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Antimicrobial Agents and Chemotherapy

VOLUME 54, PART 10, October 2010 Website

Research articles

Minireviews
Cationic Amphiphiles, a New Generation of Antimicrobials Inspired by the Natural Antimicrobial Peptide Scaffold
Brandon Findlay, George G. Zhanel, and Frank Schweizer
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Antiviral Agents
Maternal-Fetal Pharmacokinetics and Dynamics of a Single Intrapartum Dose of Maraviroc in Rhesus Macaques
Mark A. Winters, Koen K. A. Van Rompay, Angela D. M. Kashuba, Nancy S. Shulman, and Mark Holodniy
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Phosphorothioate 2' Deoxyribose Oligomers as Microbicides That Inhibit Human Immunodeficiency Virus Type 1 (HIV-1) Infection and Block Toll-Like Receptor 7 (TLR7) and TLR9 Triggering by HIV-1
Joseph A. Fraietta, Yvonne M. Mueller, Duc H. Do, Veronica M. Holmes, Mary K. Howett, Mark G. Lewis, Alina C. Boesteanu, Sefik S. Alkan, and Peter D. Katsikis
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Phase 2a Study of the CCR5 Monoclonal Antibody PRO 140 Administered Intravenously to HIV-Infected Adults
Jeffrey M. Jacobson, Jacob P. Lalezari, Melanie A. Thompson, Carl J. Fichtenbaum, Michael S. Saag, Barry S. Zingman, Paul D'Ambrosio, Nancy Stambler, Yakov Rotshteyn, Andre J. Marozsan, Paul J. Maddon, Stephen A. Morris, and William C. Olson
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No Evidence for Induction of ABC Transporters in Peripheral Blood Mononuclear Cells in Humans after 14 Days of Efavirenz Treatment
Jürgen Burhenne, Anne-Kathrin Matthée, Ivana Pasáková, Claudia Röder, Tilman Heinrich, Walter Emil Haefeli, Gerd Mikus, and Johanna Weiss
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HIV-1 Protease Mutations and Protease Inhibitor Cross-Resistance
Soo-Yon Rhee, Jonathan Taylor, W. Jeffrey Fessel, David Kaufman, William Towner, Paolo Troia, Peter Ruane, James Hellinger, Vivian Shirvani, Andrew Zolopa, and Robert W. Shafer
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The Virucidal EB Peptide Protects Host Cells from Herpes Simplex Virus Type 1 Infection in the Presence of Serum Albumin and Aggregates Proteins in a Detergent-Like Manner
Hermann Bultmann, Gary Girdaukas, Glen S. Kwon, and Curtis R. Brandt
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Identification of a Dendrimeric Heparan Sulfate-Binding Peptide That Inhibits Infectivity of Genital Types of Human Papillomaviruses
Manuela Donalisio, Marco Rusnati, Andrea Civra, Antonella Bugatti, Donatella Allemand, Giovanna Pirri, Andrea Giuliani, Santo Landolfo, and David Lembo
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Pharmacokinetics of Darunavir/Ritonavir and Rifabutin Coadministered in HIV-Negative Healthy Volunteers
Vanitha Sekar, Ludo Lavreys, Tom Van de Casteele, Cindy Berckmans, Sabrina Spinosa-Guzman, Tony Vangeneugden, Martine De Pauw, and Richard Hoetelmans
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Lersivirine, a Nonnucleoside Reverse Transcriptase Inhibitor with Activity against Drug-Resistant Human Immunodeficiency Virus Type 1
Romuald Corbau, Julie Mori, Chris Phillips, Lesley Fishburn, Alex Martin, Charles Mowbray, Wendy Panton, Caroline Smith-Burchnell, Adele Thornberry, Heather Ringrose, Thorsten Knöchel, Steve Irving, Mike Westby, Anthony Wood, and Manos Perros
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ADS-J1 Inhibits HIV-1 Entry by Interacting with gp120 and Does Not Block Fusion-Active gp41 Core Formation
Emmanuel González-Ortega, Maria-Pau Mena, Marc Permanyer, Ester Ballana, Bonaventura Clotet, and José A. Esté
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Experimental Therapeutics
Antifungal Therapy in a Murine Model of Disseminated Infection by Cryptococcus gattii
Enrique Calvo, F. Javier Pastor, M. Mar Rodríguez, Isabel Pujol, and Josep Guarro
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Increased Temperature Enhances the Antimicrobial Effects of Daptomycin, Vancomycin, Tigecycline, Fosfomycin, and Cefamandole on Staphylococcal Biofilms
Stefan Hajdu, Johannes Holinka, Sonja Reichmann, Alexander M. Hirschl, Wolfgang Graninger, and Elisabeth Presterl
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In Vivo Efficacy of Simulated Human Dosing Regimens of Prolonged-Infusion Doripenem against Carbapenemase- Producing Klebsiella pneumoniae
Catharine C. Bulik and David P. Nicolau
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In Vivo Protection Provided by a Synthetic New Alpha-Galactosyl Ceramide Analog against Bacterial and Viral Infections in Murine Models
Kun-Hsien Lin, Jian-Jong Liang, Wen-I Huang, Shao-Ying Lin-Chu, Ching-Yao Su, Yi-Ling Lee, Jia-Tsong Jan, Yi-Ling Lin, Yih-Shyun E. Cheng, and Chi-Huey Wong
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Silver Coordination Polymers for Prevention of Implant Infection: Thiol Interaction, Impact on Respiratory Chain Enzymes, and Hydroxyl Radical Induction
Oliver Gordon, Tünde Vig Slenters, Priscilla S. Brunetto, Amer E. Villaruz, Daniel E. Sturdevant, Michael Otto, Regine Landmann, and Katharina M. Fromm
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Impact of recA on Levofloxacin Exposure-Related Resistance Development
Renu Singh, Kimberly R. Ledesma, Kai-Tai Chang, and Vincent H. Tam
Antimicrob. Agents Chemother.

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Activity of a Trisubstituted Pyrrole in Inhibiting Sporozoite Invasion and Blocking Malaria Infection
Dhruv Panchal and Purnima Bhanot
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Impact of Burden on Granulocyte Clearance of Bacteria in a Mouse Thigh Infection Model
G. L. Drusano, Christine Fregeau, Weiguo Liu, D. L. Brown, and Arnold Louie
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Discovery of Novel Orally Bioavailable Oxaborole 6-Carboxamides That Demonstrate Cure in a Murine Model of Late-Stage Central Nervous System African Trypanosomiasis
Bakela Nare, Stephen Wring, Cyrus Bacchi, Beth Beaudet, Tana Bowling, Reto Brun, Daitao Chen, Charles Ding, Yvonne Freund, Eric Gaukel, Ali Hussain, Kurt Jarnagin, Matthew Jenks, Marcel Kaiser, Luke Mercer, Elena Mejia, Andy Noe, Matt Orr, Robin Parham, Jacob Plattner, Ryan Randolph, Donna Rattendi, Cindy Rewerts, Jessica Sligar, Nigel Yarlett, Robert Don, and Robert Jacobs
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Efficacy of Daptomycin against Bacillus anthracis in a Murine Model of Anthrax Spore Inhalation
Henry S. Heine, Jennifer Bassett, Lynda Miller, Bret K. Purcell, and W. Russell Byrne
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In Vivo Efficacy of Anidulafungin against Mature Candida albicans Biofilms in a Novel Rat Model of Catheter-Associated Candidiasis
Sona Kucharíková, Hélène Tournu, Michelle Holtappels, Patrick Van Dijck, and Katrien Lagrou
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Efficacy of PTX3 in a Rat Model of Invasive Aspergillosis
Pietro Lo Giudice, Silvia Campo, Antonio Verdoliva, Vincenzo Rivieccio, Franco Borsini, Rita De Santis, and Giovanni Salvatori
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Clinical Therapeutics
Costs of Bloodstream Infections Caused by Escherichia coli and Influence of Extended-Spectrum-β-Lactamase Production and Inadequate Initial Antibiotic Therapy
Mario Tumbarello, Teresa Spanu, Rossella Di Bidino, Marco Marchetti, Matteo Ruggeri, Enrico Maria Trecarichi, Gennaro De Pascale, Enrica Maria Proli, Roberto Cauda, Americo Cicchetti, and Giovanni Fadda
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Efficacy and Safety of Nemonoxacin versus Levofloxacin for Community-Acquired Pneumonia
Dirkie J. J. van Rensburg, Reury-Perng Perng, Ismail H. Mitha, Andrè J. Bester, Joseph Kasumba, Ren-Guang Wu, Ming-Lin Ho, Li-Wen Chang, David T. Chung, Yu-Ting Chang, Chi-Hsin R. King, and Ming-Chu Hsu
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Randomized Comparison of Safety and Pharmacokinetics of Caspofungin, Liposomal Amphotericin B, and the Combination of Both in Allogeneic Hematopoietic Stem Cell Recipients
Andreas H. Groll, Gerda Silling, Charlotte Young, Rainer Schwerdtfeger, Helmut Ostermann, Werner J. Heinz, Joachim Gerss, Hedwig Kolve, Claudia Lanvers-Kaminsky, João Paulo Vieira Pinheiro, Sibylle Gammelin, Oliver A. Cornely, and Gudrun Wuerthwein
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Comparative Effectiveness of Linezolid and Vancomycin among a National Cohort of Patients Infected with Methicillin-Resistant Staphylococcus aureus
Aisling R. Caffrey, Brian J. Quilliam, and Kerry L. LaPlante
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International Retrospective Analysis of 73 Cases of Invasive Fusariosis Treated with Voriconazole
Olivier Lortholary, Gaelle Obenga, Pinaki Biswas, Denis Caillot, Elisabeth Chachaty, Anne-Lise Bienvenu, Muriel Cornet, John Greene, Raoul Herbrecht, Claire Lacroix, Frédéric Grenouillet, Issam Raad, Karine Sitbon, Peter Troke and the French Mycoses Study Group
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Mechanisms of Resistance
Differential Selection of Single-Step AmpC or Efflux Mutants of Pseudomonas aeruginosa by Using Cefepime, Ceftazidime, or Ceftobiprole
Anne Marie Queenan, Wenchi Shang, Karen Bush, and Robert K. Flamm
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Fluoroquinolone Efflux by the Plasmid-Mediated Multidrug Efflux Pump QacB Variant QacBIII in Staphylococcus aureus
Hidemasa Nakaminami, Norihisa Noguchi, and Masanori Sasatsu
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Genetic Determinants Involved in the Susceptibility of Pseudomonas aeruginosa to β-Lactam Antibiotics
Carolina Alvarez-Ortega, Irith Wiegand, Jorge Olivares, Robert E. W. Hancock, and José Luis Martínez
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Characterization and PCR-Based Replicon Typing of Resistance Plasmids in Acinetobacter baumannii
Alessia Bertini, Laurent Poirel, Pauline D. Mugnier, Laura Villa, Patrice Nordmann, and Alessandra Carattoli
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An Ertapenem-Resistant Extended-Spectrum-β-Lactamase-Producing Klebsiella pneumoniae Clone Carries a Novel OmpK36 Porin Variant
Aurora García-Fernández, Vivi Miriagou, Costas C. Papagiannitsis, Alessandra Giordano, Mario Venditti, Carlo Mancini, and Alessandra Carattoli
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Genetic Factors Associated with Elevated Carbapenem Resistance in KPC-Producing Klebsiella pneumoniae
Brandon Kitchel, J. Kamile Rasheed, Andrea Endimiani, Andrea M. Hujer, Karen F. Anderson, Robert A. Bonomo, and Jean B. Patel
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Prevalence and Dissemination of oqxAB in Escherichia coli Isolates from Animals, Farmworkers, and the Environment
Jingjing Zhao, Zhangliu Chen, Sheng Chen, Yuting Deng, Yahong Liu, Wei Tian, Xianhui Huang, Congming Wu, Yongxu Sun, Yan Sun, Zhenling Zeng, and Jian-Hua Liu
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Expression, Purification, and Characterization of Aspergillus fumigatus Sterol 14- Demethylase (CYP51) Isoenzymes A and B
Andrew G. S. Warrilow, Nadja Melo, Claire M. Martel, Josie E. Parker, W. David Nes, Steven L. Kelly, and Diane E. Kelly
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Azole Binding Properties of Candida albicans Sterol 14- Demethylase (CaCYP51)
Andrew G. S. Warrilow, Claire M. Martel, Josie E. Parker, Nadja Melo, David C. Lamb, W. David Nes, Diane E. Kelly, and Steven L. Kelly
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Dissemination of an Enterococcus Inc18-Like vanA Plasmid Associated with Vancomycin-Resistant Staphylococcus aureus
Wenming Zhu, Patrick R. Murray, W. Charles Huskins, John A. Jernigan, Lawrence C. McDonald, Nancye C. Clark, Karen F. Anderson, Linda K. McDougal, Jeff C. Hageman, Melissa Olsen-Rasmussen, Mike Frace, George J. Alangaden, Carol Chenoweth, Marcus J. Zervos, Barbara Robinson-Dunn, Paul C. Schreckenberger, L. Barth Reller, James T. Rudrik, and Jean B. Patel
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Structural Characterization of ISCR8, ISCR22, and ISCR23, Subgroups of IS91-Like Insertion Elements
Kathleen M. Schleinitz, Tatiana Vallaeys, and Sabine Kleinsteuber
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High-Resolution Crystal Structure of the Subclass B3 Metallo-β-Lactamase BJP-1: Rational Basis for Substrate Specificity and Interaction with Sulfonamides
Jean-Denis Docquier, Manuela Benvenuti, Vito Calderone, Magdalena Stoczko, Nicola Menciassi, Gian Maria Rossolini, and Stefano Mangani
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Origin and Molecular Evolution of the Determinant of Methicillin Resistance in Staphylococci
Sae Tsubakishita, Kyoko Kuwahara-Arai, Takashi Sasaki, and Keiichi Hiramatsu
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Membrane Efflux and Influx Modulate both Multidrug Resistance and Virulence of Klebsiella pneumoniae in a Caenorhabditis elegans Model
Suzanne Bialek, Jean-Philippe Lavigne, Jacqueline Chevalier, Estelle Marcon, Véronique Leflon-Guibout, Anne Davin, Richard Moreau, Jean-Marie Pagès, and Marie-Hélène Nicolas-Chanoine
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Overexpression of Resistance-Nodulation-Cell Division Pump AdeFGH Confers Multidrug Resistance in Acinetobacter baumannii
Sébastien Coyne, Nicolas Rosenfeld, Thierry Lambert, Patrice Courvalin, and Bruno Périchon
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The ABC Transporter AnrAB Contributes to the Innate Resistance of Listeria monocytogenes to Nisin, Bacitracin, and Various β-Lactam Antibiotics
Barry Collins, Nicola Curtis, Paul D. Cotter, Colin Hill, and R. Paul Ross
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Lysogenic Transfer of mef(A) and tet(O) Genes Carried by m46.1 among Group A Streptococci
Maria Chiara Di Luca, Stefania D'Ercole, Dezemona Petrelli, Manuela Prenna, Sandro Ripa, and Luca A. Vitali
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Lysyl-Phosphatidylglycerol Attenuates Membrane Perturbation Rather than Surface Association of the Cationic Antimicrobial Peptide 6W-RP-1 in a Model Membrane System: Implications for Daptomycin Resistance
Erin Kilelee, Antje Pokorny, Michael R. Yeaman, and Arnold S. Bayer
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IncI1 Plasmid Carrying Extended-Spectrum-β-Lactamase Gene bla_CTX-M-1 in Salmonella enterica Isolates from Poultry and Humans in France, 2003 to 2008
Axel Cloeckaert, Karine Praud, Martine Lefevre, Benoît Doublet, Maria Pardos, Sophie A. Granier, Anne Brisabois, and François-Xavier Weill
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Complete Nucleotide Sequence of KPC-3-Encoding Plasmid pKpQIL in the Epidemic Klebsiella pneumoniae Sequence Type 258
Azita Leavitt, Inna Chmelnitsky, Yehuda Carmeli, and Shiri Navon-Venezia
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Sequence of pNL194, a 79.3-Kilobase IncN Plasmid Carrying the bla_VIM-1 Metallo-β-Lactamase Gene in Klebsiella pneumoniae
V. Miriagou, C. C. Papagiannitsis, S. D. Kotsakis, A. Loli, E. Tzelepi, N. J. Legakis, and L. S. Tzouvelekis
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Pharmacology
Pharmacokinetics, Safety, and Tolerability of Voriconazole in Immunocompromised Children
Thomas J. Walsh, Timothy Driscoll, Peter A. Milligan, Nolan D. Wood, Haran Schlamm, Andreas H. Groll, Hasan Jafri, Antonio C. Arrieta, Nigel J. Klein, and Irja Lutsar
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Effects of Tuberculosis, Race, and Human Gene SLCO1B1 Polymorphisms on Rifampin Concentrations
Marc Weiner, Charles Peloquin, William Burman, Chi-Cheng Luo, Melissa Engle, Thomas J. Prihoda, William R. Mac Kenzie, Erin Bliven-Sizemore, John L. Johnson, and Andrew Vernon
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In Vitro Pharmacokinetic and Pharmacodynamic Evaluation of S-013420 against Haemophilus influenzae and Streptococcus pneumoniae
Tomoyuki Homma, Toshihiko Hori, Merime Ohshiro, Hideki Maki, Yoshinori Yamano, Jingoro Shimada, and Shogo Kuwahara
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Activities of High-Dose Daptomycin, Vancomycin, and Moxifloxacin Alone or in Combination with Clarithromycin or Rifampin in a Novel In Vitro Model of Staphylococcus aureus Biofilm
Jorge Parra-Ruiz, Celine Vidaillac, Warren E. Rose, and Michael J. Rybak
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High Cefepime Plasma Concentrations and Neurological Toxicity in Febrile Neutropenic Patients with Mild Impairment of Renal Function
F. Lamoth, T. Buclin, A. Pascual, S. Vora, S. Bolay, L. A. Decosterd, T. Calandra, and O. Marchetti
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Bioavailability and Population Pharmacokinetics of Voriconazole in Lung Transplant Recipients
K. Han, B. Capitano, R. Bies, B. A. Potoski, S. Husain, S. Gilbert, D. L. Paterson, K. McCurry, and R. Venkataramanan
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Population Pharmacokinetic-Pharmacogenetic Study of Nevirapine in HIV-Infected Cambodian Patients
Monidarin Chou, Julie Bertrand, Olivier Segeral, Céline Verstuyft, Laurence Borand, Emmanuelle Comets, Clotilde Le Tiec, Laurent Becquemont, Vara Ouk, France Mentre, and Anne-Marie Taburet
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Colistin Dosing and Nephrotoxicity in a Large Community Teaching Hospital
C. Andrew DeRyke, Amanda J. Crawford, Nizam Uddin, and Mark R. Wallace
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Analytical Procedures
Clinical Evaluation of a Dried Blood Spot Assay for Atazanavir
Trevor Van Schooneveld, Susan Swindells, Sarah R. Nelson, Brian L. Robbins, Ryan Moore, and Courtney V. Fletcher
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Rapid and Sensitive Liquid Chromatography/Mass Spectrometry Assay for Caspofungin in Human Aqueous Humor
Chin Fen Neoh, Hui He, Jian Li, Robert O. Fullinfaw, Lok Leung, Anant Misra, Rasik B. Vajpayee, Geoffrey E. Davies, Kay Stewart, and David C. M. Kong
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Susceptibility
Simple Model for Testing Drugs against Nonreplicating Mycobacterium tuberculosis
Claudia Sala, Neeraj Dhar, Ruben C. Hartkoorn, Ming Zhang, Young Hwan Ha, Patricia Schneider, and Stewart T. Cole
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Trypanocidal Activity of Aziridinyl Nitrobenzamide Prodrugs
Chris Bot, Belinda S. Hall, Noosheen Bashir, Martin C. Taylor, Nuala A. Helsby, and Shane R. Wilkinson
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In Vitro Sensitivity of Plasmodium falciparum Clinical Isolates from the China-Myanmar Border Area to Quinine and Association with Polymorphism in the Na⁺/H⁺ Exchanger
Hao Meng, Rongping Zhang, Henglin Yang, Qi Fan, Xinzhuan Su, Jun Miao, Liwang Cui, and Zhaoqing Yang
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Efficacy of the Combination of Tobramycin and a Macrolide in an In Vitro Pseudomonas aeruginosa Mature Biofilm Model
Marie Tré-Hardy, Carole Nagant, Naïma El Manssouri, Francis Vanderbist, Hamidou Traore, Mario Vaneechoutte, and Jean-Paul Dehaye
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Mechanisms of Action
Antimicrobial Mechanism of Action of Transferrins: Selective Inhibition of H⁺-ATPase
María T. Andrés and José F. Fierro
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Short Cationic Antimicrobial Peptides Interact with ATP
Kai Hilpert, Brett McLeod, Jessie Yu, Melissa R. Elliott, Marina Rautenbach, Serge Ruden, Jochen Bürck, Claudia Muhle-Goll, Anne S. Ulrich, Sandro Keller, and Robert E. W. Hancock
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Furanyl-Rhodanines Are Unattractive Drug Candidates for Development as Inhibitors of Bacterial RNA Polymerase
Katherine R. Mariner, Rachel Trowbridge, Anil K. Agarwal, Keith Miller, Alex J. O'Neill, Colin W. G. Fishwick, and Ian Chopra
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Affinity of Ceftobiprole for Penicillin-Binding Protein 2b in Streptococcus pneumoniae Strains with Various Susceptibilities to Penicillin
Todd A. Davies, Wenping He, Karen Bush, and Robert K. Flamm
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Chemistry; Biosynthesis
Purification and Characterization of Avian β-Defensin 11, an Antimicrobial Peptide of the Hen Egg
Virginie Hervé-Grépinet, Sophie Réhault-Godbert, Valérie Labas, Thierry Magallon, Chrystelle Derache, Marion Lavergne, Joël Gautron, Anne-Christine Lalmanach, and Yves Nys
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Letters
Reservoir of Antimicrobial Resistance Determinants Associated with Horizontal Gene Transfer in Clinical Isolates of the Genus Shewanella
María Soledad Ramírez, Andrea Karina Merkier, Marisa Almuzara, Carlos Vay, and Daniela Centrón
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Update on Fusidic Acid (CEM-102) Tested against Neisseria gonorrhoeae and Chlamydia trachomatis
Ronald N. Jones, Douglas J. Biedenbach, Patricia M. Roblin, Stephan A. Kohlhoff, and Margaret R. Hammerschlag
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Gamma Interferon Supplementation for Melioidosis
Gavin C. K. W. Koh, Direk Limmathurotsakul, and Steven W. Dow
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Role of Mutations in Dihydrofolate Reductase DfrA (Rv2763c) and Thymidylate Synthase ThyA (Rv2764c) in Mycobacterium tuberculosis Drug Resistance
Claudio U. Köser, Richard N. Veerapen-Pierce, David K. Summers, John A.C. Archer, Pablo Bifani, René Wintjens, Vanessa Mathys, Barun Mathema, Alain Baulard, Pierre Forgacs, Sarah K. Zimmerman, Mark L. Silverman, Nancy L. Wengenack, Leslie Hall, and Glenn D. Roberts
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Errata
New Fixed-Dose Artesunate-Mefloquine Formulation against Multidrug-Resistant Plasmodium falciparumin Adults: a Comparative Phase IIb Safety and Pharmacokinetic Study with Standard-Dose Nonfixed Artesunate plus Mefloquine
S. Krudsood, S. Looareesuwan, N. Tangpukdee, P. Wilairatana, W. Phumratanaprapin, W. Leowattana, K. Chalermrut, S. Ramanathan, V. Navaratnam, P. Olliaro, M. Vaillant, J. R. Kiechel, and W. R. J. Taylor
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