunch - Landing Space Biology, Medicine and Biotechnology Research: Russian Unmanned Spaceflights Scheduled for 2016 - 2025 - Flight №2 №3 №1 BION-M No. 2 Project Beginning of funding – 2015 Planned launch date– 2022 Flight duration– 30 days Orbital height– 800-1000 km The hardware will be analogous to BION-M1, but it will be modified based on the results of flight tests. Bioobjects –C57BL/6 mice, insects, plants, cell cultures, microorganisms Main task: Comprehensive study of combined biological impact of increased space radiation levels and weightlessness on organism and its separate functional systems at te cellular and molecular levels. 37 Technical Specifications for space experiments aboard BION-M2 from 23 RAS institutes, universities, and other research institutions submitted to the Interagency committee: 1. Institute of Biomedical Problems of RAS 2. Federal Research Center – Institute of Cytology of RAS 3. FSBRI – Institute of Fundamental Problems of Biology of RAS 4. FSBRI – Institute of Physicochemical and Biological Problems of Soil Science of RAS 5. FSBRI – Institute of Systems of Image Processing of RAS 6. FSBRI – Institute of Crystallography of RAS 7. FSBRI – Institute of Solid State Physics of RAS 8. Orenburg Research Center of Ural Branch of RAS 9. FSUE Special Design Bureau of the Institute of Radiotechnique and electronics of RAS 10. Biological Department of Lomonosov Moscow State University 11. State Research Institute of Genetics and Selection of Industrial Microorganisms 12. The All-Russian Research Institute for Optical and Physical Measurements Federal State Unitary Enterprise 13. Space Rocket Center “Progress” 14. Laboratory of Radiation Biology in Joint Institute for Nuclear Research ; 15. Tuscia University, Italy 16. Sapienza — Università di Roma, Italy 17. FSUE Branch - Center for Operation of Ground-based Space Infrastructure – Research Institute of Launch Facility 18. FSBRI Perm State National Research University 19. Institute of Space Instrument Engineering of the Korolev’s Samara State Aerospace University 20. Samara State Medical University of Health Ministry 21. FSUE “Samara Regional Center of Planned Parenthood and Reproduction” 22. Samara State University 23. FSBRI – Samara Research Institute of Agriculture After review of the TS-SE: 27 + 3* ) experiments and investigations have been included into the BION-M2 flight tests program,
) ) and investigations have been included conditionally, and 4 experiments have been rejected. The experiments and investigations during flight tests of BION-M No. 2 SV will be conducted in the following fields: 1. Experiments with animals - 3 2. Experiments with animals cell cultures 3. Experiments with plants, plant cells cultures, seeds, and algae – 6 4. Experiments with microorganisms – 4 5. Exobiological and astrobiological experiments – 4+1* 6. Radiobiological experiments and radiation studies – 1 7. Biotechnological experiments – 2 8. Investigations and experiments on space materials science 1+1* 9. Physical and technical experiments – 4+1* 10. Educational experiments – the program will be formed based on the applications from educational institutions at the finals stages of SV preparation. Note: * )
into the preliminary list of SH, approved by the RAS Space Board on 03.12.2014 Experiments with animals 1. SE «Study of С57BL/6 mice during flight of the BION-M No. 2 space vehicle”, Code «MLZh-02». Principle Investigator: Doctor of Biological Sciences, Prof. Olga Vinogradova. Leading institution: Institute of Biomedical Problems of RAS
2. SE «Study of С57BL/6 mice during flight of the BION-M No. 2 space vehicle”, Code «MLZh-02-02». Principle Investigator: Doctor of Biological Sciences, Prof. Olga Vinogradova. Leading institution: Institute of Biomedical Problems of RAS
C57Bl/6 mice (n=75) Males Females Food type Paste
68% water (n=60)
Dry + water
(n=15) Hardware Bios-02 Significantly Modified Bios-01 Bios-02-02 Re-designed habitats suitable for centrifugation Areas of research: • CNS & sensory system • Muscles • Bones • Fluid-electrolyte
• Cardiovascular system • Gender differences
Group formation Surgeries Tests
Animal selection Orbital flight Metabolism, BP & HR, behavior monitoring Animal in vivo examinations and tissue investigations 1 hr, 12 hr, 5 & 15 days after recovery Group formation Surgeries Tests
Animal selection Group formation Surgeries Tests
Animal selection Simulated flight Metabolism, BP & HR, behavior monitoring Animal in vivo examinations and tissue investigations 1 hr, 12 hr, 5 & 15 days after recovery
Metabolism, BP & HR, behavior monitoring Animal in vivo examinations and tissue investigations 1 hr, 12 hr, 5 & 15 days after recovery
List of foreign participants of the BION-M2 project submitted their proposals Country Institution Financing institution USA NASA NASA JSC NASA ARC NASA US universities (will be determined after selection process organized by NASA till 30 September 2017) Applications have been submitted by: Berkeley University (California) Washington University (Washington) California University(San Francisco) California University (San Diego) Minnesota University (Minneapolis) Stanford University (California) Florida University List of foreign participants of the BION-M2 project submitted their proposals France CNES Cannes University Montpellier University Lille University Angers University Marcel University CNES Italy Genoa University Rome University Padua University Bari University ASI Germany Otto-von Guericke-University Magdeburg DLR Kazakhstan Institute of Human and Animal Physiology Ministry of Education and Science Malaysia Department of Technologies and Innovations of Angkasa Agensi Angkasa Negara China Center of Space Life Science & Life Support Technology, School of Biological Science and Medical Engineering Ministry of Education and Science Country Institution Financing institution 3. SE «Search of potential mechanosensors of Drosophila melanogaster cells exposed to the conditions of BION-M No. 2 space flight, code «MSKD». Principle Investigator : Doctor of Physico-mathematical Sciences Irina Ogneva. Leading Institution: Institute of Biomedical Problems of RAS Aim: search of candidates to the role of target proteins which are potential mechanosensors in Drosophila melanogaster cells exposed to the conditions of BION-M No. 2 space flight. Experiments with animals 1. SE «Study of SF factors effect on morpho-functional state, proliferative and developmental potential of hematopoietic stem cells», code – «MULTIINCUBATOR». Principle Investigator : MD, Prof. I. Davydkin. Leading institutions: Samara State Medical University of Health Ministry; FSUE “Samara Regional Center of Planned Parenthood and Reproduction”; Samara State University
2. SE «Study of SF factors effect on transcriptome of human mesenchymal stromal cells”, code «TRANSCRIPTOME MSK». Principle Investigator : RAS Corresponding Member L. Buravkova. Leading institutions: Institute of Biomedical Problems of RAS Samara State University
1. SE «Study of SF factors influence on higher plants which are used in medical and pharmaceutical practice” (by the example of Calendula officinalis L. and Echinacea Purpurea), code – «PHYTO-2». Principle Investigator : Doctor of Pharmaceutical Sciences Prof. V. Kurkin. Leading Institution: Samara State Medical University of Health Ministry. Aim: assessment of the effect of combination of SF factors on anatomic- morphofunctional parameters and chemical composition of medical plants in ontogenesis (by the example of Calendula officinalis L. and Echinacea Purpurea). 2. SE «Study of the dynamics of phototropic reactions of higher plants bines, by the example of Physcomitrella patens (Hedw.) B.S.G.moss, under the influence of light stimulus in different areas of light spectrum in microgravity”, code - «GRAVISENSOR-3». Principle Investigator : Doctor of Technical Sciences, Prof. Yury Berkovich. Leading institutions: Institute of Biomedical Problems of RAS; Biological Department of Lomonosov Moscow State University Aim: study of the dynamics of phototropic reactions of Physcomitrella patens (Hedw.) B.S.G. moss bines under the impact of light stimulus in different areas of light spectrum in microgravity. Experiments with plants, plant cell cultures, seeds, and algae 3. SE “Study of SF factors effect on physiology, biochemistry, and genetics of plant cells and tissues of food-significant agricultural plants” , code «GENETIKA-2». Principle Investigator : Candidate of Agricultural Sciences A. Milyokhin Leading institute: FSBRI – Samara Research Institute of Agriculture
4. SE «Assessment of the SF factors influence on the seeds obtained from rare plants of natural flora cultivated from the seeds exposed on board BION-M No. 1 and FOTON-M No. 4”– «FLORA-BS2». Principle Investigator : Doctor of biological sciences Prof. L. Kavelenova. Leading Institute: Samara State University
5. SE «Study of space flight factors influence on genetic, morphobiological, and biochemical signs and characteristics of cell culture of Rhodiola rosea L. rootstock”, code – “RHODIOLA”. Principle Investigator: Candidate of Agricultural Sciences A. Milyokhin Leading institutions : FSBRI – Samara Research Institute of Agriculture; Samara State Medical University of Health Ministry Aim: Study of the spaceflight factors impact on the pattern and dynamics of resynthesis substance accumulation by various strains of cellular biomass of roseroot (Rhodiola rosea L.) rootstock that represent interest for pharmaceutical industry, and also to receive in cells positive genetically fixed mutations and develop new effective genetically stable strains and their further use in modern pharmaceutical drugs and nutritive bioactive additives for humans and animals 6. SE “Study of peculiarities of the growth and genetic-morphological changes in algae cells in space flight”, code “VOZROZHDENIYE”. Principle Investigator: Doctor of Biological Sciences Prof. A. Kurakov Leading institute: Biological Department of Lomonosov Moscow State University Aim: study of peculiarities of the growth and genetic-morphological changes in algae cells in space flight conditions for the benefit of fundamental botanic, and creation of biosensors on the basis of cells for control of ecological quality of aquatic habitats, also in space greenhouses. Experiments with plants, plant cells cultures, seeds, and algae 1. SE «Study of space flight factors influence on morphobiological characteristics and properties of fungi of soil rhizosphere Trichoderma viride and Trichoderma harzianum», code–
«BIOMICROBE». Principle Investigator: Candidate of Agricultural Sciences A. Milyokhin Leading institute: FSBRI – Samara Research Institute of Agriculture. Aim: study of SF factors influence on genetics, physiology, and morphology of fungi of soil rhizosphere Trichoderma viride and Trichoderma harzianum and further creation on its basis of highly productive biological products of new generation for the use in agricultural sector of Russian Federation. 2. SE «Study of space flight factors influence on life activity of microorganisms of different classes”, code «BIOCOSM». Principle Investigator: Doctor of Medical Sciences Prof V. Ilyin Leading institutions: Institute of Biomedical Problems of RAS; Biological Department of Lomonosov Moscow State University Biological Department of Lomonosov Moscow State University State Research Institute of Genetics and Selection of Industrial Microorganisms
3. SE «Study of space flight factors influence on interaction between microorganisms and non- metallic materials», code: «VZAIMODEYSTVIYE». Principle Investigator: Doctor of Biological Sciences N. Novikova Leading institute: Institute of Biomedical Problems of RAS;
4. SE «Study of the effects of SF factors influence on bioprofiles of enterobacteria and staphylococci», code: «ENDOFLORA-2».0 Principle Investigator: Doctor of Medical Sciences Prof. A. Zhestkov Leading institutions: Samara State Medical University of Health Ministry Samara State Medical University of Health Ministry Samara State University Aim: study of SF factors influence on bioprofiles of enterobacteria and staphylococci, typical representatives of human microbiota, also in the conditions of simultaneous cultivation. Experiments with microorganisms 1. SE «Study of a possibility of bioobjects surviving in mineral section of imitator of meteorite while it is passing dense
atmosphere with accompanying heating and melting», code «METEORITE». Principle Investigator: Doctor of Medical Sciences Prof V. Ilyin Leading institutions: Institute of Biomedical Problems of RAS; Biological Department of Lomonosov Moscow State University.
2. SE «Study of combined impacts of SF factors and minerals of exterrestrial origin on the synthesis and resistance of bioorganic molecules”, code “EXOBIOLOGIYA” Principle Investigator: Doctor of Biological Sciences E. Kuzicheva Leading Institute: Federal Research Center – Institute of Cytology of RAS Purpose of the experiment – study of the effects of combined impact of SF factors and mineral bases on the process of abiogenic synthesis of bioorganic compounds - polypeptides and nucleotides. 3. SE «Reaction of permafrost microorganisms to the impact of SF factors”, code “EXOBIOFROST”. Principle Investigator Candidate of Biomedical Sciences E. Rivkina Leading institute: FSBRI – Institute of Physicochemical and Biological Problems of Soil Science of RAS
4. SE «Study of SF factors impact on bioprofiles of lichen and micromycete”, code “EXOMIKOLOGIYA”. Principle Investigator: Doctor of Biological Sciences A. Kurakov Leading institute: Biological department of Lomonosov Moscow State University
5*. SE «Study of a possibility of synthesis of prebiotic compounds from mixture “formamidemete + meteoritic material” under the open space conditions during BION-M No. 2 space flight”, code “ASTROBIO”. PIs: RAS academician A. Rozanov, Prof. R. Saladino, Prof. E. Di Mauro Leading institutions: Laboratory of Radiation Biology in Joint Institute for Nuclear Research; Tuscia University, Italy Sapienza — Università di Roma, Italy
1. SE «Study of SF factors impacts on the processes of microbial utilization of organic substrates”, code «BIOUTILIZATSIYA». Principle Investigator: Doctor of Medical Sciences Prof V. Ilyin Leading institution: Institute of Biomedical Problems of RAS.
2. SE «Study of the SF factors impact on electric-chemical characteristics of microbial fuel element», code «MTE-2». Principle Investigator: Candidate of Chemical Sciences I. Smirnov Leading institution: Institute of Biomedical Problems of RAS. Purpose of the experiment – study of the effect of the factors of space flight in high orbit SV on electrical-chemical characteristics of newly developed scientific hardware – microbial fuel element with electrodes based on capillary-porous materials, and on the changes in specific and quantitative composition of microbial association Biotechnological experiments 1. SE «Growing of protein crystals by the methods of liquid and gas diffusion on board BION-M No. 2 SV inside BELKA-2 scientific hardware”, code “BELKA-2”. Principle Investigator: Doctor of Physico-mathematical Sciences A. Voloshin Leading institutions: FSBRI – Institute of Crystallography of RAS National Research Center «Kurchatov’s Institute»; FSUE Branch - Center for Operation of Ground-based Space Infrastructure – Research Institute of Launch Facility
Purposes of the experiment: • To study the SF conditions impact on the process of protein crystals growing by means of different methods; • To grow in SF conditions the crystals of high structural perfection of practically useful protein compounds, which crystallization is not possible or hardly possible in laboratory conditions on the Earth. 1*. SE
«Growing of biocrystals with active control of crystallization process, and determination of incubation period crystal nucleation in space flight conditions on board BION-M No. 2 SV, code «CRYSTAL-M». Principle Investigator: Doctor of Technical Sciences B. Zakharov Leading institutions: FSUE Special Design Bureau of the Institute of Radiotechnique and electronics of RAS FSBRI – Institute of Crystallography of RAS
1. SE «Study of biologically significant characteristics of space ionizing radiation on board BION-M No. 2 SV”, code «BIORADIATSIYA-2». Principle Investigator: Candidate of
Leading institute: Institute of Biomedical Problems of RAS
1. SE «Control of the state and compensation of micro-accelerations on board the BION-M No. 2 SV by KSKM-2 hardware/software means”, code «KSKM-2». Principle Investigator : Candidate of Technical Sciences N. Stratilatov Leading institution: Space Rocket Center “Progress”
2. SE «Monitoring of the state of the gas environment parameters, acceleration field, and kinematic parameters of moving inside the descent module BION-M No. 2 SV”, code
«MONITOR-SA». Principle Investigator : Candidate of Technical Sciences N. Stratilatov Leading institution: Space Rocket Center “Progress” Purpose of the experiment - Monitoring of the state of the gas environment parameters, acceleration field, and kinematic parameters of moving inside the descent module BION- M No. 2 SV during operations of ground preparation of the SV as a part of carrier rocket, launch of carrier rocket, and insertion of SV to the orbit, work out of deceleration pulse, descent of SV to the Earth and landing . Physical and technical experiments 3. SE «Study of the impacts of the factors of open space on thin-film instrumental structures”, code – «CARBON-2». Principle Investigator: Doctor of Technical Sciences Prof. Yu. Gorelov Leading institutions: Samara State University; FSBRI – Institute of Systems of Image Processing of RAS Purpose of the experiment – study of the impacts of open space factors on electro-physical and optical characteristics of engineering models of thin-film instrumental structures, and also on electro-physical and optical characteristics of engineering models of diffraction structures based on quartz, chrome film, and resist. 4. SE «Multichannel recorder of temperatures in the containers with scientific hardware on the external surface of space vehicle” , code – «MRT-2». Principle Investigator: Doctor of Technical Sciences Prof. Yu. Gorelov Leading Institution: Samara State University. Purpose of the experiment – registration of temperatures of the scientific hardware elements allocated in the containers with scientific hardware under open space conditions on the external surface of space vehicle (descent module). Physical and technical experiments 5*. SE «Study of the prototype of high-stable board source of IR light based on the phase transfer of eutectic alloy indium – bismuth in space flight conditions”, code «CALIBR-2». Principle Investigator: Doctor of Technical Sciences Prof. V. Sapritskiy. Leading institution: The All-Russian Research Institute for Optical and Physical Measurements Federal State Unitary Enterprise Purpose of the experiment – Study of the phase transfer of melting-crystallization of eutectic alloy In-Bi with simultaneous testing of the prototype of on-board black body based on the phase transfer of melting In-Bi as a perspective high-stable source of IR light for on- board calibration of the hardware for Earth observation under conditions closed to weightlessness (microgravity). Physical and technical experiments Thank you for your attention! Yüklə 102,71 Kb. Dostları ilə paylaş:
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