Teaching Notes Understanding Immunity: a modeling Activity
| Is memory acquired?
If so, what cells? |
No memory |
Memory B cells |
|
Memory T cells |
2. Compare and contrast MHC I and MHC II. What is the significance of each? Which cells have MHC II? How does the presence of MHC relate to the functions of these cells?
MHC I and MHC II are the two classes of the major histocompatibility complex. Both MHC I and MHC II are cell surface proteins. They function by displaying the epitope of the processed antigen. When certain cells, such as macrophages and dendritic cells are infected, they process the antigen and display the antigenic epitopes (e.g. short peptides) on the MHC complex. T cells recognize the presented antigens by binding to the MHC complexes via T-Cell Receptors and are activated by this presentation. MHC I proteins are found on nearly all nucleated cells; when displaying the epitope of the antigen, these will activate cytotoxic T cells. MHC II proteins are found on dendritic cells, macrophages and B cells; when displaying the epitope of the antigen will activate helper T cells.
3. What in the complement system? Is it involved in both innate and adaptive immunities? Explain.
The complement system is a group of proteins found in blood plasma. They function in both innate and adaptive immunities. In innate immunity, the activated complement proteins can stimulate the release of more histamine, which attracts phagocytes. In adaptive immunity, complement proteins bind to the antigen-antibody complex on the pathogenic cell and promote the formation of a pore in the pathogen which allows water and ions to rush in and lyse the pathogen.
4. You have an ear infection and the culprit is the adenovirus. Using a flow chart or infographic, show how the immune system responds to the virus.
Answers may vary. Students should show both innate and adaptive immunities and include the major events of each immune response.
Developed as part of the RCSB Collaborative Curriculum Development Program 2014
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