Course : Chem 401F

Course : Chem-511L

(Physical Chemistry Practical)

Examination - 24 (Twenty four) hours (4 days)

Full Marks: 200 (2 unit, 8 credit)

Experiment-140, continuos Lab. assessment-60

[N.B. In addition to the experiments listed below more experiments on physical chemistry may be done subject to the availability of the Lab. facilities.]

1. 
   Determination of the molar mass of a given polymer.
   
2. 
   Determination of the limit of homogeneous phase in the three component system: chloroform-acetic acid-water.
   
3. 
   Determination of the rate constant and order of S₂O₈^2- in the reaction S₂O₈^2-_(aq)+29^-_(aq) 2SO₄^2- +9_2(S)
   
4. 
   Kinetic studies on the oxidation of ethanedioic acid.
   
5. 
   Determination of the Avogadro constant.
   
6. 
   Studies on the substituent effect on reactivity by measuring the rate of base catalysed hydrolysis of methyl benzoate.
   
7. 
   Determination of the G°, S°, H° & C_p° for the equlibrium reaction I₂ + I^- I₃^-.
   
8. 
   Determination of the energy of activation for the reaction 5 KBr + KBrO₃ + 2H₂SO₄ = 3Br₂ +3K₂SO₄ + 3H₂O.
   
9. 
   Studies of adsorption on liquid surfaces by surface tension measurements.
   
10. 
    Verification of the formula of inorganic big molecules, e.g., KMnO₄ , K₂Cr₂O₇ by the ebullioscopic / Cryoscopic methods.
    
11. 
    Determination of percentage composition of a binary mixture of nonvolatile nonelectrolyte, e.g., urea, glucose by ebullioscopic / Cryoscopic methods.
    
12. 
    Determination of Vant Hoff factor of an electrolyte by ebullioscopic / Cryoscopic methods.
    
13. 
    Determination of the dissociation constant of a weak acid (e.g. acetic acid, oxalic acid etc.) near 100°C/0°C by ebullioscopic / Cryoscopic methods and estimation of pH of the solution.
    
14. 
    Determination of the hydrolysis constant of a salt conductometrically.
    
15. 
    Determination of activity coefficient conductometrically.
    
16. 
    Kinetic studies on the saponification of an ester conductometrically.
    
17. 
    Determination of the solubility product constant of a suitable salt conductometrically.
    
18. 
    Determination of the standard oxidation –reduction potential of the Fe²⁺/Fe³⁺ system.
    
19. 
    Determination of the instability constant of the argentamine complex potentiometrically.
    
20. 
    Determination of the hydrolysis constant of a salt potentiometrically.
    
21. 
    Determination of the mean activity coefficient of an electrolyte potentiometrically.
    
22. 
    Determination of the equilibrium constant of Sn⁴⁺ + 2 Fe²⁺ Sn²⁺ + 2 Fe³⁺ potentiometrically.
    
23. 
    Potentiometric titration of a dibasic acid with NaOH and determination of the first and second dissociation constant of the acid.
    
24. 
    Determination of Isobestic point.
    
25. 
    Determination of the indicator constant of an indicator.
    
26. 
    Study of the equlibrium in aqueous solution between ferric nitrate and sodium thiocyanate spectrophotometrically and estimation of stability constant and coordination number of Fe³⁺.
    
27. 
    Determination of the solubility product constant of Cu(II) Iodate spectrophotometrically.
    

Recommended Books:

1. D.P. Shoemaker et al : Experiment in Physical Chemistry

2. G.S. Weiss et al : Experiments in General Chemistry

3 A. Findlay : Practical Physical Chemistry

4. R.C. Das : Experimental Physical Chemistry

5. J.N. Gurtu : Advanced Experimental Chemistry

6. K.K. Sharma : An Introduction of Practical Chemistry

7. J.C. Muhler et al : Introduction to Experimental Chemistry

8. J. Rose : A Textbook of Practical Physical Chemistry

9. J.B. Yadav : Advanced Practical Physical Chemistry

10. Newcomb, Wilson et al : Experiments in Physical Chemistry

11. Daniels et al : Practical Physical Chemistry

12. Brennan et al : Experiments in Physical Chemistry

13. S.R. Palit : Practical Physical Chemistry

14. C.D. Hodgman et al : Handbook of Chemistry and Physics

15. R.C. West et al : CRC Handbook of Physics and Chemistry

16. L.A. Lange : Handbook of Chemistry


ORGANIC CHEMISTRY:

Courses	Course Title	Units	Credits	Marks
Chem-521F	Methods and Synthesis	1.0	4	100
Chem-522F	Synthetic Organic Chemistry & Biomolecules	1.0	4	100
Chem-523F	Advanced Organic Spectroscopy	1.0	4	100
Chem-524F	Industrial and Polymer Chemistry	1.0	4	100
Chem-525F*	Stereochemistry and conformations	1.0	4	100
Chem-526F*	Advanced Organic Reactions	1.0	4	100
Chem-527F*	Bioorganic Chemistry	1.0	4	100
Chem-521AH	Class Assessment –V	0.5	2	50
Chem-521VH	Viva-voce–V	0.5	2	50
Chem-521L**	Organic Chemistry Practical –V OR	2	8	200
Chem-599***	Thesis –I (Organic / Industrial)

* Any one course shall be chosen out of the three optional courses subject to the approval of the branch.

** Laboratory courses include 30% (60) marks for continuous Lab. assessment.

*** Thesis includes 30% (60) marks for oral examination on the thesis.

Examination of the theory courses of 100 marks (1.0 unit, 4 credit) shall be of 4 (four) hours duration, of 50 marks (0.5 unit, 2 credit of 2 (two) hours duration and of the practical of 100 marks (1.0 unit, 4 credit) shall be of 12 (twelve) hours duration (2 days). 30% marks of the practical courses are assigned for continuous Lab. assessment. The students shall submit a report after each Lab. class to the Lab. teacher(s) for evaluation. After evaluation the report shall be returned to the students. The Lab. teacher(s) shall submit the average marks of all Lab. evaluation in sealed envelopes to the chairman of the relevant examination committee within three weeks from the last Lab. class held.

Class assessment course includes tutorial, terminal, home assignment, and /or class examinations taken on theoretical courses by the relevant course teacher(s) during the academic year. Class assessment comprises (a) 80% marks in tutorial, terminal home assignment and /or class examinations and (b) 20% marks for attendance in the class. The class teacher(s) of each course shall submit the average consolidated marks of class assessments and attendance in sealed envelope to the Chairman of the relevant examination committee within three weeks from the last class held.

Viva-voce examination includes the assessment of the students through oral examination of all the courses. No student shall be allowed to sit for the examination having less than 60% class attendance.

Course : Chem-521F

(Organic reactions and stereochemistry)

Examination – 4 hours

Full Marks : 100

(80 Lectures; 1 Unit; 4 Credit)

1. Purification and important uses of some solvents & reagents (20 Lectures): Methanol and ethanol, acetone, N,N dimethyl formamide (DMF), dimethyl sulfoxide (DMSO), acetone, chloroform, dichloro methane, benzene, ether, tetrahydorfuran, (THF) toluene, diethylene glycol (DEG) BBr₃, BF₃ (etherate), AlCl₃, dicyclohexyl carbodiimide (DCC), Girad reagents, perbenzoic and periodic acids, N-bromosuccinimide (NBS) polyphosphoric acid (PPA) trifluoroacetic acid (TFAA), trimethyl silyl chloride (TMS), Raney nickel, Köser’s reagents, Dess Martin reagents tri- Köser’s reagents, triisobutyl tin hydride, thulliam trinitrate (TTN).

2. Redox reactions :

a) Oxidation reactions (10 Lectures): Oxidation of alcohols with Cr(VI) with DMSO and DCC, oxidation with PCC, with Jone’s reagent, Collin’s reagent. Allylic oxidation (SeO₂ and Pb(OAc)₄). Peracid and periodate oxidation. Lemieux oxidation, Prevost and Woodward oxidation.

b) Reduction reactions (10 Lectures): Catalytic hydrogenation, metal hydride reductions, [LiAlH₄,
LiAlH(OC₄H₉)₃], B₂H₆, DIBAL, Na-cyanoborohydirde, reduction with dissolving metals, Birch reduction.

3. Alkylation of active methylene compounds (10 Lectures):): The formation of enols and enolate anion and their importance, alkylation of relatively active methylene compounds (C-alkylation and O-alkylation), alkylation of 1,3-dicarbonyl compounds, alkylation of ketones, the formation and alkylation of enamines.

4. Interconversion and protection of functional groups (15 Lectures):): Hydroxyl (alcoholic and phenolic), carbonyl, carboxyl, amino and thiol groups.

5. Stereochemistry and Conformations (15 Lectures): Stereochemistry, optical activity and chirality, cis-trans isomerism, conformational analysis, strains, methods of correlation for configurations, ORD, CD, etc. Conformation and stereochemistry of cholesterol, cholestane etc.
Recommended Books:

1. Adams et.al. (ed.) : Organic Reactions (all volumes)

2. H.O. House : Synthetic Application of Organic Reactions

3. Carruthers : Some Modern Methods of

Organic Synthesis

4. H. Gilman : Advanced Organic Chemistry, (Vol-1 to IV)

5. L.F. Fieser and M. Fieser : Topics in Organic Chemistry

6. I.L. Finar : Organic Chemistry Vol. 2

7. R.KJ. Mackil & D.M. Smith : A Guidebook to Organic Synthesis

8. P. Simpson : Organometallic Chemistry of the Main

Group Elements

9. T.W. Green : Protective Groups in Organic Synthesis.

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Course: Chem 522F

(Synthetic Organic Chemistry)

Examination - 4 hours

Full Marks : 100

(80 Lectures, 1 Unit, 4 Credit)

1. 
   Multinuclear aromatic heterocycles (15 Lectures): General nature, preparation and properties; Benzo-derivatives of furan, pyrrole and thiophene; acridine, phenathridine and diazanaphthalenes.
   
2. 
   Polycyclic aromatic compounds (10 lectures): General nature, structure, reactions and synthesis of annulenes, rotanes, twist compounds, prism compounds, propellanes,cyclophanes, crownethers.
   
3. 
   Organometallic Chemistry (20 Lectures): Alkyl metal compounds of alkali group, organo-copper compounds, organo-zinc compounds, organo-palladium compounds, organo-silicon compounds, organomagnesim and organoselenium compounds, preparation, properties and synthetic uses.
   
4. 
   Designing organic synthesis (15 Lectures): Designing organic synthesis involving one step disconnections: disconnection of simple alcohols, olefins and ketones. Two group disconnections: -Hydroxy carbonyl compounds, , -unsaturated carbonyl compounds and 1,3-dicarbonyl compounds.
   

5. Synthesis of (20 Lectures):

a) Agrochemicals:

i) Herbicides : Vegadex, Avadex, Eptam and Carbyne

ii) Fungicides : Vapam, Nabam and Zineb

iii) Insecticides : Sevin and Furadam

iv) Pyrifenox : 4-(dichloro metheylene)-2-[N-(ά-methyl benzyl )]-imino-1,2-dithiolane.

b) Some important drugs: Salbutamol, trimethoprime, indomethacin, acetazolamide, naproxen and tolmetin sodium.

Recommended Books:

1. E.S. Gould : Mechanism and Structure in

Organic Chemistry

2. R.T. Morison & R.N. Boyd : Organic Chemistry

3. S. Warren : Disconnection Approach.

4. P. Simpson : Organometallic Chemistry of the Main

Group Elements.

5. A. Kar : Medicinal Chemistry

6. A. Burger : Medicinal Chemistry vol. I & II

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Course: Chem-523F

(Advanced Organic Spectroscopy)

Examination - 4 hours

Full Marks : 100

(80 Lectures; 1 Unit; 4 Credit)

1. NMR Spectroscopy (20 Lectures): ¹H, ¹³C, ³¹P, ¹⁹F NMR spectroscopy: preamble, principles of NMR, situation for other Nuclei, continuous wave and pulsed NMR experiments, FID & processing FID, relaxation, chemical shifts and factors influencing it, origin of coupling, long-range coupling, coupling constant, Signal-to-Noise ratio (SNR), integration of signals, NOE, DEPT, APT; 2D NMR: basic of 2D NMR, general experimental scheme for 2D NMR, COSY, SECSY etc.; Extensive application of NMR to organic molecules.

2. UV- VIS (20 Lectures): Definition of some simple terms: hyperchromic and hypochromic effect, bathochromic and hypsochromic effect, chromophore; conjugation and wavelength shifting; solvent effect on UV-Vissble spectroscopy; Woodward, Woodward-Fieser and Nielsen’s rules for the determination of _max to different organic molecules; structural study of simple and complex organic compounds and application to macromolecules, qualitative and quantitative uses.

3. IR and RAMAN (20 Lectures): IR: Mode of vibration, overtone, combination and difference bands in IR spectroscopy; influencing factors of force constant, approach towards the analysis of an IR spectra; structural study of simple and complex organic compounds and application to macromolecules, qualitative and quantitative uses. Raman: Raman techniques, stocks and anti-stocks lines, utility to organic molecules.

4. MS: GC-MS, LC-MS etc (20 Lectures): MS: Base peak, molecular ion peak, metastable peak and their utility, fragmentation patterns to various organic molecules, description of LIMA, SIMS and FAB techniques in Mass spectroscopy; structural study of simple and complex organic compounds and application to macromolecules. GC-MS, LC-MS: principle and instrumentation of GC and LC; combined techniques (GC-MS, LC-MS) for chemical analyses.

Recommended Books:

1. P.S. Sindhu : Molecular Spectroscopy

2. J.D. Graybeal : Molecular Spectroscopy

3. R.K. Harris : Nuclear Magnetic Resonance

Spectroscopy

4. D.L. Pavia, G.M. Lampman : Introduction to Spectroscopy

and G.S.C. Kriz

5. Y.R. Sharma : Elementary Organic Spectroscopy

6. H.Gunther : NMR Spectroscopy

7. J.K.M. Sanders and B.K. Hunter : Modern NMR Spectroscopy

8. R.J. Abraham and P. Loftus : Proton and Carbon-13 NMR

Spectroscopy

9. E.A.V. Ebsworth, D.W.H. Roukin & : Structural Methods in

S. Croadock Inorganic Chemistry

10. I.D. Campbell and R.A. Dwek : Biological Spectroscopy.
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Course: Chem-524F

(Industrial and Polymer Chemistry)

Examination - 4 hours

Full Marks : 100

(80 Lectures, 1 Unit, 4 Credit)

1. Petrochemicals (15 Lectures): Definition, chemistry & technology of the production of glycerin and chloroderivatives, detergents, hydrocarbon and chemical solvents: SBP, white spirit, alcohols; the oxoprocesses, future prospect of petrochemicals.

2. Coal (10 Lectures): Origin, classification, coke oven gas; the cooking processes, high and low temperature carbonization processes. Analysis of coal; sampling, proximate and ultimate analysis, calorific value and ignition point.

3. Fermentation and enzymes (7 Lectures): Conditions for fermentation, enzymes and their actions; production of industrial alcohol, purification, by-product, production of absolute alcohol.

4. Fibers and dying (8 Lectures): Fibers: Natural and synthetic fibers (cotton, silk, wool, jute, polyamides and polyesters); Dyeing: classification of dyes based on chemical constitution and application; factors effect the method of applying dye; basic operation of dyeing; techniques of dyeing.

5. General idea on polymer (10 Lectures): Introduction: idea of repeating units, structure of polymers, classification of polymers, intermolecular forces, biological and industrial importance of polymers, end group analysis, polymer solutions: thermodynamics of polymer dissolution, size and shape of macromolecules in solution.

6. Types and mechanism of polymerization (20 Lectures): Polymerization techniques: bulk, solution, suspension, emulsion and gas phase polymerization; types of polymerization reaction: chain polymerization (free radical, ionic, coordination) step polymerizations (poly-condensation, poly-addition, ring-opening); co-polymerization: copolymer composition, monomer reactivity ratio; mechanism of each polymerization reaction; dead and active polymers; microstructure of polymer: linear, branched, cross-linked and stereo-regular polymers & random, alternating, block and graft copolymers, tacticity of polymer (iso-, syn-, atactic).

7. Polymer colloids (10 Lectures): Definition, latex, chemistry of polymer colloid formation, strategies for imparting colloidal stability, application of polymer colloids.
Recommended Books:

1. Royal Dutch (shell company) : The Petroleum Handbook

2. Nelson : Petroleum Refining Engineering

3. Lawry : Chemistry for Coal Utilization.

4. R.N. Shreve : Chemical Process Industries

5. B. K. Sharma : Industrial Chemistry

7. V.R. Gowariker et.al. : Polymer Science

8. George Odian : Principles of Polymerization

1. Fred W. Bill Maeyer : A Textbook of Polymer Science

2. Robert M. Fitch : Polymer Colloids: A Comprehensive

Introduction
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Course: Chem-525F

(Stereochemistry and Conformations)

Examination - 4 hours

Full Marks : 100

(80 Lectures, 1 Unit, 4 Credit)
1. Conformations of heterocyclic rings (15 Lectures): Six-membered ring with one heteroatom; conformation of cholesterols, cholestenone etc.

2. Stereochemistry of macromolecules (10 Lecturer): Stereochemistry and stereo chemical control of polymerization by Zieglar Natta catalysts especially in polymerization of propylene, butadiene, isoprene etc.

3. Asymmetric synthesis using chiral reagents and achiral substrates (15 Lectures): Hydrogen transfer from chiral reducing agents; use of asymmetric MPV reduction to determine the configuration of biphenyl derivatives; use of asymmetric Grignard reagents in creating chiral centers with stereoselectively.

4. The chemistry of organo transition-metal compounds (20 Lectures): -Organotitanium compounds, the Tebbe reagent,. Acyl-iron complexes in enantioselective synthesis and in ketone synthesis, alkyne-cobalt complex, Pauson-Khand reaction in the synthesis of enones, telomerization from conjugated dienes; chromium (Cr)-arene complexes and its synthetic importance.

5. Stereochemistry of steroids (12 Lectures): Configuration of nucleus and substituent groups; conformational analysis of steroids.

6. Stereochemistry of bi-cyclic systems (8 Lectures): 5-3, 5-4, 5-5 (vit. biotin) and 6-6 (decalin) combinations.
Recommended Books:

1. Adams et.al. (ed.) : Organic Reactions (all volumes)

2. H.O. House : Synthetic Application of

Organic Reactions

3. Carruthers : Some Modern Methods of

Organic Synthesis

4. H. Gilman : Advanced Organic Chemistry, (Vol-1 to IV)

5. L.F. Fieser and M. Fieser : Topics in Organic Chemistry

6. L.L. Finar : Organic Chemistry Vol. 2

7. R.KJ. Mackil and D.M. Smith : A Guidebook to Organic Synthesis

8. P. Simpson : Organometallic Chemistry of the

Main Group Elements

9. T.W. Green : Protective Groups in Organic Synthesis

10. R.O.C. Norman & J.M. Coxon : Principles of Organic Synthesis.

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Course: Chem-526F

(Advanced Organic Reactions)

Examination - 4 hours