Biotop-report 2013



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BioTOP-Report 

2013

Biotech and Pharma in Berlin-Brandenburg




BioTOPics 46 | September 2013 

BioTOP-Report

Editorial

Unique Chances to Create Value in Biotechnology and Life Sciences 

3

Biotechnology



More Companies, More Employees and New Deals 

4

Pharma



The German Capital Region: Highly Attractive for the Pharmaceutical Industry 

14

Diagnostics



An Excellent Location for the Development of Innovative Diagnostics 

18

Industrial Biotechnology 



Focus: Biopolymers and Bio-based Plastics 

22

Global Business



New Markets and Horizons for Global Business 

25

Business Location



Excellent Services for Berlin-Brandenburg 

28

Technology Transfer



Technology Transfer between Science and Business 

30

Life Sciences



A Science and Research Hub 

34

Know-how in Systems Medicine and Systems Biology  



36

Biotech 2020+  

41

Biotech Parks



The BioCampus Network Berlin-Brandenburg 

50

 



Addresses  

55

Publisher: Berlin Partner für Wirtschaft und Technologie GmbH  · BioTOP Berlin-Brandenburg

Fasanenstraße 85 · 10623 Berlin · Germany · Phone +49 30 318622–0 · Fax +49 30 318622–22 · biotop@biotop.de · www.healthcapital.de

Editor: Yvonne Küchler

Design & Production: supiran.de

Translation: Textbüro Reul GmbH · Frankfurt

Photos/Figures: BioTOP or Authors and:  

Page 10 Ralfpoller*, Wladimir Bulgar*; Page 13 Werner Popp  (Profile organobalance), Vanillla * (Profile BPI); Page 14 Phartisan*, Idrutu*; Page 18 Stratum*, 

Stanislav Perov*; Page 20 Alx, fotolia.com (Profile Dr. Nothgi); Page 22 BASF; Page 25 C. Keating*, Moth*; Seite 32 Bayer HealthCare; Page 33 Eric1513*, 

Jankaliciak*, Grafoo*, Eraxion*, Kjpargeter*, Andrey Armyagov*; Page 37 Christoph Heidrich; Page 40 Illustration: webersupiran, photo Sofiaworld *; 

Page 41 Paulus Rusyanto*, Collpicto*, 18percentgrey*; Page 46 Natalia Pavlichenko*/Patho (Profile Predemtec)

*dreamstime.com

Content



3

BioTOPics 46 | September 2013 

BioTOP-Report

Editorial

The German Capital Region – Unique Chances to 

Create Value in Biotechnology and Life Sciences

In an emerging health environment, manufacturers of drugs, diagnostics and devices will need to be able to 

prove not only the safety and efficacy but also the value of their products. Thus all players in the value chain – 

reaching from scientific institutions and biotech companies to clinics and healthcare providers – are rethinking 

their products, services and business models. They find perfect conditions in Berlin-Brandenburg.   

Obviously, most participants in the value chain have realised that 

cooperation is the most important factor for success and are shap-

ing their cooperation strategies: 

 

k



Cross-innovation at the interface of life sciences, information 

technology and engineering takes place everywhere. This 

innovation sector will not only create value through new tools 

and cost reduction in healthcare delivery, but also enable 

all of us to take control of our own health and wellness. The 

most recent example is the Joint Lab for Bioelectronics of 

the Technische Universität Berlin and the Leibniz Institute for 

Microelectronics.

 

k

Basic and clinical research of the Max Delbrück Center of 



Molecular Medicine (MDC) and the Charité – Universitäts-

medizin Berlin will come together in the Berlin Institute of 

Health (BIH) to create the new flagship of German life sci-

ences.


 

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Scientific excellence and development experience will team 



up in the CoLaborator, established by Bayer to incubate start-

ups.


 

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Entrepreneurial skills will be strengthened in the Entrepre-



neurial Network University of the Freie Universität Berlin, 

Charité and several companies.

Berlin-Brandenburg is indeed the European hotspot for collab-

oration. More than 200 biotechnology and 30 pharmaceutical 

companies benefit from close cooperation with five universities 

and more than a dozen institutes of the Helmholtz, Max Planck, 

Fraunhofer and Leibniz societies and associations, as well as 

more than 130 hospitals – among them Europe’s largest univer-

sity hospital: Charité – Universitätsmedizin Berlin. 

As a consequence, the sector has grown more than 6% in 2012 

and is growing continuously since 10 years. This fertile ground 

will be further strengthened with the new master plan for the 

healthcare industry. BioTOP is pleased to present the most im-

portant developments in life sciences, pharma and biotechnology 

in our new annual report. 

We hope you enjoy reading our report, and we invite you to play 

an active role in one of the most vibrant European life sciences 

networks. Don’t hesitate to contact us.



Dr. Kai Bindseil

Dr. Kai Bindseil

Cluster Manager HealthCapital

Director BioTOP Berlin-Brandenburg 

bindseil@biotop.de

www.healthcapital.de



4

BioTOPics 46 | September 2013 

BioTOP-Report

Biotechnology

More Companies, More Employees and New Deals

The positive development of the regional corporate landscape got new momentum in 2012. The number of 

employees in the sector rose by 6.5 %. Compared to average growth rates of 3.5% during recent years, this has 

been a clear and very welcome sign of the dynamism in the Berlin-Brandenburg region, where 222 companies 

now employ a workforce numbering 4,348 people.

Development of the Companies in 2012

BioTOP conducted its anual survey of regional companies for the 

year 2012 to obtain a comprehensive overview of the current 

development of the corporate scene. During 2012, twelve new 

companies joined the ranks of surveyed companies, of which 

nine were newly founded and three included in the survey for 

the first time. Five companies ceased operations or moved to a 

different region. The new companies are still smaller firms focus-

ing on services and product development in the field of biomed-

icine. As an example, we refer to t-cell Europe, which received 

funding from the High-Tech Gründerfonds (HTGF). The aim of 

t-cell Europe, a spin-off of the Berlin-Brandenburg Centre for Re-

generative Therapies, is to use its patented platform technology 

to develop and market new t-cell-based regenerative therapies. 

The company’s first reference product will be a t-cell product for 

kidney transplants. Another interesting start-up is Drug Response 

Dx GmbH in Hennigsdorf. DRDx is developing a robust compan-

ion diagnostic test which permits secure stratification regarding 

failure in TNF

α blocker (TBA) therapy for rheumatism patients 

and therefore addresses a very big market.

The sizes of companies barely changed during the past few years. 

Smaller enterprises with less than ten employees make up 63% 

of all companies, but these firms also account for only app. 15% 

of all employees. More than 54% of those employed in the re-

gional biotech sector work in the 19 companies with more than 

50 employees. The thematic focus of the industry also remained 

unchanged during recent years and continues lie on biomedicine, 

and here particularly diagnostics.



MARCH 2012

10. BIONNALE in Berlin – 10 years of success – Biggest biotech industry meet-

ing in Berlin-Brandenburg celebrates its jubilee

APRIL 2012

NOXXON's NOX-A12 delays recidivation in preclinical glioblastoma model 

++++ 

Epigenomics AG enrolls first participant in its FIT comparative study 



with Epi proColon

®

MAY 2012

MOLOGEN AG: Promising start in financial year 2012, quarterly record pre-

sented 


++++ 

ifp and Romer Labs join in world-wide sales cooperation for 

EnzymeFast

®

 food test kits



JUNE 2012

ORGANOBALANCE presents new research results on ACHEMA 2012: Extend-

ed application range for yeast strains in biotechnological production 

++++ 


CellTrend GmbH and One Lambda Inc. agree to world-wide sales contract 

++++ 


United States Patent and Trademark Office grants co.don AG patent for 

production of autologous spinal disc cell transplants 

++++ 

NOXXON initiates 



phase IIa study of anti-CCL2/MCP-1 Spiegelmer

®

 NOX-E36 for treatment of 



diabetic neuropathy 

++++ 


ATLAS Biolabs extends spectrum of services by 

Variant AnalysisTM and iReportTM by Ingenuity

®

 Systems for data analysis 



and interpretation

JULY 2012

Epigenomics appreciates reimbursement of Septin-9 blood test for early rec-

ognition of colon cancer by Swiss Life in France 

++++ 


MOLOGEN AG capital 

increase of 22 million Euros



AUGUST 2012

co.don


®

 AG reaches another milestone on the path to central approval; Recruit-

ment phase for clinical phase II trial completed successfully 

++++ 


Merck buys 

Biochrom AG 

++++ 

Indian pharma firm Piramal invests in molecular imaging 



in Germany

SEPTEMBER 2012

Epigenomics AG announces changes in executive board 

++++ 

Charité and 



Sanofi extend partnership by diabetes alliance 

++++ 


MOLOGEN AG: Current 

data of kidney cancer therapy MGN1601 shows further improved results



OCTOBER 2012

50 years Klosterfrau Berlin GmbH 

++++ 

ATLAS Biolabs takes part in European 



projects on the research of DNA repair and cell aging 

++++ 


co.don

®

 AG from 



Teltow presents gentle alternative – preserve joints instead of replacing them


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