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This report contains the collective views of an international group of
experts and does not necessarily represent the decisions or the stated policy
of the United Nations Environment Programme, the International Labour
Organization or the World Health Organization.
Environmental Health Criteria 226
PALLADIUM
First draft prepared by Dr Christine Melber, Dr Detlef Keller and Dr Inge
Mangelsdorf, Fraunhofer Institute for Toxicology and Aerosol Research,
Hanover, Germany  
Please note that the layout and pagination of this pdf
file are not necessarily identical to those in the
printed EHC
Published under the joint sponsorship of the United Nations
Environment Programme, the International Labour
Organization and the World Health Organization, and
produced within the framework of the Inter-Organization
Programme for the Sound Management of Chemicals.
World Health Organization
Geneva, 2002


The  International  Programme  on  Chemical  Safety  (IPCS),  established
i n  1980,  is  a  joint  venture  of  the  United  Nations  Environment  Program m e
(UNEP),  the  International  Labour  Organization  (ILO)  and  the  World  Health
Organization (WHO). The overall objectives of the IPCS are to establish the
scientific  basis  for  assessment  of  the  risk  to  human  health  and  the  environment
from  exposure  to chemicals, through international peer review processes, as a
prerequisite  for  the  promotion  of  chemical safety, and to provide technical
assistance  in  strengthening  national  capacities  for  the  sound management of
chemicals.
T he  Inter-Organization  Programme  for  the  Sound  Managemen t   o f
Chemicals  (IOMC) was established in 1995 by UNEP, ILO, the Food and
Agriculture  Organization  of  the  United  Nations,  WHO,   the  United  Nat i o n s
Industrial  Development  Organization, the United Nations Institute for Training
and  Research  and  the  Organisation  for  Economic  Co-operation  and  Development
(Participating Organizations), following recommendations made by the 1992 UN
Conference  on  Environment  and  Development  to  strengthen cooperation and
increase  coordination in the field of chemical safety. The purpose of the IOMC
is to promote coordination of the policies and activities pursued by the
Participating  Organizations, jointly or separately, to achieve the sound manage-
ment of chemicals in relation to human health and the environment.
WHO Library Cataloguing-in-Publication Data
Palladium.
(Environmental health criteria ; 226)
1.Palladium  -  toxicity  2.Palladium - adverse effects  3.Environmental
exposure
4.Occupational exposure  5.Risk assessment  I.International Programme for
Chemical Safety  II.Series
ISBN 92 4 157226 4    
                     (NLM classification: QV 290)
 
ISSN 0250-863X
The  World  Health  Organization  welcomes  requests  for  permission to
reproduce  or  translate  its  publications,  in  part  or  in  full.  Applications and
enquiries  should  be  addressed  to  the  Office  of  Publications, World Health
Organization,  Geneva,  Switzerland,  which  will be glad to provide the latest
information  on  any  changes  made  to  the  text,  plans  for  new  editions, and reprints
and translations already available.
©World Health Organization 2002 
Publications  of  the World Health Organization enjoy copyright protection
in  accordance with the provisions of Protocol 2 of the Universal Copyright
Convention. All rights reserved.
The  designations  employed and the presentation of the material in this
publication do not imply the expression of any opinion whatsoever on the part
of  the  Secretariat  of  the  World  Health  Organization  concerning  the  legal  status
of  any  country,  territory,  city  or  area  or  of  its  authorities,  or  concerning the
delimitation of its frontiers or boundaries.
The  mention of specific companies or of certain manufacturers’ products
does not imply that they are endorsed or recommended by the World Health
Organization  in  preference  to  others  of  a  similar nature that are not mentioned.
Errors 
and 
omissions 
excepted, the names of proprietary products are
distinguished by initial capital letters.
The  Federal  Ministry  for  the  Environment,  Nature conservation and Nuclear
Safety,  Germany,  provided  financial  support for, and undertook the printing of,
this publication


iii
CONTENTS
ENVIRONMENTAL HEALTH CRITERIA FOR
PALLADIUM
PREAMBLE
x
ACRONYMS AND ABBREVIATIONS
xx
1.
SUMMARY
1
1.1
Identity, physical and chemical properties and 
analytical methods
1
1.2  
Sources of human and environmental exposure
1
1.3  
Environmental transport, distribution and
transformation
2
1.4  
Environmental levels and human exposure
3
1.5  
Kinetics and metabolism in laboratory animals
and humans
4
1.6  
Effects on laboratory mammals and in vitro test
systems
6
1.7  
Effects on humans
10
1.8  
Effects on other organisms in the laboratory
and field
12
2.
IDENTITY, PHYSICAL AND CHEMICAL 
PROPERTIES AND ANALYTICAL METHODS
 14
2.1  
Identity
 14
2.2 
Physical and chemical properties
14
2.2.1
Palladium metal
14
2.2.2
Palladium compounds
14
2.3  
Analytical methods
18
2.3.1
Sample collection and pretreatment
18
2.3.2
Reference materials
22
2.3.3
Analysis
23


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