Vanadium pentoxide
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- Males
IARC MONOGRAPHS VOLUME 86 246
system and bronchial lymph nodes in mice in a 2-year inhalation study of vana- dium pentoxide No. of mice exposed to vanadium pentoxide at concentrations (mg/m 3 ) of 0 (chamber control) 1 2 4 Males Lung Total no. examined 50 50
50 50
No. with: Alveolar epithelium, hyperplasia
3 (3.0)
a
41 b (2.2) 49 b (3.3)
50 b (3.9)
Bronchiole epithelium, hyperplasia 0
15 b (1.0) 37 b (1.1) 46 b (1.7) Inflammation, chronic
6 (1.5) 42 b (1.5) 45 b (1.6) 47 b (2.0) Alveolus, infiltration cellular, histiocyte 10 (2.4) 36 b (2.4) 45 b (2.6) 49 b (3.0) Interstitial fibrosis 1 (1.0) 6 (1.7) 9
b (1.2)
12 b (1.7) Alveolar/bronchiolar adenoma, multiple 1
1 11 b 5
Alveolar/bronchiolar adenoma (includes multiple) 13
16 26 b 15
Alveolar/bronchiolar carcinoma, multiple 1
10 b
16 b
13 b
Alveolar/bronchiolar carcinoma (includes multiple) 12
29 b
30 b
35 b
Alveolar/bronchiolar adenoma or carcinoma 22
42 b
43 b
43 b
Larynx Total no. examined 49 50
48 50
No. with: Respiratory epithelium, epiglottis, metaplasia, squamous
2 (1.0) 45 b (1.0)
41 b (1.0)
41 b (1.0) Nose Total no. examined 50 50
50 50
No. witth: Inflammation, suppurative
16 (1.3) 11 (1.4)
32
(1.2)
23 c (1.3)
Olfactory epithelium, atrophy 6 (1.0) 7 (1.6) 9 (1.3) 12 (1.2) Olfactory epithelium, degeneration, hyaline 1 (1.0) 7
c (1.0)
23 b (1.1) 30 b (1.2) Respiratory epithelium, degeneration, hyaline 8 (1.1) 22 b
38 b (1.2) 41 b (1.4) Respiratory epithelium, metaplasia, squamous 0
6 c (1.2) 6 c (1.3) 2 (1.5) Lymph node, bronchial
Total no. examined 40 38
36 40
No. with: Hyperplasia
7 (2.1) 7 (2.4)
12 (2.1) 13 (2.2)
pp227-292.qxp 31/05/2006 09:49 Page 246 VANADIUM PENTOXIDE 247
No. of mice exposed to vanadium pentoxide at concentrations (mg/m 3 ) of
0 (chamber control) 1 2 4 Females Lung
Total no. examined 50 50
50 50
No. with: Alveolar epithelium, hyperplasia
0
31 b (1.6)
38 b (2.0)
50 b (3.3) Bronchiole epithelium, hyperplasia 0 12
(1.0) 34 b (1.0) 48 b (1.5) Inflammation, chronic 4 (1.0) 37 b
39 b (1.8) 49 b (2.0) Alveolus, infiltration cellular, histiocyte 0
34 b (2.4) 35 b (2.4) 45 b (2.7) Interstitial fibrosis 0 1 (2.0) 4 c (2.5) 8 b (1.5) Alveolar/bronchiolar adenoma, multiple 0
3 5
c
6 c
Alveolar/bronchiolar adenoma (includes multiple) 1 17 b 23 b 19 b Alveolar/bronchiolar carcinoma, multiple 0 9
b
5 c
5 c
Alveolar/bronchiolar carcinoma (includes multiple) 0 23 b 18 b 22 b Alveolar/bronchiolar adenoma or carcinoma 1 32
35 b 32 b Larynx Total no. examined 50 50
50 50
No. with: Respiratory epithelium, epiglottis, metaplasia, squamous
0 39 b (1.0)
45 b (1.0)
44 b (1.1) Nose
Total no. examined 50 50
50 50
No. with: Inflammation, suppurative
19 (1.1) 14 (1.2)
32
(1.2)
30 b (1.3)
Olfactory epithelium, atrophy 2 (1.5) 8 c
5 (1.0) 14 b (1.3) Olfactory epithelium, degeneration, hyaline 11 (1.2) 23 b (1.0) 34 b (1.2) 48 b (1.3) Respiratory epithelium, degeneration, hyaline 35 (1.3) 39 (1.5) 46 b (1.7) 50 b (1.8) Respiratory epithelium, metaplasia, squamous 0 3 (1.3) 7 b (1.1) 8 b (1.1) Respiratory epithelium, necrosis 0
0 1 (2.0) 7 b
Lymph node, bronchial
Total no. examined 39 40
45 41
No. with: Hyperplasia
3 (2.0) 13 b (1.8)
14 b (2.3)
20 b (2.3) From National Toxicology Program (2002) a Average severity grade of lesions in affected animals: 1, minimal; 2, mild; 3, moderate; 4, marked b Significantly different (p ≤ 0.01) from the chamber control group by the Poly-3 test c Significantly different (p ≤ 0.05) from the chamber control group by the Poly-3 test pp227-292.qxp 31/05/2006 09:49 Page 247 Yüklə 0,63 Mb. Dostları ilə paylaş:
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