Pathology of the urinary system

ACUTE TUBULAR NECROSIS (NEPHROSIS) & CRYSTAL PRECIPITATES

 

 

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renal tubular epithelium, especially that of proximal convoluted tubules, is metabolically very active 

and thus highly susceptible to ischemia or to toxic damage; 

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acute necrosis of tubular epithelial cells is the primary process of nephrosis; microscopic lesions are 

characteristic; 

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persistence of an intact tubular basement membrane, or lack thereof, determines whether tubular 

epithelial regeneration can occur or whether repair is by fibrosis; this, in turn, influences the 

prognosis for the kidney and the animal; 

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affected animals are oliguric or anuric and die within a few days unless given appropriate therapy. 

 

 

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