10th anniversary International Multiconference «Bioinformatics of Genome Regulation and Structure\ Systems Biology»

Estimates of solutions to a system describing the spread of avian influenza

Maria Skvortsova

Sobolev Institute of Mathematics SBRAS, Novosibirsk, Russia

NSU, Novosibirsk, Russia

12.25–12. 50

Elucidation of molecular signal of transcription response to desiccation stress in chironomid P. vanderplanki Elena Shagimardanova^1, R.M. Deviatiyarov^1, T Kikawada^2, O.A. Gusev^1,3 Kazan Federal University, Kazan, Russia National Institute of Agrobiological Sciences, Tsukuba, Japan RIKEN, Yokohama, Japan

12.25–12.50

Ageing of multicellular organisms as a stage of ontogenesis Igor Erokhin National Biotechnological Company LLC, Moscow, Russia

12:10–12:25

Predictive models of early-onset preeclampsia based on the blood plasma microRNA expression level Ivan Balashov^1, O.S. Altukhova^1, А.V. Timofeeva^1, V.А. Gusar^1, K.N. Prozorovskaya^1, N.E. Kan^1, P.I. Borovikov^1, M.Y. Bobrov^1 ^1Research Center for Obstetrics, Gynecology and Perinatology, Moscow, 117997, Russia

12:10−12:25

Association of RS505151 in PCSK9 gene with lipid profile in Russian population Kseniya Astrakova, E.V. Shakhtshneider, D.E. Ivanoshchuk, Yu.I. Ragino, M.I. Voevoda Institute of Internal and Preventive Medicine, Novosibirsk, Russia

12:25–12:40

A new algorithm to the reconstruction of a set of points from the multiset of n 2 pairwise distances in n^2 steps for the de novo sequencing problem Eduard Fomin Institute of Cytology and Genetics SBRAS, Novosibirsk, Russia

12:25−12:40

Commonability of the combinations of polymorphic regulatory sites in the cytokine genes in pathogenetically diverse diseases in women Alla Shevchenko, V.F. Prokof`ev , V.I. Konenkov Scientific Institute of Clinical and Experimental Lymрhology, Novosibirsk, Russia

12:40–12:55

Estimating the survival rates of northern fur seals (callorhinus ursinus, tyuleniy herd) and modeling the population number dynamics Oksana Zhdanova^1, A.E. Kuzin^2 , E.Ya. Frisman^3 ^1Institute of Automation and Control Processes FEB RAS, Vladivostok, 690041, Russia ^2Pacific Research Fisheries Center (PRF-Center), Vladivostok, 690091, Russia ^3Institute of Complex Analysis of Regional Systems FEB RAS, Birobidzhan, 679000, Russia

12:40−12:55

Techniques of stochastic modeling and inhomogeneous sequential pattern recognition procedure in prediction of polygenic disease Viktor Prokof'ev, A.V. Shevchenko, M.A. Korolev, V.I. Konenkov SICEL, Novosibirsk, Russia

12:55−13:00

Discussion

31 August, Wednesday (14:00-18:10) 13:00−14:00 Lunch

Time

Small hall

Time

Library

Time

223

Time

Music Hall

Time

Exhibition Hall

14.00–18.10

Section “Computational Pharmacology” (House of Scientists SB RAS, Small Hall) Chairpersons: Vladimir Poroikov, Institute of Biomedical Chemistry, Moscow, Russia; Elena Schwartz, Elena Schwartz Ami-Go-Science LLC, Rockville, MD United States BGRS\SB

14.00–18.10

Section “Systems Biology of Aging” (House of Scientists SB RAS, Library) Chairpersons: Vladimir Anisimov, N.N. Petrov Research Institute of Oncology, Saint-Petersburg, Russia; Alexey Moskalev, Institute of Biology, Komi Science Centre; Natalya Kolosova ICG SB RAS, Novosibirsk, Russia BGRS\SB

14.00–18.45

Section ”Bioinformatics and Molecular Biology of DNA Damage Response” (House of Scientists SB RAS, Room 223) Chairpersons: Grigory Dianov, University of Oxford, United Kindom & Institute of Cytology & Genetics, Novosibirsk, Russia BGRS\SB

14:00−15:50

Section «Clinical Genomics and Epigenetics» Chairs: Tatjana Merculova, Marina Zenkova SBioMED

14:00–16:30

Afternoon session “Data mining methods and text data analysis in natural sciences” Chairpersons: Prof. S.S.Goncharov, Yu.L.Orlov, Prof. A.Yu. Rzhetsky MM-HPC-BBB

14.00–14.35

Infant nasopharyngeal microbiome in respiratory syncytial virus cohort–a case study in developing and applying "Do It Yourself analysis tools" for the bench scientists Andrey Tovchigrechko Research Bioinformatics, Medimmune LLC, Gaithersburg, MD United States

14:00-14:25

Systemic role of allelic variants in a 2q22 region in major age-related diseases and lifespan Alexander Kulminski, L. He, I. Culminskaya, Y. Loika, Y. Kernogitski, K.G. Arbeev, E. Loiko, L. Arbeeva, O. Bagley, M. Duan, A. Yashkin, F. Fang, M. Kovtun, S.V. Ukraintseva, D. Wu, A.I. Yashin; Duke University, Durham, USA

14:00-14:15

Base excison repair mechanisms. Introduction. Grigory Dianov University of Oxford, United Kindom; Institute of Cytology and Genetics, Novosibirsk, Russia

14:00−14:15

Functional analysis of mutations revealed by NGS diagnostics M. Skoblov^1,2,7, N.V. Zernov^1, A.V. Marakhonov^1,2, Y. Shimomura^4, F.A. Konovalov^1,3, A.V. Abrukova^5, A.Yu. Filatova^1, T.A. Vasilyeva^1, R.A. Zinchenko^1,6,7 ^1Research Centre for Medical Genetics, Moscow;^2The Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region; ^3Regenerative and Genetic Medical Center of the Human Stem Cells Institute, Moscow, Russia; ^4Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan; ^5Ministry of Health and Social Development of Chuvash Republic, Cheboksary; ^6Pirogov Russian National Research Medical University, Moscow; ^7Moscow State University of Medicine and Dentistry, Moscow, Russia

14:00–14:30

Big Data in biology and medicine Evgeniy Pavlovsky NSU, Novosibirsk, Russia

14:30–14:45

The application of optimal partitioning based approaches for estimation of the adverse outcome risk in patients discharged after acute coronary syndrome Rustam Guliev^1, O.V. Senko^2, D.A. Zateyshchikov^3, V.V. Nosikov^1, A.V. Kuznetsova^1, M.A. Evdokimova^3, V.A. Brazhnik^3, I.N. Kurochkin^1,4 ^1Emanuel Institute of Biochemical Physics RAS, Moscow, Russia; ^2Computer Center of Russian Academy of Science, Moscow, Russia ^3Central State Medical Academy of Department of Presidential Affairs, Moscow, Russia; ^4Lomonosov Moscow State University, Moscow, 119991, Russia

14.35–15.00

Disease models for cancer to select candidate biomarkers and drug target Elena Schwartz^1, Anton Yuryev^2, Che Ross^3, Irene Riz^4 and Alexandra McPherron^1. ^1Ami-Go-Science, 5917 Barbados Place, Rockville MD, USA ^2Elsevier, Rockville, MD, USA; ^3Johns Hopkins University, Baltimore, MD, USA ^4George Washington University, Washington DC, USA

14:25-14:50

Neuronal transcriptional regulation of Drosophila life span O. Y. Rybina^1,2, A. V. Symonenko^1, N. V. Roshina^1, A. V. Krementsova^1,3, E. R. Veselkina^1, M.I. Schelkunov^4, S. V. Sarantseva^5, Elena Pasyukova^1 ^1 Institute of Molecular Genetics of RAS, Moscow, Russia; ^2 Moscow State Pedagogical University, Institute of Biology and Chemistry, Russia; ^3 N. M. Emmanuel Institute of Biochemical Physics of RAS, Moscow, Russia; ^4 Moscow State University, Russia; ^5 B. P. Konstantinov Petersburg Nuclear Physics Institute, Russia

14:15-14:45

Regulation of base excision repair-canonical and non-canonical processing of genomic uracil Hans Krokan, H.S. Pettersen, R. Mjelle, S.A. Hegre, P. Sætrom, F. Drabløs, A. Sarno, A. Galashevskaya, P.A. Aas, N.B. Liabakk, B. Doseth, G. Slupphaug, B. Kavli Norwegian University of Science and Technology, Trondheim, Norway

14:15−14:30

Mutations spectra of mayor oncogenes in patients with multiple primary neoplasia Gennadiy Vasiliev^1, A.V. Savkova^2, A.V. Gerasimov^3 ^1ICG SB RAS, Novosibirsk, Russia; ^2Centre for Postgraduate Medical Education, NSU, Novosibirsk, Russia; ^3Novosibirsk Regional Clinical Oncology Hospital, Novosibirsk, Russia

14:45–15:00

Mutational landscape of prostate tumors based on whole exome sequencing Irina Gilyazova^1,2, M.A. Yankina^1, G.B. Kunsbaeva^2, A.A. Izmaylov^3, A.T.Mustafin^3, V.N. Pavlov^3, E.K. Khusnutdinova^1,2 ^1Institute of Biochemistry and Genetics, Ufa Scientific Centre, RAS, Ufa, Russia ^2Bashkir State University, Ufa ^3Bashkir State Medical University, Ufa

15.00–15.25

In silico screening for sulfonate-based inhibitors against promising anticancer targets Dmitry Nilov^1*, I.V. Gushchina^2, V.K. Švedas^1,2 ^1Belozersky Institute of Physicochemical Biology, Moscow State University; ^2Faculty of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russia

14:50–15.15

Comparative expression landscapes in replicative and stress induced premature senescence K.C. Kural^1, N. Tandon^2, O.V. Kel-Margoulis^2, Anna Baranova^1,3,4 ^1School of Systems Biology, George Mason University, Fairfax, USA; ^2geneXplain, Wolfenbüttel Germany; ^3Research Centre for Medical Genetics, Moscow, Russia ^4ATLAS Biomed Group, Moscow, Russia

14:45-15:15

Poly(ADP-ribose) polymerase 1 and regulation of DNA repair Olga Lavrik ICBFM SB RAS, Novosibirsk, Russia NSU, Novosibirsk, Russia

14:30−14:45

Circulating DNA as a source of novel type of cancer biomarkers V. Mileyko^1,2, M. Ivanov^1, E. Morozkin^2, Ancha Baranova^1,3,4 ^1ATLAS Biomed Group, Moscow, Russia ^2ICBFM, Novosibirsk, Russia ^3Federal State Budgetary Institution "Research Centre for Medical Genetics", Moscow, Russia ^4School of Systems Biology, George Mason University, Fairfax, VA USA

15:00–15:15

Computational tools for data processing of medical imaging Mikhail Kurako^1, An.G. Marchuk ^2, F.P.Kapsargin^3, L. Cadena^1, Simonov K.V.^4 ^1Siberian Federal University, Krasnoyarsk, 660041,Russia ^2Institute of Computational Mathematics and Mathematical Geophysics SB RAS, Novosibirsk, Russia ^3Krasnoyarsk State Medical University, Krasnoyarsk, Russia; ^4Institute of Computational Modelling SB RAS, Krasnoyarsk, Russia

15.25–15. 50

Identification of proteins associated with drug-induced liver injury using in silico prediction of drug-target interactions Sergey Ivanov^1,2*, M.I. Semin^1,2, A.A. Lagunin^1,2, D.A. Filimonov^1, V.V. Poroikov^1,2 ^1Institute of Biomedical Chemistry, Moscow, Russia ^2Pirogov Russian National Research Medical University, Medico-Biological Faculty, Moscow, Russia

15.15–15.35

Changes in the brain transcriptome of OXYS rats as the signs of Alzheimer’s disease develop and effects of SkQ1 Natalia Stefanova, N.I. Ershov, N.A. Muraleva, N.G. Kolosova ICG SB RAS, Novosibirsk, Russia

15:15-15:45

Speed reading at the molecular scale: how enzymes find typos in a DNA text Dmitrij Zharkov ICBFM SB RAS, Novosibirsk, Russia

14:45−15:00

Circulating microRNA dynamics in lung cancer patients during therapy Аnastasia Ponomaryova^1,3, E. Rykova^2,4, N. Cherdyntseva^1,5, E. Morozkin^2,6, I. Zaporozhchenko^2, T. Skvortsova^2, А. Dobrodeev^1, A. Zav’yalov^1, S. Tuzikov^1, Vlasov^2, P. Laktionov^2,6 ^1Tomsk Cancer Research Institute, Tomsk; ^2ICBFM SB RAS, Novosibirsk; ^3 Tomsk Polytechnic University, Tomsk; ^4NSTU, Novosibirsk; ^5 TSU, Tomsk; ^6Meshalkin Research Institute, Novosibirsk, Russia

15:15–15:30

Censoring of noisy objects and attributes with function of rival similarity in medical and biological tasks Olga Kutnenko, I.A. Borisova Sobolev Institute of Mathematics SBRAS, Novosibirsk, Russia

15.35–15:50

The mitochondria-targeted plastoquinone SkQ1 affects Drosophila melanogaster lifespan in various environment Anna Krementsova^1, N. V. Roshina^2, E. A. Tsybulko^2, O. Y. Rybina^2, A. V. Symonenko^2, E. G. Pasyukova^2 ^1Emmanuel Institute of Biochemical Physics of RAS, Moscow, Russia ^2Institute of Molecular Genetics of RAS, Moscow, Russia

15:00−15:15

Somatic DNA methylation landscape of coronary artery disease patients Maria Nazarenko^1, A.V.Markov^1, A.A. Sleptsov^1, O.L. Barbarash^2, V.P. Puzyrev^1 ^1Research Institute of Medical Genetics, Tomsk, Russia;^2Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia

15:30–15:45

VlincRNA database: tool for very long intergenic non-coding RNA functional annotation Denis Antonets^1,2,4, Y. Vyatkin^2,3, D. Luppov^2,3, P. Kapranov^3,5, M. Ri^2,3, O. Saik^2,3,6, D. Shtokalo^1,2,3 ^1A.P.Ershov Institute of Informatics Systems SBRAS, Novosibirsk, Russia; ^2AcademGene LLC, Novosibirsk, Russia’ ^3St. Laurent Institute, Woburn, USA; ^4State Research Center of Virology and Biotechnology ‘Vector’, Novosibirsk, Russia ^5Institute of Genomics, School of Biomedical Sciences, Huaqiao University, Xiamen, China; ^6Institute of Cytology and Genetics SBRAS, Novosibirsk, Russia

15:15−15:30

Features of miRNA interaction with mRNA genes in coronary artery disease A. Ivashchenko, R.E. Niyazova, S.A. Atambayeva, A.Y. Pyrkova Al-Farabi Kazakh National University, Almaty, Kazakhstan

15:30−15:45

Epigenomic changes in postmortem brains of human alcoholics Igor Ponomarev Waggoner Center for Alcohol and Addiction Research, The University of Texas, Texas, USA

15:45−15:50

Discussion

Coffee break: 15.50–16.10

16.10–16.35

Computer-aided drug repurposing: new uses for old drugs or filling gaps in biomedical knowledge? Vladimir Poroikov, D.A. Filimonov, A.A. Lagunin, T.A. Gloriozova Institute of Biomedical Chemistry, Moscow, Russia

16:10–16.35

Geroprotector and criteria for its evaluation Alexey Moskalev, M. Shaposhnikov, E.Proshkina, V.Tsvetkov, A.Fedintsev, E. Chernyagina, A.Zhavironkov ^1Institute of Biology of Komi Science Center of UB RAS; Syktyvkar, Russia

16:10-16:30

Ku antigen displays the apurinic/ apyrimidinic (AP) lyase activity on a certain types of duplex DNA Anastasiya Kosova, S.N. Khodyreva, O.I. Lavrik ICBFM SB RAS, Novosibirsk, Russia

16:10−17:00

Discussion and closing remarks

16:05–16:15

A fenomenon of multistability in a simple ecological evolutionary population model Oksana Zhdanova^1, E.Ya. Frisman^2 ^1Institute of Automation and Control Processes FEB RAS, Vladivostok; ^2Institute of Complex Analysis of Regional Systems FEB RAS, Birobidzhan, Russia

16.35–17.00

In silico design of aptamers containing g-quadruplexes Arthur Zalevsky^1,2, A.O. Demkiv^2, A.V. Golovin^1,2 ^1Apto-Pharm LLC, Moscow, Russia ^2Moscow State University, Moscow, Russia

16.35–17.00