Arendt J, Aldhous M, Marks V. Alleviation of jet lag by melatonin: preliminary results
of controlled double blind trial. Br Med J 1986;292:1170.
88 Arendt ( published data only)
* *Arendt J, Aldhous M. Further evaluation of the treatment of jet lag by melatonin: a
double blind crossover study. Ann Rev Chronopharmacol 1988;5:53-55.
Skene DJ, Aldhous M, Arendt J. Melatonin, jet lag and sleep-wake cycle. In: Horne J,
ed. Sleep '88. Proceedings of the 9th European Congress of Sleep Research, Jerusalem
1988. :39-41.
89 Petrie ( published data only)
Petrie K, Conaglen JV, Thompson, Chamberlain K. Effect of melatonin on jet lag after
long haul flights. BMJ 1989;298:705-707.
91 Nickelsen (published data only)
Nickelsen T, Lang A, Bergau L. The effect of 6-, 9- and 11-hour time shifts on circadian
rhythms: adaptation of sleep parameters and hormonal patterns following the intake of
melatonin or placebo. In: Arendt J, Pevet P, editor(s). Advances in Pineal Research. Vol.
5. 1991:303-6.
92 Claustrat (published data only)
Claustrat B, Brun J, David M, Sassolas G, Chazot G. Melatonin and jet lag:
confirmatory result using a simplified protocol. Biological Psychiatry 1992;32:705-711.
93 Petrie (published data only)
Petrie K, Dawson AG, Thompson L, Brook R. A double-blind trial of melatonin as a
treatment for jet lag in international cabin crew. Biological Psychiatry 1993;33:526-530.
97 Spitzer (published data only)
*Spitzer RL, Terman M, Williams JBW, Terman JS, Malt UF, Singer F, Lewy AJ. Jet
lag: clinical features, validation of a new syndrome-specific scale, and lack of response
to melatonin in a randomized double-blind trial. American Journal of Psychiatry
1999:1392-1396.
Spitzer RL, Terman M, Malt U, Singer F, Terman JS, Williams JBW, Lewy AJ. Failure
of melatonin to affect jet lag in a randomized double blind trial. Society for Light
Treatment and Biological Rhythms: SLTBR Abstracts 1997;9:1.
98 Suhner a ( published data only)
Suhner A, Schlagenhauf P, Johnson R, Tschopp A, Steffen R. Comparative study to
determine the optimal melatonin dosage form for the alleviation of jet lag.
Chronobiology International 1998b;15:655-666.
98 Suhner b ( published data only)
Suhner A, Schlagenhauf P, Hoefer I, Johnson R, Tschopp A, Steffen R. Efficacy and
tolerability of melatonin and zolpidem for the alleviation of jet-lag. In: Suhner A.
Melatonin and jet-lag. Dissertation ETH No. 12823. Zurich, Switzerland: Swiss Federal
Institute of Technology, 1988:85-103.
Suhner A, Schlagenhauf P, Hoefer I, Johnson R, Tschopp A, Steffen R. Efficacy and
tolerability of melatonin and zolpidem for the alleviation of jet-lag. In: Book of
Abstracts, 6th Conference of the International Society of Travel Medicine, Montreal,
Canada, June 6-10,1999. 1999:95, abs G03.
* indicates the major publication for the study
References to studies excluded from this review
Arendt 95, 97a, 97b
Arendt J, Deacon S. Treatment of circadian rhythm disorders. Chronobiology
International 1997;14:185-204.
Arendt J, Deacon S, English J, Hampton S, Morgan L. Melatonin and adjustment to
phase shift. J Sleep Res 1995;4(Suppl 2):74-79.
Arendt J, Skene DJ, Middleton B, Lockley S, Deacon S. Efficacy of melatonin treatment
in jet lag, shift work and blindness. J Biol Rhythms 1997;12:604-17.
Comperatore 96
Comperatore CA, Lieberman HR, Kirby AW, Adams B, Crowley JS. Melatonin efficacy
in aviation missions requiring rapid deployment and night operations. Aviation, Space
and Environmental Medicine 1996;67:520-524.
Additional references
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Armstrong SM, Cassone VM, Chesworth MJ, Redman JR, Short RV. Synchronizaion of
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Bardazzi 98
Bardazzi F, Placucci F, Neri I, D'Antuono A, Patrizi A. Fixed drug eruption due to
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Cochrane Handbook 99
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Comperatore CA, Krueger GP. Circadian rhythm desynchronosis, jet lag, shift lag and
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Dalton 00
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Ellis 96
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Force 97
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Lewy 92
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Lewy 95
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Martindale 99
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SED 96
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Aronson JK, ed. Side Effects of Drugs Annual. Vol. 10-23. Amsterdam: Elsevier, 1986
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Sheldon SH. Pro-convulsant effects of oral melatonin in neurologically disabled
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