The 2nd International Symposium On The Calcium-sensing Receptor

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The 2nd International Symposium On The Calcium-sensing Receptor

Omni Hotel, San Diego, USA

Meeting Program

March 3, 2015
7:00-8:00 Networking Breakfast
8:00-8:10 Introduction and Housekeeping: Dolores Shoback
8:10-8:40 Session 1: Keynote Presentation in Basic and Translational Research

Chair: Wenhan Chang

Gerda Breitwieser (Weis Center for Research, USA): Physiological Implications of Calcium-sensing Receptor Trafficking as a Regulator of Signaling

8:40-10:15 Session 2: Molecular and Cellular Physiology of the CaSR

Co-chairs: Gerda Breitwieser and Christopher Loretz

8:40-9:00 Jenny Yang (Georgia State University, USA): Molecular Basis of Receptor-mediated Extracellular Calcium Signaling

9:00-9:20 Christopher Loretz (State University New York Buffalo, USA): Evolutionary History of the Extracellular Calcium-sensing Receptor (CaSR)

9:20-9:40 Geoffrey Hendy (McGill University, Canada): Calcium-sensing Receptor: Regulation of Gene Expression

9:40-10:00 Hans Brauner-Osborne (University of Copenhagen, Demark): Biased Agonists of the Calcium-sensing Receptor

10:00-10:10 Katie Leach (Monash University, Australia): Biased Signaling from the Calcium-sensing Receptor (CaSR)
10:10-10:30 Networking Coffee Break
10:30-11:50 Session 3: CaSR and Parathyroid Function

Co-chairs: Geoffrey Hendy and Edward Brown

10:30-10:50 Arthur Conigrave (University of Sydney, Australia): Calcium-sensing Receptor and the Parathyroid: Past, Present and Future

10:50-11:10 Donald Ward (University of Manchester, UK): CaSR and Parathyroid Cell Signaling

11:10-11:30 Maria Luisa Brandi (University of Florence, Italy): Recent Advances in Parathyroid Cell Secretory Models

11:30-11:50 Wenhan Chang (University of California San Francisco, USA): Parathyroid GABAbR1 is the Molecular Basis for the Development of Hyperparathyroidism Due to CaSR Deficiency

12:00-13:00 Working Lunch Session: Eat and Listen (Oral Poster Presentation)

Chair: Eniko Kallay

** Oral presentations will be selected from the top scoring abstracts submitted to the conference for an additional 5-minute slide presentation preceding the poster viewing.
13:00-14:00 Poster Viewing
14:00-15:15 Session 4: CaSR and Kidney Function

Co-chairs: William Goodman and Daniela Riccardi

14:00-14:25 Pascal Houillier (Université Paris Descartes, France): Extraparathyroid CaSR Controls Blood Calcium Concentration Independently of Parathyroid Hormone Secretion

14:25-14:50 Hakan Toka (Harvard Medical School, USA): Lessons Learned from Kidney-specific CaSR

14:50-15:15 Tyler Miller (University of Texas Southwestern Medical Center, USA): The Extracellular Calcium-sensing Receptor (CaSR) Activates adam10 to Cleave Membrane-Bound Klotho
15:15-16:00 Networking Coffee Break
16:00-17:00 Session 5: CaSR and Digestive Function

Co-chairs: Arthur Conigrave and Sam Cheng

16:00-16:25 Sam Cheng (University of Florida, USA): The Calcium-sensing Receptor and Regulation of Intestinal Secretion and Inflammation

16:25-16:50 John MacLeod (Queen’s University, Canada): The Extracellular Calcium-sensing Receptor (CaSR) and Intestinal Paracrine Interaction

16:50-18:15 Session 6: CaSR in Bone and Marrow

Co-chairs: Dolores Shoback and Dengshun Miao

16:50-17:15 David Goltzman (McGill University, Canada): The Role of CaSR in Bone Homeostasis

17:15-17:40 Romuald Mentaverri (Université de Picardie Jules Verne, France): CaSR and Osteoclasts Functions

17:40-18:05 Gregor Adams (University of Southern California, USA): Calcium-sensing Receptor-Mediated Regulation of Cell Proliferation and Interactions with the Bone Marrow Microenvironment in Multiple Myeloma

18:05-18:15 Mark Rybchyn (University of Sydney, Australia): The Upstream and Downstream of CaSR-dependent Akt Signaling in Human Osteoblasts

March 4, 2015
7:00-8:00 Networking Breakfast
8:00-8:30 Session 7: Clinical Keynote Presentation

Chair: Edward Nemeth

Edward Brown (Harvard University, USA): The Extracellular Calcium (Ca2+o)-sensing Receptor and Disorders of Ca2+o-Sensing
8:30-9:30 Session 8: CaSR Function in Breast, Skin, and inflammation

Chairs: Daniel Bikle and Dolores Shoback

8:30-8:50 John Wysolmerski (Yale University, USA): The Calcium-sensing Receptor in the Normal Breast and in Breast Cancer

8:50-9:10 Chia-Ling Tu (University of California San Francisco, USA): CaSR in Epidermal Differentiation and Wound Healing

9:10-9:30 Ulf Wagner (Leipzig University, Germany): Extracellular Calcium Ions Act as a Pro-Inflammatory Danger Signal
9:30-9:55 Networking Coffee Break
9:55-11:05 Session 9: CaSR Function in the Brain and Blood Vessels

Co-chairs: Wenhan Chang and Stephen Smith

9:55-10:00 Wenhan Chang (University of California San Francisco, USA): Introduction

10:00-10:25 Stephen Smith (Oregon Health & Science University, USA): Calcium-sensing Receptor Regulates Numerous Signaling Pathways in Neurons

10:25-10:50 Ubaldo Armato (University of Verona, Italy): Could Calcilytics Stall Alzheimer’s Disease (AD) Progression?

10:50-11:00 Martin Schepelmann (University of Cardiff, UK): The Calcium-sensing Receptor (CaSR) Regulates Blood Pressure, Vessel Tone and Cardiac Function

11:00-12:10 Session 10: CaSR and Cancer

Co-chairs: Enikö Kallay and John Wysolmerski

11:00-11:10 Enikö Kallay (Medical University Vienna, Austria): The Calcium-sensing Receptor Paradox in Cancer

11:10-11:30 Daniel Bikle (University of California San Francisco, USA): CaSR and VDR in Skin Cancer

11:30-11:50 Carmen de Torres (Hospital Sant Joan de Déu, Barcelona, Spain): The Calcium-sensing Receptor and Neuroblastoma

11:50-12:00 Cristina Dumitru (Yale University): Heterodimerization of The CaSR and GABA-BR1 Alters G-protein Coupling in Att-20 and HEK-293 cells

12:00-12:10 Abhishek Aggarwal (Medical University of Vienna): The CaSR: A Novel Target In Colorectal Cancer Prevention
12:10-14:00 Lunch and Poster Viewing
12:10-13:00 Young Investigator Session: Lunch with CaSR Senior Investigators
14:00-15:40 Session 11: Treatment of Hyperparathyroidism with Calcimimetics

Co-chairs: Edward Nemeth and Masafumi Fukagawa

14:00-14:25 Geoffrey Block (Denver Nephrologists, USA): Treatment with Cinacalcet and Cardiovascular Outcomes: Analysis of the Evolve Trial

14:25-14:50 Masafumi Fukagawa (Tokai University School of Medicine, Japan): Cinacalcet, FGF-23/Klotho, and Parathyroid Hyperplasia

14:50-15:15 Dolores Shoback (University of California San Francisco, USA): Cinacalcet and primary HPT

15:15-15:40 William Goodman (Consulting Nephrologist, USA): AMG 416: A Second Generation Calcimimetic

15:40-16:30 Session 12: Genetic Disorders of the CaSR

Co-chairs: Maria Luisa Brandi and Raj Thakker

15:40-16:05 Rajesh Thakker (University of Oxford, UK): Familial Hypocalciuric Hypercalcemia Types 1-3

16:05-16:30 Michael Mannstadt (Harvard Medical School, USA): Autosomal Dominant Hypocalcaemia (Hypoparathyroidism) Types 1 and 2

16:30-16:50 Networking Coffee Break
16:50-18:30 Session 13: Potential New Indications for Calcimimetics and Calcilytics

Co-chairs: Arthur Conigrave and Edward Nemeth

16:50-17:15 Edward Nemeth (MetisMedica, Canada): The Calcium Receptor as a Therapeutic Target

17:15-17:40 Daniela Riccardi (Cardiff University, UK): Calcilytics as Novel Therapeutic for Treating Asthma

17:40-18:05 Jason Yuan (University of Arizona, USA): CaSR, a novel therapeutic target for pulmonary arterial hypertension

18:05-18:30 Fadil Hannan (University of Liverpool, UK): Calcium-sensing Receptor (CaSR) and Glucose Metabolism: Lessons from NUF Mice, with an Activating CaSR Mutation

18:30-18:40 Closing Remarks



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