Centres registered as undertaking large scale work with GMMs and their reply or comments in response to a letter and follow-up phone calls from GeneWatch requesting further information about their activities and monitoring arrangements.
CENTRE NAME AND ADDRESS
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REPLY
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BRF
Lyttel Hall, Nuffield, Redhill Surrey RH1 4HY
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None
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Carlsberg Tetley Brewing Ltd
107 Station Street, Burton upon Trent, Staffs,
DE14 1BZ
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Used for testing GM yeast in beer production - not in commercial use.
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Celltech
Therapeutics Ltd, 216 Bath Road, Slough, SL1 4EN
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Have sold their commercial production division using GMMs to Lonza Biologics
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Chiroscience Group Plc
Holmewood Hall, Holme, PE7 3PG
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Use large scale but claimed commercial confidentiality
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Delta Biotechnology
Mabel Street, The Meadows, Nottingham NG2 3ED
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None
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Delta Biotechnology
5 Crocus Street, The Meadows, Nottingham
NG2 3DE
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None
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Delta Biotechnology Ltd
Castle Court, 59 castle Boulevard, Nottingham
NG7 1FD
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None
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Eli Lily & Co Ltd
Fleming Road, Speke, Liverpool, L24 9LN
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None
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Genzyme Biochemicals
50 Gibson Drive, King's Hill, West Malling, Kent ME19 6HG
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None
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Hoechst Roussel Vet Ltd
Walton Manor, Milton Keynes MK7 7AJ
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None
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Imperial Biotechnology Ltd
Southbank Technopark, 90 London Road, London SE1 6LN
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None - could not locate for follow-up call.
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Lonza Biologics Plc
226/228 Bath Road, Slough, SL1 4DY
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None
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Medeva Pharmecuticals Ltd
Gaskill Road, Speke, Liverpool, L24 9GR
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None
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MRC Cell Mutation Unit
University of Sussex, Falmer, Brighton, BN1 9RR
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No large scale IB use - small scale only, no commercial.
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Murex Biotech Ltd
Central Road, Temple Hill, Dartford, Kent,
DA1 5LR
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None
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Pfizer Central Research Ltd
Ramsgate Road, Sandwich, Kent, CT13 9NJ
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None
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Queen Mary & Westfield College
University of London, Mile End Road, London
E1 4NS
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Research only, no commercial.
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Continued overleaf…
Quest International
Menstrie, Clackmannanshire, FK11 7ES
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Research use only, no commercial.
|
U
Continued…
niversity of Newcastle upon Tyne
School of Biological and Nutritional Sciences, Newcastle-upon-Tyne, NE1 7RU
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None
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Sigma Aldrich Co Ltd
Fancy Road, Poole, Dorset, BH12 4NZ
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None
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Smithkline Beecham
Coldharbour Road, The Pinnacles, Harlow, Essex CM19 5AD.
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None
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Smithkline Beecham
Shewalton Road, Irvine, Ayrshire, KA11 5AP
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None
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Smithkline Beecham Pharmaceuticals
Great Burgh, Yew Tree Bottom Road, Epsom, Surrey, KT18 5XQ.
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Closed
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Smithkline Beecham Pharmaceuticals
Clarendon Road, Worthing, West Sussex
BN14 8QH.
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None
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Tate and Lyle Citric Acid
Denison Road, Selby, North Yorkshire, YO8 8EF.
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No large scale use
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Unilever Research
Colworth Laboratory Colworth House, Sharnbrook, Bedfordshire, MK44 1LQ.
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No large scale use
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University of Cambridge
Hills Road, Cambridge, CB2 2QL
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None
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University of Cambridge
Tennis Court Road, Cambridge, CB2 1QT.
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None
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University of Coventry
Biology Department, Priory Street, Coventry
CV1 5FB
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None
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University of Cranfield
Biotechnology Department, Cranfield, Bedfordshire, MK43 0AL
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No IB since 1989 and never commercial
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University of Westminster
115 Cavendish Street, London W1M 8JS
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No commercial use large scale pre 1992
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Zeneca Agrochemicals Limited
Jealott’s Hill Research Station, Bracknell, Berkshire, RG12 6EY.
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None
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Zeneca Bioproducts
PO Box 2, Belasis Avenue, Billingham Cleveland TS23 1YN
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None
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Zeneca Pharmaceuticals
Alderley Park, Macclesfield, Cheshire, SK10 4TG
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None
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REFERENCES
1Wright, S (1994) Molecular Politics. Developing American and British Regulatory Policy for Genetic Engineering, 1972-1982. University of Chicago Press: Chicago.
2Doyle, J.D., Stotzty, G., McClung, G. & Handricks, C.W. (1995) Effects of genetically engineered micro-organisms on microbial populations and processes in natural habitats. Advances in Applied Microbiology 40:237-286.
3Kane, J.F. (1993) Environmental assessment of recombinant DNA fermentations. Journal of Industrial Microbiology. 11: 205-208.
4Muth, W.L., Counter, F.T., Richardson, K.K. & Fisher, L.F. (1993) Escherichia coli K12 does not colonise the gastrointestinal tract of Fischer-344 rats. Journal of Industrial Microbiology. 11: 253-257.
5Yancey, R.J., Kotarski, S.F., Thurn, K.K., Lepley, R.A. & Mott, J.E. (1993) Absence and transfer of genetic material by recombinant Escherichia coli in conventional, antibiotic-treated mice. Journal of Industrial Microbiology 11: 259-271.
6Dalboge, H., Masden, B., Jorgensen, K Damm. & Carlsen, S. (1988) Assessment of risks in connection with use of a recombinant E.coli strain for production of human growth hormone. Danish Medical Bulletin 35: 84-91.
7Williams Smith, H. (1975) Survival of orally administered E.coli K12 in alimentary tract of man. Nature 255: 500-502.
8Anderson, E.S. (1975) Viability of, and transfer of a plasmid from, E.coli K12 in the human intestine. Nature 255: 502-504.
9Advisory Committee on Genetic Modification (1997) Compendium of Guidance from the Health and Safety Commission’s Advisory Committee on Genetic Modification. Health and Safety Executive: London.
10Tschäpe, H. (1994) The spread of plasmids as a function of bacterial adaptability FEMS Microbiology Ecology 15: 23-32.
11Recorbet, G., Steinberg, C. & Faurie, G. (1992) Survival in soil of genetically engineered Escherichia coli as related to inoculum density, predation and competition. FEMS Microbiology Ecology. 101: 251-260.
12Heitkamp, M.A., Kane, J.F., Morris, P.J.L., Bianchini, M., Hale, M.D. & Bogosian, G. (1993), Fate in sewage of recombinant Escherichia coli K-12 strain used in commercial production of bovine somatotropin. Journal of Industrial Microbiology, 11: 243-252.
13Flint, K.P. (1987) The long term survival of Escherichia coli in river water. Journal of Bacteriology 63: 261-270.
14McClure, N.C., Weightman, A.J. & Fry, J.C. (1989) Survival of Pseudomonas putida UWC1 containing cloned catabolic genes in a model activated sludge unit. Applied Environmental Microbiology 55: 2627-2634.
15Clegg, C.D., Anderson, J.M., Lappin-Scott, H.M, van Eslas, J.D. & Jolly, J.M. (1995) Interaction of a genetically modified Pseudomonas fluorescens with the soil-feeding earthworm Octolasion cyaneum (Lumbricidae). Soil Biology and Biochemistry 11: 1423-1529.
16Clegg, C.D., van Eslas, J.D., Anderson, J.M. & Lappin-Scott, H.M. (1994) Assessment of the role of a terrestrial isopod in the survival of a genetically modified pseudomonad and its detection using the polymerase chain reaction. FEMS Microbiology Letters 15: 161-168.
17Colwell, R.R., Brayton, P.R., Grimes, D.J., Roszak, D.B., Huq, S.A. & Palmer, L.M. (1985) Viable but non-culturable Vibrio cholerae and related pathogens: implications for release of genetically engineered micro-organisms. Bio/Technology 3: 817-820.
18Turpin, P.E., Maycroft, K.A. & Wellington, E.M.H. (1993) Viable but non-culturable salmonellas in soil. Journal of Applied Bacteriology 74: 421-427.
19Bogosian, G., Morris, P.J.L. & O’Neil, J.P. (1998) A mixed culture recovery method indicates that enteric bacteria do not enter the viable but nonculturable state. Applied and Environmental Microbiology 64: 1736-1742.
20Lorenz, G. & Wackernagel, W. (1994) Bacterial Gene Transfer by Natural Genetic Transformation in the Environment. Microbiological Reviews 58: 563-602.
21Mazodier, P. & Davies, J. (1991) Gene transfer between distantly related bacteria. Annual Review of Genetics 25: 147-171.
22Maeda, M. & Taga, N. (1974) Occurrence and distribution of deoxyribonucleic acid-hydrolysing bacteria in sea water. Journal of Experimental Marine Biology and. Ecology. 14: 157-169.
23Paget, E. & Simonet, P. (1994) On the track of natural transformation in soil. FEMS Microbiology Ecology 15: 109-118.
24Recorbet, G., Picard, C., Normand, P. & Simonet, P. (1993) Kinetics of the persistence of chromosomal DNA from genetically engineered Escherichia coli introduced into soil. Applied Environmental Micobiology 59: 4289-4294.
25Paul, J.H., Frischer, M.E. & Thurmond, J.M. (1991) Gene transfer in the marine water column and sediment microcosms by natural plasmid transformation. Applied and Environmental Microbiology 57: 1509-1515.
26Veal, D.A., Stokes, H.W. & Daggard, G. (1992) Genetic exchange in natural microbial communities. Advances in Microbial Ecology 12: 383-430.
27Gallori, E., Bazzicalupo, M., Dal Canto, L., Fani, R., Nannipieri, P., Vettori, C. & Stotzky, G. (1994) Transformation of Bacillus subtilis by DNA bound on clay in non-sterile soil. FEMS Microbiology Ecology 15: 119-126.
28Selvaratnam, S. & Gealt, M.A. (1992) Recombinant plasmid gene transfer in amended soil. Water Research 26: 39-43.
29Lebaron, Ph., Batailler, N. & Baleux, B. (1994) Mobilisation of a recombinant nonconjugative plasmid at the interface between wastewater and the marine coastal environment. FEMS Microbiology Ecology 15: 61-70.
30Duval-Ifah, Y., Gainche, I., Qurier, M-F., Lett, M-C. & Hubert, J-C. (1994) Recombinant DNA transfer to Escherichia coli of human faecal origin in vitro and in digestive tract of gnotobiotic mice. FEMS Microbiology Ecology 15: 79-88.
31Rinkel, M., Hubert, J-C., Roux, B. & Lett, M-C. (1994) Transposon Tn 5403, a mobilization-helper element: complete nucleotide sequence and distribution in aquatic strains. FEMS Microbiology Ecology 15: 89-96.
32Salyers, A.A., Shoemaker, N.B., Stevens, A.M. & Li, L-Y. (1995) Conjugative transposons: an unusual and diverse set of integrated gene transfer elements. Microbiological Reviews 59: 579-590.
33Schlimme, W., Marchani, M., Hanselmann, K. & Jenni, B. (1997) Gene transfer between bacteria within digestive vacuoles of protozoa. FEMS Microbiology Ecology 23: 239-247.
34Daane, L.L., Molina, J.A.E., Berry, E.C. & Sadowsky, M.J. (1996) Influence of earthworm activity on gene transfer from Pseudomonas fluorescens to indigenous soil bacteria. Applied and Environmental Microbiology 62: 515-521.
35Isberg, R.R. & Falkow, S. (1985) A single genetic locus encoded by Yersinia pseudotuberculosis permits invasion of cultured animal cells by E.coli K12. Nature 317: 262-264.
36Barinaga, M. (1996) A shared strategy for virulence. Science 272: 1261- 1263.
37Traavik, T. (1999) Too early may be too late. Ecological risks associated with the use of naked DNA as a tool for research, production and therapy. Directorate for Nature Management, Trondheim, Norway.
38Advisory Committee on Genetic Modification (1995) Genetic Modification Risks and Safeguards. HSE Books: Sheffield.
39Advisory Committee on Genetic Modification (1997) Compendium of Guidance from the Health and Safety Commission’s Advisory Committee on Genetic Modification. Health and Safety Executive: London
40Shoji, I., Aizaki, H., Tani, K., Chiba, C., Saito, I., Miyamura, T. & Matsura, Y. (1997) Efficient gene transfer into various mammalian cells, including non-hepatic cells, by baculovirus vectors. Journal of General Virology 78: 2657-2664.
41HSE, Advisory Committee on Genetic Modification. Technical Sub-Committee. Risk Assessment enquiry – use of baculovirus vectors. ACGM/TSC/98/11/P3.
42HSE, Advisory Committee on Genetic Modification. Technical Sub-Committee. Minutes of the 4th Meeting on 5th February 1998, 9.
43HSE, Advisory Committee on Genetic Modification. Technical Sub-Committee. Minutes of the 4th Meeting on 5th February 1998, p 10.
44HSE, Advisory Committee on Genetic Modification. Technical Sub-Committee. Minutes of the 3rd Meeting on 10th November 1997 p 2.
45Information from John Furlong, HSE, 7th April 1999.
46House of Commons, Hansard Written Answers. 26 October 1998, column 13.
47Letter from Paul Logan, HSE, to GeneWatch dated 13 January 1999.
48Novo Nordisk. Environmental and Bioethics Report 1997. Novo Nordisk: Bagsvaerd, Denmark.
49House of Commons, Hansard, Written Answers 26th October 1998, column 13.
50Draft Regulatory Impact Assessment for Revised Regulations on Contained Use of Genetically Modified Organisms (GMOs). Annex 4 of the Proposals for revised genetically modified (contained use) regulations. Consultative Document. HSE Books, Sudbury, Suffolk. May 1999.
51HSE. Advisory Committee on Genetic Modification. Technical Sub-Committee. Minutes of the 3rd meeting. 10th November 1997 p 3-8.
52HSE. Advisory Committee on Genetic Modification. Technical Sub-Committee. ‘Genetic modification of enveloped RNA viruses’. ACGM/TSC/98/05/P4.
53HSE. Advisory Committee on Genetic Modification. Technical Sub-Committee. Minutes of the 3rd meeting. 10th November 1997 p 4.
54HSE. Advisory Committee on Genetic Modification. Technical Sub-Committee. 5 February 1998. Insertion of the H5 avian influenza haemagglutinin gene into a human influenza background. ACGM/TSC/98/05/P5. Annex 3.
55Bartels, D. (1997) Escape of the cancer genes? New Scientist 30 July 1987, p52-54.
56HSE. Advisory Committee on Genetic Modification. Technical Sub-Committee. Minutes of the 3rd meeting. 10th November 1997 p 3.
57House of Commons, Hansard, Written Answers 3rd November 1998, column 451.
58 ‘For discharges to water …there is no requirement to inform us if GM material (whether de-activated or not) is present.’ Letter from Dr Jan Pentreath, Environment Agency to GeneWatch, dated 14 December 1998.
59Dörnenburg, H. & Lang-Hinrichs, C. (1994) Genetic engineering in food biotechnology. Chemistry and Industry 4 July 1994 pp 506-510.
60Crook, B. and Cottram, A.N. (1996) The Current Status of Monitoring for Process Micro-organisms in Biotechnology: Results of an Industry Questionnaire. Annals of Occupational Hygiene 40(2): 223-232.
61Ashcroft J and Pomeroy, N.P. (1983) The generation of aerosols by accident which may occur during plant-scale production of micro-organisms. Journal of Hygiene 91:81-91.
62Jones, J.G. & Simon, B.M. (1975) Journal of Bacteriology 60: 455-462.
63HSE (1999) Proposals for revised Genetically Modified Organisms (Contained Use) Regulations. Consultative Document. HSE Books: Suffolk.
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