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姓名: 郭毓良, Yu-Liang Kuo

學校: 中山醫學大學

學系: 醫學影像暨放射技術學系

職稱: 助理教授
郭毓良研究論文PUBLICATIONS(2016/08/08)：


  1. Chuan-Pin  Yang*, Yu-Liang  Kuo*, Yi-Chao  Lee, Kuen-Haur  Lee, Chi-Wu   Chiang, Ju-Ming  Wang, Che-Chia  Hsu, Wen-Chang  Chang , Ding-Yen Lin. RINT-1 interacts with MSP58 within nucleoli and plays a role in ribosomal gene transcription. Biochemical And Biophysical Research Communications. (Chuan-Pin Yang* and Yu-Liang Kuo*, both the authors contributed equally to this work) (2016/08/07 Accepted ,BBRC-16-5155)

  2. Jui-Hung Weng, Yueh-Chun Lee, Cheng-Chia Yu, Cheng-Wei Lin, Wen-Wei
    Chang, Yu-Liang Kuo. miR-494-3p induces cellular senescence and enhances radiosensitivity in human oral squamous carcinoma cells. International Journal of Molecular Sciences. 2016 (2016/07/08 Published, Manuscript ID: ijms-125481. )

  3. Han-Chien Li*n, Yu-Liang Kuo*, Wen-Ru Lee, Hui-Yi Yap ,Shao-Hung Wang Antidermatophytic activity of ethanolic extract from Croton tiglium. BioMed Research International. 2016. (*Han-Chien Lin, *Yu-Liang Kuo, both the authors contributed equally to this work). (Published 2016/07/04)

  4. Ching-Wen Liu, Yu-Tse Wu, Kai-Jen Lin, Tsan-Jung Yu,  Yu-Liang Kuo, Chang, Li-Ching. Hydrogel-based Epirubicin Delivery System for Intravesical Chemotherapy. Molecules 2016. (Published 2016/06/01)

  5. Wei-Sheng W. Sun, Jenn-Wei Chen, Yi-Chih Wu, Hsin-Yuan Tsai, Yu-Liang Kuo, Wan-Jr Syu. A detrimental role of mpc on the expression of polycistronic lee3 genes of enterohaemorrhagic E. coli. PLOS ONE 2016 (Published online 2016 May 16. )

  6. Hang Leung, Yu-Liang Kuo, Ting-Wei Weng, Chiun-Li Chin. Hybrid-neuro-fuzzy System and Adaboost-classifier for Classifying Breast Calcification. Journal of Computers 2016. (2016/04/11 Accepted)

  7. Yu-Chao Chang , Cheng-Wei Lin , Cheng-Chia Yu , Bing-Yen Wang , Yu-Liang Kuo, Wen-Wei Chang Resveratrol ameliorates oral submucous fibrosis by epigenetic inhibition of ZEB1 expression. Oncotarget. 2016 (2016/02/18 Published)

  8. Dom Gene Tu, Yun Yu, Che Hsin Lee, Yu Liang Kuo, Yin Che Lu, Chi Wen Tu and Wen Wei Chang Hinokitiol inhibits vasculogenic mimicry activity of breast cancer stem/progenitor cells through proteasome mediated degradation of epidermal growth factor receptor. Oncology Letters. 2016. (2016/03/02, Published)

  9. Yu-Liang Kuo, Ting-Wei Weng, Chi-Wen Huang, Man-Ling Huang, Ding-Wei Chang, Chiun-Li Chin. The Interaction Inquire System among Chinese Medicine, Western Medicine and Food in Smartphone. Chung Shan Medical Journal 2015 26:35-46.

  10. Yu-Liang Kuo, Chiun-Li Chin, Cheng-Che Lu, Yi-Ju Wu. Intelligent Reminder System for Taking of Medicine and Potential Interactions. Chung Shan Medical Journal 2015; 26:15-22

  11. Pan-Fu Kao, Yu-Liang Kuo, Po-Tsun Lai, Wei-Chen Chen, Ya-Ling Hsu, Chiun-Li Chin. Fully Automatic Abdominal Fat Segmentation System from A Low Resolution CT Image. Journal of Computers. 2015

  12. Yueh-Chun Lee, Cheng-Chia Yu, Chih Lan, Che-Hsin Lee, Hsueh-Te Lee, Yu-Liang Kuo, Po-Hui Wang and Wen-Wei Chang. Plasminogen activator inhibitor-1 regulates tumor initiating cell properties in head and neck cancer. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK Online publication, 2015

  13. Gu-Jiun Lin, Huey-Kang Sytwu, Jyh-Cherng Yu, Yuan-Wu Chen, Yu-Liang Kuo, Chiao-Chi yu, Hao-Ming Chang, De-Chuan Chan, Shing-Hwa Huang. Dimethyl Sulfoxide inhibits spontaneous diabetes and autoimmune recurrence in non-obese diabetic mice by inducing differentiation of regulatory T cells. Toxicology and Applied Pharmacology. 2015.

  14. Wei-Kuang Wang, Man-Chin Chen, Hon-Fai Leong, Yu-Liang Kuo, Chun-Yu Kuo, Che-Hsin Lee. Connexin 43 suppresses tumor angiogenesis by downregulation vascular endothelial growth factor via hypoxic-induced factor-1 α Received: International Journal of Molecular Sciences. 2015.

  15. Yeu-Sheng Tyan, Ming-Chi Wu, Chiun-Li Chin, Yu-Liang Kuo, Ming-Sian Lee, Hao-Yan Chang. Ischemic stroke detection system with an computer-aided diagnosis ability using an unsupervised feature perception enhancement method. International Journal of Biomedical Imaging. 2014

  16. Wu Ming-Chi, Yu-Liang Kuo, Chen-Wei Chen, Cheng-An Fang, Chiun-Li Chin, Hao-Hung Tsai, Yeu-Sheng Tyan, James Cheng-Chung Wei. Degenerative disc segmentation and diagnosis technology using important features from MRI of spine in images. Biomedical Engineering - Applications, Basis and Communications. 2014,

  17. Huijun Zhi, Liangpeng Yang, Yu-Liang Kuo, Yik-Khuan Ho, Hsiu-Ming Shih,and Chou-Zen Giam NF-κB Hyper-activation by HTLV-1 Tax Induces Cellular Senescence, but Can Be Alleviated by the Viral Anti-sense Protein HBZ. PLoS Pathogens. 2011

  18. Fan-Yun Mong, Yu-Liang Kuo, Ching-Wen Liu, Wen-Sheng Liu, Li-Ching Chang Association of gene polymorphism in prolactin and its receptor with breast cancer risk in Taiwanese women. Molecular Biology Reports 2011

  19. Zhang Ling, Huijun Zhi, Meihong Liu, Yu-Liang Kuo and Chou-Zen Giam Induction of p21(CIP1/WAF1) expression by human T-lymphotropic virus type 1 Tax requires transcriptional activation and mRNA stabilization. Retrovirology. 2009

  20. Merling Randall, Chunhua Chen, Sohee Hong, Ling Zhang, Meihong Liu, Yu-Liang Kuo and Chou-Zen Giam HTLV-1 Tax mutants that do not induce G1 arrest are disabled in activating the anaphase promoting complex. Retrovirology. 2007

  21. Sohee Hong, Ling-Chi Wang, Xiang Gao, Yu-Liang Kuo, Baoying Liu, Randall Merling, Hsing-Jien Kung, Hsiu-Ming Shih, and Chou-Zen Giam. Heptad repeats regulate protein phosphatase 2A recruitment to I-kappa B kinase gamma /NF-kappa B essential modulator and are targeted by human T-lymphotropic virus type 1 tax. Journal of Biological Chemistry 2007

  22. Tian Feng, Xuan Wu, Honggan Pan, Hong Jiang, Yu-Liang Kuo, Ann M. Marini. Inhibition of protein kinase C protects against paraoxon-mediated neuronal cell death. Neurotoxicology, 2007.

  23. Kuo, Yu-Liang and Chou-Zen Giam Activation of the anaphase promoting complex by HTLV-1 Tax leads senescence. EMBO Journal 2006,

  24. Soung Nak-kyun, Young Hwi Kang, Keetae Kim, Keiju Kamijo, Heejeong Yoon, Yeon-Sun Seong, Yu-Liang Kuo, Toru Miki, Seung R Kim, Ryoko Kuriyama, Chou-Zen Giam, Chang H Ahn and Kyung S. Lee. Requirement of hCenexin for Proper Mitotic Functions of Polo-Like Kinase 1 at the Centrosomes. Molecular and Cellular Biology 2006

  25. Liao Wei, Tang Yong, Yu-Liang Kuo, Liu Baoying, CJ Xu, and Chou-Zen Giam. Kaposi’s sarcoma-associated herpesvirus/human herpesvirus 8 transcriptional activator Rta is an oligomeric DNA-binding protein that interacts with tandem arrays of phased A/T-trinucleotide motifs. Journal of Virology. 2003,

  26. Liu Baoying, Min-Hui Liang, Yu-Liang Kuo, Wei Liao, Imres Boros, T. Kleinberger and Chou-Zen Giam. Human T-lymphotropic virus type 1 oncoprotein Tax promotes unscheduled degradation of Pds1p/seurin and Clb2p/cyclin B1 and causes chromosomal instability. Molecular and Cellular Biology 2003,

  27. Fu, Dexue, Yu-Liang Kuo, Liu Baoying, Jeang Kuan-Teh, and Chou-Zen Giam. Human T-lymphotropic virus-1 tax activates I-kappa B kinase by inhibiting I-kappa B kinase associated serine/threonine protein phosphotase 2A. Journal of Biological Chemistry 2003,

  28. Kuo, Yu-Liang, Yong Tang, Robert Harrod, Peng Cai, and Chou-Zen Giam. Kinase-inducible domain-like of the HTLV-1 Tax is important for NF-kappa B activation. AIDS Research and Human Retroviruses. 2000,

  29. Harrod Robert, Yu-Liang Kuo, Yong Tang, Yao Yao, Alex Vassilev, Yoshihiro Nakatani, and Chou-Zen Giam. P300 and p300/cAMP-responsive element-binding protein associated factor interact with human T-cell lymphotropic virus type-1 Tax in a multi-histone acetyltransferase/activator-enhancer complex. Journal of Biological Chemistry. 2000,

  30. Kuo, Yu-Liang and Ling-Pai Ting. Differential regulation of major surface promoter in Hepatitis B virus. DNA and Cell Biology. 1997,


ABSTRACTS AND PRESENTATIONS




  1. Kuo, Yu-Liang, Xiaoyan Han, Gongshe Han, Merling Randall, Ling Zhang, Meihong Liu, Andrew Koff, Hsiu-ming Shih, and Chou-Zen Giam. Loss of Sic1 or p27KIP1 Prevents HTLV-1 Tax-Induced Rapid Senescence. Oral presentation at 5th Salk Institute Cell Cycle meeting, San Diego, CA, 2007.

  2. Kuo, Yu-Liang and Chou-Zen Giam Activation of the anaphase promoting complex by HTLV-1 Tax leads to p27kip1-mediated senescence. Poster presentation at the meeting of Retroviruses, Cold Spring Harbor, New York, 2006.

  3. Merling Randall, Ling Zhang, Meihong Liu, Sohee Hong, Yu-Liang Kuo, Chunhua Chen and Chou-Zen Giam Activation of the anaphase promoting complexby HTLV-1 Tax is required for cell transformation. Poster presentation at the meeting of Retroviruses, Cold Spring Harbor, New York, 2006.

  4. Giam, Chou-Zen, Yu-Liang Kuo, Meihong Liu, Randall Merling, Ling Zhang Activation of the anaphase promoting complex by HTLV-1 Tax leads to chromosome instability and senescence. Oral presentation by Dr. Chou-Zen Giam at the meeting of Society of Chinese Bioscientists in America the 11th International Symposium. San Francisco, CA, USA, July 2006.

  5. Soung N, Y. H. Kang, K. Kamijo,Y. Seong, Y. Kuo, T. Miki, S.R. Kim, R. Kuriyama, C. Giam, K. S. Lee Requirement of hCenexin for proper mitotic Functions of Polo-like Kinase 1 at centrosomes. Poster presentation at the 46th annual meeting of the American Society for Cell Biology (ASCB), San Diego, CA, 2006.

  6. Kuo, Yu-Liang, and Chou-Zen Giam. Premature Activation of the Anaphase Promoting Complex by the HTLV I Tax Leads to Irreversible G1 Arrest. Oral presentation by Dr. Chou-Zen Giam at the meeting of 12th International Conference on Human Retrovirology: HTLV & RELATED VIRUSES. Jamaica, June 22-25, 2005.

  7. Kuo, Yu-Liang, Baoying Liu and Chou-Zen Giam HTLV-1 Tax induces a mitotic crisis that is coupled with replicative senescence. Oral presentation by Dr. Chou-Zen Giam at the meeting of Retroviruses, Cold Spring Harbor, New York, May, 2004.

  8. Kuo, Yu-Liang, Ling-Chi Wang, Min-Hui Liang, Yong Tang, Dexue Fu, Baoying Liu , Robert Harrod, Hsing-Jien Kung, Hsiu-Ming Shih, and Chou-Zen Giam. HTLV-1 trans-activator, Tax, is a non-competitive inhibitor of protein phosphotase 2A and biological consequences. Oral presentation by Dr. Chou-Zen Giam at the meeting of Retroviruses, Cold Spring Harbor, New York, May, 2002.

  9. Kuo, Yu-Liang, Ling-Chi Wang, Yong Tang, Dexue Fu, Robert Harrod, Hsing Jien Kung, Hsiu-Ming Shih, and Chou-Zen Giam Human T-lymphotropic virus type 1 transactivator, Tax, is a non-competitive inhibitor of protein phosphatase 2A. Oral presentation by Dr. Chou-Zen Giam at the meeting of Society of Chinese Bioscientists in America the 11th International Symposium. Taiwan. 2001.

  10. Liu, Baoying, Imre Boros, Peng Cai, Yu-Liang Kuo, Charles Di Como and Chou-Zen Giam. HTLV-1 oncoprotein Tax inhibits cell growth and perturbs spindle checkpoint in Saccharomyces cerevisiae. Poster presentation at the meeting of American Society Cell Biology (ASCB), Washington, D.C., Dec, 2001.

  11. Kuo, Yu-Liang, Ling-Chi Wang, Yong Tang, Dexue Fu, Robert Harrod, Hsing-Jien Kung, Hsiu-Ming Shih, and Chou-Zen Giam. HTLV-1 trans-activator, Tax, is a non-competitive inhibitor of protein phosphotase 2A. Oral presentation at the meeting of Retroviruses, Cold Spring Harbor, New York, 2001

  12. Yao Yao, Yu-Liang Kuo, Ling-Chi Wang, Robert Harrod, Yong Tang, Peng Cai, William J. Harrington jr. Imre Boros, Hsiu-Ming Shih Chou-Zen Giam. Mechanisms of action of HTLV-1 Tax. Poster presentation at the HTLV Molecular Biology and Pathogenesis meeting, Virginia, Mar, 2000.

  13. Kuo, Yu-Liang and Ling-Pai Ting. Differential regulation of HBV major surface promoter. Poster presentation at the meeting of Molecular Biology of Hepatitis B Virus, Cold Spring Harbor, New York, 1996

  14. Kuo, Yu-Liang and Ling-Pai Ting. Differential regulation of HBV major surface promoter. Oral presentation at the 29th Annual Meeting of the Taiwan Microbiology Society, Taipei, Taiwan, 1995

  15. Kuo, Yu-Liang and Ling-Pai Ting. Differential regulation of HBV major surface promoter. Oral presentation at the 10th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 1995

  16. Kuo, Yu-Liang and Ling-Pai Ting. Differential regulation of HBV major surface promoter. Oral presentation at the 27th Annual Meeting of the Taiwan Microbiology Society, Tao-Yuan, Taiwan, 1993

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