Leaking From The Lab


APPENDIX 2: REGISTERED LARGE-SCALE GMM USERS



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APPENDIX 2: REGISTERED LARGE-SCALE GMM USERS

Centres registered as undertaking large scale work with GMMs and their reply or comments in response to a letter and follow-up phone calls from GeneWatch requesting further information about their activities and monitoring arrangements.




CENTRE NAME AND ADDRESS

REPLY

BRF

Lyttel Hall, Nuffield, Redhill Surrey RH1 4HY



None

Carlsberg Tetley Brewing Ltd

107 Station Street, Burton upon Trent, Staffs,

DE14 1BZ


Used for testing GM yeast in beer production - not in commercial use.

Celltech

Therapeutics Ltd, 216 Bath Road, Slough, SL1 4EN



Have sold their commercial production division using GMMs to Lonza Biologics

Chiroscience Group Plc

Holmewood Hall, Holme, PE7 3PG



Use large scale but claimed commercial confidentiality

Delta Biotechnology

Mabel Street, The Meadows, Nottingham NG2 3ED



None

Delta Biotechnology

5 Crocus Street, The Meadows, Nottingham

NG2 3DE


None

Delta Biotechnology Ltd

Castle Court, 59 castle Boulevard, Nottingham

NG7 1FD


None

Eli Lily & Co Ltd

Fleming Road, Speke, Liverpool, L24 9LN



None

Genzyme Biochemicals

50 Gibson Drive, King's Hill, West Malling, Kent ME19 6HG



None

Hoechst Roussel Vet Ltd

Walton Manor, Milton Keynes MK7 7AJ



None

Imperial Biotechnology Ltd

Southbank Technopark, 90 London Road, London SE1 6LN



None - could not locate for follow-up call.

Lonza Biologics Plc

226/228 Bath Road, Slough, SL1 4DY



None

Medeva Pharmecuticals Ltd

Gaskill Road, Speke, Liverpool, L24 9GR



None

MRC Cell Mutation Unit

University of Sussex, Falmer, Brighton, BN1 9RR



No large scale IB use - small scale only, no commercial.

Murex Biotech Ltd

Central Road, Temple Hill, Dartford, Kent,

DA1 5LR


None

Pfizer Central Research Ltd

Ramsgate Road, Sandwich, Kent, CT13 9NJ



None

Queen Mary & Westfield College

University of London, Mile End Road, London

E1 4NS


Research only, no commercial.


Continued overleaf…
Quest International

Menstrie, Clackmannanshire, FK11 7ES



Research use only, no commercial.

U
Continued…

niversity of Newcastle upon Tyne

School of Biological and Nutritional Sciences, Newcastle-upon-Tyne, NE1 7RU



None

Sigma Aldrich Co Ltd

Fancy Road, Poole, Dorset, BH12 4NZ



None

Smithkline Beecham

Coldharbour Road, The Pinnacles, Harlow, Essex CM19 5AD.



None

Smithkline Beecham

Shewalton Road, Irvine, Ayrshire, KA11 5AP



None

Smithkline Beecham Pharmaceuticals

Great Burgh, Yew Tree Bottom Road, Epsom, Surrey, KT18 5XQ.



Closed

Smithkline Beecham Pharmaceuticals

Clarendon Road, Worthing, West Sussex

BN14 8QH.


None

Tate and Lyle Citric Acid

Denison Road, Selby, North Yorkshire, YO8 8EF.



No large scale use

Unilever Research

Colworth Laboratory Colworth House, Sharnbrook, Bedfordshire, MK44 1LQ.



No large scale use

University of Cambridge

Hills Road, Cambridge, CB2 2QL



None

University of Cambridge

Tennis Court Road, Cambridge, CB2 1QT.



None

University of Coventry

Biology Department, Priory Street, Coventry

CV1 5FB


None

University of Cranfield

Biotechnology Department, Cranfield, Bedfordshire, MK43 0AL



No IB since 1989 and never commercial

University of Westminster

115 Cavendish Street, London W1M 8JS



No commercial use large scale pre 1992

Zeneca Agrochemicals Limited

Jealott’s Hill Research Station, Bracknell, Berkshire, RG12 6EY.



None

Zeneca Bioproducts

PO Box 2, Belasis Avenue, Billingham Cleveland TS23 1YN



None

Zeneca Pharmaceuticals

Alderley Park, Macclesfield, Cheshire, SK10 4TG



None


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25Paul, J.H., Frischer, M.E. & Thurmond, J.M. (1991) Gene transfer in the marine water column and sediment microcosms by natural plasmid transformation. Applied and Environmental Microbiology 57: 1509-1515.

26Veal, D.A., Stokes, H.W. & Daggard, G. (1992) Genetic exchange in natural microbial communities. Advances in Microbial Ecology 12: 383-430.

27Gallori, E., Bazzicalupo, M., Dal Canto, L., Fani, R., Nannipieri, P., Vettori, C. & Stotzky, G. (1994) Transformation of Bacillus subtilis by DNA bound on clay in non-sterile soil. FEMS Microbiology Ecology 15: 119-126.

28Selvaratnam, S. & Gealt, M.A. (1992) Recombinant plasmid gene transfer in amended soil. Water Research 26: 39-43.

29Lebaron, Ph., Batailler, N. & Baleux, B. (1994) Mobilisation of a recombinant nonconjugative plasmid at the interface between wastewater and the marine coastal environment. FEMS Microbiology Ecology 15: 61-70.

30Duval-Ifah, Y., Gainche, I., Qurier, M-F., Lett, M-C. & Hubert, J-C. (1994) Recombinant DNA transfer to Escherichia coli of human faecal origin in vitro and in digestive tract of gnotobiotic mice. FEMS Microbiology Ecology 15: 79-88.

31Rinkel, M., Hubert, J-C., Roux, B. & Lett, M-C. (1994) Transposon Tn 5403, a mobilization-helper element: complete nucleotide sequence and distribution in aquatic strains. FEMS Microbiology Ecology 15: 89-96.

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33Schlimme, W., Marchani, M., Hanselmann, K. & Jenni, B. (1997) Gene transfer between bacteria within digestive vacuoles of protozoa. FEMS Microbiology Ecology 23: 239-247.

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37Traavik, T. (1999) Too early may be too late. Ecological risks associated with the use of naked DNA as a tool for research, production and therapy. Directorate for Nature Management, Trondheim, Norway.

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40Shoji, I., Aizaki, H., Tani, K., Chiba, C., Saito, I., Miyamura, T. & Matsura, Y. (1997) Efficient gene transfer into various mammalian cells, including non-hepatic cells, by baculovirus vectors. Journal of General Virology 78: 2657-2664.

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58 ‘For discharges to water …there is no requirement to inform us if GM material (whether de-activated or not) is present.’ Letter from Dr Jan Pentreath, Environment Agency to GeneWatch, dated 14 December 1998.

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63HSE (1999) Proposals for revised Genetically Modified Organisms (Contained Use) Regulations. Consultative Document. HSE Books: Suffolk.



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