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In its broadest terms, synthetic biology can be described as the engineering of biological entities not found in
nature. The applications for such entities are numerous, including bioremediation, biosensing, and synthesis of
value-added chemicals.
Ducat and Silver (2012)
Synthetic biology is well-situated to provide original approaches for compartmentalizing and enhancing
photosynthetic reactions in a species independent manner.
Ellis and Goodacre (2012)
One of the main goals of synthetic biology is to generate the desired material with a good conversion from
substrate(s) to product whilst reducing unwanted (side-) products(…)Synthetic biology is here to stay and
rational metabolic engineering of bacteria, yeast, fungi and mammalian-based systems will become an
important growth area, urgently needed to sustain the planet’s needs as the population continues to expand
at alarming rates whilst consuming valuable non-renewable resources.
Forster (2012)
Synthetic biology is a powerful experimental approach, not only for developing new biotechnology
applications, but also for testing hypotheses in basic biological science”. … “It should be noted that some of
the work on purified translation systems covered in this review doesn’t really fit our previously published
definition of synthetic biology as “the complex engineering of replicating systems” [5], even though the work
was a spin-off of putting together the biomolecular parts towards in vitro replication of peptidomimetics. Thus
it may be viewed more accurately as the “synthesis” described by Benner or perhaps “synthetic biochemistry.”
Nevertheless, the work presented does fit within some common definitions of synthetic biology, such as “the
design and construction of new biological parts, devices and systems” (http://syntheticbiology.org).
Hoesl and Budisa (2012)
One of the main goals of Synthetic Biology is to generate new and emergent biological functions in streamlined
cells which are equipped with ‘tailor-made biochemical production lines.
Juhas (2012)
One of the main aims of synthetic biology is to create a cell whose genome harbors the minimal set of
essential genes.
Karlsson and Weber (2012)
The field of synthetic biology is rapidly expanding and has over the past years evolved from the development
of simple gene networks to complex treatment-oriented circuits. The reprogramming of cell fate with open-
loop or closed-loop synthetic control circuits along with biologically implemented logical functions have
fostered applications spanning over a wide range of disciplines, including artificial insemination, personalized
medicine and the treatment of cancer and metabolic disorders,
Kittleson et al. (2012)
Synthetic biology relies on engineering concepts such as abstraction, standardization, and decoupling to
develop systems that address environmental, clinical, and industrial needs. Recent advances in applying
modular design to system development have enabled creation of increasingly complex systems.
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Lin and Levchenko (2012)
A large facet of synthetic biology involves placing rationally designed genetic circuits in living cells to engineer
predicted outputs
Lux et al. (2012)
The aim of synthetic biology is to make genetic systems more amenable to engineering, which has naturally
led to the development of computer-aided design (CAD) tools.
Macia et al. (2012)
Synthetic biology (SB) offers a unique opportunity for designing complex molecular circuits able to perform
predefined functions.
Malinova et al. (2012)
The topic synthetic biology appears still as an ‘empty basket to be filled’. However, there is already plenty of
claims and visions, as well as convincing research strategies about the theme of synthetic biology. First of all,
synthetic biology seems to be about the engineering of biology – about bottomup and top-down approaches,
compromising complexity versus stability of artificial architectures, relevant in biology. Synthetic biology
accounts for heterogeneous approaches towards minimal and even artificial life, the engineering of
biochemical pathways on the organismic level, the modeling of molecular processes and finally, the
combination of synthetic with nature-derived materials and architectural concepts, such as a cellular
membrane. Still, synthetic biology is a discipline, which embraces interdisciplinary attempts in order to have a
profound, scientific base to enable the re-design of nature and to compose architectures and processes with
man-made matter.
Morey et al. (2012)
A goal of synthetic biology is to apply the same engineering principles to the rational design of biological
systems, including regulatory genetic circuits, metabolic systems, and signal transduction.
Olson and Tabor (2012)
Synthetic biology is improving our understanding of and ability to control living organisms.
Planson et al. (2012)
Synthetic biology aims at creating novel functional devices and systems that together with new ideas coming
from the field of systems biology are enriching the toolbox of metabolic engineering for therapeutic
development.
Slusarczyk et al (2012)
One goal in synthetic biology is to design parts and modules in such a fashion as to make systems-level fitness
landscapes smoother: for example, by orthogonalization.
Yuzawa (2012)
One definition of synthetic biology is “the deliberate design and fabrication of novel biologically-based
components as well as the redesign of existing biological systems.
Zhu et al. (2012)
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