Syllabus relating

Title of the Course Pharmaceutical & Medicinal Chemistry-III

Marks 50

Number of Hours per week 2

Total Hours 30

Class T.Y. B.Pharm.

Semester V

Sr.No Topic Hrs.

1. Basics principles of medicinal chemistry:

a) Physicochemical properties of drug molecules like aqueous solubility, log

P, pKa and their relation to drug transport.

b) Functional group and their effects of on drug action, concept of isosterism,

bioisosterism, homologs and analogs.

c) Steric properties of drugs- enantiomers and diastereomers, geometrical

isomerism etc.

d) Drug metabolism principles- Phase I and Phase II.

e) Drug receptor interaction

3

3

2

4

2

Study of the following classes of drugs with respect to their classification, chemical nomenclature,

structure including stereochemistry, generic names, chemistry, physicochemical properties, SAR,

metabolism, molecular mechanism of action and synthesis and introduction to rational development,

if any.

2 a) Non Steroidal Anti-inflammatory Agents:

i) Antipyretic analgesics

ii) Salicylates

iii) Aryl alkanoic acids

iv) N-aryl anthranillic acids

v) Oxicams

vi) Selective COX-2 inhibiotrs

b) Antihistaminic agents:

i) H1 antagonists- Classical antagonists & Non-sedative H1

antagonists

c) Antiulcer agents:

ii) H2 antagonists

iii) Proton Pump inhibitors

iv) Others

1

1

3

1

1

1

4

1

1

1

49

Books Recommended: As under Pharmaceutical Medicinal Chemistry-II

Title of the Course Pharmaceutical Analysis-III

Marks 50

Number of Hours per week 2

Total Hours 30

Class T.Y. B.Pharm.

Semester V

Sr.

No.

Topic Hrs.

1. Solvent extraction-basic principles, classification, mechanism of extraction,

equilibria, techniques and applications,

4

2. Absorption spectroscopy: Introduction to interaction between electromagnetic –

radiation and matter ,absorption of radiation by molecules, quantitative uses of

absorption spectroscopy – Beer and Lambert’s law and its derivation, limitation.

Application of Beer’s law to single component analysis and multi component

systems, measurement of equilibrium constant and rate constants by spectroscopy,

6

3. Molecular structure and electronic spectra – theory of electronic transitions and

electronic spectra, spectra of isolated chromophores –auxochromes, bathochronic

shifts and hyposochromic shift; Hyperchromisms and hypochromism, conjugated

chromophores and aromatic molecules; Effect of solvent on absorption spectra;

2

4. Molecular structure and infra red spectra, vibrational transition, frequency –

structure correlations, various regions of IR bands – hydrogen stretching, C-C

stretching, C=C stretching and bending effect of hydrogen bonding: Measurement

of absorption spectra;

3

5. Instrumentation- discussions of light sources, frequency selector, intensity control,

detectors, samples preparation, ray diagrams of typical UV-Visible (double beam)

and I.R. spectrophotometers;

5

6. Fluorescence Spectroscopy; Theory of fluorescence phenomenon – origin of

fluorescence and phosphorescence multiplicities, singlet and triplet states;

Excitation and fluorescence spectra; Molecular structure and fluorescents;

Quantitative fluorescence analysis; Practical fluorescence analysis, Application of

fluorescence analysis to drug; Instrumentation;

4

7. Refractometry; theory, instrumentation and application. 3

8. Polarimetry. theory, instrumentation and application. 3

Books Recommended: As under Pharmaceutical Analysis –II and additional as follows

Sr.No Title Of The Book Author/Editor Edition/Year Publisher

1 Pharmaceutical

Analysis-

Higuchi &

Brochmann- Hanssen-

1961 Interscience

2 Analytical Profiles Of

Drug Substances

Florey- 1990 Academic Press

3 Instrumental Methods

Of Analysis

Willard, Dean, Merrit

And Settle-

6th , 1986 Wadsworth

Pub. Co.

50

4 Pharmaceutical Drug

Analysis

Ashutosh Kar. 2001

5 Calculation Of

Analytical Chemistry

Hamilton, Simpson

And Ellis-

5th , 1954 McGraw Hill

Title of the Course Pharmaceutical Management-II

Marks 50

Number of Hours per Week 2

Total Hours 30

Class T.Y. B. Pharm.

Semester V

Sr.

No.

Topic Hrs.

1 Sales & Marketing Management: Marketing Management Concepts, behavior of

doctors, retailers and customers; Marketing research;

5

2 Advertising and sales promotion; Pricing; Distribution; Selling; Sales management;

Retail management; Product management;

5

3 Legal frame work of industry; Budges; Human resource planning & audit; New

product management;

5

4 Sales forecasting; Medium planning; Budgeting; Operations management: Production

planning & control systems; Materials management systems; Quality management

systems; Financial planning and control systems; Inventory & third party

10

5 money management; Labour laws; Project Management. Taxation; Direct taxes -

Income tax, corporate tax; Indirect taxes -excise duty, sales tax and octroi;.

5

Books Recommended: Will be recommended by teacher.

Title of the course Cosmetics

Marks 50

Number of hours per week 2

Total hours 30

Class T.Y. B.Pharm.

Semester V

Sr.No. Topic Hrs.

1. Definition of cosmetics; historical background, classification of cosmetics and

primary functions

1

2. Structure of skin, hair, nails, tooth and skin appendages and interactions with

cosmetics

2

3. Microbial contamination in cosmetics; Perfumes, colours and other raw material

used in cosmetics- a brief review

2

4. Toxicology of cosmetics- irritation and sensitization reactions to cosmetics, tests to

predict such reactions

2

5. Study of following Skin cosmetics with respect to raw materials, formulations, 5

51

processing equipment and quality control: skin creams and lotions- cold creams,

vanishing creams, bleach creams, acne creams, hand and body creams and lotions

(barrier preparations), emollient creams, sunscreen products- sun tan and anti

sunburn products, insect repellants, face powder, lipstick, rouge, face packscleansing

preparations- moisturizers, bath oils

6. Study of following Hair care cosmetics with respect to raw materials,

formulations, processing equipment and quality control: shampoos, women’s hair

dressings, men’s hair dressings, hair tonics, hair conditioners, hair rinses, hair

colorants, hair waving and straightening preparations, depilatories, shaving

preparations and aids (after shave solution/ lotion/ cream), anti-lice preparations;

5

7. Study of following Nail products with respect to raw materials, formulations,

processing equipment and quality control: pedicure and manicure preparations (nail

polish, nail paint removers, cuticle removers, nail whiteners etc);

4

8. Study of following Dental care products with respect to raw materials,

formulations, processing equipment and quality control: toothpaste, tooth powder,

mouth washes and denture cleansers;

2

9. Study of following Eye makeup products with respect to raw materials,

formulations, processing equipment and quality control: eye shadow, eye liner,

mascara etc

2

10. Baby cosmetics; 1

11. Herbal cosmetics 2

12. Schedule S of Drug and Cosmetics Act in relation to cosmetic manufacture- hygiene

pollution control-ecological concern.

2

Book Recommended

Sr.No Title Author/Editor Edition Publisher

1 Harry’s Cosmeticology Rieger 8th, 2000 Leonard Hill Book &

Intertext Publisher,London

2 Cosmetic Science(Vol 2) M.M. Breuer 1978 Academic Press, London

3 Cosmetics:Formulation,Manufac

turing & Quality Control

P.P. Sharma 1998 Vandana Publications,

New Delhi

4 A Formulary Of Cosmetic

Preparations

Michael &

Irene Ash

1st ,

1977

George Godwin Ltd.,London

5 Drugs & Cosmetics Act 1940 Vijay Malik 16th

1997

Eastern Book Company

52

Title of the Course Molecular Biology & Biotechnology

Marks 50

Number of Hours per Week 2

Total Hours 30

Class T.Y. B. Pharm

Semester V

Sr. No Topic Hrs.

1 Nucleic acids: Definition of DNA and RNA, nitrogenous bases, nucleosides,

nucleotides, structure of DNA, shorthand notation of DNA polymers, melting and

annealing of DNA, brief introduction to semiconservative replication and

information flow via mRNA to proteins. Types of RNA-mRNA, tRNA and rRNA –

their structure and their biological role.

8

2 Solid phase DNA synthesis, DNA sequencing (Maxim-Gilbert method, Sanger

dideoxy method and automation of DNA sequencing)

2

3 DNA replication: Conceptual introduction to DNA replication. Conceptual

explanation of replication of circular and linear chromosomes. Error correction

during DNA replication. Examples of drugs that are used due to role in interaction

with DNA or interfering with DNA replication.

4

4 Protein Biosynthesis: Conceptual introduction to DNA transcription and RNA

translation, differences between prokaryote and eukaryotes, concepts of introns and

exons and intron splicing, concept of posttranslational modifications (examples of

gylcosylated proteins, conjugated proteins, insulin). Examples of protein synthesis

inhibitors used and drugs.

8

5 Recombinant DNA technology: Introduction to the concept, introduction to

prokaryotic and eukaryotic cell systems and their DNA organization, plasmids,

restriction enzymes, methods to prepare rDNA molecules (plasmids and phages),

methods for introduction of DNA into cells, selection methods. Differences

between cloning and expression. Properties of cloning and expression vectors &

cloning and expression systems. Examples of production of insulin and human

growth hormone.

8

Books Recommended: As recommended by the Teacher

Title of the Course Assignments (Biochemistry)

Marks 50

Number of Hours per week 2

Total Hours 30

Class T. Y. B.Pharm.

Semester V

Sr.No Topic

1. There will be several problem solving sessions where there will be discussions on

methodology and approaches to solve problems including discussions on how to gather

information from internet and literature. The problems will be given to the students as home

assignments where students can go through the literature and come out with solutions and

53

present it in the class. There shall be many assignments. No assignment shall be of more than

10 marks. The student shall submit the assignment in A4 size paper either hand written or

typed and pinned together. Marks will be awarded by the teacher and at the end of the

semester teacher will submit the marks along with the assignment copies of all the students

to the office.

Laboratory

Title of the Course Computer Applications in Pharmacy

Marks 50

Number of Hours per Week 4

Total Hours 60

Class T.Y B.Pharm

Semester V

Sr.No. Experiment Hrs.

1 Application of mathematical and statistical packages like (R, Mupad, MatLab, Excel

etc) Basic

15

2 Applications in Pharmacy of the packages and others 15

Title of the course Pharmacology Laboratory-I

Marks 50

Number of hours per week 4

Total hours 60

Class T.Y. B.Pharm

Semester V

Sr. No. Experiments Hrs.

1 Studies of commonly used instruments, common and standard technique used and

animal handling in experimental pharmacology.

4

2 Study of different routes of administration of drugs in mice/rats.[DEMO]

4

3 Effect of autonomic drugs on rabbit’s eye. [DEMO] 4

4 Effect of various agonists and antagonists and their characterization using suitable

isolated preparations.

48

54

Books Recommended

Sr. No. Title of the book Author/Editor Edition/Year Publisher

1 Hand Book of

Experimental

Pharmacology,

Kulkarni S.K., 3rd 1999 Vallabh Prakashan, New

Delhi

2 Practicals in

Pharmacology

R.K.Goyal, 6th, 2006-

2007

B.S.Shah

Prakashan, Ahmedabad

3 Selected Topics in

Experimental

Pharmacology

U.K.Seth,

N.K.Dadkar, Usha

G.Kamat,

1st 1972 Kothari Book Depot

Mumbai

4 Fundamentals of

Experimental

Pharmacology

Ghosh M.N.

3rd 2005 Hilton and Co, Kolkata

Title of the course Cosmeticology Laboratory

Marks 50

Number of hours per week 4

Total hours 60

Class T.Y. B.Pharm

Semester V

Sr.No. Experiment

1 At least one representative example of each formulation type included in theory

Books Recommended : As recommended by teacher

Title of the Course Molecular Biology & Biotechnology Laboratory

Marks 50

Number of Hours per Week 4

Total Hours 60

Class T.Y B.Pharm

Semester V

Sr.No. Experiment Hrs

1 Sterility testing

Aqueous and oily injectables, Powders, Eye drops and Ointments

8

2 Microbial assay of antibiotics 4

3 Microbial Limit test on Starch, gelatin, talc and lactose of pharmaceutical grade. 4

4 Special Biochemical Tests: Sugar fermentation, hydrolysis of gelatin, starch and

urea, Nitrate reduction, Coagulase test, Oxidase test, Catalase test, IMIVC test

8

5 Observation of Pathogens on Selective media: McConkey, Vogel- Johnson, and

Cetrimide agar.

4

55

6 Air and Water analysis 8

7 Demonstrations:

Alcohol production by Yeast

Lactic acid fermentation in milk

Widal test

4

4

4

8 Enzyme Production

Ammonium Sulphate Precipitation

Demonstrations:

Immobilization of enzymes

Electrophoresis

Isolation and Extraction of DNA & RNA.

12

Books Recommended: As recommended by Teacher

T.Y. B.Pharm.

SEMESTER VI

Title of the course Pharmaceutics-V

Marks 50

Number of hours per week 2

Total hours 30

Class T.Y. B.Pharm

Semester VI

Sr.No. Topic Hrs.

1. Tablet Coating: Need, advantages, types 1

2. Sugar coating: Method, advantages, coating formulation, problems 2

3. Film coating : Polymers for coating, properties and selection, Coating

formulation development, Evaluation of free films, enteric and non enteric film

coating

3

4. Equipment for sugar and film coating: Coating pan, Modified coating pans, Fluid

bed coating, spray systems,

4

5. Quality control of coated tablets: Enteric and non enteric 2

6. Problems in coating, Introduction to Aqueous coating 2

7. Microencapsulation: Introduction, advantages, applications in dosage forms 1

8. Methods of microencapsulation: Physical, Physicochemical and chemical, Phase

separation coacervation, Mutiorifice centrifugal process, spray drying and

congealing, orifice methods, polymerization techniques

4

9. Formulation of microcapsules into dosage forms and evaluation of microcapsules

and dosage forms.

1

10.: Stability testing: Accelerated stability testing and shelf life determination using

Arrhenius equation, determination of overages, Degradation kinetics from dosage

4

56

Books Recommended: As under Pharmaceutics-II and in addition the following

Sr.No. Title Author/Editor Edition/Year Publisher

3 Microencapsulation &

Related Drug Processes

Patrick B.Deasy 1984 Marcel Dekker Inc.

4 Microcapsule

Processing &

Technology

Asaji Kondo 1st , 1979 Marcel Dekker Inc.

5 Treatise On Controlled

Drug Delivery

Kydonieus ,Agis 1978 Marcel Dekker Inc.

6 Controlled Drug

Delivery:Fundamentals

& Applications

Joseph

R.Robinson,

Vincent H.Lee

2nd, 1987 Marcel Dekker Inc.

Title of the course Pharmacology - III

Marks 50

Number of hours per week 2

Total hours 30

Class T.Y.B.Pharm.

Semester VI

Sr. No. Topic Hrs.

1 Drugs acting on CNS:

Alcohol: Ethanol, Methanol, Disulfiram

General Anaesthetics: History, classification, stages of anaesthesia,

preanaesthetic medicine, Basal anaesthetic agents, Neuroleptanalgesia, Latest

agents: Sedative, hypnotics, anxiolytics. Anticonvulsants; Antidepressants;

Antiparkinsonism. CNS stimulant, Opiod analgesics/NSAIDS.Centrally acting

muscle relaxants

18

2 Drugs acting on ANS: Cholinergic, anticholinergic agents

Adrenergic, adrenergic blocking agents

Drugs acting on NMJ; Ganglion Blockers/stimulators

12

Books Recommended: Same as under Pharmacology-II

forms,

11. Routes of degradation((physical, chemical and microbiological) 2

12. Factors affecting stability and methods of stabilization, interactions with

containers and closures

3

13. Introduction to ICH guidelines 1

57

Title of the Course Pharmacognosy - I

Marks 50

Number of Hours per Week 2

Total Hours 30

Class T.Y. B. Pharm.

Semester VI

Sr.No Topic Hrs.

1 General Pharmacognosy: Definition, history, indigenous systems of medicine. Source

of drugs, organized drugs and unorganized drugs

2

2 Scope of Pharmacognosy: Origin, geographical source & habitat, history, cultivation,

pest control, preparation for market, identification, chemical constituents, uses, allied

drugs, substitutes, adulterants

4

3 Plant growth regulators : 1

4 Cell cultures as source of drugs 1

5 Classification of crude drugs: Alphabetical, biological, morphological,

pharmacological, chemical, chemo-taxonomical

2

6 Standardization of drugs of natural origin: Organoleptic, microscopic, macroscopic,

biological, chemical, spectral, and physical methods. Application of chromatographic

techniques in evaluation of herbal drugs. Evaluation of crude drugs, extracts and

phytoconstituents

3

7 Plant description, morphology, cell differentiation and ergastic cell contents: Study

of plant parts, cell and tissue, underground or subterranean drugs, roots, rhizomes,

corms, bulb, tubers, stolen, runners, and suckers; Leaves: Simple and compound,

stomata, stomata number, stomatal index, palisade - ratio, hydathodes and water pores,

epidermal trichomes, calcium oxalate crystals, vein-islet number, vein termination

number; Inflorescence and flowers; Fruits; Seeds; Barks, and wood.

4

8 Unorganised drugs: Dried latex, dried juices, dried extracts, gums and mucilages,

resins.

1

9 Phytochemistry: General properties, structures, classification, methods of extraction,

etc. of Carbohydrates, proteins, enzymes, lipids, volatile oils, glycosides (anthraquinone,

cyanogenic, steroidal, triterpenoidal, coumarin, flavonoid, glucosinolate, etc.) tannins,

alkaloids.

8

10 Biosynthesis : Building blocks, reactions involved in the biosynthesis, biosynthesis of

building blocks. (acetate, isopenntenyl pyrophosphate, phenyl propane, etc.,)

3

11 Extraction: Methods employed for the extraction of natural products mentioned

under phytochemistry. Types of extracts. Methods used for separation of

phytoconstituents

2

12 Minerals- Kiselghur, Chalk, Talc, and Bentonite 1

Books Recommended ; Will be recommended by the teacher

58

Title of the Course Pharmaceutical Analysis- IV

Marks 50

Number of Hours per week 2

Total Hours 30

Class T.Y. B.Pharm.

Semester VI

Sr.No Topic Hrs.

1. Electrochemical methods: Theory, introduction and application of voltametry,

coulometry, polarography, amperometry, introduction to pulse polarography,

electrogravimetry

5

2. Chromatography: Terminologies, development of chromatogram, dynamic of

chromatography, classification (absorption, partition, gas, liquid, exclusion,

electrochromatography, ion exchange), thin layer chromatography (TLC), high

performance thin layer chromatography (HPTLC), gas liquid chromatography

(GLC), and high performance liquid chromatography (HPLC), column

chromatography, paper chromatography, ion pair chromatography, details of

components of instruments (eg. Rheodyne injector, pumps, etc) and accessories (eg,

detectors, integrators autosampler, etc.)

Introduction to UPCL, Instrumentation, application, advantages and disadvantages.

10

3. Introduction, theory, instruments, and applications of

1H NMR;13C NMR; Mass Spectrometry; Near IR

6

4. Problem solving based on UV, IR, NMR, MS of simple molecules and drug

substances

5

5. Hyphanated techniques: LC-MS; GC-MS 4

Books Recommended As Recommended under Pharmaceutical Analysis –III

Title of the Course Pharmaceutical & Medicinal Chemistry-IV

Marks 50

Number of Hours per week 2

Total Hours 30

Class T.Y. B.Pharm.

Semester VI

Sr.No Topic Hrs.

Study of the following classes of drugs with respect to their classification, chemical

nomenclature, structure including stereochemistry, generic names, chemistry, physicochemical

properties, SAR, metabolism, molecular mechanism of action and synthesis and introduction to

rational development, if any.

1 Adrenergic Drugs or drugs affecting adrenergic neurotransmission:

a) General aspects of adrenergic receptors and Non-selective adrenergic

agonists- nor-epinephrine and epinephrine.

b) Selective α1-adrenergic agonists and α2-adrenergic agonists

2

1

59

c) β1 and β2- adrenergic agonists

d) Mixed-acting sympathomimetics

e) Non-selective and Selective α-adrenergic antagonists

f) β-adrenergic antagonists

g) Mixed α/β-adrenergic antagonists

Ergot alkaloids.

1

1

1

2

1

2 Cardiovascular Drugs:

a) Cardiac agents:

I. Cardiac glycosides and non-glycosides.

II. Antianginal agents:

III. Nitrates and nitrites, nitric oxide donors

IV. Calcium channel blockers

V. Antiarrhythmic drugs: Class I to IV.

b) Diuretics:

I. Osmotic diuretics

II. Carbonic anhydrase inhibitors.

III. Thiazide and thiazide like diuretics

IV. Loop diuretics

V. Aldosterone antagonists

VI. Potassium sparing diuretics

c) Antihypertensive agents:

I. ACE inhibitors

II. Ca channels blockers

III. Adrenergic blockers

IV. Vasodilators

V. Misc.

d) Antihyperlipidemic agents and cholesterol reducing agents.

e) Drugs affecting blood clotting -Anticoagulants: Heparin and oral, Direct

thrombin inhibitors, Thrombolytics, antiplatelet drugs and Anitfibrinolytic

agents.

2

1

2

2

4

5

2

3

Books Recommended: As recommended under Pharmaceutical and Medicinal

Chemistry-II