Syllabus relating

1

1

1

2

2

7 Virus: * Morphological characteristics

* Cultivation of viruses, Reproduction

* Oncogenic and HIV viruses

2

8 Yeasts / Molds: * Morphology, habitat, nutrition

* Reproduction in yeast

* Molds of Clinical significance

1

9 Algae * Morphology habitat

* Economic significance of algae

1

10 Protozoa * Morphology

* Clinical significance of protozoa

1

11 Rickettsiae * Morphology (diseases caused malaria, amoebic dysentery)

* Diseases caused by rickettsiae

1

12 Microbial Mutation

* Types of mutation

* Mutagenic agents

* Mechanism of mutation

2

13 Diseases caused by the following microorganisms and their detection

1) Mycobacterium

2) Salmonella

3) E. coli

4) Clostridium

5) Staphylococcus

2

14 Sterilization - Different methods of sterilization

- Aseptic techniques

5

15 Disinfection and disinfectants 1

16 Tutorials 3

13

Books Recommended

Sr. No. Title Of The Book Author/Editor Edition/Year Publisher

1 Microbiology Concepts

And Applications

M. J. Pelczar Jr., E.

C. S. Chan And N.

R. Krieg

5th ,1996 McGraw Hill, Inc., USA

2 Fundamentals Of

Microbiology

M.Frobisher, R. D.

Hinsdill, K. T.

Crabtree And C. R.

Goodheart

9th ,1968 Saunders College

Publishing, Philadelphia

3 Pharmaceutical

Microbiology

W. B.Hugo And A.

D. Russel

6th , 2003 Blackwell Science Ltd. Uk,

4 Text Book Of

Microbiology

R. Ananthanarayan

And C.K. J.

Paniker

7th , 2005 Orient Longman Pvt. Ltd.

Hyderabad,

14

Laboratory

Title of the Course Organic Chemistry Laboratory-I

Marks 50

Number of Hours per Week 4

Total Hours 60

Class F.Y. B.Pharm

Semester I

Sr.No Experiment Hrs.

Organic Spotting: Qualitative analysis of organic compounds -aspects to be covered are:

1 Solubility, characterization and preliminary tests, 16

2 Elements detection, 8

3 Functional group characterization, 20

4 Derivative preparation. 16

Books Recommended Will be recommended by the teacher

Title of the Course Microbiology Laboratory

Marks 50

Number of Hours per Week 4

Total Hours 60

Class F.Y B.Pharm.

Semester I

Sr.No. Experiment Hrs.

1 Study of microscope 4

2 Study of common laboratory equipments: autoclave, incubator, hot air oven etc. 4

3 Gram Staining 4

4 Monochrome staining 4

5 Negative staining 4

6 Cell Wall Staining 4

7 Spore Staining 4

8 Capsule Staining 4

9 Motility by hanging drop technique 4

10 Preparation and sterilization of nutrient broth, agar, slants, stab etc. 4

11 Inoculation techniques: Colony characteristics, Growth patterns in broth, slant- pour

& streak plate technique.

4

12 Total count by Haemocytometer Growth by optical density+ 4

13 Total plate count, TDP, TDT 4

14 Study of yeast- Aspergillus, Penicillium with respect to morphology 4

15 Studies as prepared sides – malarial parasite in blood smear, intestinal amoeba in

stools.

4

Books Recommended: Will be recommended by teacher

15

Title of the Course Anatomy, Physiology & Pathophysiology Laboratory

Marks 50

Number of Hours per Week 4

Total Hours 60

Class F.Y B. Pharm

Semester I

Sr.

No.

Experiment Hrs.

1 HEMATOLOGY

1. Red Blood Cell (RBC) Count,

2. Total leukocyte Count

3. Differential Leukocyte (WBC) count

4. Hemoglobin content of blood

5. Bleeding/Clotting time

6. Blood groups

7. Erythrocyte Sedimentation rate (ESR)/Hematocrit (Demonstration)

8. Measurement of blood pressure

4

4

4

4

4

4

2

2

2 Study of human skeleton 4

3 Microscopic study of permanent slides

Tissues:

- Columnar, Cuboidal, Squamous, Ciliated Epithelium

- Cardiac/Skeletal/Smooth muscle

- Ovary, testis, Liver, Pancreas, Thyroid, Tongue, Stomach, Intestine,

Kidney, Lung, Spinal Cord, Cerebrum, Artery, Vein

12

4 Discussion on some common investigational procedures used in diagnosis of diseases

with the help of charts/ slides

Name and Importance of following Tests:

1) Electroencephalogram(EEG) in diagnosis of epilepsy

2) Electrocardiagram (ECG) in diagnosis of cardiac arrhythmia

3) Liver Function tests-

- Serum Bilirubin, Serum glutamate oxaloacetate transaminase (SGOT), Serum

glutamate pyruvate transaminase (SGPT)

- Urine Bilirubin, Urine Urobilinogen

Kidney Function Tests

Serum Creatinine, Serum Urea, Uric acid, Serum Urea Nitrogen BUN)

Blood Glucose

Serum Cholesterol/Triglycerides

Serum Alkaline phosphate (ALT)

Serum acid phosphatase (APT)

Serum Lipase, Serum Amylase, Serum Calcium

12

16

Serum Lactate dehydrogenase ( LDH)

Thyroid Function tests- T3, T4

Diagnostic tests for infectious diseases like

- Malaria, Tuberculosis, Dengue, Leptospirosis

Books Recommended

Sr.No. Title Of The Book Author/Editor Edition/Year Publisher

1 Textbook Of Medical

Laboratory Technology

Praful B. Godkar 2nd 2006 Bhalani Publishing House,

Mumbai

2 A Textbook Of Practical

Physiology

V.G. Ranade,

P.N. Joshi And

Shalini Pradhan

3rd 1982 P.V.G. Prakashan, Pune-30

First Year B.Pharm.

SEMESTER-II

Title of the Course Organic Chemistry-II

Marks 50

Number of Hours per Week 2

Total Hours 30

Class F.Y. B.Pharm

Semester II

Sr.No. Topic Hrs.

Heterocyclic Compounds

Discussion of the following classes of compounds including (aromatic to saturated)

with regard to IUPAC nomenclature, structure, pKa, etc. sources, methods of

preparation, structure and physical properties(Structure property relationships), and

reactivity:

1 Three and four member ring compounds containing N, O 3

2 Five membered rings containing N,O,S 10

3 Six membered rings containing N,O,S 5

4 Seven membered rings containing N, O, S 2

Stereochemistry

5 Enantiomers, diastereomers, configuration notations, Properties to

characterize the enantiomers

4

6 Conformations and conformational analysis: n-butane, alicyclic, and

saturated heterocyclic systems and implication on reactivity

6

17

Books Recommended

Sr.No Title of the Book Author/Editor Edition/Year Publisher

1 Adv.Org. Chemistry Carey 4th, 2001 Plenum Press NY

2 Organic Chemistry Morrison, R. T 6th, 1992 Pearson Education

3 Organic Chemistry Solomons, T. W.G 8th , 2004 John Wiley & Sons, Inc

4 Organic Chemistry Loudon, G. Marc 4th ,2002 Oxford University Press

5 Introduction to Organic

Chemistry

Andrew 4th,1992 Macmillan Publishing

6 Organic Chemistry

Structure and Reactivity

Seyhan Ege 5th , 2004 Houghton Millin

Company, NY

7 Chemistry of

Heterocyclic Compounds

Weissberger, N. 1972 John Wiley & Sons, Inc

Title of the Course Mathematics-II

Marks 50

Number of Hours per Week 2

Total Hours 30

Class F.Y. B. Pharm.

Semester II

Prerequisites: Notions of sets and functions, basic probability theory, Measures of

central tendency: Arithmetic mean, median and mode; Measures of dispersion: Range,

quartile deviation, mean deviation and standard deviation; Coefficient of variation,

moments, skewness and kurtosis.

Sr. No. Topic Hrs.

1 Probability Distributions: Discrete and continuous random variables,

Probability distribution functions, expectation of random variables, mean,

variance and moments of random variables, moment generating function,

Binomial, Poisson and Geometric distributions, Normal, uniform and Gammabeta

distribution functions, chi-square distribution, F-distribution, Joint

distributions, notion of covariance.

9

2 Sampling distribution, Point and interval estimations of mean, variance and

proportion of single and multiple samples.

4

3 Hypothesis testing: Inferences concerning mean, variance and proportions, Chisquare

test, goodness of fit.

4

4 Regression and Correlation: Linear non linear regression, Correlation,

multilinear regression.

5

5 Design of experiments: One-way and two way ANOVA tests. 5

6 Non Parametric tests: Sign test, Rank sum test, Wilcoxon and Kruskal-Vallis test. 3

18

Books Recommended

Sr.No. Title of The Book Author/Editor Edition/Year Publisher

1. A First Course In

Probability

Sheldon Ross 6th , 2002 Prentice Hall

2. Miller & Freund's

Probability And Statistics

For Engineers

Richard Johnson,

Irwin Miller,

John Freund

7th , 2005 Pearson Education

3. Pharmaceutical Statistics:

Practical And Clinical

Applications

Sanford Bolton,

Charles Bon

4th, 2004 Marcel Dekker

4. Essential Statistics For The

Pharmaceutical Sciences:

Philip Rowe 1st, 2007 John Wiley & Sons Ltd

5. Pharmaceutical Statistics David Jones 1st, 2002 Pharmaceutical Press UK

6. Applied Statistics And

Probability For Engineers

Douglas C M.,

Alasdair G M

Nairn, G. Runger

4th, 2006 Wilely

7 Statistics Methods S. P. Gupta 2nd , 1969 S. Chand & Co.

Title of the Course Pharmaceutics-II

Marks 50

Number of Hours per Week 2

Total Hours 30

Class F.Y. B. Pharm.

Semester II

Sr.No. Title Hrs

1. Monophasic liquid orals: Preformulation considerations 2

2. Principles of Solubilization and Taste masking 3

3. Formulation considerations in the development of Monophasic liquid oral dosage

forms and quality control of : aromatic waters, solutions, syrups, elixirs, linctuses,

drops, glycerites, paints, lotions, liniments, sprays. examples of official

preparations belonging to this class.

10

4. Large scale manufacture and packaging 2

5. Biphasic disperse systems: Suspensions: Preformulation considerations and

Physicochemical principles underlying the formulation of suspensions including

principles of wetting, Zeta potential etc.

4

6. Formulation considerations in the development of suspensions for internal and

external use and quality control - examples of official preparations belonging to

this class.

5

7. Large scale manufacturing, packaging 3

8. Layout design of liquid section. 1

19

Books Recommended

Sr.No. Title Author/Editor Edition Publisher

1 Pharmaceutical Dosage Forms

And Drug Delivery Systems

Howard C. Ansel,

Nicholas G.

Popovich, Loyd

V.

6th , 1995 B.I. Waverly Pvt.Ltd.,

New Delhi

2 Remington’s-The Science And

Practice Of Pharmacy (Vol.1

& 2)

David B. Troy 21st, 2006 Lippincott Williams &

Wilkins

3 Dispensing For Pharmaceutical

Students

Cooper & Gunn’s

Revised By

S.J.Carter

12th, 1975 Cbs Publishers &

Distributers

4 Pharmaceutics:The Science Of

Dosage Form Design

Michael E.Aulton 6th, 1998 Churchill-Livingstone

5 Physical Pharmacy-Physical

Chemical Principles In

Pharmaceutical Sciences

Alfred

N.Martin,James

Swarbrick,Arthur

Cammarata

2nd, 1969 Lea &

Febiger,Philadelphia

6 Theory & Practice Of

Industrial Pharmacy

Leon

Lachman,Herbert

A.Lieberman &

Joseph Kanig

2nd , 1976

3rd , 1987

Lea & Febiger,

Philadelphia

7 Prescription Pharmacy Goseph. B.

Sprowls

2nd , 1970 -

8 Bentley’s Textbook Of

Pharmaceutics

Bentley 8th , 1977 E. A. Rawlins

9 Introduction Of

Pharmaceutical Dosage Forms

Howard Ansel 3rd , 1981 Lea & Febiger

Title of the Course Pharmaceutical Engineering-II

Marks 50

Number of Hours per Week 2

Total Hours 30

Class F.Y. B. Pharm.

Semester II

Sr.No. Topic Hrs.

1. Fluidization: Particulate fluidization, aggregate fluidization- 3

2. Separation by mass transfer: Solid-liquid extraction and liquid extraction,

equipment and methods of operation- distillation, batch fractionation, vacuum and

still distillation, azeotropic and extractive distillation, fractional distillation and

fractionating columns; Recovery of solvents.

6

3. Energy and mass transfers: Crystallisation-crystal shapes and habits, crystal

growth, crystallisation in melts, nucleation, crystallisation from solutions, rate of

crystallisation,

5

20

4. .Energy effect in the process, size of crystal, different crystallisers, principles

underlying the design and operations;

4

5. Theories of Absorption and adsorption, Absorption of gases in liquids, Adsorption

of liquids on carriers

6

6. Drying: Fluid bed dryers, Microwave dryers, Freeze dryers, Spray dryers, tray

dryer, tunnel dryer, turbo dryer

6

Books Recommended

Title of the Course Physical Pharmacy-I

Marks 50

Number of Hours per Week 2

Total Hours 30

Class F.Y. B. Pharm.

Semester II

Sr.No. Topic Hrs

1. State of matter: Gases: Ideal and Nonideal gases, van der Waals equation, critical

phenomenon, determination of gas constants, liquefaction

5

2. Thermodynamics: first law, second law, third law, thermochemistry, free energy

function and its applications, chemical potential, Clausius-Clapeyron equation, free

energy and equilibrium, the van’t Hoff equation

5

3. Physical properties of Drug Molecules: Dipole moment and its determination,

refractive index and molar refraction, viscosity.

4

4. Solutions of Nonelectrolytes: Units for expressing concentration and calculations

involving the same, ideal and real solutions, Raoult’s law, Henry’s law

5

5. Colligative properties, elevation of b.p., depression of freezing point, osmotic

pressure, molecular weight determination based on colligative properties, molecular

weight by steam distillation.

5

6. Solution of electrolytes: Properties of solutions of electrolytes, Arrhenies theory of

electrolytic dissociation, theory of strong electrolytes, coefficients for expressing

colligative properties.

6

Sr.No. Title Author/Editor Edition Publisher

1 Introduction to

Chemical

Engineering

Walter L.Badger, Julius

T. Banchero

International

Student Edi.

McGraw Hill Book

Company

2 Perry’s Chemical

Engineer’s Handbook

Perry Robert H.

Green Don W.

7th, 1997 McGraw Hill Book

Company

3 Tutorial Pharmacy J.W. Cooper, Colin

Gunn

4th, 1950 Sir Isaac Pitman &

Sons,London

4 Introduction to

Pharmaceutical

Engineering

A.R. Paradkar 6th, 2004 Nirali Prakashan

21

Books Recommended

Sr.No. Title Author/Editor Edition Publisher

1 Physical Pharmacy-Physical

Chemical Principles in

Pharmaceutical Sciences

Alfred N. Martin,

James Swarbrick,

Arthur Cammarata

2nd, 1969 Lea & Febiger,

Philadelphia

2 Tutorial Pharmacy J.W. Cooper, Colin

Gunn

4th, 1950 Sir Isaac Pitman &

Sons Ltd.,London

3 Essentials of Physical

Chemistry

Bahl B.S. 23rd S.Chand & Sompany

4 Remington’s-The Science

and Practice of

Pharmacy(vol.1 & 2)

David B. Troy 21st, 2006 Lippincott Williams &

Wilkins

Title of the Course Anatomy, Physiology & Pathophysiology-II

Marks 50

Number of Hours per Week 2

Total Hours 30

Class F.Y. B. Pharm

Semester II

Sr.No Topic Hrs.

1 Muscular system: Anatomy-Physiology of smooth and skeletal muscles

Physiology of NMJ, Skeletal muscles contraction, energy metabolism, types of

contraction of muscles.

Definition: Myasthemis gravis, tetanus, spasticity.

10

2 Physiology of pain: Headache, Types of Headache (migraine, tension headache,

headache affecting elderly)

Joint pain (RA/Osteoarthritis/gout)

2

3 Reproductive System: Anatomy- Physiology of male and female reproductive

system, Menstruation, oocytogenesis, spermatogenesis.

5

4 Endocrine system: Anatomy- Physiology of pituitary, thyroid, parathyroid, adrenal,

pancreas, testis, ovaries, control of hormone secretion. Diseases associated with

hypo-hypersecretion of hormones.

Pathophysiology of Diabetes Mellitus

13

Books : Same as under Anatomy, Physiology and Pathophysiology-IV

22

Title of the Course Pharmaceutical Analysis-I

Marks 50

Number of Hours per week 2

Total Hours 30

Class F. Y. B.Pharm.

Semester II

Sr.

No.

Topic Hrs.

1. Introduction:

a. Significance of quantitative analysis in quality control, different

techniques of analysis, preliminaries and definitions, types of errors,

selection of sample, precision and accuracy.

b. Fundamentals of volumetric analysis, methods of expressing concentrations, primary

and secondary standards. Calculation of equivalent weight and stoichiometry.

3

2. Aqueous Acid-Base titrations:

a. Law of mass action, hydrolysis of salts, neutralization curves, and

theory of indicators, choice of indicators, mixed indicator.

b. Application** in assay of Benzoic acid, Boric acid, Aspirin.

4

3

3. Non-Aqueous titrations:

a. Types of solvents, end point detection,

b. Application** in assay of Sodium acetate, Sodium benzoate, Norfloxacin tablet.

3

4. Oxidation-Reduction titrations:

a. Theory of redox titration, measurement of electrode potential,

oxidation-reduction curves, redox Indicators.

Titrations involving

b. Potassium permanganate, potassium dichromate, potassium

bromate, potassium iodate, cerium (IV) sulfate, Iodine (Iodimetry

and Iodometry), titanous chloride.

c. Applications** in assay of Ferrous sulfate, Ascorbic acid, Isoniazide, Hydrogen

peroxide.

5

5. Complexometric Titrations:

a. Theory, formation of complex and its stability, titration curves,

metallochrome indicators, types of EDTA titrations,

b. Application** in assay of Magnesium sulfate, Lead nitrate and calcium gluconate.

3

6. Argentometric Titrations:

a. Theory, factors affecting solubility of a precipitate, titration methods-

Mohr’s, Volhard’s, Gay lussac, and Fajan’s method, indicators.

b. Applications** in assay of Potassium chloride, Sodium chloride and

Ammonium chloride.

3

7. Miscellaneous methods of analysis:**

a. Diazotisation titrations,

b. Kjeldahl’s method of nitrogen determination

c. Oxygen flask combustion method.

3

23

8. Gravimetric analysis:

a. Precipitation techniques, solubility products, colloidal state,

supersaturation, co-precipitation, post precipitation, digestion, filtration,

ignition, weighing and calculation.

b. Application** in assay of Alum by oxime reagent, Calcium as calcium oxalate and

magnesium as magnesium pyrophosphate.

3

**Applications should cover all different techniques and methods and may also include

other compounds to which the techniques are applicable.

Books Recommended

Sr.No. Title of the Book Author/Editor Edition/

Year

Publisher

1. Vogel’s Textbook of

Quantitative

Inorganic Analysis

Bassett J, Denny R

C, Jeffery G H,

Mendharn J,

7th , 1998 ELBS/Longman, London.

2. Statistical Quality control

6. Instrumental methods

of Analysis- Ewing.

Grant 6th , 1988 McGraw Hill

3. A Textbook of

Pharmaceutical Analysis,

Connors K A 3rd , 1982 Wiley Interscience, New

York.

4. Practical Pharmaceutical

Chemistry Vol. I

Beckett A. H. and

Stenlake J B,

4th , 1988 TheAnthlone Press of

University of London.

5. Analytical Chemistry an

Introduction,

Skoog/ West/

Holler

4th , 1986 CBS Publications, Japan

6. The Quantitative

Analysis of Drug

Garrat 3rd , 2005 Toppan & Co.

7. Analytical Chemistry Gary Christian- 3rd, 1971 John Wiley

8. IP, BP, USP, EP and

International

Pharmacopoeia.

Current

Editions

24

Title of the Course Assignments (Pharmaceutical Engineering)

Marks 50

Number of Hours per week 2

Total Hours 30

Class F. Y. B.Pharm.

Semester II

Sr. No. Topic

1. There will be several problem solving sessions where there will be discussions on

methodology and approaches to solve problems including discussions on how to gather

information from internet and literature. The problems will be given to the students as

home assignments where students can go through the literature and come out with

solutions and present it in the class. There shall be many assignments. No assignment shall

be of more than 10 marks. The student shall submit the assignment in A4 size paper either

hand written or typed and pinned together. Marks will be awarded by the teacher and at

the end of the semester teacher will submit the marks along with the assignment copies of

all the students to the office.

Laboratory

Title of the Course Organic Chemistry Laboratory-II

Marks 50

Number of Hours per Week 4

Total Hours 60

Class F.Y. B.Pharm

Semester II

Sr.No Experiment Hrs.

Techniques in Organic Chemistry:

1 Qualitative separation of binary organic mixture by physical and chemical methods

-mixture of different types including compounds with more than one functional

group to be given, characterization of individual components by physical constants;

followed by preparation of suitable derivative;

16

2 testing purity by TLC. 4

3 Purification techniques

solvent sélection for recristallisation, recristallisation techniques

simple distillation, fractional distillation, steam distillation.

16

16

4 Exercises 8

Books Recommended Will be recommended by the teachers

25