Name: Manuel F. Casanova



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Casanova MF, AS, Kamat SS, Dombroski BA, Khalifa F, Elnakib A, Soliman A, Allison-McNutt A, Switala AE. Focal cortical dysplasias in autism spectrum disorder. Acta Neuropathologica Communications 1:67, 2013. doi:10.1186/2051-5960-1-67




  1. Casanova MF. Canonical circuits of the cerebral cortex as enablers of neuroprosthetics. Special Issue on Augmentation of Brain Function: Facts, Fiction and Controversy. Frontiers in Systems Neuroscience, 7(77):1-3, 2013.




  1. Opris I, Casanova MF. Prefrontal cortical minicolumn: from executive control to disrupted cognitive processing. Brain 137(7):1863-1875; doi: 10.1093/brain/awt359.




  1. Dombroski BA, Nitzken MJ, Elnakib AA, Khalifa F, Switala AE, El-Baz AS, Casanova MF. Cortical surface complexity in a population-based normative simple. Translational Neuroscience 5(1):17-24, 2014.




  1. Thangavel M, Seelan RS, Lakshmanan J, Vadnal RE, Stangner JI, Parthasarathy LK, Casanova MF, Parthasarathy RN. Proteomic analysis of rat prefrontal cortex after chronic valproate treatment. Journal of Neuroscience Research, 92(7):927-36, 2014.




  1. Casanova MF. Autism as a sequence: from heterochronic germinal cell divisions to abnormalities of cell migration and cortical dysplasias. Medical Hypothesis, 83(1):32-8, 2014.




  1. Zeidan-Chulia F, Neves de Oliveira B-H, Salmina AB, Casanova MF, Pens Gelain D, Verkhratsky A, Fonseca Moreira JC. Altered expression of Alzheimer’s disease related genes in the cerebellum of autistic patients: a model for disrupted brain connectome and therapy. Cell Death and Disease, 2014 May 22;5:e1250. doi: 10.1038/cddis.2014.227.




  1. Elnakib A, Soliman A, Nitzken M, Casanova MF, Gimel'farb G, El-Baz A. Magnetic resonance imaging findings for dyslexia: a review. J Biomed Nanotechnology 10:2778-2805, 2014.




  1. Nitzken MJ, Casanova MF, Gimel’farb G, Inanc T, Zurada JM, El-Baz A. Shape analysis of the human brain: a brief survey. The Journal of Biomedical and Health Informatics 18(4):1337-1354, 2014.




  1. Sokhadze E, El-Baz A, Sears L, Opris I, Casanova MF. rTMS neuromodulation improves electrocortical functional measures of information processing and behavioral responses in autism. Frontiers in Systems Neuroscience, 2014 Aug 6;8:134. doi: 10.3389/fnsys.2014.00134. eCollection 2014.




  1. Casanova MF. The modular organization of the cerebral cortex: minicolumns and minicolumnopathies. The Siberian Journal of Special Education, Thematic Issue: International Experience of Education and Socialization of Children and Adults with Autism, 1(13): 9-13, 2014. ISSN: 2221-1160

https://cloud.mail.ru/EDA150D61DDF4503AB6C5B3F87D2F682


  1. Sokhadze EM, El-Baz AS, Tasman A, Sears LL, Wang Y, Lamina EV, Casanova MF. Neuromodulation integrating rTMS and neurofeedback for the treatment of autism spectrum disorder: an exploratory study. Appl Psychophysiol Biofeedback, 39(3-4):237-257, 2014. DOI 10.1007/s10484-014-9264-7.




  1. Casanova MF, Hensley M, Sokhadze EM, El-Baz A, Wang Y, Li X, Sears L. Effects of weekly low-frequency rTMS on autonomic measures in children with autism spectrum disorder, Frontiers in Human Neuroscience, 8:851. Doi:10.3389/fnhum.2014.00851. eCollection 2014.




  1. Alansary A. Soliman A, Nitzken M, Khalifa F, Elnakib A, Casanova MF, El-Baz A. An integrated geometrical and stochastic approach for accurate infant brain extraction. Proc IEEE International Conference on Image Processing (ICIP’14), Paris, France, October 27-30, pp.3542-3546, 2014.




  1. Casanova EL and Casanova MF. Genetics studies indicate that neural induction and early neuronal maturation are disturbed in autism. Frontiers in Cellular Neuroscience, 2014 Nov 19;8:397. doi: 10.3389/fnhum.2014.01034.




  1. Elnakib A, Soliman A, Nitzken M, Casanova MF, Gimel’farb G, El-Baz A. Magnetic resonance imaging findings for dyslexia: a review. Journal of biomedical nanotechnology 10(10):2778-2805, 2014. Doi: 10.1166/jbn.2014.1895




  1. Mostapha M, Alansary A, Soliman A, Khalifa F, Nitsken M, Kohodeir R, Casanova M, El-Baz A. Atlas-based approach for the segmentation of infant DTI MR Brain Images. IEEE International Symposium on Biomedical Imaging, 11:1255-1258, 2014.




  1. Casanova EL, Casanova MF. Genetic studies indicate that neural induction and early neuronal maturation are disturbed in autism. Front Cell Neurosci 8:397, 2014. PMID: 25477785




  1. Nitzken M, Casanova MF, El-Baz A. SPHARM Analysis of the brain cortex for diagnosing dyslexia. Proc IEEE International Symposium on Biomendical Imaging: From Nano to Macro (ISBI’14), Bejing, China, April 29-May 2, 2014.




  1. Mostapha M, Soliman A, Khalifa F, Elnakib A, Alansary A, Nitzken M, Casanova MF, El-Baz A. A statistical framework for the classification of infant DT Images. Proc IEEE International Conference on Image Procesing (ICIP’14), Paris, France, October 27-30, pp. 2222-2226, 2014.




  1. Nitzken M, Casanova MF, Gimel’farb G, Inanc T, Zurada JM, El-Baz AS. Shape analysis of the human brain: a brief survey. IEE Journal of Biomedical and Health Informatics 18(4):1337-1354, 2014 doi.10.1109/JBHI. 2014.2298139




  1. Wang Y, Sokhadze E, El-Baz A, Sears L, Tasman A, Casanova MF. Prefrontal neurofeedback training approaches in autism. NeuroRegulation 1(3-4):275-7, 2014.




  1. Oberman LM, Enticott PG, Casanova MF, Rotenberg A, Pascual-Leone A, McCracken J. Transcranial magnetic stimulation (TMS) Therapy for autism: an international consensus conference held in conjunction with the International Meeting for Autism Research on May 13th and 14th, 2015, Frontiers in Neuroscience 8:1034, 2015. Doi:10.3389




  1. Casanova MF, Sokhadze E, Opris I, Wang Y, Li X. Autism spectrum disorders: linking neuropathological findings to treatment with transcranial magnetic stimulation. Acta Paediatrica 104(4):346-55, 2015.




  1. Hutsler JJ, Casanova MF. Cortical construction in autism spectrum disorder: columns, connectivity and the subplate. Neurology and Applied Neuropathology, 2015, doi:10.1111/nan.12227 [Epub ahead of print]. PMID: 25630827




  1. Alansary A, Ismail M, Soliman A, Khalifa F, Nitzken M, Elnakib A, Mostapha M, Black A, Casanova MF, Zurada JEl-Baz A. Infant brain extraction in T1weighted MR images using BET and refinement using LCDG and MGRF models. IEEE Journal of Biomedical and Health Informatics, Epub ahead of print. PMID:25823048.




  1. Zeidan-Chulia F, Neves de Oliveira B-H, Casanova MF, Casanova EL, Noda M, Salmina AB, Verkhratsky A, Fonseca Moreira JC. Up-regulation of oligodendrocyte lineage markers in the cerebellum of autistic patients: evidence from network analysis of gene expression. Molecular Neurobiology, in press. PMID: 26189831




  1. Wang Y, Hensley MK, Tasman A, Sears L, Casanova MF, Sokhadze EM. Heart Rate Variability and Skin Conductance during repetitive TMS course in children with autism. Applied Psychophysiology and Biofeedback, in press. PMID: 26341093




  1. Oberman LM, Enticott PG, Casanova MF, Rotenberg A, Pascual-Leone A, McCracken JT, and the TMS in ASD Consensus Group. Transcranial magnetic stimulation in autism spectrum disorder: challenges, promise and roadmap for future research. Autism Research, in press.




  1. Sokhadze EM, Tasman A, Sokhadze G, El-Baz AS, Casanova MF. Behavioral, cognitive, and motor preparation deficits in a visual cued spatial attention task in autism spectrum disorder. Applied Psychophysiology and Biofeedback, in press. PMID: 26377686




  1. Wegiel J, Flory M, Schaen NC, Cook EH, Nowicki K, Kuchna I, Imaki H, Yong Ma S, Wegiel J, London E, Casanova MF, Wisniewski T, Brown WT. Clinicopathological correlations in idiopathic autism and syndromic autism caused by 15q11.2-q13 duplications. Acta Neuropathologica, submitted for publication.




  1. Li J, Wang Y, Yue P, Liu W, Yu W, Ren P, Sokhadze EM, Casanova MF, Li X. Resting-state EEG relative power and functional connectivity in children with autism spectrum disorders. Cl Neurophysiol, Submitted for publication.




  1. Wang Y, El-Baz A, Li X, Sears L, Casanova MF, Tasman A, Sokhadze EM. A study of relative power of specific EEG bands and their ratios during neurofeedback training in children with autism spectrum disorder. Autism Research, submitted for publication.




  1. Alansary A, Nitzken M, Khalifa J. Mohammed FA, Elnakib A, Casanova MF, El-Baz AS. An integrated geometrical and stochastic approach for accurate infant brain extraction. IEEE International Conference on Image Processing, 2014, submitted for publication.




  1. Li J, Wang Y, Ren P, Sokhadze EM, Casanova MF, Li X. Transcranial direct current stimulation and challenging behaviors in autism spectrum disorder: a case study. Neuroscience, submitted for publication.




  1. Kirk G, Dentico D, Birn R, Blumensath T, Taylor B, Michael L, Casanova MF, Alexander A. Analysis of functional connectivity by local fMRI signal Synchrony, NeuroImage, submitted for publication.




  1. Opris I, Lebedev MA, Sokhadze EM, Casanova MF. Repair and augmentation of cognition: neural stimulation and brain-machine interfaces. Special Issue on Augmentation of Brain Function: Facts, Fiction and Controversy. Frontiers in Systems Neuroscience, in preparation.

Other Publications (Non-Refereed Articles, Book Chapters, etc.)


1. Casanova MF, Velez-Borras J, Llado I, Rodriguez RJ: Sleep apnea -- a diagnosis by itself? Clini-Pearls 5:4-5, 1982.
2. Casanova MF, Melendez R: A painful anesthesia. Clini-Pearls 5: 4-5, 1982.

3. Casanova MF: Thinning of digits. Clini-Pearls 6:2-3, 1983.


4. Price DL, Struble RG, Whitehouse PJ, Kitt CA, Cork LC, Walker LC, Casanova MF: Alzheimer's Disease: a multisystem disorder. In: Neuropeptides in Neurologic and Psychiatric Disease. Research Publications: Association for Research in Nervous and Mental Disease, JB Martin and JD Barchas (eds), New York, Raven Press, Vol. 64, pp 209-214, 1986.

5. Price DL, Struble RG, Kitt CA, Cork LC, Walker LC, Casanova MF, Powers RE: Neurobiological probes for specific constituents of senile plaques in aging and Alzheimer's disease. In: Amyloidosis. GG Glenner, EF Osserman, EP Benditt, E. Calkins, AS Cohen and D Zucker-Franklin (eds), New York, Plenum Publishing, pp 703-708, 1986.

6. Moore GW, Polacsek RA, Casanova MF, Erozan YS, Hershey J, Miller RE and Hutchins GM: Multilingual respelling rules for an English medical word list. In: Medinfo 86. R Salamon, B Blum and M Jorgensed (eds), Amsterdam, Elsevier Science Publishers, pp. 1106-1110, 1986.

7. Wagner HN, Weinberger DR, Kleinman JE, Casanova MF, Gibbs C, Gur RE, Hornykiewicz O, Kuhar MJ, Pettegrew J, Seeman P: Scientific directions: a plan for research on schizophrenia. Neuroimaging and neuropathology panel. A National Plan for Schizophrenia Research: Report of the National Advisory Mental Health Council. DHHS Publication No. (ADM) 88-1571, pp 19-22, 1988.

8. Wagner HN, Weinberger DR, Kleinman JE, Casanova MF, Gibbs CJ, Gur RE, Hornykiewicz O, Kuhar MJ, Pettegrew JW, Seeman P: A national plan for schizophrenia research: panel recommendations. Neuroimaging and neuropathology panel. DHHS Publication No. (ADM) 88-1570, pp 39-53, 1988.
9. Altshuler LL, Stevens JR, Casanova MF, Stevens CD, Bogerts B, Falkai P, Buchan J, Germain L: Gliosis in schizophrenia? Comparison of histologic techniques. J Schizophrenia Res 1:153- 154, 1988.
10. Wagner HN, Weinberger DR, Kleinman JE, Casanova MF, Gibbs CJ, Gur RE, Hornykiewicz O, Kuhar MJ, Pettegrew JW, Seeman P: Neuroimaging and neuropathology. Schiz Bull 14(3):383-397, 1989.

11. Weinberger DR, Suddath R, Casanova MF, Christison GW, Torrey EF: Morphometric studies of brain anatomy with MRI in normal monozygotic twins and monozygotic twins discordant for schizophrenia. Clinical Neuropharmacology. Raven Press, New York. 13(2):164-165, 1990.


12. Hyde TM, Casanova MF, Kleinman JE, Weinberger DR: Neuroanatomical and neurochemical pathology in schizophrenia. Tasman A and Goldfinger S (eds), The American Psychiatric Press Review of Psychiatry, Washington, DC, Vol 10, Chapter 1, pp 7-23, 1991.

13. Casanova MF, Stevens JR, Kleinman JE: The neuropathology of schizophrenia: Old and new findings. In JP Lindenmayer (ed): New Biological Vistas on Schizophrenia, Clinical and Experimental Psychiatry Monographs No.6, Brunner/Mazel publishers, New York, ch. 4, pp. 82-109, 1991.


14. Casanova MF: Astrocytosis and schizophrenia. Schizophrenia Research, 5(3):186-187, 1991.

15. Casanova MF, Atkinson DA, Goldberg TE, Zito M, Torrey EF, Bigelow LB, Weinberger D: A quantitative study of the corpus callosum and cingulate cortex in schizophrenia: an MRI study. Racagni G, Brunello N, Fukuda T (eds). Biological Psychiatry, International Congress Series 968, Excerpta Medica, vol 2, pp 373-375, 1992.

16. Casanova MF, Saunders R, Altshuler L, Goldberg T, Armstrong E, Weinberger D, Kleinman J: Entorhinal cortex pathology in schizophrenia and affective disorders. Racagni G, Brunello N, Fukuda T (eds). Biological Psychiatry, International Congress Series 968, Excerpta Medica, vol 1, pp 504-506, 1992.

17. Casanova MF: Book Review: The Concept of Schizophrenia: Historical Perspectives. JG Howells (ed). H and CP 43(3):848-849, 1992.


18. Casanova MF: Book Review: Schizophrenia and Related Syndromes, PJ McKenna (au) Psychiatric Services 48(4):547-548, 1997.
19. Casanova MF: Being a Friend (A Manual for Children with Alopecia Areata), electronically published through the Internet (http://npntserver.mcg.edu/html/alopecia/AAColoringBook.html), 1998.
20. Casanova MF: Alopecia Areata FAQ (Frequently Asked Questions), electronically published through the Internet (http:// npntserver.mcg.edu/default.htm#npindex-2.1000), 1998.



  1. Casanova MF, Buxhoeveden D, Sohal GS: Brain Development and Evolution. In Functional Neuroimaging in Child Psychiatry. M Ernst and J Rumsey editors. Cambridge University Press, Ch 7, pp113-136, 2000.




  1. Casanova MF: Introduction. In MF Casanova (ed) Neocortical Modularity and the Cell Minicolumn. Nova Science Publishers, Inc. New York:New York, pp ix-xii, 2005.




  1. Casanova MF: Vernon B. Mountcastle: A life that transformed the neuroscience. In MF Casanova (ed) Neocortical Modularity and the Cell Minicolumn. Nova Science Publishers, Inc. New York:New York, ch 1, pp 1-13, 2005.




  1. Trippe II J, Casanova MF: Vernon B. Mountcastle: Scientific Achievements. In MF Casanova (ed) Neocortical Modularity and the Cell Minicolumn. Nova Science Publishers, Inc. New York:New York, ch 2, pp 15-32, 2005.




  1. Casanova MF: An apologia for a paradigm shift in the neuroscience. In MF Casanova (ed) Neocortical Modularity and the Cell Minicolumn. Nova Science Publishers, Inc. New York:New York, ch 3, pp 33-55, 2005




  1. Buxhoeveden D, Casanova MF: The cell column in comparative anatomy. In MF Casanova (ed) Neocortical Modularity and the Cell Minicolumn. Nova Science Publishers, Inc. New York:New York, ch 5, pp 93-116, 2005.




  1. Buxhoeveden D, Casanova MF: Encephalization, minicolumns, and hominid evolution. In MF Casanova (ed) Neocortical Modularity and the Cell Minicolumn. Nova Science Publishers, Inc. New York:New York, ch 6, pp 117-136, 2005.




  1. Casanova MF, Switala AE: Minicolumnar morphometry: Computerized image analysis. In MF Casanova (ed) Neocortical Modularity and the Cell Minicolumn. Nova Science Publishers, Inc. New York:New York, ch 9, pp 161-180, 2005.




  1. Casanova MF: Introduction. In MF Casanova (ed) Recent Developments in Autism Research. NOVA Science Publishers, Inc. New York:New York, pages ix-xiii, 2005.




  1. Casanova MF: Minicolumnar Pathology in Autism. In MF Casanova (ed) Recent Developments in Autism research. NOVA Science Publishers, Inc. New York:New York, pages 133-144, 2005.




  1. Casanova MF: Anomalías en los circuitos corticales en los cerebros de pacientes con autismo. Martos, J., González, M. P., Llorente, M., Nieto, C., (Comps) (2005). Nuevos desarrollos en autismo: el futuro es hoy. Madrid: APNA y Ministerio de Trabajo y Asuntos Sociales, páginas 345-371, 2005.




  1. Casanova MF: Cortical circuit abnormalities in the brains of autistic patients. In New Developments in Autism: The Future is Today. J Martos and Gonzales MP, Llorente M, Nieto C (eds.). Jessica Kingsley Publishers, Ltd, London, England, ch. 12, pages 267-288, 2006.




  1. El-Zehiry N Y, Casanova M, Hassan H, Fahmi R, Farag AA: Volumetric MRI analysis of dyslexic subjects using a level-set framework. Jasjit Suri and Aly Farag (Eds.) Parametric and Geometric Derformable Models: An application in Medical Imagery , Volume II, Chapter 14, Springer-Verlag, New York, May 2006.




  1. Parthasarathy L, Seelan RS, Tobias C, Casanova MF, Parthasarathy R: Mammalian inositol 3-phosphate synthetase: its role in the biosynthesis of brain inositol and its clinical use as a psychoactive agent. In Lahiri Majumder A and Biswas BB (eds.) Biology of Inositols and Phsophoinositides, series of Subcellular Biochemistry, Volume 39, chapter 12, 2006.




  1. El-Baz A, Farag A, Ali A, Gimel’farab G, Casanova MF. A framework for unsupervised segmentation of multimodal medical images. Lectures Notes in Computer Science. Proc. of the Second International Workshop of Computer Vision Approaches to Medical Image Analysis(CVAMIA’06), Graz, Austria, May 2006, Springer Berlin, Heidelberg, 4241:120-131, 2006.




  1. Johnson SB, Datta S, Hornung CA, Casanova MF: Mathematical models of epigenetic Influences in Autism: a new perspective based on neuropathological findings. Paul C. Carlisle (ed) Progress in Autism Research, Nova Science Publishers, Inc., New York:New York, chapter 3, p. 101-114, 2007.




  1. Fahmi R, El-Baz A, Abdel-Munim H, Abdel-Hakim A, Farag A, Casanova MF. Robust Neuroimaging-Based Classification Techniques of Autistic vs. Typically Developing Brain. In Handbook of Deformable Models: Biomedical and Clinical Applications, (J. S. Suri, A. Farag, Eds.), Springer, vol. II, pp. 535-566, February, 2007.




  1. Abd El Munim H, Fahmi R, Youssry El-Zehiry N, Farag AA, Casanova MF. Volumetric MRI Analysis of Dyslexic Subjects Using Level Set Framework,” J. Suri and A. Farag, Editors, Deformable Models II: Theory & Biomaterial Applications, Chapter 14, pp. 461-492,  Springer-Verlag, New York, July 2007. 




  1. Casanova MF, Steele J. Autism: An Overview. Louisville Medicine, Louisville Medicine. The Greater Louisville Medical Society 54(11): 503-505, 531, 2007.




  1. Casanova MF. Neuropathological findings in Asperger Syndrome. JL Rausch ME Johnson, and MF Casanova (eds) Asperger’s Disorder. Informa Healthcare: New York, ch. 9, pp. 155-170, 2008.




  1. Rausch JL, Johnson ME, Casanova MF (eds) Asperger’s Disorder. Informa Healthcare: New York, 2008.




  1. Casanova MF. The significance of minicolumnar size variability in autism: a perspective from comparative anatomy. In A Zimmerman (ed) Autism Current Theories and Evidence, Current Clinical Neurology, The Human Press, Inc., ch. 16, pp. 349-360, 2008.




  1. Crespo FA, Fernandez-Botran R, Tillquist CR, Mott M, Casanova MF. Immune Alterations in Autism: The Role of Cytokine Polymorphisms. In Chauhan A and Brown T (eds) Autism:Oxidative Stress, Inflammation and Immune Abnormalities. Taylor and France Group, LLC, ch. 16, pp. 315-324, 2009.




  1. Johnson SB, Casanova MF. Interhemispheric Connectivity: The Evolution and Nature of the Corpus Callosum. In TB Westland and Calton RN (eds) Handbook on White Matter: Structure, Function and Changes. Nova Science Publishers, Inc., New York, ch. 1, pp 3-15, 2009.




  1. Casanova MF, Trippe J. Radial cytoarchitecture and patterns of connectivity in autism. F. Happe and U Frith (eds) Autism and Talent. Oxford University Press: Oxford, ch. 11, pp. 135-140, 2010.




  1. Casanova MF, Sokhadze E, El-Baz A, Baruth J, Mathai G, Sears L. Research at the University of Louisville Autism Center. Siri K and Lyons T (eds). Cutting Edge Therapies for Autism, Skyhorse Publishing: New York, ch. 68, pp. 410-413, 2010.




  1. Baruth J, Sokhadze E. El-Baz A, Mathai G, Sears L, Casanova MF. Transcaranial Magentic Stimulation as a Treatment for Autism. Siri K and Lyons T (eds). Cutting Edge Therapies for Autism, Skyhorse Publishing: New York, ch. 63, pp. 388-397, 2010.




  1. Farag A, Elhabian S, Abdelrahman M, Graham J, Farag A, Chen D, Casanova MF. Surface Modeling of the Corpus Callosum from MRI Scans. In George Bebis, Richard Boyle, Bahram Parvin, Darko Koracin, Ronald Chung, Taid Hammoud, Muhammad Hussain, Tan KarHan, Roger Crawfis, Daniel Thalmann, David Kao, Lisa Avila (ed.s) Advances in Visual Computing: 6th International Symposium, ISVC 2010, Las Vegas, NV, USA, November 29-December 1, 2010, proceedings part III. Lectures Notes in Computer Science 2010 December 13:6455: 9-18.




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