Toxicological Profile for Plutonium
Yüklə 4,8 Kb. Pdf görüntüsü
|
- Bu səhifədəki naviqasiya:
- SAMPLE 1 → Table 3-1. Levels of Significant Exposure to [Chemical x] – Inhalation
- APPENDIX C. ACRONYMS, ABBREVIATIONS, AND SYMBOLS
PLUTONIUM B-5 APPENDIX B (18) Estimated Upper-Bound Human Cancer Risk Levels. This is the range associated with the upper- bound for lifetime cancer risk of 1 in 10,000 to 1 in 10,000,000. These risk levels are derived from the EPA's Human Health Assessment Group's upper-bound estimates of the slope of the cancer dose response curve at low dose levels (q 1 *). (19) Key to LSE Figure. The Key explains the abbreviations and symbols used in the figure. SAMPLE 1 → Table 3-1. Levels of Significant Exposure to [Chemical x] – Inhalation LOAEL (effect) Exposure Key to frequency/ NOAEL Less serious Serious (ppm) figure a Species duration System (ppm) (ppm) Reference 2 3 4 → INTERMEDIATE EXPOSURE 5 6 7 8 9 10 → Systemic ↓ ↓ ↓ ↓ ↓ ↓ 18 Rat 13 wk Resp 3 b 10 (hyperplasia) → 5 d/wk Nitschke et al. 1981 6 hr/d CHRONIC EXPOSURE Cancer 11 ↓ 38 Rat 18 mo 20 (CEL, multiple Wong et al. 1982 5 d/wk organs) 7 hr/d 39 Rat 89–104 wk 10 (CEL, lung tumors, NTP 1982 5 d/wk nasal tumors) 6 hr/d 40 Mouse 79–103 wk 10 (CEL, lung tumors, NTP 1982 5 d/wk hemangiosarcomas) 6 hr/d 12 → a The number corresponds to entries in Figure 3-1. b Used to derive an intermediate inhalation Minimal Risk Level (MRL) of 5x10 -3 ppm; dose adjusted for intermittent exposure and divided by an uncertainty factor of 100 (10 for extrapolation from animal to humans, 10 for human variability). P LUT O NI UM B -6 AP PEN D IX B P LUT O NI UM B -7 AP PEN D IX B PLUTONIUM B-8 APPENDIX B This page is intentionally blank. PLUTONIUM C-1 APPENDIX C. ACRONYMS, ABBREVIATIONS, AND SYMBOLS ACGIH American Conference of Governmental Industrial Hygienists ACOEM American College of Occupational and Environmental Medicine ADI acceptable daily intake ADME absorption, distribution, metabolism, and excretion AED atomic emission detection AFID alkali flame ionization detector AFOSH Air Force Office of Safety and Health ALI annual limits on intake ALT alanine aminotransferase AMAD activity median aerodynamic diameter AML acute myeloid leukemia AOAC Association of Official Analytical Chemists AOEC Association of Occupational and Environmental Clinics AP alkaline phosphatase APHA American Public Health Association AST aspartate aminotransferase atm atmosphere ATSDR Agency for Toxic Substances and Disease Registry AWQC Ambient Water Quality Criteria BAT best available technology BCF bioconcentration factor BEI Biological Exposure Index BMD/C benchmark dose or benchmark concentration BMD X dose that produces a X% change in response rate of an adverse effect BMDL X 95% lower confidence limit on the BMD X BMDS Benchmark Dose Software BMR benchmark response Bq Becquerel BSC Board of Scientific Counselors C centigrade CAA Clean Air Act CAG Cancer Assessment Group of the U.S. Environmental Protection Agency CAS Chemical Abstract Services CDC Centers for Disease Control and Prevention CEL cancer effect level CELDS Computer-Environmental Legislative Data System CERCLA Comprehensive Environmental Response, Compensation, and Liability Act CFR Code of Federal Regulations Ci curie CI confidence interval CL ceiling limit value CLP Contract Laboratory Program cm centimeter CMAD count median aerodynamic diameter CML chronic myeloid leukemia CPSC Consumer Products Safety Commission CWA Clean Water Act DAC derived air concentration DHEW Department of Health, Education, and Welfare PLUTONIUM C-2 APPENDIX C DHHS Department of Health and Human Services DNA deoxyribonucleic acid DOD Department of Defense DOE Department of Energy DOL Department of Labor DOT Department of Transportation DOT/UN/ Department of Transportation/United Nations/ NA/IMDG North America/Intergovernmental Maritime Dangerous Goods Code DWEL drinking water exposure level ECD electron capture detection ECG/EKG electrocardiogram EEG electroencephalogram EEGL Emergency Exposure Guidance Level EPA Environmental Protection Agency F Fahrenheit F 1 first-filial generation FAO Food and Agricultural Organization of the United Nations FDA Food and Drug Administration FEMA Federal Emergency Management Agency FIFRA Federal Insecticide, Fungicide, and Rodenticide Act FPD flame photometric detection fpm feet per minute FR Federal Register FSH follicle stimulating hormone g gram GC gas chromatography gd gestational day GLC gas liquid chromatography GPC gel permeation chromatography GSD geometric standard deviation Gy gray HPLC high-performance liquid chromatography HRGC high resolution gas chromatography HSDB Hazardous Substance Data Bank IARC International Agency for Research on Cancer ICRP International Commission on Radiological Protection IDLH immediately dangerous to life and health ILO International Labor Organization IRIS Integrated Risk Information System ITRI Inhalation Toxicology Research Institute kBq kiloBequerel Kd adsorption ratio kg kilogram kkg metric ton K oc organic carbon partition coefficient K ow octanol-water partition coefficient L liter LC liquid chromatography LC 50 lethal concentration, 50% kill LC Lo lethal concentration, low LD 50 lethal dose, 50% kill Yüklə 4,8 Kb. Dostları ilə paylaş:
|