Seems hyperactive. But since there are fewer noradrenergic neurons, this can lead to a deficiency.
Adverse childhood experiences can produce an over-active responsiveness in this system that persists into adulthood.
In situations that most people may not find too stressful, the vulnerable depressed individual does feels very stressed and may deplete NE. Depletion of NE with AMPT causes depression in recovered patients but not normals.
Restraint stress in animals causes NE depletion and hopelessness. Hopelessness is part of major depression.
Dopamine Function is Deficient in Major Depression
Parkinson’s Disease associated with depression.
CSF shows low homovanillic acid (HVA).
Neuroendocrine challenges: blunted responses to dopamine agonists
Depletion of dopamine with AMPT causes depression in recovered patients but not normals.