Biotop-report 2011

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Biotech Companies

Novamol GmbH

Development and manufacture of human and veterinary food supplements and health-

enhancing products

novamol.com

NOXXON Pharma AG

NOXXON Pharma is a biotechnology company developing a promising new class of thera-

peutics called Spiegelmers, which are oligonucleotides made from the L-stereoisomer of 

RNA. Spiegelmers can be engineered to bind specifically to a precisely defined biological 

target and have been shown to be potent inhibitors. Clinical and pre-clinical studies of 

Spiegelmers to date have shown them to be exceptionally safe, well-tolerated, biologically 

stable and non-immunogenic. NOXXON has three programs in development, two of which 

have successfully completed their first Phase I clinical studies. The company has approxi-

mately 60 employees based at its headquarter in Berlin, Germany.

noxxon.com

NutriNeu GmbH

NutriNeu GmbH develops a new generation of pre and probiotics. First products are 

based on microorganisms that were isolated with our proprietary GlycoScreen technology 

(antibody directed isolation of microorganisms expressing specific carbohydrate structures). 

Besides developing own products, NutriNeu GmbH offers services in the fields of micro-

biology, process development and Glycoanalytic. NutriNeu GmbH also helps customers to 

investigate the probiotic properties of their microorganisms.

OpTricon Entwicklungsgesellschaft f. optische 

Technologien

OpTricon develops and produces mobile readers for quantitative analyzes of Immunoas-

says for Point-of-Care-diagnostics, especially Lateral Flow Assays (LFA). Additional business 

segments are components and Systems for signal transmission and sensors for lbioanalyt-

ics. opTricon develops the devices in partnership with the customers and works as OEM-

suppliers and is certified by TÜV Rheinland according EN ISO 13485:2003+AC: 2007 and EN 

ISO 9001:2008.

optricon.de

ORGANOBALANCE GmbH

ORGANOBALANCE is a company specializing in microbial strain development and screen-

ing. As a R&D contractor ORGANOBALANCE develops new biological products in the areas 

of nutrition, personal care and health care. The company draws on its own collection of 

microbial strains suitable for food applications and its OASSYS

®

 bioassay systems. In the 

field of ?metabolic engineering? ORGANOBALANCE exploits Saccharomyces cerevisiae yeast for 

synthesis of substances for the industrial and pharmaceutical industry.

organobalance.com

ORGANOBALANCE Medical AG

ORGANOBALANCE Medical AG funds and promotes the research and development of novel 

therapies based on specific probiotic cultures, aiming to develop active substances and 

mechanisms for innovative medicinal products and medical devices, as well as offer new 

therapeutic concepts for hitherto inadequately treatable indications.

organobalancemedical.com

ovalehn GmbH

Production and application of specific recipes -containing IgY for diagnostics and oral, 

passive immune therapy

ovalehn.de

Pentracor GmbH

In the case of cardiac infarction, C-reactive protein (CRP) results in an increase of the 

primary damage. Based on a new prototype, the company Pentracor GmbH aims to develop 

an adsorber for therapeutic reduction of CRP, lead it to approval, establish its certified 

production and market the product after clinical validation.

pentracor.com

Peptides&elephants GmbH

Custom synthesis of peptides and peptide libraries. Development parallel Synthesis tech-

nologies. Distributor of Peptide Synthesis Automation.

peptides.de

PharmaSol GmbH

Modification of ingredients or introduction of new metabolic pathways in plants with 

gene-technology methods

pharmasol-berlin.de

PlasmaChem GmbH

PlasmaChem GmbH is an innovative R&D and manufacturing company specializing in 

nanomaterials, plasma- and ultra-thin film technologies. The company manufactures 

nano-coated medical implants (stents), nanomaterials, additives for metal plating (applied 

e. g. by Siemens AG), new additives to engine oils on the base of nanodiamonds and other 

industrial nanoproducts.

plasmachem.com

PolyAn, Gesellschaft zur Herstellung von 

Polymeren für spezielle Anwendungen und 

Analytik mbH

PolyAn is specialised in Molecular Surface Engineering (MSE) and Surface Molecular Imprint-

ing (SMI). PolyAn's proprietary MSE-technology platform is used for the production of 

microarray slides, e. g. for oligo-, peptide or protein arrays. For multiplex-bead arrays Poly-

An has developed a range of functionalised, fluorescence encoded PMMA microparticles. 

poly-an.de

Preclinics Gesellschaft für präklinische 

 Forschung  mbH

Preclinics is a commercial cooperation partner for preclinical research and development. 

As a competent, creative and experienced partner preclinics investigates pharmaceutical 

substances, therapeutic methods and proceedings as well as medical products during the 

preclinical phase.Additional we provide custom antibody production in llama, goat, sheep, 

rabbit and other species.

preclinics.com

ProBioGen AG

ProBioGen is a specialist in mammalian cell development, process engineering and GMP 

manufacturing of biopharmaceutical drug substances. Offering state-of-the-art contract 

development and manufacturing services as well as access to proprietary cell lines (AGE1.

cell lines(R)) for the manufacturing of biopharmaceuticals and vaccines.
The company 

possesses the manufacturing authorisation from the competent authority and meets the 

quality standards required by the EMEA and the FDA guidelines.

probiogen.de

ProteaImmun GmbH

ProteaImmun produces a unique range of recombinant proteases for medical and phar-

maceutical research. Our proteins are designed for structural and functional studies of 

proteases screening and evaluation of protease inhibitors and modulators. Furthermore, 

we develop highly sensitive ELISA Kits and antibodies. 

proteaimmun.de

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Biotech Companies

PROTEKUM - Umweltinstitut GmbH, Oranien-

burg

We plan to eliminated fluid und solid waste products in a manner which is compatible 

with environment protection. Our methodology is largely based on painstaking analysis. 

We use modern equipment and scientific methods. Protekum offers high-quality products 

and services in environmental analysis redevelopment.

protekum.de

Proteome Factory AG

Biomarker & target discovery, validation, analysis of food and ingredients, absolute 

quantification of proteins and peptides, sequencing and characterization of proteins and 

antibodies (CDR), 2DE and LC-MS based proteomics studies, pharmacokinetics, pharmaco, 

immuno and membrane proteomics, protein identification, characterization of proteins 

and peptides (PTMs, e. g. phosphorylation, glycosilation), quality control, mass determina-

tion, N-terminal amino acid sequencing, silver staining kit etc.

proteomefactory.com

Provitro GmbH

Provitro combines more than ten years of experiences in commercialisation of cell culture 

technologies, Tissue Microarrays and immunohistochemical analyses with the scientific 

expertise of the Pathological Institute of the Charité, Berlin. Based on a quality manage-

ment system according to ISO 9001:2008, we provide our customers not only with high-

quality products, CE marked in-vitro diagnostics and state-of-the-art services but also 

with individual solutions for their specific requests.

provitro.de

Rapidozym Gesellschaft für Laborhandel und 

DNA Diagnostika mbH

Expertise of cell biologists cell manufacturing and clean room technology specialists. 

Focuses on clinical stem cell product development portfolio are stroke, myocardial infarc-

tion and plastic surgery.

RENESA UG (haftungsbeschränkt)

Manufacturing and distribution of rapid tests, mainly for medical purposes (Point of Care 

Testing).

renesa.de

Revotar Biopharmaceuticals AG

Revotar develops innovative small molecule drugs (SMD) for the treatment of chronic 

inflammatory disorders such as, chronic obstructive pulmonary disease (COPD), Acute Lung 

Injury (ALI/ARDS) and ischemia/reperfusion. With its drug candidate bimosiamose, Revotar 

has the worldwide most advanced pan-selectin-antagonist in clinical development in its 

product pipeline.

revotar.de

RiNA GmbH

RiNA has developed systems for cell-free protein biosynthesis based on pro- and eukaryotic 

cell lysates. A synthesis service is realised in RiNA's own laboratories and complements the 

EasyXpress Kits (Qiagen). The purchase of Roche’s RTS-products enables RiNA now to be 

a key player in the field of cellfree biosynthesis with a large variety of products. Another 

research focus is the development of aptamers (DNA and RNA) for biosensors.

rina-gmbh.eu

RIPAC-LABOR GmbH

RIPAC-LABOR offers high-quality diagnoses of bacterial infections, particularly in poultry, 

pigs and cattle, but also in other farm and domestic animals. The company uses pathogen 

differentiation to provide quick and effective methods for fighting pathogens. It performs 

resistance tests and epidemiological analyses and also focuses on producing herd-specific 

vaccines.

ripac-labor.de

RNAx GmbH

RNAx specializes in RNA-Interference services. It offers functional validations of si- and 

shRNAs, target validation studies using automated high throughput approaches, as well as 

whole genome screens with automated assays.

RNAx.de

RNL Europe GmbH

Manufacturing of stem cells from bone marrow and adipose tissue for therapeutic and 

plastic-aesthetical application. Manufacturing of adult stem cells for research (mesenchy-

mal stem cells, endothelial precursor cells). Banking of stem cells.

pharmicell.eu

Roboklon GmbH

Distribution, Marketing and Development of Products for Molecular Biological Research and 

Genetic Engineering.

roboklon.de

ROVALAB GmbH

Our Master Mixes for QPCR, Standard-, Hot Start- and High Fidelity PCR as well as our high 

quality critical raw materials and reagents such as DNA Polymerases and dNTPs are designed 

to help you successfully and rapidly solve your scientific and manufacturing tasks.

rovalab.com

Royal Biotech GmbH

Royal focuses on developing, manufacturing and marketing innovative kits, portable or 

micro-structured systems, and the next generation of diagnostic chips for near real-time 

environmental, food safety, disease and laboratory diagnostics

royalbiotech.de

Scienion AG

Scienion is a life science company in the markets of dispensing systems and microar-

ray technologies. The product portfolio comprises hardware, consumables and services. 

Scienion’s leading product is the sciFLEXARRAYER dispensing system, available in a product 

line of six size versions. The dispenser allows the aspiration of ultra low liquid volumes 

from different reservoirs and non-contact micro drop delivery in the picoliter to microliter 

range onto a variety of carriers.

scienion.de

Sepiatec GmbH

Production, development and sales of automated HPLC machines for high-throughput 

purification and fractioning of complex substance compounds

sepiatec.com

Seramun Diagnostica GmbH

Seramun offers peptide synthesis, purification and conjugation of proteins, production 

of antibodies, customer research, In-vitro Diagnostics. We focus on the development and 

production of enzyme immunoassays for diagnosis of viral and bacterial infections and 

autoimmune diseases of the gastrointestinal tract, the development of multi-parameter 

assays as microtitre plate assays and as membrane immunoassays, as well as development 

of ready-to-use substrate solutions and for protein stabilizers.

seramun.com

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Biotech Companies

SGS INSTITUT FRESENIUS Berlin GmbH & Co. KG

Analytical laboratory services and consulting for development, production and quality 

control of drugs

institut-fresenius.de

SIFIN Institut für Immunpräparate und Nähr-

medien GmbH Berlin

Development, production and purification of monoclonal antibodies for use in diagnostics. 

Development and production of blood grouping reagents, Serafol

®

 bedside cards and test 

reagents for serotyping of Salmonellae, Shigellae, E. coli and Yersiniae. Development and 

production of culture media for microbiological diagnosis.

sifin.de

Signature Diagnostics AG

Signature Diagnostics is dedicated to the discovery, validation and commercial develop-

ment of novel diagnostic products that predict outcome and drug response in patients with 

colorectal cancer (CRC), non-small cell lung cancer (NSCLC) and ovarian cancer. Signature 

believes that patient selection and stratification based on molecular gene signatures will 

soon become an important component of routine cancer treatment.

signature-diagnostics.de

Silence Therapeutics AG

SILENCE Therapeutics AG, Berlin, is a leading RNAi therapeutics company with strong patents 

issued in the US and Europe. SILENCE has developed novel, proprietary short interfering RNA 

(?siRNA?) molecules and proprietary systemic delivery systems for siRNA. SILENCE has vali-

dating partnerships with AstraZeneca ($400m), Pfizer ($95m), Quark/Novartis ($80m) and 

Dainippon Sumitomo (n.d.). There are 5 clinical AtuRNAi-programs of which 4 are driven by 

its partners Pfizer & Quark/Novartis. SILENCE is listed through its holding company Silence 

Therapeutics plc, London, at the AIM. 

silence-therapeutics.com

SLM- Speziallabor für angewandte Mikrobiolo-

gie GmbH

Microbiological quality control for medical devices, pharmaceuticals, cosmetics, drinking 

water, foodstuff, monitoring in clean rooms.

slm-fiedler.de

STRATEC Molecular GmbH 

STRATEC Molecular GmbH is a globally active provider of innovative system solutions for 

nucleic acid sample collection, stabilization, and both manual and automated purifica-

tion from any sample type. Since 1992 the company is internationally respected for its 

outstanding and high performance technology platforms and offers a broad spectrum of 

superior products for molecular diagnostics, drug discovery and Life Science research.

invitek.de

Strix Diagnostics GmbH

Strix Diagnostics is a medical diagnostics company specializing in customized development 

of certified analytical systems for multiparameter in-vitro diagnostics.

strix-diagnostics.de

Surflay Nanotec GmbH

Surflay Nanotec GmbH, a spin-off company from Capsulution NanoScience AG, is  specialized 

on coating colloidal and planar materials with functional films. Key technology is the 

patented LbL-Technology

®

 with polymers. Applications are in the fields of separation mate-

rials, pigment encapsulation, bio-sensing and diagnostic particles. In addition to customer 

tailored projects Surflay offers an unique range of products of tunable multifunctional 

nano-or microparticles and dye-labeled polymers.

surflay.com

Thanares GmbH

Development, use and marketing of analytical process for diagnostic and therapeutic 

purposes. Future business activities: detection process for bioactive substances in bodily 

fluids, isolation, characterization and investigation of bioactive compounds from plants, 

in particular insoluble proteins or low concentrations of proteins, development of low cost 

genetic systems for over-expression and/or production of such proteins.

thanares.com

TheraKine BioDelivery GmbH

Development of antibody drug delivery systems and related tasks

therakine.com

TIB MOLBIOL Syntheselabor GmbH

In 1990, TIB MOLBIOL became the first German manufacturer of oligonucleotides. In 

addition to designing and synthesizing primers and probes for Real-Time PCR assays, we 

develop and produce LightMix

®

 Kits for Roche Diagnostics LightCycler

®

 Instruments, covering 

applications in Clinical Chemistry, Pharmacogenetics, Pathogen Detection, as well as Cancer 

Research. TIB MOLBIOL is ISO 13485 and ISO 9001 certified.

tib-molbiol.com

TransTissue Technologies GmbH

TransTissue has been a subsidiary of BioTissue Technologies, Freiburg since September 

2001. With more than 15 years of experience in regenerative medicine, the scientists of 

TransTissue Technologies have developed second-generation autologous tissue replace-

ments, e. g. cartilage and bone grafts. We are mainly concerned with inventions and the 

development of tissue engineering products for regenerative medicine. We offer a broad 

panel of services in the field of regenerative medicine.

transtissue.com

UGA Biopharma

UGA Biopharma a private Research and Development company, focuses on Research, Devel-

opment and Commercialization of Biopharmaceutical products under contract with other 

Biopharmaceutical companies. UGA Biopharma conducts power of biosciences to develop 

high-tech, last generation of biomedicine, diagnostic kits, molecular biology items and 

also offers world class services in biotechnology area.

ugabiopharma.com

Umwelttechnik Dr. Bartetzko GmbH

Feasibility studies, development, planning, construction and operation of biotechnological 

plants for groundwater, process water and waste water purification. Accredited microbio-

logical laboratory for the investigation of drinking water, groundwater, bath water, soils, 

food, anti-microbial active ingredients and sterility according to Ph.Eur, approved in accor-

dance with BiostoffV and the German infection protection act (Infektionsschutzgesetz).

bartetzko.com

VasoTissue Technologies GmbH

The company is active in the field of product development for advanced medical therapies. 

For its first product - the endothelialised vascular graft ("VasoGraft")- VasoTissue obtained 

a manufacturing license in 2008. Currently, VasoTissue’s focus is on conducting its first 

clinical trial.

vasotissue.de

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Biotech Companies

WITA GmbH

WITA is a high technology service and product company specialized for protein and 

proteome analysis using high resolution NEPHGE 2-DE (up to 410 mm x 300 mm gel size, 

up to 10.000 individual protein spots) and mass spectrometry. HPLC, Edman N-terminal 

sequencing, synthesis of “tricky” unusual peptides

wita.de

Zellwerk GmbH

Zellwerk produces the proprietary Z

®

 RP cell cultivation system, comprising rotating bed 

bioreactor, GMP Breeder, Control Unit, software. Bioreactors with 50-5000 ml volume, 

0,2-2 m² seeding surface, different cell carriers, can be delivered. In this culturing system 

cells grow tissue-like, being embedded in self-generated extra-cellular matrix. The 

technology opens unique opportunities for the GMP-compliant expansion of stem cells and 

primary cells, manufacturing of cell-seeded implants as well as production of recombinant 

proteins.

zellwerk.biz

Zentrum für molekulare Onkologie GmbH

Innovative methods for diagnostic and therapy of tumor diseases - Molecular genetics 

(K-RAS, PCA3, Septin9, ...) - Chemoresistance assay for prediction of chemotherapy - 

Pathology Development of new biomarkers and analytical services for studies

molekulare-onkologie.eu

Zytomed Systems GmbH

Zytomed Systems’ focus is the development, production and distribution of antibodies and 

detection systems for immunohistochemical cancer diagnostics as well as reagents and kits 

for in-situ hybridisation.

zytomed-systems.de

Are you a technology-based firm in the bio-tech branch, and are you planning to invest

in the State of Brandenburg? We can support your project with grants, loans at reduced

interest rates and risk and equity capital. Just contact us!

InvestitionsBank des Landes Brandenburg 

Phone: [phone] · E-mail: [e-mail] · www.ilb.de

Promotion and Financing for Bio-Tech Firms

150-1471_060306_AZ_Biotech  08.03.2006  13:02 Uhr  Seite 1

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Life Sciences.

Living Research. 

Berlin. Brandenburg.

Ready for take off 2012:

Airport Berlin Brandenburg International

T H E  G ER M AN  C API TAL  R EG I O N

MORE VALUE FOR YOUR INVESTMENT

A vibrant network

Berlin-Brandenburg is one of Europe’s leading 

locations for the Life Sciences. It is also an 

R&D capital that magnetically attracts the 

world’s top scientists. Here you’ll find attrac-

tive subsidy conditions, close linkages between 

business and science, the highest concentra-

tion of R&D in Europe, a dynamic start up scene 

and a multifaceted entrepreneurial environ -

ment made up of roughly 480 pharmaceutical, 

biotech and medical engineering companies. 

Come discover this one-of-a-kind landscape for 

scientists and entrepreneurs.

www.biotop.de/business

210x297_U4_BioTop_report_en_rz.indd   5

01.06.2011   9:41:49 Uhr