Sethoxydim Risk Assessment
Yüklə 4,8 Kb. Pdf görüntüsü
|
- Bu səhifədəki naviqasiya:
- Appendix 1
- Appendix 3
- Poast 2 , 19.3% a.i.) for 96 hours under static conditions (Mean measured concentrations of 0.21, 0.37, 0.59, 1.0, 1.7
- Poast 2 , 19.3% a.i.) for 96 96-hour NOEL = 0.18 mg/L (±0.04 g), mean hours under static standard length = 20 conditions (Mean
Appendix 1: Toxicity of Sethoxydim (NP-55) and Poast to experimental mammals [94-99% a.i. unless otherwise specified]. Animal Dose/Exposure Response Reference SUBCUTANEOUS-acute Rats, Fischer 344, 6 weeks old, males (avg bw 130.4 g) and females (avg bw 98.9 g), 10/sex/dose group Mice, ICR, 6 weeks old, males (avg bw 29.3 g) and females (avg bw 24.0 g), 10/sex/dose group single dose of 0, 1929, 2315, 2778, 3333, 4000, 4800, or 5760 mg/kg NP-55 by sc injection to cerival or dorsal part; 14-day observation period NP-55 suspended in 0.5% CMC in distilled water w/0.2% Tween 80 single dose of 0, 1929, 2315, 2778, 3333, 4000, or 4800 mg/kg NP-55 by sc injection to cerival or dorsal part; 14-day observation period NP-55 suspended in 0.5% CMC in distilled water w/0.2% Tween 80 LD 50 = 4400 mg/kg (95% cl 4074-4752) males LD 50 = 3010 mg/kg (95% cl 2840-3191) females Mortality observed at >4000 mg/kg in males and 2778 mg/kg in females, and all rats died at 5760 mg/kg. General signs of toxicity included dose-dependent tremors and lack of reflex. Recovery occurred after 72 hours. Autopsy in non-survivors revealed common occurrence of hyperemia of the lungs and fading discoloration of the spleen and kidney hemorrhage of the stomach at 4000 mg/kg (1 male and 1 female) and at 2778 mg/kg (1 female). Autopsy in survivors revealed atrophy of the thymus at 2778 mg/kg (2 females) and 3333 mg/kg (1 female); atrophy of the lungs also was observed in surviving rats. LD 50 = 2950 mg/kg (95% cl 2611-3334) males LD 50 = 3180 mg/kg (95% cl 2891-3498) females Mortality observed at >2315 mg/kg in males and 2778 mg/kg in females, and all mice died at 4800 mg/kg. General signs of toxicity included dose related ataxia, loss of spontaneous movement, and depression. Effects were transient in survivors. Neurotoxic effects included ataxia, convulsions, and hyporeflexia. Bio-Medical Research Laboratories Co, Ltd. 1980 EPA/OTS 88-9200030 22 Bio-Medical Research Laboratories Co, Ltd. 1979 EPA/OTS 88-9200029 76 Appendix 1 - 13 Appendix 2: Toxicity of sethoxydim to birds. [96.8 to 97.3% a.i. unless otherwise specified] Animal Dose Response Reference ORAL Mallard duck 2510 mg/kg < Acute oral LD 50 BASF 1982 MRID 00100536 Mallard duck 5620 ppm < 8-day dietary LD 50 BASF 1982 MRID 00100536 Bobwhite quail 5620 ppm <8-day dietary LD 50 BASF 1982 MRID 00100536 Mallard duck 2000 mg/kg < Acute oral LD 50 Bryceland et al. 1997 – referenced to Beavers 1979, MRID 099539. Bobwhite quail 1000 ppm Dietary NOAEL for reproductive effects. Munk 1996, MRID 44003401 cited in Bryceland et al. 1997. Mallard duck 100 and 500 ppm Decrease in the number of normal hatchlings. A NOAEL was not determined. Beavers 1996, MRID 44003402 cited in Bryceland et al. 1997 Appendix 2 - 1 Appendix 3: Toxicity of Poast to fish, aquatic invertebrates, and aquatic plants. Animal Exposure Response Reference Fish Rainbow trout 97.3% a.i. 96-hour LC 50 = 170.0 mg/L BASF 1982 1 MRID 00100536 cited in Bryceland et al. 1997 as MRID 99539 Rainbow trout (Oncorhynchus mykiss), mean net weight 0.75 g (±0.11 g), mean standard length = 38 mm (±2 mm) Nominal concentrations of 0.20, 0.34, 0.58, 0.96, 1.6, or 2.7 mg/L BAS 9052 06H ( Poast 2 , 19.3% a.i.) for 96 hours under static conditions (Mean measured concentrations of 0.21, 0.37, 0.59, 1.0, 1.7, or 2.7 mg/L) 96-hour LC 50 = 1.2 mg/L (95% CI = 1.0-1.7 mg/L) 96-hour NOEL = 0.21 mg/L Bowman and Howell 1991b MRID 41885902 cited in Bryceland et al. 1997 Catfish BCF BASF 1982 1 whole fish = 0.75 MRID 00100536 edible tissue = 0.40 nonedible tissue = 0.71 Bluegill sunfish Nominal concentrations of 96-hour LC 50 = 1.6 mg/L Bowman and (Lepomis 0.20, 0.34, 0.58, 0.96, 1.6, (95% CI = 0.91-2.3 mg/L) Howell 1991a macrochirus), mean or 2.7 mg/L BAS 9052 06H MRID 41885901 net weight 0.15 g ( Poast 2 , 19.3% a.i.) for 96 96-hour NOEL = 0.18 mg/L (±0.04 g), mean hours under static standard length = 20 conditions (Mean mm (±2 mm) measured concentrations of 0.18, 0.33, 0.49, 0.91, 1.4, or 2.3 mg/L) Bluegill sunfish 97.3% a.i. 96-hour LC 50 = 265.0 mg/L BASF 1982 1 MRID 00100536 cited in Bryceland et al. 1997 as MRID 99539 Bluegill sunfish BCF BASF 1982 1 whole fish = 6.98 MRID 00100536 edible tissue = 2.87 nonedible tissue = 7.66 Appears to simply summarize Vilkas and Kuc 1981a Appendix 3-1 Yüklə 4,8 Kb. Dostları ilə paylaş:
|