THE BARTONIAN LEGACY
© Imperial College Press
http://www.worldscibooks.com/chemistry/p211.html
1
A REMINISCENCE OR TWO ON
PROFESSOR SIR DEREK BARTON,
NOBEL LAUREATE
Anthony G. M. Barrett
Department of Chemistry,
Imperial College of Science, Technology and Medicine,
London SW7 2AY, UK
I first met Sir Derek Barton in late 1972 in the Department of Chemistry
at Imperial College, when I was summoned from the undergraduate
teaching laboratories in the depths of the building to his office on
Level 7. He was writing at a roll top desk in the corner of the
T-shaped room with a small rather insignificant chalk board in the
opposite corner. I do not remember whether the board was covered
in writing or not. This board would be a significant part of my life,
in due course, but at that time its role to be passed me by. I was
rather anxious but the meeting went well; indeed it was short and
pleasant. Sir Derek asked me which book I had chosen for the Hofmann
Prize which I had won in June that year. He approved my choice of
Survey of Organic Syntheses by Buchler and Pearson and asked to see
my copy of the book. Reassured that I had chosen an appropriate
learned text he inquired as to the price. Satisifed, he wrote and gave
me a personal check with the explanation that as Hofmann Professor
of Chemistry it was his duty to cover my winnings. On February 22
1998, Derek and I sat side by side in business class on a charter flight
from London Gatwick to Male in the Maldives to attend a conference,
Perspectives on the 21st Century-II, on Kureda Island in celebration
of his 80th Birthday (to be). It amazes me that some charter airlines
can equate a single plastic flute of champagne alone with the
designation Business Class; I complained but Derek just chuckled to
THE BARTONIAN LEGACY
© Imperial College Press
http://www.worldscibooks.com/chemistry/p211.html
2
A
NTHONY
G. M. B
ARRETT
himself. He was, as always, energetically engaged in academic pursuits
and avidly reading. He was disappointed that I chose to sleep since
he had brought a book for me to read as well; it was a night flight.
On a regular basis as I passed from fitful sleep to aching wakefullness,
the book on the history of organic chemistry was thrust in my direction.
Had I the foreseen that Derek’s allocation of time was almost over I
would have accepted the loan with more grace. How could I have
known at that time? “Prof”, the “the old man” and “DHRB” seemed
immortal.
In 1973, I started a 3rd year undergraduate project with Sir Derek
on nitrone chemistry. This entailed research work overseen by one of
his senior postdoctoral research assistants, Richard Haynes, and a
weekly meeting with Sir Derek to describe my failings and occasional
successes at the bench. A research meeting was a show and tell
session where the coworker stood in front of the small chalk board,
in the corner of Sir Derek’s office. He was seated on the diagonal at
his desk, Jocelyn Thorpe’s former desk, and alternatively writing,
reading, listening and watching in an order that seemed, to me at that
time, somewhat random. He asked probing questions, made suggestions
to overcome problems and showed the importance of mechanistic
analysis. I soon realised that he had a prodigious memory for details
of experiments: the order of the addition of reagents, the range of
solvents examined, the melting points of key compounds, yields and
so on. I also learned that it was not wise to forget any such details.
It was also ill advised to belabour failings in attempts to repeat well
established chemistry. On one occasion I was told that when I grew
up I should be able to do chemistry properly: it was chastisement for
my tardiness in repeating a classic Bamberger preparation. However
this incident notwithstanding, I then found Sir Derek very fair: inspiring
albeit rather daunting.
I was delighted that he accepted me to join his research group
to start work on my Ph.D. degree and I duly arrived in the Hofmann
Laboratory in mid September 1973. I was escorted to my new bench
by the technician, Alf Coleman, met the tea lady, Elsie, and was
introduced to Richard Russell, an Australian postdoctoral charged
with my laboratory welfare. Indeed at that time the Hofmann
THE BARTONIAN LEGACY
© Imperial College Press
http://www.worldscibooks.com/chemistry/p211.html
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Laboratory was largely Australian. David Widdowson was then one of
Sir Derek’s research lieutenants and I was assigned to his care. Sir
Derek believed in the restorative properties of tea taken twice a day
at 10.30 and 4. He was the proud owner of one of the largest tea cups
I have ever seen. Tea rituals were not intended for idle chat or social
banter but as adjuncts to work at the bench or, in his case, at Thorpe’s
desk. Sir Derek asked me which area of organic chemistry I wanted
to work in; I mentioned alkaloid synthesis. I was charged with the
structural elucidation of the toxisterols; minor over-irradiation products
formed in the synthesis of vitamin D
2
from ergosterol. Sir Derek told
me that this was the only remaining problem in the steroid arena
worthy of attention. Richard Russell had already started work on the
project and I joined him in the quest.
On a weekly basis and along with others in the group entrusted
to David Widdowson, I was summoned to Sir Derek’s office. In turn,
we each performed at the chalk board. The ritual was similar to my
prior experiences earlier in the year but the audience was larger and
everyone performed in turn. Some blushed, particularly when they
failed to recall details, some trembled, others seemed confident, even
blasé. Besides probing questions and discussions of mechanisms and
the approaches to be adopted to defeat barriers to progress there were
take home messages for each and every one of us. “Very good,” even
“Excellent” were received with pleasure; “Is that all?” with pain.
Every Christmas Sir Derek organised a party for his whole group
and the inhabitants of the Hofmann Laboratory were joined by those
in the Wiffen Laboratory and other laboratories at Imperial and Chelsea
Colleges. “The Old Man” served the drinks, Norwegian Lager and
Sherry: he was a gracious host. Invariably the group continued the
festivities at a local hostelry when we had consumed the large
quantities of refreshments that Sir Derek provided. One year he gave
out cigars which some of us had considerable difficulty smoking. He
himself at that time was an avid smoker of fine Davidoff Château
Yquen and Portagas cigars and in consequence all his coworkers were
aware of when he was patrolling the laboratories to ask “Do we have
anything new to report?”
THE BARTONIAN LEGACY
© Imperial College Press
http://www.worldscibooks.com/chemistry/p211.html
4
A
NTHONY
G. M. B
ARRETT
In due course and following medical advice, Sir Derek suddenly
quit smoking and the Hofmann early warning system failed massively.
On one occasion I was performing my imitation of the “Old Man” in
front of an appreciative audience of colleagues in the laboratory. I
became puzzled as the raucous laughter turned to gray silence. This
only encouraged me to redouble my theatrical efforts but to no avail.
One looked ill, there a sad face, another terrified, on my left one
sought to appear disapproving. I was confused. All the time Sir Derek
watched standing just behind me. Needless to say, on turning, my
own complexion changed to ashes. Nothing was said, he smiled ever
so slightly and walked on. It was then I discovered his tolerance and
sense of humor.
Many considered Sir Derek to be a brutal, hard task master,
aloof, demanding and taking pleasure in overwhelming any scientist
he disagreed with. Yet in my own experiences he was kind, considerate,
supportive and generous. He was true a bon-vivant and was a delight
to be with. Yet in the early 70’s I had only a glimpse or two of these
qualities; many more came later. On occasions late in the evening, Sir
Derek would patrol to meet his group in the Hofmann laboratory. He
was always enthusiastic to hear the latest results. Yet more than once
he instructed me to go home. I was married and he told me I had
other responsibilities besides the laboratory.
In 1978, Sir Derek left Imperial College for the CNRS in Gif sur
Yvette in Paris. By that time Steven Ley and myself had been appointed
as lecturers and were his last two lieutenants in London. Both of us
were treated with excellent generosity when Derek visited or when
we were each invited to Paris. On one occasion it was shared smoked
oysters washed down with 1942 Otard Cognac on the occasion of
Charles Rees and Sir Derek meeting to discuss the affairs of Imperial
College as Charles took over the mantle of Hofmann Professor of
Chemistry. On another, a Chinese banquet with 3 bottles of Moutai,
one for me, one for Steve Ley and the other for Sir Derek and the
ladies. “I stopped you dead in your tracks” he commented to me
years later. Sir Derek introduced me to legions of culinary delights:
globe articokes, sashimi, foie gras, oysters, sea bass, Haut Brion,
Bollinger and other pleasures of the table. On one occasion he ventured
THE BARTONIAN LEGACY
© Imperial College Press
http://www.worldscibooks.com/chemistry/p211.html
A R
EMINISCENCE
OR
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ROFESSOR
S
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D
EREK
B
ARTON
, N
OBEL
L
AUREATE
5
“Earl Grey is a tea for ladies,” he liked more robust flavours. I protested
that I liked Earl Grey. Smiling almost imperceptibly he corrected himself
“Earl Grey is a tea for ladies
…………
and gentlemen of distinction.”
The same slight smile glinted.
Derek’s loneliness was forgotten when he married Judy Cobb in
August of 1993. As well as a new wife, friend and confidant, he
acquired two splendid dogs that he soon doted on. In March 1996,
I visited him in College Station. It was a happy occasion unlike my
previous visit on the occasion of Christianne’s, his beloved second
wife, memorial service. Derek was proud of his new wife, he was
proud of College Station and his association with the State of Texas
and he delighted in his venerated position in Texas A & M University.
Earlier in London, at an excellent dinner party hosted by John Taylor,
Derek challenged me to guess, from a photograph he carried in his
wallet, his new wife’s age. He was not dissuaded from his quest by
my answer that it was impolite to comment on a lady’s age and I was
forced to give an opinion. Both my answer and the truth delighted
him.
In Texas that March he showed me blue bonnets, the State flower,
which were growing in profusion. I sampled various Texan Cabernet
Sauvignon and was taken to see Washington on the Brazos to
understand the former Republic of Texas more accurately. All of these
things I had done before on my several trips to visit College Station.
But on that day everything seemed brighter and better and larger.
Nothing had changed but Derek’s mood. We talked chemistry at
length. Lunch was a simple meal at the local Red Lobster and at the
end of the meal Derek pocketed all the remaining bread rolls. A
waiter was summoned and more bread requested. It arrived, I was
instructed to take it since Derek’s pockets were full. I offered to buy
him any quantity or type of bread he needed in any store in town but
he was not to be dissuaded. We left the restaurant Judy, Derek and
I, two of us with bulging pockets, jackets and pants. Shortly thereafter
I understood. The dogs loved Red Lobster rolls. I was awarded the
honour of feeding them. I held the bread aloft as Derek released the
hounds. They liked the game; I was less sure. He smiled slightly.
THE BARTONIAN LEGACY
© Imperial College Press
http://www.worldscibooks.com/chemistry/p211.html
6
A
NTHONY
G. M. B
ARRETT
On February 23, 1998 Derek and I arrived in Male in the Maldives
Islands. Steve and Rose Ley were there, Dave and Marie Widdowson
and many other former Barton students and postdoctorals. The
organising committee for the conference escorted Derek by sea plane
to Kureda Island. Others in the party arrived some hours later by
ferry. The conference was modelled on a Gordon Conference with
morning and evening lectures with the afternoons free for less serious
pursuits. Five years earlier we had the first conference in the series
in the Caneel Bay, St. John, USAVI. Derek told me he greatly enjoyed
the occasion but that there was need for more questioning. I had
thought that there was plenty of time for discussions after each lecture.
However, when Sir Derek invited us to an extra afternoon session for
each to give an informal additional presentation, all attended. Scuba,
sailing and other diversions were forgotten. On the wall a small white
board whilst not for chalk reminded many of their first encounters
with “DHRB.” Ted Cohen, Derek’s very first postdoctoral research
associate, was there as were recent graduates from Texas A & M. All
performed, all sought to pay attention to detail, all were familiar with
the need for clear presentation of their results and all were quizzed
at length. Derek, for his part gave an overview of Gif Go-Agg oxidation
and invited a hearty discussion of mechanism. Derek arose at 3 am
each day or at least he did on the day I checked. He was writing a
story book on dogs and also composing poetry. On the journey back
to London he talked enthusiastically about his current research in
Texas, we joked, drank gin and tonic, and he and I were allowed to
join the crew in the cockpit during the flight. He asked my opinions
about heaven; this bothered me but I could not help in illuminating
his thoughts on the matter. That was March 2, 1998, my birthday.
Derek Harold Richard Barton was born on September 8, 1918 and
died on March 16, 1998. I remember him as a mentor and close
friend. Indeed in all the ways that matter “Prof”, “the old man” and
“DHRB” was indeed immortal. We all miss him but cherish his stellar
contributions to science, his sound advice, his absolute loyalty and
his friendship.
THE BARTONIAN LEGACY
© Imperial College Press
http://www.worldscibooks.com/chemistry/p211.html
A R
EMINISCENCE
OR
T
WO
ON
P
ROFESSOR
S
IR
D
EREK
B
ARTON
, N
OBEL
L
AUREATE
7
Professor Sir Derek Barton at the “Perspectives on the 21st Century-I” conference,
Caneel Bay, St. John, US Virgin Islands, June 1993.
People pictured with Sir Derek (from the left): Dr. B. J. Willis, Prof. L. Gunatilaka,
Dr. D. A. Widdowson, Dr. D. Doller.
THE BARTONIAN LEGACY
© Imperial College Press
http://www.worldscibooks.com/chemistry/p211.html
8
A
NTHONY
G. M. B
ARRETT
Professor Sir Derek Barton at the “Perspectives on the 21st Century-II” conference,
Kureda Island, Maldives, February 1998.
People pictured (standing from left): Dr. P. A. Procopiou, Dr. A. Brewster, Dr. C.
Meerholz, Dr. D. Crich, Prof. S. Rozen, Prof. S. V. Ley, Prof. Sir Derek Barton, Prof.
A. G. M. Barrett, Prof. D. Ferreira, Dr. C. R. A. Godfrey, Prof. W. Steglich, Dr. R. D.
G. Cooper; (kneeling from left): Prof. T. Shioiri, Prof. M. Silva, Prof. D. L. J. Clive,
Dr. R. S. Topgi, Dr. D. K. Taylor, Prof. I. Ninomiya, Dr. D. H. Hunter, Dr. R. W. Read.
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