Attachment a pain or Distress Classification C

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Date revised: Jun 10

Attachment A
Pain or Distress Classification
Classification C:

Animals upon which teaching, research, experiments, or tests, will be conducted involving no pain, distress or use of pain-relieving drugs. Examples:

  • Procedures performed correctly by trained personnel such as the administration of electrolytes/fluids, administration of oral medication, blood collection from a common peripheral vein per standard veterinary practice (dog cephalic, cat jugular, mouse facial) or catheterization of same, standard radiography, parenteral injections of non-irritating substances.

  • Euthanasia performed in accordance with the recommendations of the most recent American Veterinary Medical Association (AVMA) Panel on Euthanasia, utilizing procedures that produce rapid un-consciousness and subsequent humane death.

  • Manual restraint that is no longer than would be required for a simple exam; short period of chair restraint for an adapted nonhuman primate.

Classification D:
Animals upon which experiments, teaching, research, surgery or tests will be conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic, analgesic, or tranquilising drugs will be used. Examples:

  • Surgical procedures conducted by trained personnel in accordance with standard veterinary practice such as biopsies, gonadectomy, exposure of blood vessels, chronic catheter implantation, laparotomy or laparoscopy.

  • Blood collection by more invasive routes such as intracardiac or periorbital collection from species without a true orbital sinus such as rats and guinea pigs.

  • Administration of drugs, chemicals, toxins, cells or organisms that would be expected to produce pain or distress but which will be alleviated by analgesics or euthanasia.

Classification E:

Animal upon which teaching, experiments, research, surgery or tests will be conducted involving accompanying pain or distress to the animals and for which the use of appropriate anesthetic, analgesic or tranquilising drugs will adversely affect the procedures, results, or interpretation of the teaching, research, experiments, surgery or tests. Examples:

  • Procedures producing pain or distress unrelieved by analgesics such as toxicity studies, microbial virulence testing, radiation sickness, and research on stress shock and pain.

  • Surgical and postsurgical sequella from invasion of body cavities, orthopaedic procedures, dentistry or other hard or soft tissue damage that produces unrelieved pain or distress

  • Negative conditioning via electric shocks that would cause pain in humans

  • Chairing of nonhuman primates not conditioned to the procedure for the time period used

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