The cv of Hiroki Moriwaki

Hamari Chemicals, Ltd. The CV of Hiroki Moriwaki Page /

Hiroki Moriwaki

Birth date: 03/04/1961

Nationality: Japan

Resides: 1-18-27 Hanazonohigashi-machi, Higashiosaka-city, Osaka, Japan 578-0931

Mobile Phone Number: 090-2100-2496

Home Phone Number: 072-964-0621

Email: [e-mail]

• 
  Education:
  

1985 Kyoto Pharmaceutical University

• 
  Qualifications:
  

Pharmacist 1985

• 
  Work Experience
  

1985 - Present Hamari Chemicals, Ltd. Osaka, Japan

Director, Research & Development Department

April, 1985 – March, 1991 Technical section, Manufacturing Dep., Takathuki Plant

April, 1991 – March, 1992 Chemical section, Research & Development Dept

April, 1992 – March, 1994 Dispatch, Kyoto Pharmaceutical University

Prof. Yoshiaki Kiso , Medicinal Chemistry

I studied the process chemistry such as peptide synthesis and HIV protease inhibitor.

April, 1994 return to work, Chemical section, Research & Development Dept.

August,1997 Manager, Chemical section, Research & Development Dept.

August, 2000 Assistant Director, Research & Development Department

August, 2006 Director, Research & Development Department

• 
  Special field
  

Process Chemistry and Peptide Synthesis

Process Chemistry: More than 60 reactions on commercial scale such as Negishi and Suzuki reaction, reductive amination using metal catalysts, and Indoles and Quinolines using Nitration

Peptide Synthesis: Expertise technology using solution phase synthesis such as ACE inhibitor, intermediate of anti-cancer drugs and LH-RH-analogues.

1. 
   Oral presentation
   

October, 1984 The Pharmaceutical Society of Japan

Kinki branch office general meeting

(Synthesis and application of imidazole derivatives)

July, 2004 The Japanese Society for Process Chemistry (JSPC)

　 Summer Symposium　2004

(Process developments of L-carnosine derivatives)

October, 2004 Osaka Industrial Research Association

Seminar

(Development and a process Chemistry for the peptide-based useful material)

2. 
   Papers
   

Moriwaki, Hiroki; Nakagami, Yuichi.

High quality of alpha-lipoic acid. Process development and manufacturing.

Fragrance Journal (2005), 33(8), 68-74.

Kimura, Tooru; Ohtake, Jun; Nakata, Shingo; Enomoto, Hiroshi; Moriwaki, Hiroki; Akaji, Kenichi; Kiso, Yoshiaki.

Synthesis of prodrugs of HIV protease inhibitors.

Peptide Chemistry (1995), Volume Date 1994, 32nd 157-60.

Ohta, Shunsaku; Hayakawa, Satoshi; Moriwaki, Hiroki; Harada, Suzumi; Okamoto, Masao.

Synthesis and application of imidazole derivatives.

Synthesis and acyl activation of 2-acyl-1-methyl-1H-imidazoles.

Chemical & Pharmaceutical Bulletin (1986), 34(12), 4916-26.

Ohta, Shunsaku; Hayakawa, Satoshi; Moriwaki, Hiroki; Tsuboi, Shinichi; Okamoto, Masao.

Synthesis of 2-acyl-1-methyl-1H-imidazoles and reactivity of the acyl group.

Heterocycles (1985), 23(7), 1759-64.

3. 
   Patent
   

Ando, Kazuo; Shishido, Masahiko; Moriwaki, Hiroki.

Method for preparing 2E,6E-isomer-enriched farnesal via alkali metal bisulfite adducts.

Jpn. Kokai Tokkyo Koho (2008), JP 2008201736

Shishido, Masahiko; Ueno, Koichi; Nakagami, Yuichi; Moriwaki, Hiroki.

Preparation of high-purity  -lipoic acid L-ornithine salt.

Jpn. Kokai Tokkyo Koho (2008), JP 2008156282

Terasawa, Michio; Kanetani, Eiko; Moriwaki, Hiroki.

Degranulation inhibitors containing histidine-containing dipeptide.

Jpn. Kokai Tokkyo Koho (2008), JP 2008031066

Shishido, Masahiko; Ueno, Koichi; Nakagami, Yuichi; Moriwaki, Hiroki.

Method for preparation of  -lipoic acid L-lysine salt crystal.

Jpn. Kokai Tokkyo Koho (2008), JP 2008156281

Shishido, Masahiko; Nakagami, Yuichi; Moriwaki, Hiroki; Ishino, Yoshio; Mizuno, Takumi; Iwai, Toshiyuki. Preparation of crystalline  -lipoic acid L-lysine salt.

Jpn. Kokai Tokkyo Koho (2007), JP 2007070238

Moriwaki, Hiroki; Nakagami, Yuichi; Nakayama, Keiso; Sawamura, Yoshihito; Takami, Tokio.

Preparation of water-soluble  -lipoic acid amino acid salts.

Jpn. Kokai Tokkyo Koho (2006), JP 2006265202

Yamaoka, Nagatoshi; Egawa, Hiroshi; Takenaka, Shigekazu; Moriwaki, Hiroki.

Preparation of carnosine.

Jpn. Kokai Tokkyo Koho (2005), JP 2005306782

Hiraoka, Katsuyuki; Moriwaki, Hiroki.

Preparation of L-anserine from phthalyl-L-carnosine.

Jpn. Kokai Tokkyo Koho (2005), JP 2005082571

Takahashi, Motohiro; Watanabe, Teruo; Murayama, Shuichi; Moriwaki, Hiroki.

Preparation of optically active phenylpropionic acids.

Jpn. Kokai Tokkyo Koho (2000), JP 2000309557

Kimura, Tooru; Moriwaki, Hiroki; Kiso, Yoshiaki.

Preparation of tripeptides with improved water solubility as prodrugs for HIV protease inhibitors. Jpn. Kokai Tokkyo Koho (1996), JP 08109180
Maeda, Sadayuki; Moriwaki, Hiroki; Mitsumoto, Tsutomu; Kisanuki, Junji; Kato, Ryohei; Maeda, Hiroshi; Takahashi, Osamu; Kiso, Yoshiaki.

preparation of peptides derivatives as intermediates for HIV protease inhibitors.

Jpn. Kokai Tokkyo Koho (1994), JP 06220031

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