“The greatest challenge to any thinker

“The greatest challenge to any thinker

• “The greatest challenge to any thinker

• is stating the problem

• in a way that will allow a solution”

• Bertrand Russell

Aqueous systems not only provide the basis for the origin of life but also play a dynamic active role in the maintenance of allostasis, namely the ceaseless process aimed to keep stability through dynamic changes, in any cell and organism *.

• Aqueous systems not only provide the basis for the origin of life but also play a dynamic active role in the maintenance of allostasis, namely the ceaseless process aimed to keep stability through dynamic changes, in any cell and organism *.

• * McEwen B.S., Wingfield J.C. (2003) “The concept of allostasis in biology and biomedicine.”, Horm. Behav.,43(1):2-15.

Interestingly aqueous systems possess not only the longtime acknowledged biochemical properties but also some recently disclosed biophysical features providing a completely new framework to biology and medicine *.

• Interestingly aqueous systems possess not only the longtime acknowledged biochemical properties but also some recently disclosed biophysical features providing a completely new framework to biology and medicine *.

• * Foletti A., Lisi A., Ledda M., De Carlo F., Grimaldi S. (2009) “Cellular ELF signals as a possible tool in informative medicine.”, Electromagn. Biol. Med., 28(1): 71-79.

Dynamic electro magnetic fields are endogenously generated as biophysical correlates of biochemical activities into cells and tissues *.

• Dynamic electro magnetic fields are endogenously generated as biophysical correlates of biochemical activities into cells and tissues *.

• *Burr H.S, Northrop F.S.C. (1939) “Evidence for the existence of an electro-dynamic field in living organisms.”, Proc Natl Acad Sci USA, 25(6): 284-288.

• Cifra M., Fields J.Z., Farhadi A. (2010) “Electromagnetic cellular interaction.”, Prog Biophys Mol Biol., 105(3): 223-246.

• Rossi C., Foletti A., Magnani A., Lamponi S. (2011) “New Perspectives in Cell Comunication: Bioelectromagnetics Interactions.”, Seminar Cancer Biol., 21(3): 207-214.

These electro-dynamic fields meet the requirements to induce a coherent collective behavior of water molecules and other components of the nearest aqueous systems and other cell components and is self trapped in form of electro-solitons that contribute to maintain the dynamic stability of the system without loose of energy or information *.

• These electro-dynamic fields meet the requirements to induce a coherent collective behavior of water molecules and other components of the nearest aqueous systems and other cell components and is self trapped in form of electro-solitons that contribute to maintain the dynamic stability of the system without loose of energy or information *.

• *Brizhik L.S., Del Giudice E., Popp F.A., Maric-Oeler W., Schlebusch K. P. (2009) “On the dynamics of self-organization in living organisms.”, Electromagn. Biol. Med., 28(1): 28-40.

At ambient conditions our traditional view of water is an homogeneous distribution of tetrahedral structure hydrogen bonded. In spite of this very simple description a more complex picture arise from recent reports identifying the presence, even at ambient condition, of inhomogeneous structures that fit the concept of “coherence domains” in agreement with Quantum Electrodynamic Theory (QED) *.

• At ambient conditions our traditional view of water is an homogeneous distribution of tetrahedral structure hydrogen bonded. In spite of this very simple description a more complex picture arise from recent reports identifying the presence, even at ambient condition, of inhomogeneous structures that fit the concept of “coherence domains” in agreement with Quantum Electrodynamic Theory (QED) *.

• *Preparata G. (2000) “QED and medicine.”, Riv Biol., 93 : 467-512.

• Del Giudice E., Tedeschi A. (2009) “Water and autocatalysis in living matter.”, Electomagn Biol Med., 28(1): 46-52.

Consequently aqueous system, such ones enfolded in livings, could play an additional role in modulating biological functions by generating dissipative structure providing basis for processing, storing and retrieving information mediated by electro-magnetic signals*.

• Consequently aqueous system, such ones enfolded in livings, could play an additional role in modulating biological functions by generating dissipative structure providing basis for processing, storing and retrieving information mediated by electro-magnetic signals*.

• *Marchettini N., Del Giudice E., Voeikov V., Tiezzi E. (2010) “Water: a medium in where dissipative structures are produced by a coherent dynamics.”, J. Theor. Biol., 265(4): 511-516.

Furthermore any pattern of electro-magnetic signals, both endogenous and exogenous, when became resonant with some of the coherent domains of water, can induce a dipole moments re-patterning inducing them to oscillate coherently each other generating a new phase correlation described as a super-coherent, a true fourth phase of water *.

• Furthermore any pattern of electro-magnetic signals, both endogenous and exogenous, when became resonant with some of the coherent domains of water, can induce a dipole moments re-patterning inducing them to oscillate coherently each other generating a new phase correlation described as a super-coherent, a true fourth phase of water *.

• * Del Giudice E., Elia V., Tedeschi A. (2009) “The role of water in the living organisms.”, Neural Network World, 19(4): 355-360.

Therefore external patterns of electro-magnetic signals can be stored, translated and transferred by the water structure of the aqueous systems to biological targets selectively modulating their activity both at cellular and systemic level *.

• Therefore external patterns of electro-magnetic signals can be stored, translated and transferred by the water structure of the aqueous systems to biological targets selectively modulating their activity both at cellular and systemic level *.

• * Jerman I., Berden M., Ruźic R. (1996) “Biological influence of ultraweak supposedly EM radiation from organisms mediated through water.”, Electro and Magnetobiology., 15(3): 229-244.

• Kreisl P. (1998) “Test on the transduction of acetic acid information via an electronic amplifier.”, Acta Medica Empirica, 47(3): 17-24.

“To the powerful theories of chemistry and physics must be added

• “To the powerful theories of chemistry and physics must be added

• a late arrival : a theory of information.

• Nature must be interpreted as matter, energy and information.”

• Jeremy Campbell

Endler P.C., Citro M., Pongratz W., Smith C.W., Vinattieri C., Senekowitsch F. (1995) “Transfer of molecular information using a bioresonance instrument (BICOM) in amphibian trial.”, Acta Medica Empirica, 44(3): 1-16.

• Endler P.C., Citro M., Pongratz W., Smith C.W., Vinattieri C., Senekowitsch F. (1995) “Transfer of molecular information using a bioresonance instrument (BICOM) in amphibian trial.”, Acta Medica Empirica, 44(3): 1-16.

• Jerman I., Ruźic R., Krašovec R., Škarja M., Mogilnicki L. (2005) “Electrical transfer of molecule information into water, its storage, and bioeffects on plants and bacteria.”, Electromagn Biol Med., 24(3): 341-353.

Thomas Y., Schiff M., Belkadi L., Jurgens P., Kahhak L., Benveniste J., (2000) “Activation of human neutrophils by electronically transmitted phorbol-myristate acetate.”, Medical Hypotheses., 54: 33-39.

• Thomas Y., Schiff M., Belkadi L., Jurgens P., Kahhak L., Benveniste J., (2000) “Activation of human neutrophils by electronically transmitted phorbol-myristate acetate.”, Medical Hypotheses., 54: 33-39.

• Smith C.W. (2004) “Quanta and coherence effects in water and living systems.”, J Altern Complement Med.,10(1): 69-78.

Montagnier L., Aissa J., Ferris S., Montagnier J.-L., Lavallée C. (2009) “Electromagnetic signals are produced by aqueous nanostructures derived from bacterial DNA sequences.”, Interdiscip. Sci., 1(2): 81-90. BRT

• Montagnier L., Aissa J., Ferris S., Montagnier J.-L., Lavallée C. (2009) “Electromagnetic signals are produced by aqueous nanostructures derived from bacterial DNA sequences.”, Interdiscip. Sci., 1(2): 81-90. BRT

• Montagnier L., Aissa J., Del Giudice E., Lavallée C., Tedeschi A., Vitello G. (2011) “DNA waves and water.” J Phys: Conf Ser., 306: 012007.

Heredia-Rojas J.A., Torres-Flores A.C., Rodriguez-De la Fuente A.o., Mata-Cardenas B.D., Rodriguez-Flores L.E., Barron-Gonzales M.P., Torres-Pantoja A.C., Alcocer-Gonzales G.M. (2011) “Entamoeba histolytica and Trichomonas vaginalis: Trophozoite growth inhibition by metronidazole electro-transferred water.”, Exp parasitol., 127(1): 80-83.

• Heredia-Rojas J.A., Torres-Flores A.C., Rodriguez-De la Fuente A.o., Mata-Cardenas B.D., Rodriguez-Flores L.E., Barron-Gonzales M.P., Torres-Pantoja A.C., Alcocer-Gonzales G.M. (2011) “Entamoeba histolytica and Trichomonas vaginalis: Trophozoite growth inhibition by metronidazole electro-transferred water.”, Exp parasitol., 127(1): 80-83.

• Heredia-Rojas J.A., Gomez-Flores A.C., Rodriguez-De la Fuente A.O., Monreal-Cuevas E., Torres-Flores A.C., Rodriguez-Flores L.E., Beltcheva M., Torres-Pantoja A.C. (2012) “Antibicrobial effect of amphotericin B electronically-activated water against Candida Albicans.”, African J Microbiology Res.,6(15):3684-3689.

• Foletti A., Grimaldi S. (2010) “Differentiation of Human LAN-5 Neuroblastoma Cells by Electronically Trasmitted Retinoic Acid (RA).”, Progress In Electromagnetics Research Symposium Proceedings, Cambridge, Usa, July 5-8: 1078-1082.

• Foletti A., Ledda M., De Carlo F., Grimaldi S., Lisi A. (2010) “Calcium ion cyclotron resonance (ICR), 7.0 Hz, 9.2 microT magnetic field exposure initiate differentiation of pituitary corticotrope-derivated AtT20 D16V cells.”, Electromagn Biol Med., 29(3): 63-71.

Foletti A., Grimaldi S., D’Emilia E., Ledda M., Lisi A. (2010) “Electronically trasmitted (EMIT) retinoic acid (RA) signals on LAN-5 neuroblastoma cells as a possibile model of a specific informative effect in biology.”, 6th International Workshop on Biological Effect of Electromagnetic Fields Proceedings, Bodrum, Turkey, October 10-14: 32-33.

• Foletti A., Grimaldi S., D’Emilia E., Ledda M., Lisi A. (2010) “Electronically trasmitted (EMIT) retinoic acid (RA) signals on LAN-5 neuroblastoma cells as a possibile model of a specific informative effect in biology.”, 6th International Workshop on Biological Effect of Electromagnetic Fields Proceedings, Bodrum, Turkey, October 10-14: 32-33.

• Foletti A., Ledda M., D’Emilia E., Grimaldi S., Lisi A. (2011) “Differentiation of Human LAN-5 Neuroblastoma Cells Induced by Extremely Low Frequency Electronically Trasmitted Retinoic Acid.”, J Altern Complement Med., 17(8): 701-704.

We was able to confirm this hypotheses transferring the signal of retinoic acid to human neuroblastoma and teratocarcinoma cell line *.

• We was able to confirm this hypotheses transferring the signal of retinoic acid to human neuroblastoma and teratocarcinoma cell line *.

• * Foletti A., Ledda M., D’Emilia E., Grimaldi S., Lisi A. (2012) “Eperimental Finding on the Electromagnetic Information Transfer of Specific Molecular Signals Mediated Through Aqueous System on Two Human Cellular Models.”, J Altern Complement Med., 18(3): 258-261.

Moreover we translate this concept into a clinical trial in which we demonstrate that patterns of endogenous dysfunctional signals recorded by an electro-medical device (Med Select 729) and transferred to an aqueous system (Nomabit Base) were able to induce both systemic and local effect on pain in respect to placebo *.

• Moreover we translate this concept into a clinical trial in which we demonstrate that patterns of endogenous dysfunctional signals recorded by an electro-medical device (Med Select 729) and transferred to an aqueous system (Nomabit Base) were able to induce both systemic and local effect on pain in respect to placebo *.

• * Baron P, Bucci G., Rinaudo A., Rocco R., Sclauzero E., Foletti A. (2013) “System Information Therapy in the management of pain: a pilot study.”, In: Proceedings PIERS, Progress in Electromagnetics Research Symposium, Stockholm, Sweden, August 12–15 2013, pp. 1698-1702.

A pilot clinical trial was designed to assess the effectiveness of a biophysical treatment recorded on an aqueous system compared to a common anti inflammation drug (ibuprofen) and compared to placebo. A total of 66 patient (40 females and 26 males) was enrolled in the study, in the respect of the declaration of Helsinky, upon delivery of an informed consent.

• A pilot clinical trial was designed to assess the effectiveness of a biophysical treatment recorded on an aqueous system compared to a common anti inflammation drug (ibuprofen) and compared to placebo. A total of 66 patient (40 females and 26 males) was enrolled in the study, in the respect of the declaration of Helsinky, upon delivery of an informed consent.

The 66 patients was divided into 3 groups as follow:

• The 66 patients was divided into 3 groups as follow:

• 26 in the Biophysical group (17 f, 9 m),

• 23 in the pharmacological group (11 f, 9 m);

• 17 in the placebo group (12 f, 5 m).

• Visual Analogue Scale (VAS) score was recorded at the beginning, after one week, after one month.

The System Information Therapy group was treated by a 2 step protocol using an electro-medical device (Med Select 729). Synchronously a copy of the output therapeutic signals were recorded on a commercial available aqueous system (Nomabit Base) placed into the output coil built-in into the device. The aqueous solution was taken daily by the patients to allows the recorded therapeutic information to be delivered once a day.

• The System Information Therapy group was treated by a 2 step protocol using an electro-medical device (Med Select 729). Synchronously a copy of the output therapeutic signals were recorded on a commercial available aqueous system (Nomabit Base) placed into the output coil built-in into the device. The aqueous solution was taken daily by the patients to allows the recorded therapeutic information to be delivered once a day.

The Pharmacological therapy group: Ibuprofen 600mg twice a day, on full stomach, for 10 days, was administered to each patient of this group.

• The Pharmacological therapy group: Ibuprofen 600mg twice a day, on full stomach, for 10 days, was administered to each patient of this group.

The Placebo group. The patients of this group was receiving only Nomabit Base solution as placebo, therefore not placed into the Med Select to be selectively recorded, and administered with the same protocol as in the System Information Therapy group.

• The Placebo group. The patients of this group was receiving only Nomabit Base solution as placebo, therefore not placed into the Med Select to be selectively recorded, and administered with the same protocol as in the System Information Therapy group.

Biophysical therapy mimic the dynamics of the pharmacological treatment and is long lasting in their effects. Interestingly a very low amount of worsening cases was reported in the biophysical group ad especially no side effect was referred . Moreover many patients of the Biophysical group reported feeling of a general relaxation following the treatment as presumably to be due to a systemic effect of the biophysical therapy besides the effect on pain.

• Biophysical therapy mimic the dynamics of the pharmacological treatment and is long lasting in their effects. Interestingly a very low amount of worsening cases was reported in the biophysical group ad especially no side effect was referred . Moreover many patients of the Biophysical group reported feeling of a general relaxation following the treatment as presumably to be due to a systemic effect of the biophysical therapy besides the effect on pain.

Importantly the use of a single recording procedure during the System Information Therapy allowed to perform a unique treatment of the patient, lasting only 20 minutes, saving time and cost due to repetition of the treatment. Biophysical treatment therefore was time effective and cost effective.

• Importantly the use of a single recording procedure during the System Information Therapy allowed to perform a unique treatment of the patient, lasting only 20 minutes, saving time and cost due to repetition of the treatment. Biophysical treatment therefore was time effective and cost effective.

The treatment fulfill the requirement to be considered as a personalized medication because the pattern of signals are recorded on the site of the pain, such pattern of endogenous electromagnetic signal being unique for any single person at any single time, this way the procedure is actually tailored on the patient.

• The treatment fulfill the requirement to be considered as a personalized medication because the pattern of signals are recorded on the site of the pain, such pattern of endogenous electromagnetic signal being unique for any single person at any single time, this way the procedure is actually tailored on the patient.

Moreover the recording of the output signals on the aqueous system, a commercial available solution of micro elements is consistent with previous findings and demonstrate the clinical feasibility of such a procedure as a useful integrative tool in general practice as reported by further studies in agreement with the hypotheses that aqueous system could be able to record, store, and transfer biophysical active information to biological targets.

• Moreover the recording of the output signals on the aqueous system, a commercial available solution of micro elements is consistent with previous findings and demonstrate the clinical feasibility of such a procedure as a useful integrative tool in general practice as reported by further studies in agreement with the hypotheses that aqueous system could be able to record, store, and transfer biophysical active information to biological targets.

Further clinical trials are certainly requested to confirm and widen the data presented in this preliminary pilot study and someone are already in process to better define the clinical areas besides pain in which a biophysical strategy could improve quality of life to the increasing number of patients with chronic diseases and multiple comorbidities that require to be treated effectively and safely reducing the number of drugs to be used.

• Further clinical trials are certainly requested to confirm and widen the data presented in this preliminary pilot study and someone are already in process to better define the clinical areas besides pain in which a biophysical strategy could improve quality of life to the increasing number of patients with chronic diseases and multiple comorbidities that require to be treated effectively and safely reducing the number of drugs to be used.

“There are two possible outcomes:

• “There are two possible outcomes:

• If the result confirm the hypothesis, then you’ve made a measurement.

• If the result is contrary to the hypothesis, then you’ve made a discovery.”

• Enrico Fermi

The emerging perspective is that aqueous systems, could play an additional role in modulating biological functions providing basis for processing, storing and retrieving information mediated by electro-magnetic signals with both short-range and long-range, namely local and systemic, effects with potential very fruitful application in medical practice *.

• The emerging perspective is that aqueous systems, could play an additional role in modulating biological functions providing basis for processing, storing and retrieving information mediated by electro-magnetic signals with both short-range and long-range, namely local and systemic, effects with potential very fruitful application in medical practice *.

• *Foletti A., Grimaldi S. (2011) “Systems Information Therapy and the central role of the brain in allostasis.”, J Phys: Conf Ser., 329: 012027.

• Foletti A., Cozzolino M. (2013) “A biophysical integrated approach to autoimmune nephrotic syndrome: case report.”., Recenti Prog Med., 104(9): 488-489.

“The important thing in science is not so much to obtain new facts as to discover new ways of thinking about them.”

• “The important thing in science is not so much to obtain new facts as to discover new ways of thinking about them.”

• Sir Lawrence Bragg

Thank You

• Thank You

• from the heart

• for Your

• kind attention