Syllabus relating

Laboratory

Title of the course Pharmacology Laboratory-II

Marks 50

Number of hours per week 4

Total hours 60

Class Final Year B.Pharm.

Semester VII

Sr.No. Topic Hrs.

1 To record concentration response curve of acetylcholine, gallamine, histamine and

oxytocin using suitable isolated preparations.

48

2 Study of analgesia, anti-inflammatory activity and muscle relaxant activity of drugs

using simple experiments. [DEMO]

4

3 To study the effect of drugs on normal and hypodynamic heart using suitable

animals.

[Use of CDs and other materials to show experiments] [DEMO]

4

4 Brief explanation of regulatory toxicity studies. 4

Books Recommended : Same as under Pharmacology Lab-I

Title of the Course Pharmacognosy Laboratory -II

Marks 50

Number of Hours per Week 4

Total Hours 60

Class Final Year. B.Pharm.

Semester VII

Sr.No. Experiment

1 Detailed histological studies including powder characters of barks: Cinchona and Kurchi

2 Detailed histological studies including powder characters of leaves : datura leaf, vasaka leaf,

vinca leaf

3 Detailed histological studies including powder characters of roots : ipecac root, rauwolfia root

4 Detailed histological studies including powder characters of seeds : linseed, nux vomica seed

5 Detailed histological studies including powder characters of ephedra stem

6 Gross identification of drugs containing fixed oils, fats and waxes (10 drugs). Identification of

fixed oils by chemical tests.

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7 Gross identification of drugs containing carbohydrates (10 drugs). Identification of drugs by

chemical tests

8 Gross identification of Alkaloidal drugs (20 drugs).

9 Identification of fibers by chemical tests and microscopy (animal, vegetable, mineral and

synthetic fibers)

10 Separation of starch from potato tubers

11 Isolation of mucilage by alcohol precipitation (aloe juice)

12 Preparation of extract by Soxhlet extractor and evaluation of extract by for phytoconstituent by

spectrophotometry. (e.g. quinine, strychnine, brucine).

13 Extraction and isolation of piperine from blackpepper

Books Recommended; Will be recommended by the teacher

Title of the Course Pharmaceutical Analysis Laboratory-III

Marks 50

Number of Hours per week 4

Total Hours 60

Class Final Year B.Pharm.

Semester VII

Sr.No Experiment Hrs.

1 Atomic absorption spectroscopy (Alkali earth metal determinations) ** 8

2 Raw material analysis: Drugs ** 10

3 Pharmaceutical exciepients ** 10

4 Demonstrations: HPTLC, HPLC (With various detectors), GC (With various

detectors), Particle size analyzer, LC-MS, GC-MS, GPC,

16

5 FTIR, 1HNMR recording of spectra and interpretations** 08

6 Differential Scanning Calorimetry (DSC) recording and interpretations** 08

**Applications may also include the compounds to which the techniques are applicable.

Title of the Course Pharmaceutics IV And Biopharmaceutics Laboratory

Marks 50

Number of Hours per week 4

Total Hours 60

Class Final Year B.Pharm.

Semester VII

Sr.No. Experiment

1 At least one representative example of each formulation type included in theory of

Pharmaceutics VI.(Preparation and evaluation, WITH STRESS ON OFFICIAL

FORMULATIONS)

2 Dissolution testing of conventional marketed formulations representing- soluble drug,

poorly soluble drug (selection of medium) ; Dissolution testing of sustained released

marketed formulation; Bioavailability of an oral formulation in rabbits (demonstration)

and calculation of pharmacokinetic parameters. Problem solving sessions with t max, C max,

AUC, and other pharmacokinetic parameters.

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Final Year B.Pharm.

SEMESTER VIII

Title of the course Pharmaceutics-VII

Marks 50

Number of hours per week 2

Total hours 30

Class Final Year B.Pharm.

Semester VIII

Sr.No. Topic Hrs.

1. Oral Sustained and Controlled release formulations: Terminologies, Basic

Principles & mechanisms of sustained drug release, materials and methods, largescale

manufacture, evaluation and quality control, packaging

4

2. Novel Oral DDS: Gastro retentive DDS, Osmotic DDS, Pulsatile DDS , Colonic

DDS

10

3. Introduction to principles and concepts of transdermal, transmucosal, ocular and

targeted delivery

6

4. CGMP. and quality assurance 2

5. Documentation: 3

6. Qualification and Validation; : Types of validation, Product and process validation 5

7. Schedule M: Factory Layout, Focus on department layouts, services, etc. 5

8. Pilot plant scale up technique – groups responsibilities, facilities, example of

scaling up of liquid/solid oral formulations; biobatch preparation

4

9. Production Management; Total quality management, materials, inventories, ABC

concept, EOQ, Cost controls

5

10. IPR: Introduction to Indian Patent law:, Gatt, WTO. TRIPS; Types of patents,

Introduction to patents, parts of a patent

4

11. NDA and ANDA filing: CDER guidelines 4

12. ICH Guidelines 4

13. Packaging: Primary packaging materials including glass, plastics, rubber, materials

for strip and blister packaging, specifications, testing, selection, compatibility

evaluation, advantages and limitations ; secondary and tertiary packaging

materials.

4

Books Recommended : Same as under Pharmaceutics – VII

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Title of the Course Pharmacognosy - III

Marks 50

Number of Hours per Week 2

Total Hours 30

Class Final Year B.Pharm.

Semester VIII

Sr.No. Topic Hrs.

1 Phenyl propanoids; Peru and Tolu Balsams, Asafoetida, Vanilla, Salicin,

Capsicum*, Ginger, Benzoin, Clove, Nutmeg, Cinnamon*, Turmeric

4

2 Coumarins : Psoralea, Tonco 1

3 Lignans and lignins : Podophyllum, Phyllanthus, 1

4 Flavonoids: Fagopyrum, Orange peel, Soya isoflavone 1

5 Terpenoids: Ajowan*, Alpinia, Abelmoschus, Anise,. Amomum, Calamus,

Cardamom, Caraway, Citrus oils*, Coriander, Cummin, Dill, Eucalyptus oil,

Fennel*, Jatamansi, Lemongrass, Mints* Palmarosa, Rose, Sandalwood, Saussurea,

Star anise,, Turpentine*, Wintergreen, Vetiver, , Valerian, Jasmine, Artemisia,

Pyrethrum, Colophony*, Matricaria; Taxus, Myrrh, Shellac, Quassia, Picrorhiza,

Andrographis

12

6 Triterpenes : Acacia concinna, Bacopa, Colocynth, Gymnema, Hydrocotyl,

Licorice*, Momordica, Quillaia, Senega, Sapiandus

3

7 Cardioactive glycoside : Digitalis*, Nerium, Strophanthus, Squill, Thevetia 2

8 Steroidal saponin: Agave, Asparagus, Dioscorea*, Fenugreek ,Guggul, Smilax 2

9 Carotenoids: Saffron, Bixa, _-carotene 1

10 Naphthelene derivatives: Plumbago, Alkanna, Henna 1

11 Anthraquinone: Aloes, Andira, Cascara, Cochineal, Hypericum, Rhubarb, Rubia,

Senna

2

12 Tannins: Black catechu, Galls*, Hammamalis, Kinos, Myrobalans, Pale catechu. 2

13 Polyacetytenes:

14 Cyanophoric glycosides: Almonds, Wild cherry

Isothiocyanate glycosides: Mustard

Sulphur containing compounds: Garlic 1

Plant Allergens 1

Aflatoxin, Marine drugs, Poisonous plants 1

Drugs which are in bold are representatives of the class, meant for detailed study.

with * mark are meant for biosynthesis study of major constituent.

Books recommended; Will be recommended by the teacher

74

Title of the Course Pharmaceutical & Medicinal Chemistry- VI

Marks 50

Number of Hours per week 2

Total Hours 30

Class Final Year B.Pharm.

Semester VIII

Sr.No Topic Hrs.

Study of the following classes of drugs with respect to their classification, chemical

nomenclature, structure including stereochemistry, generic names, chemistry, physicochemical

properties, SAR, metabolism, molecular mechanism of action and synthesis and introduction to

rational development, if any.

1. Drugs Affecting the Central Nervous Systema)

General introduction to biogenic amines and other biomolecules involved in

neurotransmission.

b) General anaesthetics: Inhaled general anesthetics and Intravenous general

anesthetics.

c) Sedatives and hypnotics: Benzpdiazepines, Non-benzodiazepine,

Barbiturates, Misc.

d) Antiseizure drugs or anticonvulsant agents: Clinical drugs and newer agents

e) Antidepressants: Selective norepinephrine reuptake inhibitors (SNRIs),

Selective 5-HT reuptake inhiitors (SSRIs), Nonselective reuptake inhibitors

(NSRIs), Dopamine and norepinephrine reuptake inhibitors (DNRIs),

Serotonin antagonist/reuptake inhibitors (SARIs), nonadrenergic specific

serotonergic antidepressants (NaSSAs), monoamine oxidase inhibitors

(MAOIs), Mood stabilizers.

f) Antipsychotics: phenothiazes, thioxanthines, benzamide, benzapines,

benzisoxazole and benzisothiazoles, misc. agents.

g) Anxiolytics: Benzodiazapines, Misc agents.

h) Hallucinogens, Stimulants and related drugs of abuse or analeptics,

xanthines, psychedelics: Non classical Hallucinogens- cannabinoids,

classical hallucinogens- Indolealkylamines, phenylalkylamines, Central

stimulants-amphetamine related agents, cocaine related agents.

i) Drugs used to treat neuromuscular disorder: Antiparkinsonian and

spasmolytic agents.

j) Drugs affecting serotonergic neurotransmission- drugs for migrane, Irritable

Bowel Syndrome, Anitemetic agents.

2

1

3

2

3

2

1

2

1

2

2 Cholinergic Drugs or Drugs affecting cholinergic nerutransmission:

a) General aspects of cholinergic receptor and acetylcholine

b) Acetyl choline mimetics- muscarainic agonist or cholinergic agonists.

c) Anticholineesterases

d) Drugs for the treatment of Alzheimer’s.

e) Acetylcholine antagonists muscrinic antagonists.

f) Neuromuscular blocking agents.

1

1

1

1

1

1

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3 Analgesics:

a) Opoid or narcotic analgesics: μ-agonists, other analgesics, mixed

agonist/antagonist analgesics, μ-antagonists.

b) Antidiarrheal agents

c) Cough suprresants, anti-tussives narcotic and others.

4

Books Recommended: Same as recommended under Pharmaceutical and Medicinal

Chemistry-V

Title of the course Clinical Pharmacy and Drug Interactions

Marks 50

Number of hours per week 2

Total hours 30

Class Final Year B.Pharm.

Semester VIII

Sr.No. Topic Hrs.

1 Introduction: History and Scope of Clinical Pharmacy 4

2 Concept of Clinical Pharmacy 4

3 Role of Clinical Pharmacy in Patient care 4

4 Patient Counselling and Communication Skills 4

5 Adverse drug reactions 4

6 Drug Problems in geriatrics and pediatrics 4

7 Drug Interactions: Review of theoretical basis of possible interactions with

examples of interactions of clinical significance

6

Books Recommended

Sr.No Title Of The Book Author/Editor Edition/Year Publisher

1 The Science And

Practice Of Pharmacy

Remington

2005 Lippincott Williams

&Wilkins

2

Clinical Pharmacy And

Therapeutics

Roger Walker

And Clive

Edwards.

2nd ,1999 Churchill Livingstone,

Edinburgh

3

Drug Interactions:

Clinical Significance Of

Drug Interactions

Hansten P.D.,

5th , 1985 Lea And Febiger,

Philadelphia

4

Elements Of Clinical

Pharmacy

Dr R.K.Goyal, Dr

P.A.Bhatt, Dr

M.D.Burande,

2nd , 2004-

2005

B.S.Shah Prakashan,

Ahmedabad

5

A Handbook Of Clinical

Pharmacy

A.V.Yadav,

B.V.Yadav,

T.I.Shaikh

2nd, 2004 Nirali Prakashan, Pune

76

Title of the Course Assignments (Pharmaceutics)

Marks 50

Number of Hours per week 2

Total Hours 30

Class Final Year B.Pharm.

Semester VIII

Sr. No. Topic

1. There will be several problem solving sessions where there will be discussions on

methodology and approaches to solve problems including discussions on how to gather

information from internet and literature. The problems will be given to the students as

home assignments where students can go through the literature and come out with

solutions and present it in the class. There shall be many assignments. No assignment

shall be of more than 10 marks. The student shall submit the assignment in A4 size paper

either hand written or typed and pinned together. Marks will be awarded by the teacher

and at the end of the semester teacher will submit the marks along with the assignment

copies of all the students to the office.

Title of the Course Assignments (Pharmacology)

Marks 50

Number of Hours per week 2

Total Hours 30

Class Final Year B.Pharm.

Semester VIII

Sr. No. Topic

1. There will be several problem solving sessions where there will be discussions on

methodology and approaches to solve problems including discussions on how to gather

information from internet and literature. The problems will be given to the students as

home assignments where students can go through the literature and come out with

solutions and present it in the class. There shall be many assignments. No assignment

shall be of more than 10 marks. The student shall submit the assignment in A4 size paper

either hand written or typed and pinned together. Marks will be awarded by the teacher

and at the end of the semester teacher will submit the marks along with the assignment

copies of all the students to the office.

77

Title of the Course Assignments (Pharmacognosy)

Marks 50

Number of Hours per week 2

Total Hours 30

Class Final Year B.Pharm.

Semester VIII

Sr.No Topic

1. There will be several problem solving sessions where there will be discussions on

methodology and approaches to solve problems including discussions on how to gather

information from internet and literature. The problems will be given to the students as

home assignments where students can go through the literature and come out with

solutions and present it in the class. There shall be many assignments. No assignment shall

be of more than 10 marks. The student shall submit the assignment in A4 size paper either

hand written or typed and pinned together. Marks will be awarded by the teacher and at

the end of the semester teacher will submit the marks along with the assignment copies of

all the students to the office.

Laboratory

Title of the Course Pharmaceutics Laboratory – V

Marks 50

Number of Hours per week 4

Total Hours 60

Class Final Year B.Pharm.

Semester VIII

Sr.No. Experiment

1 Accelerated stability testing of at least two pharmaceutical formulations.

2 Oral sustained release matrix tablets – formulation and evaluation

3 Oral multiparticulate sustained release formulation - formulation and evaluation

4 Floating DDS, Pulsatile DDS, Osmotic DDS

5 Demonstration of scaleup of a liquid/solid formulation

6 Documentation of certain standard records related to manufacture and quality control

Title of the Course Pharmacognosy Laboratory -III

Marks 50

Number of Hours per Week 4

Total Hours 60

Class Final Year B.Pharm.

Semester VIII

Sr.No. Experiment

1 Detailed histological studies including powder characters of rhizomes: Ginger and

Glycyrrhiza

78

2 Detailed histological studies including powder characters of fruits : Coriander and Fennel

3 Detailed histological studies including powder characters of leaves : Senna and Digitalis

4 Detailed histological studies including powder characters of Cinnamon bark and Quassia wood

5 Detailed histological studies including powder characters of Clove and Cardamom

6 Gross identification of drugs containing volatile oils (20 drugs)

7 Gross identification of drugs containing steroids and triterpenoiods (10 drugs)

8 Gross identification of anthraquinones, tannins, lignan and coumarin, etc. containing drugs

(10 drugs)

9 Evaluation of unorganised drugs mentioned under theory by chemical tests

10 Separation of volatile oil from crude drug (e.g. clove, eucalyptus, etc)

11 Isolation of calcium Sennoside from senna leaves

12 Demonstration of column chromatography and preparative TLC.

13 Preparation of herbarium sheet

14 Visit to medicinal plant garden

Title of the Course Pharmaceutical & Medicinal Chemistry Laboratory-II

Marks 50

Number of Hours per week 4

Total Hours 60

Class Final Year B.Pharm.

Semester VIII

Sr.No Experiment Hrs.

1 Experimental determination of pKa and comparison with software generated data 4

2 Experimental determination of log P values and comparison with software

generated data

4

3 Experimental determination of simple in-vitro activity of analogs 4

4 Structure property relationship from data of experiments 1,2 and 3 4

5 Demonstration of pharmacophore development and QSAR 4

6 Demonstration of structure based drug design 4

7 Multistep drug synthesis

a) acetanilide to sulphanilamide. b) p-nitro toluene to benzocaine

8 Synthesis of analogs e.g. series of esters from suitable carboxylic acids 18

Title of the Course Project

Marks 100

Number of Hours per week 8

Total Hours 120

Class Final Year B.Pharm.

Semester VIII

Sr.No Topic

1. Project supervisor will be assigned to each student and student will work on a project

Assigned and a report will be submitted in a bound form. The project will be evaluated by

the examiners and hold viva. Marks will be awarded on the basis of project and viva.

79