Name: Manuel F. Casanova



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Casanova MF: Grey level index abnormalities in the brains of autistic patients. Proceedings Summary of the American Psychiatric Association Annual Meeting, NR726, 2001.




  1. Buxhoeveden D, Casanova MF: Computer modeling of excitation-inhibition defects in autism. Proceedings Summary of the American Psychiatric Association Annual Meeting, NR 728, 2001.




  1. Casanova MF, Buxhoeveden D, Switala A, Roy E: Anomalies in the cortical processing units of autistic brains. International Meeting for Autism Research, Society for Neurosciences, San Diego, November 9-10, 2001.




  1. Buxhoeveden D, Casanova MF: Computer modeling of excitation-inhibition defects in autism. International Meeting for Autism Research, Society for Neurosciences, San Diego, November 9-10, 2001.




  1. Casanova MF, Stevens JR, Brown R, Royston C, Bruton C. Disentangling the pathology of paraphrenia. Schizophrenia Res 53(3 Suppl):26, 2002.




  1. Buxhoeveden D, Semendeferi K, Casanova MF: Lateralization of minicolumns in human planum temporale is absent in nonhuman primate cortex. American J Physical Antrhopology Suppl 34: 51, 2002.




  1. Casanova MF, Buxhoeveden D, Switala A, Roy E: Minicolumnar Pathology in the Brains of Autistic and Asperger’s Patients. Neurology 58(7 Suppl3):A2-A3, 2002.




  1. Casanova MF, Stevens JR, Brown R, Royston C, Bruton C: Disentangling the Pathology of Schizophrenia and Paraphrenia. Neurology 58(7 Suppl 3):A356, 2002.




  1. Casanova MF, Buxhoeveden D, Switala A, Roy E: Minicolumnopathies in Rett Syndrome and other pervasive developmental disorders of childhood. International Meeting for Autism Research, Society for Neurosciences, Orlando, Florida, November 1-2, 2002.




  1. Casanova MF. Buxhoeveden D, Roy E, Switala A: Abnormalitites in the modular organization of the brain in patients with schizophrenia. International Congress of Schizophrenia Research, Denver, Colorado, 2003.




  1. Casanova MF. Buxhoeveden D, Roy E, Switala A: Abnormalitites in the modular organization of the brain in patients with schizophrenia. Society of Biological Psychiatry, San Francisco, California, 2003.




  1. Casanova MF, Araque J: Mineralization of the basal ganglia: Its relevance to psychiatric diagnosis. Society of Biological Psychiatry, San Francisco, California, 2003.




  1. Casanova MF. Buxhoeveden D, Roy E, Switala A: Minicolumnar organization in Down syndrome. Society of Biological Psychiatry, San Francisco, California, 2003.




  1. Buxhoeveden D, Casanova MF: Brain disorders in human evolution. American Association of Physical Anthropology, Tempe, Arizona, 2003.




  1. Moeller JR, Rusinek H, Casanova MF. Votaw JR, Tune LR, Perdomo C, Pratt RD, Lord JR, Josef RD: Donazepil maintains activity in a specific neural network in patients with Alzheimer’s disease. European Neurological Society, Istanbul, Turkey, June 16, 2003.

157. Moeller JR, Rusinek H, Casanova MF, Hoffman JM, Votaw JR, Tune LM, Perdomo C, Leni JR, Jewart RD: Preservation of cortical metabolic function by donepezil in patients with mild moderate Alzheimer’s dementia: A 24-week clinical trial with placebo control. Global College of Neuroprotection & Neuroregeneration (GCNN), Zermatt, Switzerland, February 8-10, 2004.




  1. Buxhoeveden D, Casanova MF: Accelerated cell column development: A comparison between normal and Down syndrome in four areas of cortex. AAPA abstracts, page 72. Presented April 15, 2004 in Tampa, Florida.




  1. Casanova MF: A study on the variability of minicolumnar width in the brains of patients with autism. Society of Biological Psychiatry, 55(8S): 146, 2004.




  1. Casanova MF, Araque J, Giedd JN, Rumsey JM: Reduced brain size and gyrification in the brains of dyslexic patients. Society of Biological Psychiatry, 55(8S): 146, 2004.




  1. Casanova MF, de Zeeuw L, Switala A, Kreczmanski P, Steinbusch H, Heinsen H, Schmitz C: Lamination abnormalities in the prefrontal cortex of patients with schizophrenia. Society of Biological Psychiatry, 55(8S): 214, 2004.




  1. Moeller JR, Rusinek H, Casanova MF, Hoffman JM, Votaw JR, Tune LM, Perdomo C, Leni JR, Jewart RD: Preservation of cortical metabolic function by donepezil in patients with mild moderate Alzheimer’s dementia: A 24-week clinical trial with placebo control. American Academy of Neurology, San Francisco, California, April 29, 2004.




  1. Schmitz C, Kreczmanski P, Heinsen H, Casanova MF, Hof PR , Steinbusch HWM: Reduced neuropil in prefrontal cortex and amygdala in schizophrenia. The Huamn Brain Modelling and Remodelling, second International Conference Santa Lucia, Rome, Italy, October 6-9, 2004.



  1. Moeller JR, Rusinek H, Casanova MF, Hoffman JM, Tune LM, Perdomo C, Leni JR, Leni JR, Jewart RD: Preservation of cortical metabolic function by donepezil in patients with mild moderate Alzheimer’s dementia: a 24-week placebo-controlled clinical trial. ACNP 43rd Annual Meeting, San Juan, Puerto Rico, December 12-16, 2004



  1. Konkachbaev AI, Casanova MF, Elmaghraby: Minicolumns Identification Using Myelinated Bundles. Research Louisville, November, 2004.



  1. Casanova MF, Switala A, Trippe J, Fobbs A: The Modular Organization of the Brain: a Postmortem Case Report on Three Distinguished Neuroscientists. NAAR Development Meeting, Integrating Clinical and Basic Sciences in Autism, November, 2004.



  1. Casanova MF, Switala A, Trippe J, Fobbs A: A Comparison Study of the Vertical Bias in Neocortex and Hippocampus. NAAR Development Meeting, Integrating Clinical and Basic Sciences in Autism, November, 2004.



  1. Casanova MF, Konkachbaev AI, Switala A, Elmaghraby A, Trippe J, Fobbs A: Identification of Pyramidal Cell Arrays Using Delaunay Triangulation. NAAR Development Meeting, Integrating Clinical and Basic Sciences in Autism, November, 2004.



  1. Casanova MF, Switala A, Trippe J, Fobbs A: The Modular Organization of the Brain: a Postmortem Case report on Three Distinguished Neuroscientists. Society of Biological Psychiatry, 57(8S):48S, 2005.



  1. Casanova MF, Switala A, Trippe J, Fobbs A: A Comparison of the Vertical Bias in Neocortex and Hippocampus. Society of Biological Psychiatry, 57(8S):48S-49S, 2005.



  1. Casanova MF, Switala A: A Negative Study on the Morphometric Variability of Minicolumns (Pyramidal Cell Arrays) in the Brains of Patients with Autism. Society of Biological Psychiatry, 57(8S):49S, 2005



  1. Casanova MF, Christensen JD, Giedd J, Rumsey JM, Garver DL, Postel GC: A Magnetic resonance Study of Brain Asymmetries in Dyslexic Patients. Society of Biological Psychiatry, 57(8S):49S, 2005.



  1. El-Zehiry N, Casanova M, Hassan H, Farag A. Effect on minicolumnar disturbance on dyslexic brains: an MRI study. Proceeding of the International Symposium on Biomedical Imaging, Virginia, USA, April 2006.



  1. Elmaghraby A, Konkachbaev AI, Casanova MF: Recursive segmentation of minicolumns using myelinated bundles. 2nd International IEEE EMBS Special Topic Conference on Neural Engineering, Arlington, Virginia, March 16-19, 2005.



  1. Konkachbaev AI, Casanova MF, Graham JH, Elmaghraby AS: Automated recursive segmentation of large neocortical images using standard deviation as termination criteria. Proceedings of the 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Shinghai, China, p. 211, September 1-4, 2005.



  1. Parthasarathy SN, Casanova MF: Cloning and expression of rat neuroglobin- a protein associated with stroke and brain ischemia. University of Louisville, Neuroscience Day Poster Presentations, April, 21, 2005.



  1. Parthasarathy SN, Casanova MF: Cloning and expression of rat neuroglobin- a protein associated with stroke and brain ischemia. University of Louisville, Neuroscience Program, First Annual Fall Neuroscience Retreat and New Student Orientation, August 12, 2005.




  1. Casanova MF. Abnormalities of brain circuitry (minicolumns) in autism. Autism AWARES Conference, October 1, 2005.



  1. Casanova MF, Kooten I van, Switala AE, Engeland H van, Heinsen H, Steinbusch HWM, Hof PR, Walker LC, Schmitz C: Minicolumnar abnormalities in the neocortex of autistic patients. Society for Neuroscience, November, 2005.



  1. Kooten I van, Casanova MF, Switala AE, Engeland H van, Heinsen H, Steinbusch HWM, Hof PR, Pickett J, Schmit C: Neuronal size and number in the neocortex of autistic patients. Society for Neuroscience, November, 2005.



  1. Trippe JT, Switala AE, Mower GD, Casanova MF: Invariance of minicolumnar structure during human prenatal and postnatal development. Society for Neuroscience, November, 2005.



  1. Casanova MF: Postmortem studies on autism spectrum disorders. 84th Annual Congress of the Association for Research in Nervous and Mental Disease, New York City, December 2, 2005.



  1. Parthasarathy R, Casanova MF, Seelan RS. The inositol synthase gene (ISYNA1) is differentially methylated in rat tissues. Research! Louisville 2005. October 31-November 4, 2005.



  1. Parthasarathy R, Casanova MF, Seelan RS. Inositol synthase identification and expression of alternate isoforms in rat tissues. Research! Louisville 2005. October 31-November 4, 2005.



  1. Casanova MF, van Kooten I, Switala AE, van Engeland H; Heinsen H; Steinbusch HWM; Hof PR; Trippe J; Stone J, Schmitz C. Minicolumnar Width Abnormalities in Autism. Biological Psychiatry 59 (8S): 19S, 2006.



  1. Casanova MF, van Kooten I, Switala AE, van Engeland H; Heinsen H; Steinbusch HWM; Hof PR; Trippe J; Stone J, Schmitz C. Neuronal Size and Numbers in Autism. Biological Psychiatry 59 (8S):20S, 2006.



  1. Casanova MF, Trippe J, Switala AE. A Temporal Continuity to the Vertical Organization of the Human Neocortex. Biological Psychiatry 59 (8S):110S, 2006.



  1. Casanova MF, Giedd J, Rumsey JM, Mannheim G. A Negative Study on the Gyrification Index in Patients with Autism. Biological Psychiatry 59 (8S):110S, 2006



  1. Casanova MF. White matter parcellation in dyslexia reveals a significant diminution of the outer (radiate) compartment. Biological Psychiatry 59 (8S):223S, 2006.



  1. Casanova MF, van Kooten I, Switala AE, van Engeland H; Heinsen H; Steinbusch HWM; Hof PR; Trippe J; Stone J, Schmitz C. Abnormalities of Cortical Minicolumnar Organization in the Prefrontal Lobes of Autistic Patients. Biological Psychiatry 59 (8S):119S, 2006.



  1. Casanova MF, van Kooten I, Switala AE, van Engeland H; Heinsen H; Steinbusch HWM; Hof PR; Trippe J; Stone J, Schmitz C. Minicolumnar Width Abnormalities in Autism. Federation of European Neuroscience Societies, Vienna, Austria, 2006.



  1. Seelam RS, Casanova MF, Parthasarathy R. Differential methylation of the gene encoding Myo-Inositol synthase in rat and human brain tissue. Neuroscience Day, April 20, 2006, University of Louisville.



  1. Seelam RS, Parthasarathy R, Casanova MF. Differential methylation of the gene encoding Myo-Inositol synthase in rat and human brain tissue. Society for Neuroscience, November 2006.



  1. Casanova MF, van Kooten I, Switala AE, van England H, Heinsen H, Steinbuch HWM, Hof PR, Schmitz C Abnormalities of cortical minicolumnar organization in the prefrontal lobes of autistic patients. Society for Neuroscience, November, 2006.



  1. Casanova MF, Giedd J, Rumsey JM, Mannheim G, Parthasarathy P. A negative study on the gyrification index in patients with autism. Society for Neuroscience, November, 2006.



  1. Hart R, Litvan I, Fernandez-Botran R, Casanova MF, Tillquist C, Crespo FA.Cytokines polymorphisms, neuroinflammation and brain disorders. Summer Research Opportunity Program (SROP) University of Louisville, August 2, 2006.



  1. Hart R, Litvan I, Fernandez-Boltran R, Casanova M, Tillquist C, Crespo FA: Cytokines polymorphisms, neuroinflammation and brain disorders. 35th Annual Autumn Immunology Conference, Chicago, IL, November 17-20, 2006.



  1. Crespo FA, Boulding JA, Fernandez-Boltran GR, Casanova MF. Tillquist CR: A global survey of cytokine expression polymorphism in human populations. Research! Louisville, 2006.



  1. Fahmi R, El-Baz A, Farag A, Casanova MF: New Neuroimaging-Based Classification Techniques For Autistic s vs. Health Brain, Research! Louisville, 2006.



  1. Chance SA, Switala A, Casanova MF, Crow TJ. Surface area asymmetries are lost and minicolumn spacing is reduced in planum temporale in schizophrenia: a postmortem study. Schizophrenia Research 81: 27, 2006.




  1. Casanova MF. The brains of autistic individuals. Autism Awares Conference, October 4, 2006.



  1. Crespo FA, Boulding JA, Fernandez-Boltran GR, Casanova MF. Tillquist CR: A global survey of cytokine expression polymorphism in human populations. 76th Annual Meeting of the American Association of Physical Anthropologists, March 27-April 1, 2007, Philadelphia.



  1. Sokhadze E, Singh S, El-Baz A, Mathai G, Sears L, Casanova M. Induced gamma oscillation, ERP, an coherence abnormalities during perceptual binding in autism. Association for Psychological Sciences, Washington DC, May 24-27, 2007.



  1. Lakshmanan J, Parthasarathy R, Casanova MF, Seelan RS. Brain Myo-inositol phosphate synthase is regulated by phosphorylation. Louisville Neuroscience Day, April 12, 2007.



  1. Parthasarathy R, Lakshmanan J, Parthasarathy KP, Seelan RS, Casanova MF. Association of Myo-Inositol Synthase with Clathrin in the brain suggests an important role for Myo-inositol in Neuronal Regulation. Louisville Neuroscience Day, April 12, 2007.



  1. Seelan RS, Lakshmanan J, Casanova MF, Parthasarathy R. Regulation of Inositol biosynthesis by Myo-inositol synthase (mIS): Identification of a 19 KDa isoform subunit of mIS. Louisville Neuroscience Day, April 12, 2007.



  1. Casanova MF, van Kooten I, Switala AE, van Engeland H, Heinsen H, Steinbusch HWM, Hof PR, Schmitz C. Abnormalities of cortical minicolumnar organization in the prefrontal lobes of autistic patients. IMFAR, Seattle, Washington, May 3-5, 2007.



  1. Trippe J, Switala AE, Casanova MF. A Temporal Continuity to the Vertical Organization of the Human Neocortex. IMFAR, Seattle, Washington, May 3-5, 2007, PS4.9, page 126.



  1. Switala AE, Trippe J, Fitzgerald M, Casanova MF. Comparison of the minicolumnar morphometry of three distinguished neuroscientists and controls. IMFAR, Seattle, Washington, May 3-5, 2007, PS4.7, page 125.



  1. Tillquist C, Trippe J, , Switala A, Casanova MF. Morphometric variability of minicolumns in the striate cortex of homosapiens, macaca mulatta, and pan troglodytes. IMFAR, Seattle, Washington, May 3-5, 2007, PS4.8, page 125.



  1. El-Baz A, Farag A, pp. 46-47, M, Hassan H, Fahmi R, Switala AE, Casanova MF. Abnormalities of the Gyral Window in Autism: A Macroscopic Correlate to a Putative Minicolumnopathy. IMFAR, Seattle, Washington, May 3-5, 2007, PS4.3, page 123.



  1. Sokhadze, T., Singh, S. , El-Baz, A., Mathai, G., Sears, L., Casanova, M. Induced gamma oscillations, ERP, and coherence abnormalities during perceptual binding in autism. 19th Annual Convention of Association for Psychological Science, Washington, DC, May 24-29, 2007.



  1. Sokhadze, T., Singh, S., El-Baz, A., Mathai, G., Sears, L., Casanova, M. Evoked and induced gamma frequency oscillations, interhemispherical coherence and ERP abnormalities during processing of illusory figures in Autism Spectrum Disorders. Abstract presented at the ISNR meeting, San Diego, CA, September 6-9, 2007.



  1. El-Zehiry N, Casanova MF. Effect of the minicolumnar disturbance on the morphometry of white matter in dyslexic brains. Proceeding of Computer Assisted Radiology and Surgery (CARS07), Berlin, Germany, June 2007.



  1. Oberst R, Crespo FA, Rafael Fernandez-Boltran G, Casanova M. Tillquist CR. A survey of cytokine expression polymorphism in European human populations, SROP, August 2007.



  1. Mott M, Casanova MF, Fernandez-Botran R, Sears L, Tillquist C, Crespo F. Cytokine polymorphisms and their role in autism: a maternal and child perspective. Society for Neurosciences, San Diego, California, November 3-7, 2007.



  1. Casanova MF, Trippe J, Tillquist CR, Switala A. Radial bias in structure of dolphin insular cortex likely reflects minicolumnar organization characteristics of mammalian isocortex. Society for Neurosciences, San Diego, California November 3-7, 2007.



  1. Crespo FA, Oberst R, Fernandez-Botran GR, Casanova MF, Tillquist CR. Expression polymorphism in European human populations. 74th Annual Meeting of the American Association of Physical Anthropologists, Columbus, OH, April 7-13, 2008.



  1. Seelan RS, Khalyfa A, Lakshmanan J, Casanova MF, Parthasarathy R. Deciphering the lithium transcriptome- Microarray analysis for gene expression profiling of human neuronal cells treated with lithium. Research Louisville, Louisville, October 18-19, 2007.



  1. Mott M, Casanova MF, Fernandez-Botran R, Sears L, Tillquist C, Crespo F. Cytokine polymorphisms and their role in autism: a maternal and child perspective. Research Louisville, Louisville, October 18-19, 2007.



  1. Van Bogaert E, Casanova MF, El-Baz A, Switala A. A new image analysis approach for automatic classification of dyslexic brains. Research Louisville, Louisville, October 18-19, 2007. First Prize student project



  1. El-Baz A, Casanova MF. Autism Diagnostics by 3D Texture analysis of cerebral white matter gyrifications. Research Louisville, Louisville, October 18-19, 2007. First Prize Potential for Major Clinical Application.



  1. Sokhadze E, Singh S, El-Baz A, Mathai G, Sears L, Casanova MF. Evoked and induced gamma frequency oscillations and coherence in EEG, and event-related potential abnormalities during processing of illusory figures in autism spectrum disorders. Research Louisville, Louisville, October 18-19, 2007. First prize Innovation in Behavioral Sciences Category.



  1. Hart R, Fernandez-Boltran R, Litvan I, Casanova M, Tillquist C, Crespo F. Cytokine polymorphisms and their role in progressive supranuclear palsy. Autumn Immunology Conference. Chicago, November 16-19, 2007.




  1. Casanova MF. The neuropathology of autism. Autism AWARES Conference, November 26, 2007.



  1. Sokhadze, T., Singh, S., El-Baz, A., Mathai, G., Sears, L., Casanova, M. Dense-array event-related potential study of novelty processing abnormalities in autism spectrum disorders. Association for Applied Psychophysiology and Biofeedback, 33: 179, 2008.




  1. Baruth, J., Sokhadze, E., Sears, L., Mathai, G., Casanova, M. Event-related potential study of novelty processing abnormalities in autism. 2008 APS Annual Convention, Chicago, Il, May 22-25, 2008.



  1. Chance S, Casanova MF, Crow TJ. Arrested neuroplasticity? Loss of ageing effect on minicolumnar organization in schizophrenia: a post-mortem study. Fourteenth Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Montreux, Switzerland, 3rd-7th February 2008.



  1. Lakshmanan JN, Seelan RS, Janckila AJ, Parthasarathy R, Parthasarathy L, Yam LT, Casanova MF. Inositol Synthase (Isn) knockout (KO) mouse exhibits syndactyly and other physical abnormalities. Society for Neurosciences (Louisville Chapter), Louisville, Kentucky, April 17th, 2008.



  1. Seelan RS, Lakshmanan J, Casanova MF, Parthasarathy R. Brain inosito homeostasis: new insights into the regulation of Myo-inositol 3-phsophate synthase. Society for Neurosciences (Louisville Chapter), Louisville, Kentucky, April 17th, 2008.



  1. El-Baz A, Casanova MF, Mott M, Switala AE. A new image- based diagnostic framework for early diagnosis of dyslexic brains. Computer Assisted Radiology 22nd International Congress and Exhibition, Barcelona, Spain, June 25-28, 2008.



  1. Oetringer E, Casanova MF. The fundamental principles by which the brain may process information. Society for Neurosciences., Washington, D.C., November 15-19, 2008.



  1. El-Zehiry N, Casanova MF, Elmaghraby AS. Analyzing the Development and the Functionality of Dyslexic and Autistic Brains by Investigating the Relationship between the Microstructures and Macrostructures. MICCAI 2008 Workshop on Imaging the Early Developing Brain: Challenges and Potential Impact, MICCAIW Imaging the Early Developing Brain:Challenges and Potential Impact, New York, NY, Sept 2008. http://www.sci.utah.edu/~gerig/ITED08-Presentations/NohaElZehiryMICCAIW_PRESENTATION.pdf



  1. Crespo FA, Fernandez-Botran GR, Casanova MF, Oberst R, Tillquist CR. What polymorphisms tell us about human population history? The case of European populations. International Cytokine Society. Montreal, October 12-16, 2008.



  1. Baruth J, Sokhadze E, Sears L, Casanova MF. The effects of Transcranial Magnetic Stimulation on Novelty Processing in Autism. Research Louisville, 2008.



  1. Sokhadze E, El-baz A, Baruth J, Tasman A, Mathai G, Sears L, Casanova MF. Electroencephalographic and behavioral outcomes of novel experimental trial of repetitive Transcranial Magnetic Stimulation in autism. Research Louisville, 2008.



  1. Oetringer E, Casanova MF. Fundamental principles by which the brain could process information- an information management perspective. Society for Neuroscience, Washington, DC, November 15-19, 2008.



  1. Tillquist CR, Fernandez-Botran GR, Casanova MF, Crespo FA. Phylogeographic variation of ASPM is determined by IL-10. AAPA meeting, Chicago, Illinois, March 31-April 4, 2009.



  1. Crespo FA, Fernandez-Botran GR, Casanova MF, Tillquist CR. What can cytokine polymorphisms tell us about human population history? The case of interleukin-6. AAPA meeting, Chicago, Illinois, March 31-April 4, 2009.



  1. Sokhadze E, El-Baz A, Baruth J, Tasman A, Mathai G, Sears L, Casanova MF. Electrocortical and Behavioral Outcomes of Novel Experimental Trial of Repetitive Transcranial Magnetic Stimulation in Autism. International Meeting for Autism Research, Chicago, Illinois, May 7-9, 2009.




  1. Baruth, J., Sokhadze, E., El-Baz, A., Ramaswamy, R., Sears, L., Casanova, M.F. TMS study of gamma frequency induction in response to illusory figures in patients with autism spectrum disorder. Presented at the conference of International Society for Neurofeedback Research, Indianapolis, IN, September 2-4, 2009.



  1. Baruth, J., Sokhadze, E., Carroll, T., Horrel, T., Ramaswamy, R., Sears, L., Casanova, M. Impaired error monitoring and correction function in autism: Reaction time and ERP study. Submitted for presentation at the annual meeting of Association for Applied Psychophysiology and Biofeedback, San Diego, CA, March 24-27, 2009.




  1. Baruth, J., Casanova, M., Mansoor, M., Sears, L., Husk, M., and Sokhadze, E. Repetitive transcranial magnetic stimulation affects novelty processing in autism. Presented at the 21st annual convention of Association for Psychological Sciences, San Francisco, CA, May 22-25, 2009.




  1. Sokhadze, E., Tasman, A., Baruth, J., Sears, L., Mathai, G., Casanova, M. Repetitive TMS affects EEG gamma and ERP during perceptual processing in autism. Presented at the annual meeting of Association for Applied Psychophysiology & Biofeedback, Albuquerque, NM, April 2-4, 2009.




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