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Cell/tissue structure and function
endocrine and neural regulatory functions, including GI hormones (eg, gastrin)
salivary, gastrointestinal, pancreatic, hepatic secretory products, including enzymes,
proteins, bile salts, and processes
synthetic and metabolic functions of hepatocytes
Repair, regeneration, and changes associated with stage of life
Gastrointestinal defense mechanisms and normal flora
Abnormal Processes: Health and Health Maintenance, Screening, Diagnosis,
Management, Risks, Prognosis
Infectious, immunologic, and inflammatory disorders
infectious disorders
bacterial: pseudomembranous colitis (
Clostridium difficile); enteritis/enteric infections
(includes gastroenteritis) (eg, Staphylococcus aureus, Escherichia coli, Listeria
monocytogenes,
Yersinia enterocolitica,
Campylobacter species,
Vibrio cholerae,
Salmonella species,
Shigella species, traveler's/infectious diarrhea); hepatic
abscess, subhepatic abscess, subphrenic abscess; peritonitis, primary and
secondary; Whipple disease
viral: infectious esophagitis (eg, CMV, herpes); hepatitis A, B, C, D, E; coxsackievirus
enteritis/colitis; Echovirus enteritis/colitis; rotavirus enteritis; mumps;
gingivostomatitis, herpetic
fungal: thrush
parasitic: Cryptosporidium, Cyclospora, Entamoeba histolytica, Giardia, Isospora belli,
Strongyloides stercoralis
immunologic and inflammatory disorders: autoimmune hepatitis; celiac disease;
eosinophilic esophagitis; granulomatous enteritis; inflammatory bowel disease,
including Crohn disease, regional enteritis, microscopic colitis (collagenous and
lymphocytic colitis), ulcerative colitis, toxic megacolon
Neoplasms
benign neoplasms, including polyps, cysts: stomach; small intestine; colon, rectum, and
anus, including polyps
malignant neoplasms and pre-malignant conditions: oral cancer (eg, lips, mouth, tongue,
salivary glands); esophageal, squamous and adenocarcinoma; Barrett esophagus;
gastrinoma, Zollinger-Ellison syndrome; gastrointestinal carcinoid tumors;
gastrointestinal stromal tumors; small intestine; stomach, adenocarcinoma,
lymphoma, MALT; colon, rectum, anus; hereditary colon cancer syndromes, familial
adenomatous polyposis (eg, Peutz-Jeghers syndrome, Gardner syndrome, Turcot
syndrome, ); MUTYH-associated polyposis; gallbladder, cholangiocarcinoma,
adenocarcinoma of the ampulla of Vater; liver, including hepatoma; peritoneal
cancer, including metastatic studding with cancer; pancreas
metastatic neoplasms
Signs, symptoms, and ill-defined disorders: upper gastrointestinal bleeding; lower
gastrointestinal bleeding; constipation; diarrhea; hematochezia; bright red rectal
bleeding; melena; nausea, vomiting, rumination
Disorders of the oral cavity, salivary glands, and esophagus
oral cavity and salivary glands: abscessed tooth; dental caries; malocclusion;
disorders of the salivary glands (eg, stones, sialadenitis, parotitis)
esophagus: achalasia and cardiospasm; dysphagia; diverticulum (eg, Zenker);
esophageal periapical abscess without sinus; esophagitis/esophageal reflux
(GERD); esophagitis, pill; Mallory-Weiss syndrome; paraesophageal (hiatal) hernia;
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stricture and stenosis of esophagus
Disorders of the stomach, small intestine, colon, rectum, anus
stomach: dyspepsia/hyperacidity; gastric ulcer; gastritis; peptic ulcer; peptic ulcer
perforation; gastroparesis
small intestine, colon: appendicitis; angiodysplasia; diverticula, diverticulitis,
diverticulosis; duodenitis, duodenal ulcer, peptic ulcer; gastroenteritis and colitis
(noninfectious); granulomatous enterocolitis; Hirschsprung disease; impaction of
intestine; intestinal obstruction/stricture; intussusception; irritable colon/irritable
bowel syndrome; mesenteric ischemia/ischemic bowel/ischemic colitis; necrotizing
enterocolitis; paralytic ileus; volvulus; malnutrition and malabsorption, including
lactose intolerance, short bowel syndrome
rectum and anus: abscess of anal and rectal regions; anal fissure; anal fistula; ulcer;
fecal incontinence; hemorrhage (rectum, anus); proctitis; hemorrhoids; rectal
prolapse
Disorders of the liver and biliary system, noninfectious
liver: cirrhosis; Dubin-Johnson, Rotor syndromes; end-stage liver disease, including
indications for transplantation; Gilbert syndrome, Crigler-Najjar syndrome; hepatic
coma/hepatic encephalopathy; hepatitis, noninfectious; hepatitis, fatty liver,
alcoholic; hepatorenal syndrome; hepatopulmonary syndrome; jaundice; non-
alcoholic fatty liver disease; portal hypertension/esophageal varices
biliary system: bile duct obstruction/cholestasis; cholangitis, including ascending;
choledocholithiasis; cholelithiasis/cholecystitis; cholestasis due to parenteral
nutrition; gallstone ileus; Mirizzi syndrome; primary biliary cirrhosis; primary
sclerosing cholangitis
Disorders of the pancreas: pancreatitis, acute; pancreatitis, chronic; pancreatitis,
hereditary; pancreatic cyst/pseudocyst; pancreatic duct obstruction; pancreatic
insufficiency
Disorders of the peritoneal cavity: ascites
Traumatic and mechanical disorders: abdominal wall defects; adhesions, postsurgical;
digestive system complications of surgery; post-gastric surgery syndromes (eg, blind loop
syndrome, adhesions); duodenal tear; foreign body in digestive system; inguinal, femoral,
and abdominal wall hernias; open wound, abdominal; perforation of hollow viscus and
blunt trauma; perforation/rupture of esophagus (Boerhaave syndrome); umbilical hernia
Congenital disorders: annular pancreas; biliary atresia; cleft lip and palate; esophageal
atresia; malrotation without volvulus; Meckel diverticulum; pyloric stenosis, gastric outlet
obstruction; tracheoesophageal fistula
Adverse effects of drugs on the gastrointestinal system: drug-induced changes in motility
(chronic laxative abuse, opioids); drug-induced gastritis, duodenitis, peptic ulcer disease
(NSAIDs); drug-induced hepatitis (eg, acetaminophen, isoniazid); drug-induced
pancreatitis (eg, thiazide diuretics)
Renal & Urinary System
Normal Processes
Embryonic development, fetal maturation, and perinatal changes
Organ structure and function
kidneys, ureters, bladder, urethra
glomerular filtration and hemodynamics
urine concentration and dilution