Immunogen Immunogen Antigen (Ag) Hapten Antibody (Ab)
Foreignness
Foreigness Foreigness Size Chemical Composition Physical Form - Particulate > Soluble
- Denatured > Native
Foreigness Foreigness Size Chemical Composition Physical Form Degradability - Ag processing by Ag Presenting Cells (APC)
Genetics
Dose Dose Route - Subcutaneous > Intravenous > Intragastric
Adjuvant - Substances that enhance an immune response to an Ag
Proteins Proteins Polysaccharides Nucleic Acids Lipids
Polysaccharides
Proteins
Definition
Composition Composition - Proteins, polysaccharides, nucleic acids, haptens
- Sequence (linear) determinants
- Conformational determinants
Size
Composition Composition Size Number - Limited (immunodominant epitopes)
- Located on the external surfaces of the Ag
Composition Composition - Proteins (some lipids)
- Sequence determinants
- Processed
- MHC presentation (lipid presentation by MHC-like CD1)
Size Number
Definition Definition Examples - Staphylococcal enterotoxins
- Staphylococcal toxic shock toxin
- Staphylococcal exfoliating toxin
- Streptococcal pyrogenic exotoxins
Adaptive Immune System – Discrete Determinants - Reacts with a specific pathogen
- Reacts with a variety of pathogens
PAMPs – Pathogen Associated Molecular Patterns PRRs – Pattern Recognition Receptors
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