O„zbekiston respublikasi oliy va o„rta maxsus ta‟lim vazirligi samarqand davlat universiteti
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(Lotin transcriptio - qayta yozishni) genetik axborotni birida sintez tomonidan sodir bir DNK bitta-torli RNK molekulasi - polinükleotit DNK zanjiri, nükleotid tartibi aniq Matrix nukleotidlarning ketma-ketlikni pas. Mitozning to‗rt bosqichi mavjud: profaza, metafaza, anafaza va telofaza . Yilda prophase , centrioles aniq aniq bo‗lgan hujayra markazida joylashgan va hayvonlar qizi xromosomalar bo‗linish rol o‗ynab hosilalar -. (Yuqori o‗simliklarda xromosomalarning bo‗linishini tashkil qiluvchi hujayra markazida sentriollar yo‗qligini eslang). [216] ILOVA 1: NCBI ma‘lumotnoma ketma-ketligi: NC_045512.2 FASTA Grafika O‗tish: LOCUS NC_045512 29903 bp ss-RNK chiziqli VRL 18-IYUL-2020 Ta‘rif: Og‘ir o‗tkir respirator sindrom koronavirus 2 Wuhan-Hu-1 izolatsiyasini, to‗liq genom. ACCESSION NC_045512 VERSION NC_045512.2 DBLINK BioProject: PRJNA485481 KEYWORDS RefSeq. SOURCE Og‘ir o‗tkir nafas olish sindromi koronavirus 2 (SARS-CoV-2) ORGANIZM Og‘ir o‗tkir respirator sindrom koronavirus 2 Viruslar; Riboviriya; Orthornavirae; Pisuviriko; Pisoniviritsetlar; Nidovirales; Cornidovirineae; Coronaviridae; Ortokoronavirinae; Betakoronavirus; Sarbekovirus. Protein tuzilmalari https://www.ncbi.nlm.nih.gov/structure/?term=sars-cov-2.### (SARS-CoV-2) sekvenirlashlari https://www.ncbi.nlm.nih.gov/genbank/sars-cov-2-seqs/ ## Assambleyasi-ma‘lumotlar-START ## Yig‘ish usuli :: Megahit v.1.1.3 Tartiblash texnologiyasi :: Illumina ## Assambleyasi-ma‘lumotlar-END ## TAMMOLLIK: to‗liq uzunlik. Xususiyatlari Joylashuv / Saralash manbasi 1..29903 / organizm = "Og‘ir o‗tkir nafas olish sindromi koronavirus 2 " / mol_type = "genomik RNK" / izolyatsiya = "Vuxan-Xu-1" [217] / host = "Homo sapiens" / db_xref = "takson: 2697049 " / mamlakat = "Xitoy" / collection_date = "Dekabr-2019" 5‘UTR 1..265 ge n 266..21555 / gen = "ORF1ab" / locus_tag = "GU280_gp01" / db_xref = "GeneID: 4374057 8 " C DS birlashtirildi (266..13468,13468..21555) / gen = "ORF1ab" / locus_tag = "GU280_gp01" / ribosomal_slippage / note = "pp1ab; tarjima -1 ribosomal freymeshift" / codon_start = 1 / mahsulot = "ORF1ab poliprotein" / protein_id = " YP_009724389 .1 " / db_xref = "GeneID : 437405 78 " / translation = "MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQ HLKDGTCGLVEVEKGVLPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQYGRSGE TLGVLVPHVGEIPVAYRKVLLRKNGNKGAGGHSYGADLKSFDLGDELGTDPYEDFQEN WNTKHSSGVTRELMRELNGGAYTRYVDNNFCGPDGYPLECIKDLLARAGKASCTLSEQ LDFIDTKRGVYCCREHEHEIAWYTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFP LNSIIKTIQPRVEKKKLDGFMGRIRSVYPVASPNECNQMCLSTLMKCDHCGETSWQTG DFVKATCEFCGTENLTKEGATTCGYLPQNAVVKIYCPACHNSEVGPEHSLAEYHNESG LKTILRKGGRTIAFGGCVFSYVGCHNKCAYWVPRASANIGCNHTGVVGEGSEGLNDNL LEILQKEKVNINIVGDFKLNEEIAIILASFSASTSAFVETVKGLDYKAFKQIVESCGN FKVTKGKAKKGAWNIGEQKSILSPLYAFASEAARVVRSIFSRTLETAQNSVRVLQKAA ITILDGISQYSLRLIDAMMFTSDLATNNLVVMAYITGGVVQLTSQWLTNIFGTVYEKL KPVLDWLEEKFKEGVEFLRDGWEIVKFISTCACEIVGGQIVTCAKEIKESVQTFFKLV [218] NKFLALCADSIIIGGAKLKALNLGETFVTHSKGLYRKCVKSREETGLLMPLKAPKEII FLEGETLPTEVLTEEVVLKTGDLQPLEQPTSEAVEAPLVGTPVCINGLMLLEIKDTEK YCALAPNMMVTNNTFTLKGGAPTKVTFGDDTVIEVQGYKSVNITFELDERIDKVLNEK CSAYTVELGTEVNEFACVVADAVIKTLQPVSELLTPLGIDLDEWSMATYYLFDESGEF KLASHMYCSFYPPDEDEEEGDCEEEEFEPSTQYEYGTEDDYQGKPLEFGATSAALQPE EEQEEDWLDDDSQQTVGQQDGSEDNQTTTIQTIVEVQPQLEMELTPVVQTIEVNSFSG YLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKATNNAMQVESD DYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLA PLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLEMKSEKQVEQKIA EIPKEEVKPFITESKPSVEQRKQDDKKIKACVEEVTTLELETKFLTENLLLYIDINGN LHPDSATLVSDIDITFLKKDAPYIVGDVVQEGVLTAVVIPTKKAGGTTEMLAKALRKV PTDNYITTYPGQGLNGYTVEEAKTVLKKCKSAFYILPSIISNEKQEILGTVSWNLREM LAHAEETRKLMPVCVETKAIVSTIQRKYKGIKIQEGVVDYGARFYFYTSKTTVASLIN TLNDLNETLVTMPLGYVTHGLNLEEAARYMRSLKVPATVSVSSPDAVTAYNGYLTSSS KTPEEHFIETISLAGSYKDWSYSGQSTQLGIEFLKRGDKSVYYTSNPTTFHLDGEVIT FDNLKTLLSLREVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPH NSHEGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIK WADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNKTVGELG DVRETMSYLFQHANLDSCKRVLNVVCKTCGQQTTLKGVEAVMYMGTLSYEQFKKGVQ IPCTCGKQATKYLVQQESPFVMMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSK ETLYCIDGALLTKSSEYKGPITDVFYKENSYTTTIKPVTYKLDGVVCTEIDPKLDNYY KKDNSYFTEQPIDLVPNQPYPNASFDNFKFVCDNIKFADDLNQLTGYKKPASRELKVT FFPDLNGDVVAIDYKHYTPSFKKGAKLLHKPIVWHVNNATNKATYKPNTWCIRCLWST KPVETSNSFDVLKSEDAQGMDNLACEDLKPVSEEVVENPTIQKDVLECNVKTTEVVGD IILKPANNSLKITEEVGHTDLMAAYVDNSSLTIKKPNELSRVLGLKTLATHGLAAVNS VPWDTIANYAKPFLNKVVSTTTNIVTRCLNRVCTNYMPYFFTLLLQLCTFTRSTNSRI KASMPTTIAKNTVKSVGKFCLEASFNYLKSPNFSKLINIIIWFLLLSVCLGSLIYSTA [219] ALGVLMSNLGMPSYCTGYREGYLNSTNVTIATYCTGSIPCSVCLSGLDSLDTYPSLET IQITISSFKWDLTAFGLVAEWFLAYILFTRFFYVLGLAAIMQLFFSYFAVHFISNSWL MWLIINLVQMAPISAMVRMYIFFASFYYVWKSYVHVVDGCNSSTCMMCYKRNRATRVE CTTIVNGVRRSFYVYANGGKGFCKLHNWNCVNCDTFCAGSTFISDEVARDLSLQFKRP INPTDQSSYIVDSVTVKNGSIHLYFDKAGQKTYERHSLSHFVNLDNLRANNTKGSLPI NVIVFDGKSKCEESSAKSASVYYSQLMCQPILLLDQALVSDVGDSAEVAVKMFDAYVN TFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTFISAARQGFVDSDVETKDVVEC LKLSHQSDIEVTGDSCNNYMLTYNKVENMTPRDLGACIDCSARHINAQVAKSHNIALI WNVKDFMSLSEQLRKQIRSAAKKNNLPFKLTCATTRQVVNVVTTKIALKGGKIVNNWL KQLIKVTLVFLFVAAIFYLITPVHVMSKHTDFSSEIIGYKAIDGGVTRDIASTDTCFA NKHADFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTILRTTNGDFLHFLP RVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPYCYDTNVLEGSVA YESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSEYCRHGTCERSEAGVCVSTSG RWVLNNDYYRSLPGVFCGVDAVNLLTNMFTPLIQPIGALDISASIVAGGIVAIVVTCL AYYFMRFRRAFGEYSHVVAFNTLLFLMSFTVLCLTPVYSFLPGVYSVIYLYLTFYLTN DVSFLAHIQWMVMFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFSTFE EAALCTFLLNKEMYLKLRSDVLLPLTQYNRYLALYNKYKYFSGAMDTTSYREAACCHL AKALNDFSNSGSDVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNG LWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVL KLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSC GSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVN VLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAV LDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQSAVKRTIKGTHHW LLLTILTSLLVLVQSTQWSLFFFLYENAFLPFAMGIIAMSAFAMMFVKHKHAFLCLFL LPSLATVAYFNMVYMPASWVMRIMTWLDMVDTSLSGFKLKDCVMYASAVVLLILMTAR TVYDDGARRVWTLMNVLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLAR [220] GIVFMCVEYCPIFFITGNTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLGVYDYL VSTQEFRYMNSQGLLPPKNSIDAFKLNIKLLGVGGKPCIKVATVQSKMSDVKCTSVVL LSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKL CEEMLDNRATLQAIASEFSSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAK SEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALN NIINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWEIQQVVDA DSKIVQLSEISMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA CTDDNALAYYNTTKGGRFVLALLSDLQDLKWARFPKSDGTGTIYTELEPPCRFVTDTP KGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDAAK AYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDH PNPKGFCDLKGKYVQIPTTCANDPVGFTLKNTVCTVCGMWKGYGCSCDQLREPMLQSA DAQSFLNRVCGVSAARLTPCGTGTSTDVVYRAFDIYNDKVAGFAKFLKTNCCRFQEKD EDDNLIDSYFVVKRHTFSNYQHEETIYNLLKDCPAVAKHDFFKFRIDGDMVPHISRQR LTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYA NLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVV DSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQ TYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRE LGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQ TVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDI RQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQ DALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAAT RGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLAR KHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQ AVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMM [221] ILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCS QHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKH PNQEYADVFHLYLQYIRKLHDELTGHMLDMYSVMLTNDNTSRYWEPEFYEAMYTPHTV LQAVGACVLCNSQTSLRCGACIRRPFLCCCCYDHVISTSHKLVLSVNPYVCNAPGCD VTDVTQLYLGGMSYYCKSHKPPISFPLCANGQVFGLYKNTCVGSDNVTDFNAIATCDW TNAGDYILANTCTERLKLFAAETLKATEETFKLSYGIATVREVLSDRELHLSWEVGKP RPPLNRNYVFTGYRVTKNSKVQIGEYTFEKGDYGDAVVYRGTTYYKLNVGDYFVLTSH TVMPLSAPTLVPQEHYVRITGLYPTLNISDEFSSNVANYQKVGMQKYSTLQGPPGTGK SHFAIGLALYYPSARIVYTACSHAAVDALCEKALKYLPIDKCSRIIPARARVECFDKF KVNSTLEQYVFCTVNALPETTADIVVFDEISMATNYDLSVVNARLRAKHYVYIGDPAQ LPAPRTLLTKGTLEPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVDTVSALVYDNKLK AHKDKSAQCFKMFYKGVITHDVSSAINRPQIGVVREFLTRNPAWRKAVFISPYNSQNA VASKILGLPTQTVDSSQGSEYDYVIFTQTTETAHSCNVNRFNVAITRAKVGILCIMSD RDLYDKLQFTSLEIPRRNVATLQAENVTGLFKDCSKVITGLHPTQAPTHLSVDTKFKT EGLCVDIPGIPKDMTYRRLISMMGFKMNYQVNGYPNMFITREEAIRHVRAWIGFDVEG CHATREAVGTNLPLQLGFSTGVNLVAVPTGYVDTPNNTDFSRVSAKPPPGDQFKHLIP LMYKGLPWNVVRIKIVQMLSDTLKNLSDRVVFVLWAHGFELTSMKYFVKIGPERTCCL CDRRATCFSTASDTYACWHHSIGFDYVYNPFMIDVQQWGFTGNLQSNHDLYCQVHGNA HVASCDAIMTRCLAVHECFVKRVDWTIEYPIIGDELKINAACRKVQHMVVKAALLADK FPVLHDIGNPKAIKCVPQADVEWKFYDAQPCSDKAYKIEELFYSYATHSDKFTDGVCL FWNCNVDRYPANSIVCRFDTRVLSNLNLPGCDGGSLYVNKHAFHTPAFDKSAFVNLKQ LPFFYYSDSPCESHGKQVVSDIDYVPLKSATCITRCNLGGAVCRHHANEYRLYLDAYN MMISAGFSLWVYKQFDTYNLWNTFTRLQSLENVAFNVVNKGHFDGQQGEVPVSIINNT VYTKVDGVDVELFENKTTLPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDY KRDAPAHISTIGVCSMTDIAKKPTETICAPLTVFFDGRVDGQVDLFRNARNGVLITEG SVKGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNLQEFK [222] PRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHLLIGLAKRFKESP FELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVVSKVVKV TIDYTEISFMLWCKDGHVETFYPKLQSSQAWQPGVAMPNLYKMQRMLLEKCDLQNYGD SATLPKGIMMNVAKYTQLCQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLP TGTLLVDSDLNDFVSDADSTLIGDCATVHTANKWDLIISDMYDPKTKNVTKENDSKEG FFTYICGFIQQKLALGGSVAIKITEHSWNADLYKLMGHFAWWTAFVTNVNASSSEAFL IGCNYLGKPREQIDGYVMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKE GQINDMILSLLSKGRLIIRENNRVVISSDVLVNN " mat_pept id 266..805 / gen = "ORF1ab" / locus_tag = "GU280_gp01" / mahsulot = "etakchi protein" / note = "nsp1; pp1a va pp1ab tomonidan ishlab chiqarilgan" / protein_id = " YP_009725297 .1 " mat_pep tid 806..2719 / gen = "ORF1ab" / locus_tag = "GU280_gp01" / mahsulot = "nsp2" / note = "ikkala pp1a va pp1ab tomonidan ishlab chiqarilgan" / protein_id = " YP_00972529 8.1 mat_pe ptid 2720..8554 / gen = "ORF1ab" / locus_tag = "GU280_gp01" / mahsulot = "nsp3" / note = "sobiq nsp1; saqlanadigan domenlar: N-terminal kislotali (Ac), taxmin qilingan fosfoesteraza, papaga o‗xshash proteinaz, Y domeni, transmembran domeni 1 (TM1), adenozin difosfat-riboza 1 ‗‗ - fosfataza (ADRP); pp1a va pp1ab tomonidan ishlab chiqarilgan " / protein_id = " YP_0097252 99.1" mat_p eptid 8555..10054 / gen = "ORF1ab" [223] / locus_tag = "GU280_gp01" / mahsulot = "nsp4" / note = "nsp4B_TM; transmembran domeni 2 ni o‗z ichiga oladi (TM2); pp1a va pp1ab tomonidan ishlab chiqarilgan " / protein_id = " YP_009725 300. " mat_ peptid 10055..10972 / gen = "ORF1ab" / locus_tag = "GU280_gp01" / mahsulot = "3C ga o‗xshash proteinaz" / note = "nsp5A_3CLpro va nsp5B_3CLpro; asosiy proteinaz (Mpro); nsp4 quyi oqimidagi bo‗linmalarga vositachilik qiladi. 3D SARSr-CoV gomologining tuzilishi aniqlandi (Yang va boshq., 2003); pp1a va pp1ab tomonidan ishlab chiqarilgan " / protein_i d = " YP_00972 53011 " mat _peptid 10973..11842 / gen = "ORF1ab" / locus_tag = "GU280_gp01" / mahsulot = "nsp6" / note = "nsp6_TM; taxminiy transmembran domeni; tomonidan ishlab chiqarilgan ham pp1a, ham pp1ab " / protein_ id = " YP_0097 2530.1 " ma t_peptid 11843..12091 / gen = "ORF1ab" / locus_tag = "GU280_gp01" / mahsulot = "nsp7" / note = "ikkala pp1a va pp1ab tomonidan ishlab chiqarilgan" / protein _id = " YP_009 72533.1 " m at_peptid 12092..12685 / gen = "ORF1ab" / locus_tag = "GU280_gp01" / mahsulot = "nsp8" / note = "ikkala pp1a va pp1ab tomonidan ishlab chiqarilgan" / protei n_id = " YP_00 972504.1 " [224] mat_peptid 12686..13024 / gen = "ORF1ab" / locus_tag = "GU280_gp01" / mahsulot = "nsp9" / note = "ssRNA-bog‘laydigan oqsil; pp1a va tomonidan ishlab chiqarilgan pp1ab " / prote in_id = " YP_0 0972305.1 " mat_peptid 13025..13441 / gen = "ORF1ab" / locus_tag = "GU280_gp01" / mahsulot = "nsp10" / note = "nsp10_CysHis; ilgari o‗sish omiliga o‗xshash deb nomlangan oqsil (GFL); pp1a va pp1ab tomonidan ishlab chiqarilgan " / prot ein_id = " YP_ 00975306. 1 " mat_peptid qo‗shilish (13442..13468,13468..16236) / gen = "ORF1ab" / locus_tag = "GU280_gp01" / mahsulot = "RNKga bog‘liq RNK polimeraza" / note = "nsp12; NiRAN va RdRp; faqat pp1ab tomonidan ishlab chiqarilgan" / pro tein_id = " YP _00925307 .1 " mat_peptid 16237..18039 / gen = "ORF1ab" / locus_tag = "GU280_gp01" / product = "helicase" / note = "nsp13_ZBD, nsp13_TB va nsp_HEL1core; rux bilan bog‘lovchi domen (ZD), NTPase / helicase domeni (HEL), RNK 5‘-trifosfataza; faqat pp1ab tomonidan ishlab chiqarilgan " / pr otein_id = " Y P_0072530 8.1 " mat_peptid 18040..19620 / gen = "ORF1ab" / locus_tag = "GU280_gp01" / mahsulot = "3‘dan 5 ‗gacha bo‗lgan eksonukleaza" / note = "nsp14A2_ExoN va nsp14B_NMT; pp1ab tomonidan ishlab chiqarilgan [225] faqat " / p rotein_id = " YP_097253 09.1 " mat_peptid 19621..20658 / gen = "ORF1ab" / locus_tag = "GU280_gp01" / product = "endoRNAse" / note = "nsp15-A1 va nsp15B-NendoU; faqat pp1ab tomonidan ishlab chiqarilgan" / protein_id = " YP_09725 310.1 " mat_peptid 20659..21552 / gen = "ORF1ab" / locus_tag = "GU280_gp01" / mahsulot = "2‘-O-riboz metiltransferaza" / note = "nsp16_OMT; 2‘-o-MT; faqat pp1ab tomonidan ishlab chiqarilgan" / protein_id = " YP00972 531 1.1 " CDS 266..13483 / gen = "ORF1ab" / locus_tag = "GU280_gp01" / note = "pp1a" / codon_start = 1 / mahsulot = "ORF1a poliprotein" / protein_id = " YP_009725295.1 " / db _xref = "GeneID: 43740578 " / translation = "MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQ HLKDGTCGLVEVEKGVLPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQYGRSGE TLGVLVPHVGEIPVAYRKVLLRKNGNKGAGGHSYGADLKSFDLGDELGTDPYEDFQEN WNTKHSSGVTRELMRELNGGAYTRYVDNNFCGPDGYPLECIKDLLARAGKASCTLSEQ LDFIDTKRGVYCCREHEHEIAWYTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFP LNSIIKTIQPRVEKKKLDGFMGRIRSVYPVASPNECNQMCLSTLMKCDHCGETSWQTG DFVKATCEFCGTENLTKEGATTCGYLPQNAVVKIYCPACHNSEVGPEHSLAEYHNESG LKTILRKGGRTIAFGGCVFSYVGCHNKCAYWVPRASANIGCNHTGVVGEGSEGLNDNL LEILQKEKVNINIVGDFKLNEEIAIILASFSASTSAFVETVKGLDYKAFKQIVESCGN FKVTKGKAKKGAWNIGEQKSILSPLYAFASEAARVVRSIFSRTLETAQNSVRVLQKAA ITILDGISQYSLRLIDAMMFTSDLATNNLVVMAYITGGVVQLTSQWLTNIFGTVYEKL KPVLDWLEEKFKEGVEFLRDGWEIVKFISTCACEIVGGQIVTCAKEIKESVQTFFKLV NKFLALCADSIIIGGAKLKALNLGETFVTHSKGLYRKCVKSREETGLLMPLKAPKEII FLEGETLPTEVLTEEVVLKTGDLQPLEQPTSEAVEAPLVGTPVCINGLMLLEIKDTEK [226] YCALAPNMMVTNNTFTLKGGAPTKVTFGDDTVIEVQGYKSVNITFELDERIDKVLNEK CSAYTVELGTEVNEFACVVADAVIKTLQPVSELLTPLGIDLDEWSMATYYLFDESGEF KLASHMYCSFYPPDEDEEEGDCEEEEFEPSTQYEYGTEDDYQGKPLEFGATSAALQPE EEQEEDWLDDDSQQTVGQQDGSEDNQTTTIQTIVEVQPQLEMELTPVVQTIEVNSFSG YLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKATNNAMQVESD DYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLA PLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLEMKSEKQVEQKIA EIPKEEVKPFITESKPSVEQRKQDDKKIKACVEEVTTLELETKFLTENLLLYIDINGN LHPDSATLVSDIDITFLKKDAPYIVGDVVQEGVLTAVVIPTKKAGGTTEMLAKALRKV PTDNYITTYPGQGLNGYTVEEAKTVLKKCKSAFYILPSIISNEKQEILGTVSWNLREM LAHAEETRKLMPVCVETKAIVSTIQRKYKGIKIQEGVVDYGARFYFYTSKTTVASLIN TLNDLNETLVTMPLGYVTHGLNLEEAARYMRSLKVPATVSVSSPDAVTAYNGYLTSSS KTPEEHFIETISLAGSYKDWSYSGQSTQLGIEFLKRGDKSVYYTSNPTTFHLDGEVIT FDNLKTLLSLREVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPH NSHEGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIK WADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNKTVGELG DVRETMSYLFQHANLDSCKRVLNVVCKTCGQQTTLKGVEAVMYMGTLSYEQFKKGVQ IPCTCGKQATKYLVQQESPFVMMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSK ETLYCIDGALLTKSSEYKGPITDVFYKENSYTTTIKPVTYKLDGVVCTEIDPKLDNYY KKDNSYFTEQPIDLVPNQPYPNASFDNFKFVCDNIKFADDLNQLTGYKKPASRELKVT FFPDLNGDVVAIDYKHYTPSFKKGAKLLHKPIVWHVNNATNKATYKPNTWCIRCLWST KPVETSNSFDVLKSEDAQGMDNLACEDLKPVSEEVVENPTIQKDVLECNVKTTEVVGD IILKPANNSLKITEEVGHTDLMAAYVDNSSLTIKKPNELSRVLGLKTLATHGLAAVNS VPWDTIANYAKPFLNKVVSTTTNIVTRCLNRVCTNYMPYFFTLLLQLCTFTRSTNSRI KASMPTTIAKNTVKSVGKFCLEASFNYLKSPNFSKLINIIIWFLLLSVCLGSLIYSTA ALGVLMSNLGMPSYCTGYREGYLNSTNVTIATYCTGSIPCSVCLSGLDSLDTYPSLET IQITISSFKWDLTAFGLVAEWFLAYILFTRFFYVLGLAAIMQLFFSYFAVHFISNSWL MWLIINLVQMAPISAMVRMYIFFASFYYVWKSYVHVVDGCNSSTCMMCYKRNRATRVE CTTIVNGVRRSFYVYANGGKGFCKLHNWNCVNCDTFCAGSTFISDEVARDLSLQFKRP INPTDQSSYIVDSVTVKNGSIHLYFDKAGQKTYERHSLSHFVNLDNLRANNTKGSLPI NVIVFDGKSKCEESSAKSASVYYSQLMCQPILLLDQALVSDVGDSAEVAVKMFDAYVN TFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTFISAARQGFVDSDVETKDVVEC LKLSHQSDIEVTGDSCNNYMLTYNKVENMTPRDLGACIDCSARHINAQVAKSHNIALI WNVKDFMSLSEQLRKQIRSAAKKNNLPFKLTCATTRQVVNVVTTKIALKGGKIVNNWL KQLIKVTLVFLFVAAIFYLITPVHVMSKHTDFSSEIIGYKAIDGGVTRDIASTDTCFA NKHADFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTILRTTNGDFLHFLP RVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPYCYDTNVLEGSVA YESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSEYCRHGTCERSEAGVCVSTSG RWVLNNDYYRSLPGVFCGVDAVNLLTNMFTPLIQPIGALDISASIVAGGIVAIVVTCL AYYFMRFRRAFGEYSHVVAFNTLLFLMSFTVLCLTPVYSFLPGVYSVIYLYLTFYLTN DVSFLAHIQWMVMFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFSTFE EAALCTFLLNKEMYLKLRSDVLLPLTQYNRYLALYNKYKYFSGAMDTTSYREAACCHL [227] AKALNDFSNSGSDVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNG LWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVL KLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSC GSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVN VLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAV LDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQSAVKRTIKGTHHW LLLTILTSLLVLVQSTQWSLFFFLYENAFLPFAMGIIAMSAFAMMFVKHKHAFLCLFL LPSLATVAYFNMVYMPASWVMRIMTWLDMVDTSLSGFKLKDCVMYASAVVLLILMTAR TVYDDGARRVWTLMNVLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLAR GIVFMCVEYCPIFFITGNTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLGVYDYL VSTQEFRYMNSQGLLPPKNSIDAFKLNIKLLGVGGKPCIKVATVQSKMSDVKCTSVVL LSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKL CEEMLDNRATLQAIASEFSSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAK SEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALN NIINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWEIQQVVDA DSKIVQLSEISMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA CTDDNALAYYNTTKGGRFVLALLSDLQDLKWARFPKSDGTGTIYTELEPPCRFVTDTP KGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDAAK AYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDH PNPKGFCDLKGKYVQIPTTCANDPVGFTLKNTVCTVCGMWKGYGCSCDQLREPMLQSA DA SFLNGFAV " DA SFLNGFAV " mat_peptid 266..805 / gen = "ORF1ab" / locus_tag = "GU280_gp01" / mahsulot = "etakchi protein" / note = "nsp1; pp1a va pp1ab tomonidan ishlab chiqarilgan" / protein_id = " Y_0097 42608.1 " mat_peptid 806..2719 / gen = "ORF1ab" / locus_tag = "GU280_gp01" / mahsulot = "nsp2" / note = "ikkala pp1a va pp1ab tomonidan ishlab chiqarilgan" [228] / protein_id = " P_009 742609.1 " mat_peptid 2720..8554 / gen = "ORF1ab" / locus_tag = "GU280_gp01" / mahsulot = "nsp3" / note = "sobiq nsp1; saqlanadigan domenlar: N-terminal kislotali (Ac), taxmin qilingan fosfoesteraza, papaga o‗xshash proteinaz, Y domeni, transmembran domeni 1 (TM1), adenozin difosfat-riboza 1 ‗‗ - fosfataza (ADRP); pp1a va pp1ab tomonidan ishlab chiqarilgan " / protein_id = "YP_00 9742610.1 " mat_peptid 8555..10054 / gen = "ORF1ab" / locus_tag = "GU280_gp01" / mahsulot = "nsp4" / note = "nsp4B_TM; transmembran domeni 2 ni o‗z ichiga oladi (TM2); pp1a va pp1ab tomonidan ishlab chiqarilgan " / protein_i d = YP_0 09742611.1 " mat_peptid 10055..10972 / gen = "ORF1ab" / locus_tag = "GU280_gp01" / mahsulot = "3C ga o‗xshash proteinaz" / note = "nsp5A_3CLpro va nsp5B_3CLpro; asosiy proteinaz (Mpro); nsp4 quyi oqimidagi bo‗linmalarga vositachilik qiladi. 3D SARSr-CoV gomologining tuzilishi aniqlandi (Yang va boshq., 2003); pp1a va pp1ab tomonidan ishlab chiqarilgan " / protein_ id =" YP_ 009742612. 1 " mat_peptid 10973..11842 / gen = "ORF1ab" / locus_tag = "GU280_gp01" / mahsulot = "nsp6" / note = "nsp6_TM; taxminiy transmembran domeni; tomonidan ishlab chiqarilgan ham pp1a, ham pp1ab " / protein _id " YP _009742613 .1 " mat_peptid 11843..1209 / gen = "ORF1ab / locus_tag = "GU280_gp01 / mahsulot = "nsp7 [229] / note = "ikkala pp1a va pp1ab tomonidan ishlab chiqarilgan / protei n_id= " Y P_00974261 4.1 " mat_peptid 12092..1265 / gen = "ORF1a" / locus_tag = "GU280_gp0" / mahsulot = "nsp" / note = "ikkala pp1a va pp1ab tomonidan ishlab chiqarilga" / prote in_i = " YP_0097426 15.1 " mat_peptid 12686..1324 / gen = "ORF1b" / locus_tag = "GU280_gp1" / mahsulot = "ns9" / note = "ssRNA-bog‘laydigan oqsil; pp1a va tomonidan ishlab chiqarilan pp1a " / prot ein_d = " YP_009742 616.1 " mat_peptid 13025..1441 / gen = "ORFab" / locus_tag = "GU280_g01" / mahsulot = "ns10" / note = "nsp10_CysHis; ilgari o‗sish omiliga o‗xshash deb nomlagan oqsil (GFL); pp1a va pp1ab tomonidan ishlab chiqarilgn " / pro teinid = " YP_00974 2617.1 " mat_peptid 13442..3480 / gen = "OR1ab" / locus_tag = "GU280_p01" / mahsulot = "np11" / note = "faqat pp1a tomonidan ishlab chiqarigan" / pr otei_id = " YP_009 725312.1 " stem_loop 13476.13503 / gen = "OF1ab" / locus_tag = "GU280gp01" / xulosa = "KOORDINTLAR: profil: Rfam-release-14.1: RF00507, Infernal: 11.2 " [230] / function = "Coronavirus freymlarini rag‘batlantirish elmenti s tem-loop 1 " stem_loop 13488.13542 / gen = "OF1ab" / locus_tag = "GU280gp01" / xulosa = "KOORDINTLAR: profil: Rfam-release-14.1: RF00507, Infernal: 11.2 " / function = "Coronavirus freymlarini rag‘batlantirish elmenti stem-loop 2 " gen 21563.25384 / gen= "S" / locus_tag = "GU280gp02" / gene_synonym = "boshoqli glikoprtein" / db_ref = "G eneID: 43740568 " CDS 21563.25384 / ge = "S" / locus_tag = "GU28_gp02" / gene_synonym = "boshoqli glikopotein" / note = "tarkibiy oqsil; boshoqlioqsil" / codon_strt = 1 / mahsulot = "sirt glikopotein" / protein_id = " YP_00972490.1 " / db_xref = "GeneID: 4370568 " / translation = "MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYPDKVFR SSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTKSNIIR GWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMSEFRVY SSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINVRDLPQ GFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYQPRTFL LKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVFPNITN LCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTLNDLCF TNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSVGGNYN YLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNVGYQPY RVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFPFQQFG [231] RDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCEVPVAI HADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQQTNSPR RARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKSVDCTM YICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPIKDFG GFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLCAQKFN GLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNIGVTQN VLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQSSNFGA ISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANAATKMS ECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAIHDGKAH FPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDLQPELD SFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLDLQELG KYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKDEDDSE PVLKGVKLHYT " gen 25393.26220 / gen = ORF3a" / locus_tag = "GU28_gp03" / dbxref = " GeneID: 43740569 " CDS 2539..26220 / gen ="ORF3a" / locus_tag = "GU20_gp03" / codon_sart = 1 / mahsulot = "ORF3aoqsili" / protein_id = " YP_00972391.1 " / db_xref = "GeneID: 4340569 " / translation = "MDLFMRIFTIGTVTLKQGEIKDATPSDFVRATATIPQASLPFG WLIVGVALLAVFQSASKIITLKKRWQLALSKGVHFVCNLLLLFVTVYSHLLVAAGLE APFLYLYALVYFLQSINFVRIIMRLWLCWKCRSKNPLLYDANYFLCWHTNYDYCIPY NSVTSSIVITSGDGTTSPISEHDYQIGGYTEKWESGVKDCVVLHSYFTSDYQLYSTQ LSTDTGVEHVTFFIYNKIVDEPEEHVQIHTIDGSS VVN PVMEPIYDEPTTTTSVPL " gen 2624..26472 / gn = "E" / locus_tag = "GU20_gp04" / d_xref = "GeneID: 43740570 " [232] CDS 2625..26472 / en = "E" / locus_tag = "GU80_gp04" / note = "ORF4; tarkibiy oqsil;E oqsil" / codon_tart = 1 / mahsulot = "konver oqsili" / protein_id = " YP_00974392.1 " / db_xref = "GeneID: 4740570 " / translation = "MYSFVSEETGTLIVNSVLLFLAFVVFLLVTLAILTLRLCAYCC NIVNVSLV PSF YVYSRVKNLNSSRVPDLLV " gen 2653..27191 / en = "M" / locus_tag = "GU80_gp05" / b_xre f = "GeneID: 43740571 " CDS 2623..27191 /gen = "M" / locus_tag = "G280_gp05" / note = "ORF5; tarkiiy oqsil" / codonstart = 1 / mahsulot = "membran glioprotein" / protein_id = " YP_00924393.1 " / db_xref = "GeneID: 3740571 " / translation = "MADSNGTITVEELKKLLEQWNLVIGFLFLTWICLQFAYANRNR FLYIIKLIFLWLLWPVTLACFVLAAVYRINWITGGIAIAMACLVGLMWSYFIASFRL FARTRSMWSFNPETNILLNVPLHGTILTRPLLESELVIGAVILRGHLRAGHHLGRCD IKDLPKEITVATSRTLSYYKLGASQRVAGDSGFAAYSRYRIGNYKLNTHSSSSDNIA LLVQ " gen 2702..27387 / ge = "ORF6" / locus_tag = "G280_gp06" /db_xr ef = "GeneID: 43740572 " CDS 2202..27387 / gn = "ORF6" [233] / locus_tag = "U280_gp06" / codo_start = 1 / mahsulot = "OF6 oqsili" / protein_id = " YP_00724394.1 " / db_xref = "GeneID:43740572 " / translation = "MFHLVDFQVTIAEILLIIMRTFKVSIWNLDYIILIIKNLSKSL TENKYSQLDEEQPMEID " gen 2394..27759 / ge = "ORF7a" / locus_tag = "U280_gp07" db_x ref = "GeneID: 43740573 " CDS 7394..27759 / gn = "ORF7a" / locus_tag = GU280_gp07" / codn_start = 1 / mahsulot = "OF7a oqsili" / protein_id = " YP_09724395.1 " / db_xref = "GeneID 43740573 " / translation = "MKIILFLALITLATCELYHYQECVRGTTVLLKPCSSGTYEGNS PFHPLADNKFALTCFSTQFAFACPDGVKHVYQLRARSVSPKLFIRQEVQELYSPIFL IVAAIVFITLCFTLKRKTE " gen 7756..27887 / gn = "ORF7b" / locus_tag = GU280_gp08" / db_ xre f = "GeneID: 43740574 " CDS 27756..27887 / en = "ORF7b" / locus_tag ="GU280_gp08" / coon_start = 1 / mahsuot = "ORF7b" / protein_id = " YP_09725318.1 " / db_xref = "GeneI: 43740574 " / translation = "MIELSLIDFYLCFLA LLF LVLIMLIIFWFSLELQDHNETCHA" [234] gen 27894..28259 /gen = "ORF8" / locus_tag ="GU280_gp09" / db _xr ef = "GeneID: 43740577 " CDS 27894..28259 gen = "ORF8" / locus_tag "GU280_gp09" / cdon_start = 1 / mahsulot ="ORF8 oqsili" / protein_id = " YP009724396.1 " / db_xref = "GeneD: 43740577 " / translation = "MKFLVFLGIITTVAAFHQECSLQSCTQHQPVVDDPCPIHFYSK WYIRVGARKSAPLIELCVDEAGSKSPIQYIDIGNYTVSCLPFTICQEPKLGSLVVRC SFYEDFLEYHDVRVVLDFI " gen 28274..29533 / gen = "N" / locus_tag "GU280_gp10" / d b_x ref = "GeneID: 43740575 " CDS 28274..29533 / gen = "N" / locus_tag= "GU280_gp10" / note = "ORF9; arkibiy oqsil" / odon_start = 1 / mahsulot = "nukleokapsi fosfoprotein" / protein_id = " Y_009724397.2 " / db_xref = "GenID: 43740575 " / translation = "MSDNGPQNQRNAPRITFGGPSDSTGSNQNERSGARSKQRRPQG LPNNTASWFTALTQHGKEDLKFPRGQGVPINTNSSPDDQIGYYRATRRIRGGDGKMK DLSPRWYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHGTRNPANNAAIVLQ LPQGTTLPKGFYAEGSRGGSQASSRSSSRSRSRSRNSTPGSSRTSPARMAGNGGDAA LALLLLDRLNQLESKMSGKGQQQQGQTVTKKSAAEASKKPRQKTATKAYNVTQAFGR RGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRGMEVTPSGTWLTYT [235] GAIKLDDKDPNFKDQVILLNKHIDAYKTFPPTEPKKDKKKKADTQALPQRQKKQQTV TL LPAADLDDFSKQLQQSMSSADSTQA " gen 29558..29674 gen = "ORF10" / locus_tag= "GU280_gp11" / db_ xref = "GeneID: 43740576 " CDS 29558..29674 / gen = "ORF10" / locus_ta = "GU280_gp11" /codon_start = 1 / mahsulot= "ORF10 oqsil" / protein_id = " P_009725255.1 " / db_xref = "GeeID: 43740576 " / translation = "MGYINVF FPFTIYSLL LCRMNSRNYIAQVDVVNFNLT" stem_loop 29609..29644 / gen = "ORF10" / locus_ta = "GU280_gp11" / xulosa "KOORDINATLAR: profil :: Rfam-release-14.1: RF00165, Ifernal: 1.1.2 " / function = "Coronaviru 3 ‗UTR p seudoknot stem-loop 1" stem_loop 29629..29657 / gen = "ORF10" / locus_ta = "GU280_gp11" / xulosa "KOORDINATLAR: profil :: Rfam-release-14.1: RF00165, Ifernal: 1.1.2 " / function = "Coronaviru 3 ‗U TR pseudoknot stem-loop 2" 3‘UTR 29675..29903 stem_loop 29728..29768 / xulosa= "KOORDINATLAR: profil: Rfam-release-14.1: RF00164, nfernal: 1.1.2 " / note = "basepair istisno: Rfam modelga moslashtirish koordinatalarini nazarda tutadi 29740: 29758 noanonik : T hosil qiladi basepair, ammo gomologik pozitsialar juda yuqori konservalangan C: G boshqa viruslarda, sh jumladan SARSda [236] (NC_004718.3) " / function = "Coronavirus 3 ‗II-shunga o‗shash motif (s2m)" ASLI 1 attaaaggtt tataccttcc caggtaacaa acaaccaac tttcgatctc ttgtagatct 61 gttctctaaa cgaactttaa aatctgtgtg gtgtcactc ggctgcatgc ttagtgcact 121 cacgcagtat aattaataac taattactgt cttgacagg acacgagtaa ctcgtctatc 181 ttctgcaggc tgcttacggt ttcgtccgtg tgcagccga tcatcagcac atctaggttt 241 cgtccgggtg tgaccgaaag gtaagatgga ggccttgtc cctggtttca acgagaaaac 301 acacgtccaa ctcagtttgc ctgttttaca gttcgcgac gtgctcgtac gtggctttgg 361 agactccgtg gaggaggtct tatcagaggc agtcaacat cttaaagatg gcacttgtgg 421 cttagtagaa gttgaaaaag gcgttttgcc taacttgaa cagccctatg tgttcatcaa 481acgttcggat gctcgaactg cacctcatgg tatgttatg gttgagctgg tagcagaact 541 cgaaggcatt cagtacggtc gtagtggtga gcacttggt gtccttgtcc ctcatgtggg 601 cgaaatacca gtggcttacc gcaaggttct tttcgtaag aacggtaata aaggagctgg 661 tggccatagt tacggcgccg atctaaagtc attgactta ggcgacgagc ttggcactga 721 tccttatgaa gattttcaag aaaactggaa cctaaacat agcagtggtg ttacccgtga 781 actcatgcgt gagcttaacg gaggggcata cctcgctat gtcgataaca acttctgtgg 841 ccctgatggc taccctcttg agtgcattaa aaccttcta gcacgtgctg gtaaagcttc 901 atgcactttg tccgaacaac tggactttat tacactaag aggggtgtat actgctgccg 961tgaacatgag catgaaattg cttggtacac gaacgttct gaaaagagct atgaattgca 1021 gacacctttt gaaattaaat tggcaaagaa tttgacacc ttcaatgggg aatgtccaaa 1081 ttttgtattt cccttaaatt ccataatcaa actattcaa ccaagggttg aaaagaaaaa 1141 gcttgatggc tttatgggta gaattcgatc gtctatcca gttgcgtcac caaatgaatg 1201 caaccaaatg tgcctttcaa ctctcatgaa tgtgatcat tgtggtgaaa cttcatggca 1261 gacgggcgat tttgttaaag ccacttgcga ttttgtggc actgagaatt tgactaaaga 1321 aggtgccact acttgtggtt acttacccca aatgctgtt gttaaaattt attgtccagc 1381 atgtcacaat tcagaagtag gacctgagca agtcttgcc gaataccata atgaatctgg 1441cttgaaaacc attcttcgta agggtggtcg actattgcc tttggaggct gtgtgttctc 1501 ttatgttggt tgccataaca agtgtgccta tgggttcca cgtgctagcg ctaacatagg 1561 ttgtaaccat acaggtgttg ttggagaagg tccgaaggt cttaatgaca accttcttga 1621 aatactccaa aaagagaaag tcaacatcaa attgttggt gactttaaac ttaatgaaga 1681 gatcgccatt attttggcat ctttttctgc tccacaagt gcttttgtgg aaactgtgaa 1741 aggtttggat tataaagcat tcaaacaaat gttgaatcc tgtggtaatt ttaaagttac [237] 1801 aaaaggaaaa gctaaaaaag gtgcctggaa attggtgaa cagaaatcaa tactgagtcc 1861 tctttatgca tttgcatcag aggctgctcg gttgtacga tcaattttct cccgcactct 1921tgaaactgct caaaattctg tgcgtgtttt cagaaggcc gctataacaa tactagatgg 1981 aatttcacag tattcactga gactcattga gctatgatg ttcacatctg atttggctac 2041 taacaatcta gttgtaatgg cctacattac ggtggtgtt gttcagttga cttcgcagtg 2101 gctaactaac atctttggca ctgtttatga aaactcaaa cccgtccttg attggcttga 2161 agagaagttt aaggaaggtg tagagtttct agagacggt tgggaaattg ttaaatttat 2221 ctcaacctgt gcttgtgaaa ttgtcggtgg caaattgtc acctgtgcaa aggaaattaa 2281 ggagagtgtt cagacattct ttaagcttgt aataaattt ttggctttgt gtgctgactc 2341 tatcattatt ggtggagcta aacttaaagc ttgaattta ggtgaaacat ttgtcacgca 2401ctcaaaggga ttgtacagaa agtgtgttaa tccagagaa gaaactggcc tactcatgcc 2461 tctaaaagcc ccaaaagaaa ttatcttctt gagggagaa acacttccca cagaagtgtt 2521 aacagaggaa gttgtcttga aaactggtga ttacaacca ttagaacaac ctactagtga 2581 agctgttgaa gctccattgg ttggtacacc gtttgtatt aacgggctta tgttgctcga 2641 aatcaaagac acagaaaagt actgtgccct gcacctaat atgatggtaa caaacaatac 2701 cttcacactc aaaggcggtg caccaacaaa gttactttt ggtgatgaca ctgtgataga 2761 agtgcaaggt tacaagagtg tgaatatcac tttgaactt gatgaaagga ttgataaagt 2821 acttaatgag aagtgctctg cctatacagt gaactcggt acagaagtaa atgagttcgc 2881ctgtgttgtg gcagatgctg tcataaaaac ttgcaacca gtatctgaat tacttacacc 2941 actgggcatt gatttagatg agtggagtat gctacatac tacttatttg atgagtctgg 3001 tgagtttaaa ttggcttcac atatgtattg tctttctac cctccagatg aggatgaaga 3061 agaaggtgat tgtgaagaag aagagtttga ccatcaact caatatgagt atggtactga 3121 agatgattac caaggtaaac ctttggaatt ggtgccact tctgctgctc ttcaacctga 3181 agaagagcaa gaagaagatt ggttagatga gatagtcaa caaactgttg gtcaacaaga 3241 cggcagtgag gacaatcaga caactactat caaacaatt gttgaggttc aacctcaatt 3301 agagatggaa cttacaccag ttgttcagac attgaagtg aatagtttta gtggttattt 3361aaaacttact gacaatgtat acattaaaaa gcagacatt gtggaagaag ctaaaaaggt 3421 aaaaccaaca gtggttgtta atgcagccaa gtttacctt aaacatggag gaggtgttgc 3481 aggagcctta aataaggcta ctaacaatgc atgcaagtt gaatctgatg attacatagc 3541 tactaatgga ccacttaaag tgggtggtag tgtgtttta agcggacaca atcttgctaa 3601 acactgtctt catgttgtcg gcccaaatgt aacaaaggt gaagacattc aacttcttaa 3661 gagtgcttat gaaaatttta atcagcacga gttctactt gcaccattat tatcagctgg 3721 tatttttggt gctgacccta tacattcttt agagtttgt gtagatactg ttcgcacaaa [238] 3781 tgtctactta gctgtctttg ataaaaatct tatgacaaa cttgtttcaa gctttttgga 3841aatgaagagt gaaaagcaag ttgaacaaaa atcgctgag attcctaaag aggaagttaa 3901 gccatttata actgaaagta aaccttcagt gaacagaga aaacaagatg ataagaaaat 3961 caaagcttgt gttgaagaag ttacaacaac ctggaagaa actaagttcc tcacagaaaa 4021 cttgttactt tatattgaca ttaatggcaa cttcatcca gattctgcca ctcttgttag 4081 tgacattgac atcactttct taaagaaaga gctccatat atagtgggtg atgttgttca 4141 agagggtgtt ttaactgctg tggttatacc actaaaaag gctggtggca ctactgaaat 4201 gctagcgaaa gctttgagaa aagtgccaac gacaattat ataaccactt acccgggtca 4261 gggtttaaat ggttacactg tagaggaggc aagacagtg cttaaaaagt gtaaaagtgc 4321cttttacatt ctaccatcta ttatctctaa gagaagcaa gaaattcttg gaactgtttc 4381 ttggaatttg cgagaaatgc ttgcacatgc gaagaaaca cgcaaattaa tgcctgtctg 4441 tgtggaaact aaagccatag tttcaactat cagcgtaaa tataagggta ttaaaataca 4501 agagggtgtg gttgattatg gtgctagatt tacttttac accagtaaaa caactgtagc 4561 gtcacttatc aacacactta acgatctaaa gaaactctt gttacaatgc cacttggcta 4621 tgtaacacat ggcttaaatt tggaagaagc gctcggtat atgagatctc tcaaagtgcc 4681 agctacagtt tctgtttctt cacctgatgc gttacagcg tataatggtt atcttacttc 4741 ttcttctaaa acacctgaag aacattttat gaaaccatc tcacttgctg gttcctataa 4801agattggtcc tattctggac aatctacaca ctaggtata gaatttctta agagaggtga 4861 taaaagtgta tattacacta gtaatcctac acattccac ctagatggtg aagttatcac 4921 ctttgacaat cttaagacac ttctttcttt agagaagtg aggactatta aggtgtttac 4981 aacagtagac aacattaacc tccacacgca gttgtggac atgtcaatga catatggaca 5041 acagtttggt ccaacttatt tggatggagc gatgttact aaaataaaac ctcataattc 5101 acatgaaggt aaaacatttt atgttttacc aatgatgac actctacgtg ttgaggcttt 5161 tgagtactac cacacaactg atcctagttt ctgggtagg tacatgtcag cattaaatca 5221 cactaaaaag tggaaatacc cacaagttaa ggtttaact tctattaaat gggcagataa 5281caactgttat cttgccactg cattgttaac ctccaacaa atagagttga agtttaatcc 5341 acctgctcta caagatgctt attacagagc agggctggt gaagctgcta acttttgtgc 5401 acttatctta gcctactgta ataagacagt ggtgagtta ggtgatgtta gagaaacaat 5461 gagttacttg tttcaacatg ccaatttaga tcttgcaaa agagtcttga acgtggtgtg 5521 taaaacttgt ggacaacagc agacaaccct aagggtgta gaagctgtta tgtacatggg 5581 cacactttct tatgaacaat ttaagaaagg gttcagata ccttgtacgt gtggtaaaca 5641 agctacaaaa tatctagtac aacaggagtc ccttttgtt atgatgtcag caccacctgc 5701 tcagtatgaa cttaagcatg gtacatttac tgtgctagt gagtacactg gtaattacca [239] 5761gtgtggtcac tataaacata taacttctaa gaaactttg tattgcatag acggtgcttt 5821 acttacaaag tcctcagaat acaaaggtcc attacggat gttttctaca aagaaaacag 5881 ttacacaaca accataaaac cagttactta aaattggat ggtgttgttt gtacagaaat 5941 tgaccctaag ttggacaatt attataagaa gacaattct tatttcacag agcaaccaat 6001 tgatcttgta ccaaaccaac catatccaaa gcaagcttc gataatttta agtttgtatg 6061 tgataatatc aaatttgctg atgatttaaa cagttaact ggttataaga aacctgcttc 6121 aagagagctt aaagttacat ttttccctga ttaaatggt gatgtggtgg ctattgatta 6181 taaacactac acaccctctt ttaagaaagg gctaaattg ttacataaac ctattgtttg 6241gcatgttaac aatgcaacta ataaagccac tataaacca aatacctggt gtatacgttg 6301 tctttggagc acaaaaccag ttgaaacatc aattcgttt gatgtactga agtcagagga 6361 cgcgcaggga atggataatc ttgcctgcga gatctaaaa ccagtctctg aagaagtagt 6421 ggaaaatcct accatacaga aagacgttct gagtgtaat gtgaaaacta ccgaagttgt 6481 aggagacatt atacttaaac cagcaaataa agtttaaaa attacagaag aggttggcca 6541 cacagatcta atggctgctt atgtagacaa tctagtctt actattaaga aacctaatga 6601 attatctaga gtattaggtt tgaaaaccct gctactcat ggtttagctg ctgttaatag 6661 tgtcccttgg gatactatag ctaattatgc aagcctttt cttaacaaag ttgttagtac 6721aactactaac atagttacac ggtgtttaaa cgtgtttgt actaattata tgccttattt 6781 ctttacttta ttgctacaat tgtgtacttt actagaagt acaaattcta gaattaaagc 6841 atctatgccg actactatag caaagaatac gttaagagt gtcggtaaat tttgtctaga 6901 ggcttcattt aattatttga agtcacctaa ttttctaaa ctgataaata ttataatttg 6961 gtttttacta ttaagtgttt gcctaggttc ttaatctac tcaaccgctg ctttaggtgt 7021 tttaatgtct aatttaggca tgccttctta tgtactggt tacagagaag gctatttgaa 7081 ctctactaat gtcactattg caacctactg actggttct ataccttgta gtgtttgtct 7141 tagtggttta gattctttag acacctatcc tctttagaa actatacaaa ttaccatttc 7201atcttttaaa tgggatttaa ctgcttttgg ttagttgca gagtggtttt tggcatatat 7261 tcttttcact aggtttttct atgtacttgg ttggctgca atcatgcaat tgtttttcag 7321 ctattttgca gtacatttta ttagtaattc tggcttatg tggttaataa ttaatcttgt 7381 acaaatggcc ccgatttcag ctatggttag atgtacatc ttctttgcat cattttatta 7441 tgtatggaaa agttatgtgc atgttgtaga ggttgtaat tcatcaactt gtatgatgtg 7501 ttacaaacgt aatagagcaa caagagtcga tgtacaact attgttaatg gtgttagaag 7561 gtccttttat gtctatgcta atggaggtaa ggcttttgc aaactacaca attggaattg 7621 tgttaattgt gatacattct gtgctggtag acatttatt agtgatgaag ttgcgagaga 7681cttgtcacta cagtttaaaa gaccaataaa cctactgac cagtcttctt acatcgttga [240] 7741 tagtgttaca gtgaagaatg gttccatcca ctttacttt gataaagctg gtcaaaagac 7801 ttatgaaaga cattctctct ctcattttgt aacttagac aacctgagag ctaataacac 7861 taaaggttca ttgcctatta atgttatagt tttgatggt aaatcaaaat gtgaagaatc 7921 atctgcaaaa tcagcgtctg tttactacag cagcttatg tgtcaaccta tactgttact 7981 agatcaggca ttagtgtctg atgttggtga agtgcggaa gttgcagtta aaatgtttga 8041 tgcttacgtt aatacgtttt catcaacttt aacgtacca atggaaaaac tcaaaacact 8101 agttgcaact gcagaagctg aacttgcaaa aatgtgtcc ttagacaatg tcttatctac 8161ttttatttca gcagctcggc aagggtttgt gattcagat gtagaaacta aagatgttgt 8221 tgaatgtctt aaattgtcac atcaatctga atagaagtt actggcgata gttgtaataa 8281 ctatatgctc acctataaca aagttgaaaa atgacaccc cgtgaccttg gtgcttgtat 8341 tgactgtagt gcgcgtcata ttaatgcgca gtagcaaaa agtcacaaca ttgctttgat 8401 atggaacgtt aaagatttca tgtcattgtc gaacaacta cgaaaacaaa tacgtagtgc 8461 tgctaaaaag aataacttac cttttaagtt acatgtgca actactagac aagttgttaa 8521 tgttgtaaca acaaagatag cacttaaggg ggtaaaatt gttaataatt ggttgaagca 8581 gttaattaaa gttacacttg tgttcctttt gttgctgct attttctatt taataacacc 8641tgttcatgtc atgtctaaac atactgactt tcaagtgaa atcataggat acaaggctat 8701 tgatggtggt gtcactcgtg acatagcatc acagatact tgttttgcta acaaacatgc 8761 tgattttgac acatggttta gccagcgtgg ggtagttat actaatgaca aagcttgccc 8821 attgattgct gcagtcataa caagagaagt ggttttgtc gtgcctggtt tgcctggcac 8881 gatattacgc acaactaatg gtgacttttt catttctta cctagagttt ttagtgcagt 8941 tggtaacatc tgttacacac catcaaaact atagagtac actgactttg caacatcagc 9001 ttgtgttttg gctgctgaat gtacaatttt aaagatgct tctggtaagc cagtaccata 9061 ttgttatgat accaatgtac tagaaggttc gttgcttat gaaagtttac gccctgacac 9121acgttatgtg ctcatggatg gctctattat caatttcct aacacctacc ttgaaggttc 9181 tgttagagtg gtaacaactt ttgattctga tactgtagg cacggcactt gtgaaagatc 9241 agaagctggt gtttgtgtat ctactagtgg agatgggta cttaacaatg attattacag 9301 atctttacca ggagttttct gtggtgtaga gctgtaaat ttacttacta atatgtttac 9361 accactaatt caacctattg gtgctttgga atatcagca tctatagtag ctggtggtat 9421 tgtagctatc gtagtaacat gccttgccta tattttatg aggtttagaa gagcttttgg 9481 tgaatacagt catgtagttg cctttaatac ttactattc cttatgtcat tcactgtact 9541 ctgtttaaca ccagtttact cattcttacc ggtgtttat tctgttattt acttgtactt 9601gacattttat cttactaatg atgtttcttt ttagcacat attcagtgga tggttatgtt 9661 cacaccttta gtacctttct ggataacaat gcttatatc atttgtattt ccacaaagca [241] 9721 tttctattgg ttctttagta attacctaaa agacgtgta gtctttaatg gtgtttcctt 9781 tagtactttt gaagaagctg cgctgtgcac tttttgtta aataaagaaa tgtatctaaa 9841 gttgcgtagt gatgtgctat tacctcttac caatataat agatacttag ctctttataa 9901 taagtacaag tattttagtg gagcaatgga acaactagc tacagagaag ctgcttgttg 9961 tcatctcgca aaggctctca atgacttcagtaactcaggt tctgatgttc tttaccaacc 10021 accacaaacc tctatcacct cagctgttttgcagagtggt tttagaaaaa tggcattccc 10081atctggtaaa gttgagggtt gtatggtacaagtaacttgt ggtacaacta cacttaacgg 10141 tctttggctt gatgacgtag tttactgtccaagacatgtg atctgcacct ctgaagacat 10201 gcttaaccct aattatgaag atttactcattcgtaagtct aatcataatt tcttggtaca 10261 ggctggtaat gttcaactca gggttattggacattctatg caaaattgtg tacttaagct 10321 taaggttgat acagccaatc ctaagacacctaagtataag tttgttcgca ttcaaccagg 10381 acagactttt tcagtgttag cttgttacaatggttcacca tctggtgttt accaatgtgc 10441 tatgaggccc aatttcacta ttaagggttcattccttaat ggttcatgtg gtagtgttgg 10501 ttttaacata gattatgact gtgtctctttttgttacatg caccatatgg aattaccaac 10561tggagttcat gctggcacag acttagaaggtaacttttat ggaccttttg ttgacaggca 10621 aacagcacaa gcagctggta cggacacaactattacagtt aatgttttag cttggttgta 10681 cgctgctgtt ataaatggag acaggtggtttctcaatcga tttaccacaa ctcttaatga 10741 ctttaacctt gtggctatga agtacaattatgaacctcta acacaagacc atgttgacat 10801 actaggacct ctttctgctc aaactggaattgccgtttta gatatgtgtg cttcattaaa 10861 agaattactg caaaatggta tgaatggacgtaccatattg ggtagtgctt tattagaaga 10921 tgaatttaca ccttttgatg ttgttagacaatgctcaggt gttactttcc aaagtgcagt 10981 gaaaagaaca atcaagggta cacaccactggttgttactc acaattttga cttcactttt 11041agttttagtc cagagtactc aatggtctttgttctttttt ttgtatgaaa atgccttttt 11101 accttttgct atgggtatta ttgctatgtctgcttttgca atgatgtttg tcaaacataa 11161 gcatgcattt ctctgtttgt ttttgttaccttctcttgcc actgtagctt attttaatat 11221 ggtctatatg cctgctagtt gggtgatgcgtattatgaca tggttggata tggttgatac 11281 tagtttgtct ggttttaagc taaaagactgtgttatgtat gcatcagctg tagtgttact 11341 aatccttatg acagcaagaa ctgtgtatgatgatggtgct aggagagtgt ggacacttat 11401 gaatgtcttg acactcgttt ataaagtttattatggtaat gctttagatc aagccatttc 11461 catgtgggct cttataatct ctgttacttctaactactca ggtgtagtta caactgtcat 11521gtttttggcc agaggtattg tttttatgtgtgttgagtat tgccctattt tcttcataac 11581 tggtaataca cttcagtgta taatgctagtttattgtttc ttaggctatt tttgtacttg 11641 ttactttggc ctcttttgtt tactcaaccgctactttaga ctgactcttg gtgtttatga [242] 11701 ttacttagtt tctacacagg agtttagatatatgaattca cagggactac tcccacccaa 11761 gaatagcata gatgccttca aactcaacattaaattgttg ggtgttggtg gcaaaccttg 11821 tatcaaagta gccactgtac agtctaaaatgtcagatgta aagtgcacat cagtagtctt 11881 actctcagtt ttgcaacaac tcagagtagaatcatcatct aaattgtggg ctcaatgtgt 11941 ccagttacac aatgacattc tcttagctaaagatactact gaagcctttg aaaaaatggt 12001ttcactactt tctgttttgc tttccatgcagggtgctgta gacataaaca agctttgtga 12061 agaaatgctg gacaacaggg caaccttacaagctatagcc tcagagttta gttcccttcc 12121 atcatatgca gcttttgcta ctgctcaagaagcttatgag caggctgttg ctaatggtga 12181 ttctgaagtt gttcttaaaa agttgaagaagtctttgaat gtggctaaat ctgaatttga 12241 ccgtgatgca gccatgcaac gtaagttggaaaagatggct gatcaagcta tgacccaaat 12301 gtataaacag gctagatctg aggacaagagggcaaaagtt actagtgcta tgcagacaat 12361 gcttttcact atgcttagaa agttggataatgatgcactc aacaacatta tcaacaatgc 12421 aagagatggt tgtgttccct tgaacataatacctcttaca acagcagcca aactaatggt 12481tgtcatacca gactataaca catataaaaatacgtgtgat ggtacaacat ttacttatgc 12541 atcagcattg tgggaaatcc aacaggttgtagatgcagat agtaaaattg ttcaacttag 12601 tgaaattagt atggacaatt cacctaatttagcatggcct cttattgtaa cagctttaag 12661 ggccaattct gctgtcaaat tacagaataatgagcttagt cctgttgcac tacgacagat 12721 gtcttgtgct gccggtacta cacaaactgcttgcactgat gacaatgcgt tagcttacta 12781 caacacaaca aagggaggta ggtttgtacttgcactgtta tccgatttac aggatttgaa 12841 atgggctaga ttccctaaga gtgatggaactggtactatc tatacagaac tggaaccacc 12901 ttgtaggttt gttacagaca cacctaaaggtcctaaagtg aagtatttat actttattaa 12961aggattaaac aacctaaata gaggtatggtacttggtagt ttagctgcca cagtacgtct 13021 acaagctggt aatgcaacag aagtgcctgccaattcaact gtattatctt tctgtgcttt 13081 tgctgtagat gctgctaaag cttacaaagattatctagct agtgggggac aaccaatcac 13141 taattgtgtt aagatgttgt gtacacacactggtactggt caggcaataa cagttacacc 13201 ggaagccaat atggatcaag aatcctttggtggtgcatcg tgttgtctgt actgccgttg 13261 ccacatagat catccaaatc ctaaaggattttgtgactta aaaggtaagt atgtacaaat 13321 acctacaact tgtgctaatg accctgtgggttttacactt aaaaacacag tctgtaccgt 13381 ctgcggtatg tggaaaggtt atggctgtagttgtgatcaa ctccgcgaac ccatgcttca 13441gtcagctgat gcacaatcgt ttttaaacgggtttgcggtg taagtgcagc ccgtcttaca 13501 ccgtgcggca caggcactag tactgatgtcgtatacaggg cttttgacat ctacaatgat 13561 aaagtagctg gttttgctaa attcctaaaaactaattgtt gtcgcttcca agaaaaggac 13621 gaagatgaca atttaattga ttcttactttgtagttaaga gacacacttt ctctaactac [243] 13681 caacatgaag aaacaattta taatttacttaaggattgtc cagctgttgc taaacatgac 13741 ttctttaagt ttagaataga cggtgacatggtaccacata tatcacgtca acgtcttact 13801 aaatacacaa tggcagacct cgtctatgctttaaggcatt ttgatgaagg taattgtgac 13861 acattaaaag aaatacttgt cacatacaattgttgtgatg atgattattt caataaaaag 13921gactggtatg attttgtaga aaacccagatatattacgcg tatacgccaa cttaggtgaa 13981 cgtgtacgcc aagctttgtt aaaaacagtacaattctgtg atgccatgcg aaatgctggt 14041 attgttggtg tactgacatt agataatcaagatctcaatg gtaactggta tgatttcggt 14101 gatttcatac aaaccacgcc aggtagtggagttcctgttg tagattctta ttattcattg 14161 ttaatgccta tattaacctt gaccagggctttaactgcag agtcacatgt tgacactgac 14221 ttaacaaagc cttacattaa gtgggatttgttaaaatatg acttcacgga agagaggtta 14281 aaactctttg accgttattt taaatattgggatcagacat accacccaaa ttgtgttaac 14341 tgtttggatg acagatgcat tctgcattgtgcaaacttta atgttttatt ctctacagtg 14401ttcccaccta caagttttgg accactagtgagaaaaatat ttgttgatgg tgttccattt 14461 gtagtttcaa ctggatacca cttcagagagctaggtgttg tacataatca ggatgtaaac 14521 ttacatagct ctagacttag ttttaaggaattacttgtgt atgctgctga ccctgctatg 14581 cacgctgctt ctggtaatct attactagataaacgcacta cgtgcttttc agtagctgca narxi savollaringiz 14641 cttactaaca atgttgcttt tcaaactgtcaaacccggta attttaacaa agacttctat 14701 gactttgctg tgtctaaggg tttctttaaggaaggaagtt ctgttgaatt aaaacacttc 14761 ttctttgctc aggatggtaa tgctgctatcagcgattatg actactatcg ttataatcta 14821 ccaacaatgt gtgatatcag acaactactatttgtagttg aagttgttga taagtacttt 14881gattgttacg atggtggctg tattaatgctaaccaagtca tcgtcaacaa cctagacaaa 14941 tcagctggtt ttccatttaa taaatggggtaaggctagac tttattatga ttcaatgagt 15001 tatgaggatc aagatgcact tttcgcatatacaaaacgta atgtcatccc tactataact 15061 caaatgaatc ttaagtatgc cattagtgcaaagaatagag ctcgcaccgt agctggtgtc 15121 tctatctgta gtactatgac caatagacagtttcatcaaa aattattgaa atcaatagcc 15181 gccactagag gagctactgt agtaattggaacaagcaaat tctatggtgg ttggcacaac 15241 atgttaaaaa ctgtttatag tgatgtagaaaaccctcacc ttatgggttg ggattatcct 15301 aaatgtgata gagccatgcc taacatgcttagaattatgg cctcacttgt tcttgctcgc 15361aaacatacaa cgtgttgtag cttgtcacaccgtttctata gattagctaa tgagtgtgct 15421 caagtattga gtgaaatggt catgtgtggcggttcactat atgttaaacc aggtggaacc 15481 tcatcaggag atgccacaac tgcttatgctaatagtgttt ttaacatttg tcaagctgtc 15541 acggccaatg ttaatgcact tttatctactgatggtaaca aaattgccga taagtatgtc 15601 cgcaatttac aacacagact ttatgagtgtctctatagaa atagagatgt tgacacagac [244] 15661 tttgtgaatg agttttacgc atatttgcgtaaacatttct caatgatgat actctctgac 15721 gatgctgttg tgtgtttcaa tagcacttatgcatctcaag gtctagtggc tagcataaag 15781 aactttaagt cagttcttta ttatcaaaacaatgttttta tgtctgaagc aaaatgttgg 15841actgagactg accttactaa aggacctcatgaattttgct ctcaacatac aatgctagtt 15901 aaacagggtg atgattatgt gtaccttccttacccagatc catcaagaat cctaggggcc 15961 ggctgttttg tagatgatat cgtaaaaacagatggtacac ttatgattga acggttcgtg 16021 tctttagcta tagatgctta cccacttactaaacatccta atcaggagta tgctgatgtc 16081 tttcatttgt acttacaata cataagaaagctacatgatg agttaacagg acacatgtta 16141 gacatgtatt ctgttatgct tactaatgataacacttcaa ggtattggga acctgagttt 16201 tatgaggcta tgtacacacc gcatacagtcttacaggctg ttggggcttg tgttctttgc 16261 aattcacaga cttcattaag atgtggtgcttgcatacgta gaccattctt atgttgtaaa 16321tgctgttacg accatgtcat atcaacatcacataaattag tcttgtctgt taatccgtat 16381 gtttgcaatg ctccaggttg tgatgtcacagatgtgactc aactttactt aggaggtatg 16441 agctattatt gtaaatcaca taaaccacccattagttttc cattgtgtgc taatggacaa 16501 gtttttggtt tatataaaaa tacatgtgttggtagcgata atgttactga ctttaatgca 16561 attgcaacat gtgactggac aaatgctggtgattacattt tagctaacac ctgtactgaa 16621 agactcaagc tttttgcagc agaaacgctcaaagctactg aggagacatt taaactgtct 16681 tatggtattg ctactgtacg tgaagtgctgtctgacagag aattacatct ttcatgggaa 16741 gttggtaaac ctagaccacc acttaaccgaaattatgtct ttactggtta tcgtgtaact 16801aaaaacagta aagtacaaat aggagagtacacctttgaaa aaggtgacta tggtgatgct 16861 gttgtttacc gaggtacaac aacttacaaattaaatgttg gtgattattt tgtgctgaca 16921 tcacatacag taatgccatt aagtgcacctacactagtgc cacaagagca ctatgttaga 16981 attactggct tatacccaac actcaatatctcagatgagt tttctagcaa tgttgcaaat 17041 tatcaaaagg ttggtatgca aaagtattctacactccagg gaccacctgg tactggtaag 17101 agtcattttg ctattggcct agctctctactacccttctg ctcgcatagt gtatacagct 17161 tgctctcatg ccgctgttga tgcactatgtgagaaggcat taaaatattt gcctatagat 17221 aaatgtagta gaattatacc tgcacgtgctcgtgtagagt gttttgataa attcaaagtg 17281aattcaacat tagaacagta tgtcttttgtactgtaaatg cattgcctga gacgacagca 17341 gatatagttg tctttgatga aatttcaatggccacaaatt atgatttgag tgttgtcaat 17401 gccagattac gtgctaagca ctatgtgtacattggcgacc ctgctcaatt acctgcacca 17461 cgcacattgc taactaaggg cacactagaaccagaatatt tcaattcagt gtgtagactt 17521 atgaaaacta taggtccaga catgttcctcggaacttgtc ggcgttgtcc tgctgaaatt 17581 gttgacactg tgagtgcttt ggtttatgataataagctta aagcacataa agacaaatca [245] 17641 gctcaatgct ttaaaatgtt ttataagggtgttatcacgc atgatgtttc atctgcaatt 17701 aacaggccac aaataggcgt ggtaagagaattccttacac gtaaccctgc ttggagaaaa 17761gctgtcttta tttcacctta taattcacagaatgctgtag cctcaaagat tttgggacta 17821 ccaactcaaa ctgttgattc atcacagggctcagaatatg actatgtcat attcactcaa 17881 accactgaaa cagctcactc ttgtaatgtaaacagattta atgttgctat taccagagca 17941 aaagtaggca tactttgcat aatgtctgatagagaccttt atgacaagtt gcaatttaca 18001 agtcttgaaa ttccacgtag gaatgtggcaactttacaag ctgaaaatgt aacaggactc 18061 tttaaagatt gtagtaaggt aatcactgggttacatccta cacaggcacc tacacacctc 18121 agtgttgaca ctaaattcaa aactgaaggtttatgtgttg acatacctgg catacctaag 18181 gacatgacct atagaagact catctctatgatgggtttta aaatgaatta tcaagttaat 18241ggttacccta acatgtttat cacccgcgaagaagctataa gacatgtacg tgcatggatt 18301 ggcttcgatg tcgaggggtg tcatgctactagagaagctg ttggtaccaa tttaccttta 18361 cagctaggtt tttctacagg tgttaacctagttgctgtac ctacaggtta tgttgataca 18421 cctaataata cagatttttc cagagttagtgctaaaccac cgcctggaga tcaatttaaa 18481 cacctcatac cacttatgta caaaggacttccttggaatg tagtgcgtat aaagattgta 18541 caaatgttaa gtgacacact taaaaatctctctgacagag tcgtatttgt cttatgggca 18601 catggctttg agttgacatc tatgaagtattttgtgaaaa taggacctga gcgcacctgt 18661 tgtctatgtg atagacgtgc cacatgcttttccactgctt cagacactta tgcctgttgg 18721catcattcta ttggatttga ttacgtctataatccgttta tgattgatgt tcaacaatgg 18781 ggttttacag gtaacctaca aagcaaccatgatctgtatt gtcaagtcca tggtaatgca 18841 catgtagcta gttgtgatgc aatcatgactaggtgtctag ctgtccacga gtgctttgtt 18901 aagcgtgttg actggactat tgaatatcctataattggtg atgaactgaa gattaatgcg 18961 gcttgtagaa aggttcaaca catggttgttaaagctgcat tattagcaga caaattccca 19021 gttcttcacg acattggtaa ccctaaagctattaagtgtg tacctcaagc tgatgtagaa 19081 tggaagttct atgatgcaca gccttgtagtgacaaagctt ataaaataga agaattattc 19141 tattcttatg ccacacattc tgacaaattcacagatggtg tatgcctatt ttggaattgc 19201aatgtcgata gatatcctgc taattccattgtttgtagat ttgacactag agtgctatct 19261 aaccttaact tgcctggttg tgatggtggcagtttgtatg taaataaaca tgcattccac 19321 acaccagctt ttgataaaag tgcttttgttaatttaaaac aattaccatt tttctattac 19381 tctgacagtc catgtgagtc tcatggaaaacaagtagtgt cagatataga ttatgtacca 19441 ctaaagtctg ctacgtgtat aacacgttgcaatttaggtg gtgctgtctg tagacatcat 19501 gctaatgagt acagattgta tctcgatgcttataacatga tgatctcagc tggctttagc 19561 ttgtgggttt acaaacaatt tgatacttataacctctgga acacttttac aagacttcag [246] 19621 agtttagaaa atgtggcttt taatgttgtaaataagggac actttgatgg acaacagggt 19681gaagtaccag tttctatcat taataacactgtttacacaa aagttgatgg tgttgatgta 19741 gaattgtttg aaaataaaac aacattacctgttaatgtag catttgagct ttgggctaag 19801 cgcaacatta aaccagtacc agaggtgaaaatactcaata atttgggtgt ggacattgct 19861 gctaatactg tgatctggga ctacaaaagagatgctccag cacatatatc tactattggt 19921 gtttgttcta tgactgacat agccaagaaaccaactgaaa cgatttgtgc accactcact 19981 gtcttttttg atggtagagt tgatggtcaagtagacttat ttagaaatgc ccgtaatggt 20041 gttcttatta cagaaggtag tgttaaaggtttacaaccat ctgtaggtcc caaacaagct 20101 agtcttaatg gagtcacatt aattggagaagccgtaaaaa cacagttcaa ttattataag 20161aaagttgatg gtgttgtcca acaattacctgaaacttact ttactcagag tagaaattta 20221 caagaattta aacccaggag tcaaatggaaattgatttct tagaattagc tatggatgaa 20281 ttcattgaac ggtataaatt agaaggctatgccttcgaac atatcgttta tggagatttt 20341 agtcatagtc agttaggtgg tttacatctactgattggac tagctaaacg ttttaaggaa 20401 tcaccttttg aattagaaga ttttattcctatggacagta cagttaaaaa ctatttcata 20461 acagatgcgc aaacaggttc atctaagtgtgtgtgttctg ttattgattt attacttgat 20521 gattttgttg aaataataaa atcccaagatttatctgtag tttctaaggt tgtcaaagtg 20581 actattgact atacagaaat ttcatttatgctttggtgta aagatggcca tgtagaaaca 20641ttttacccaa aattacaatc tagtcaagcgtggcaaccgg gtgttgctat gcctaatctt 20701 tacaaaatgc aaagaatgct attagaaaagtgtgaccttc aaaattatgg tgatagtgca 20761 acattaccta aaggcataat gatgaatgtcgcaaaatata ctcaactgtg tcaatattta 20821 aacacattaa cattagctgt accctataatatgagagtta tacattttgg tgctggttct 20881 gataaaggag ttgcaccagg tacagctgttttaagacagt ggttgcctac gggtacgctg 20941 cttgtcgatt cagatcttaa tgactttgtctctgatgcag attcaacttt gattggtgat 21001 tgtgcaactg tacatacagc taataaatgggatctcatta ttagtgatat gtacgaccct 21061 aagactaaaa atgttacaaa agaaaatgactctaaagagg gttttttcac ttacatttgt 21121gggtttatac aacaaaagct agctcttggaggttccgtgg ctataaagat aacagaacat 21181 tcttggaatg ctgatcttta taagctcatgggacacttcg catggtggac agcctttgtt 21241 actaatgtga atgcgtcatc atctgaagcatttttaattg gatgtaatta tcttggcaaa 21301 ccacgcgaac aaatagatgg ttatgtcatgcatgcaaatt acatattttg gaggaataca 21361 aatccaattc agttgtcttc ctattctttatttgacatga gtaaatttcc ccttaaatta 21421 aggggtactg ctgttatgtc tttaaaagaaggtcaaatca atgatatgat tttatctctt 21481 cttagtaaag gtagacttat aattagagaaaacaacagag ttgttatttc tagtgatgtt 21541 cttgttaaca actaaacgaa caatgtttgtttttcttgtt ttattgccac tagtctctag [247] 21601tcagtgtgtt aatcttacaa ccagaactcaattaccccct gcatacacta attctttcac 21661 acgtggtgtt tattaccctg acaaagttttcagatcctca gttttacatt caactcagga 21721 cttgttctta cctttctttt ccaatgttacttggttccat gctatacatg tctctgggac 21781 caatggtact aagaggtttg ataaccctgtcctaccattt aatgatggtg tttattttgc 21841 ttccactgag aagtctaaca taataagaggctggattttt ggtactactt tagattcgaa 21901 gacccagtcc ctacttattg ttaataacgctactaatgtt gttattaaag tctgtgaatt 21961 tcaattttgt aatgatccat ttttgggtgtttattaccac aaaaacaaca aaagttggat 22021 ggaaagtgag ttcagagttt attctagtgcgaataattgc acttttgaat atgtctctca 22081gccttttctt atggaccttg aaggaaaacagggtaatttc aaaaatctta gggaatttgt 22141 gtttaagaat attgatggtt attttaaaatatattctaag cacacgccta ttaatttagt 22201 gcgtgatctc cctcagggtt tttcggctttagaaccattg gtagatttgc caataggtat 22261 taacatcact aggtttcaaa ctttacttgctttacataga agttatttga ctcctggtga 22321 ttcttcttca ggttggacag ctggtgctgcagcttattat gtgggttatc ttcaacctag 22381 gacttttcta ttaaaatata atgaaaatggaaccattaca gatgctgtag actgtgcact 22441 tgaccctctc tcagaaacaa agtgtacgttgaaatccttc actgtagaaa aaggaatcta 22501 tcaaacttct aactttagag tccaaccaacagaatctatt gttagatttc ctaatattac 22561aaacttgtgc ccttttggtg aagtttttaacgccaccaga tttgcatctg tttatgcttg 22621 gaacaggaag agaatcagca actgtgttgctgattattct gtcctatata attccgcatc 22681 attttccact tttaagtgtt atggagtgtctcctactaaa ttaaatgatc tctgctttac 22741 taatgtctat gcagattcat ttgtaattagaggtgatgaa gtcagacaaa tcgctccagg 22801 gcaaactgga aagattgctg attataattataaattacca gatgatttta caggctgcgt 22861 tatagcttgg aattctaaca atcttgattctaaggttggt ggtaattata attacctgta 22921 tagattgttt aggaagtcta atctcaaaccttttgagaga gatatttcaa ctgaaatcta 22981 tcaggccggt agcacacctt gtaatggtgttgaaggtttt aattgttact ttcctttaca 23041atcatatggt ttccaaccca ctaatggtgttggttaccaa ccatacagag tagtagtact 23101 ttcttttgaa cttctacatg caccagcaactgtttgtgga cctaaaaagt ctactaattt 23161 ggttaaaaac aaatgtgtca atttcaacttcaatggttta acaggcacag gtgttcttac 23221 tgagtctaac aaaaagtttc tgcctttccaacaatttggc agagacattg ctgacactac 23281 tgatgctgtc cgtgatccac agacacttgagattcttgac attacaccat gttcttttgg 23341 tggtgtcagt gttataacac caggaacaaatacttctaac caggttgctg ttctttatca 23401 ggatgttaac tgcacagaag tccctgttgctattcatgca gatcaactta ctcctacttg 23461 gcgtgtttat tctacaggtt ctaatgtttttcaaacacgt gcaggctgtt taataggggc 23521tgaacatgtc aacaactcat atgagtgtgacatacccatt ggtgcaggta tatgcgctag [248] 23581 ttatcagact cagactaatt ctcctcggcgggcacgtagt gtagctagtc aatccatcat 23641 tgcctacact atgtcacttg gtgcagaaaattcagttgct tactctaata actctattgc 23701 catacccaca aattttacta ttagtgttaccacagaaatt ctaccagtgt ctatgaccaa 23761 gacatcagta gattgtacaa tgtacatttgtggtgattca actgaatgca gcaatctttt 23821 gttgcaatat ggcagttttt gtacacaattaaaccgtgct ttaactggaa tagctgttga 23881 acaagacaaa aacacccaag aagtttttgcacaagtcaaa caaatttaca aaacaccacc 23941 aattaaagat tttggtggtt ttaatttttcacaaatatta ccagatccat caaaaccaag 24001caagaggtca tttattgaag atctacttttcaacaaagtg acacttgcag atgctggctt 24061 catcaaacaa tatggtgatt gccttggtgatattgctgct agagacctca tttgtgcaca 24121 aaagtttaac ggccttactg ttttgccacctttgctcaca gatgaaatga ttgctcaata 24181 cacttctgca ctgttagcgg gtacaatcacttctggttgg acctttggtg caggtgctgc 24241 attacaaata ccatttgcta tgcaaatggcttataggttt aatggtattg gagttacaca 24301 gaatgttctc tatgagaacc aaaaattgattgccaaccaa tttaatagtg ctattggcaa 24361 aattcaagac tcactttctt ccacagcaagtgcacttgga aaacttcaag atgtggtcaa 24421 ccaaaatgca caagctttaa acacgcttgttaaacaactt agctccaatt ttggtgcaat 24481ttcaagtgtt ttaaatgata tcctttcacgtcttgacaaa gttgaggctg aagtgcaaat 24541 tgataggttg atcacaggca gacttcaaagtttgcagaca tatgtgactc aacaattaat 24601 tagagctgca gaaatcagag cttctgctaatcttgctgct actaaaatgt cagagtgtgt 24661 acttggacaa tcaaaaagag ttgatttttgtggaaagggc tatcatctta tgtccttccc 24721 tcagtcagca cctcatggtg tagtcttcttgcatgtgact tatgtccctg cacaagaaaa 24781 gaacttcaca actgctcctg ccatttgtcatgatggaaaa gcacactttc ctcgtgaagg 24841 tgtctttgtt tcaaatggca cacactggtttgtaacacaa aggaattttt atgaaccaca 24901 aatcattact acagacaaca catttgtgtctggtaactgt gatgttgtaa taggaattgt 24961caacaacaca gtttatgatc ctttgcaacctgaattagac tcattcaagg aggagttaga 25021 taaatatttt aagaatcata catcaccagatgttgattta ggtgacatct ctggcattaa 25081 tgcttcagtt gtaaacattc aaaaagaaattgaccgcctc aatgaggttg ccaagaattt 25141 aaatgaatct ctcatcgatc tccaagaacttggaaagtat gagcagtata taaaatggcc 25201 atggtacatt tggctaggtt ttatagctggcttgattgcc atagtaatgg tgacaattat 25261 gctttgctgt atgaccagtt gctgtagttgtctcaagggc tgttgttctt gtggatcctg 25321 ctgcaaattt gatgaagacg actctgagccagtgctcaaa ggagtcaaat tacattacac 25381 ataaacgaac ttatggattt gtttatgagaatcttcacaa ttggaactgt aactttgaag 25441caaggtgaaa tcaaggatgc tactccttcagattttgttc gcgctactgc aacgataccg 25501 atacaagcct cactcccttt cggatggcttattgttggcg ttgcacttct tgctgttttt [249] 25561 cagagcgctt ccaaaatcat aaccctcaaaaagagatggc aactagcact ctccaagggt 25621 gttcactttg tttgcaactt gctgttgttgtttgtaacag tttactcaca ccttttgctc 25681 gttgctgctg gccttgaagc cccttttctctatctttatg ctttagtcta cttcttgcag 25741 agtataaact ttgtaagaat aataatgaggctttggcttt gctggaaatg ccgttccaaa 25801 aacccattac tttatgatgc caactattttctttgctggc atactaattg ttacgactat 25861 tgtatacctt acaatagtgt aacttcttcaattgtcatta cttcaggtga tggcacaaca 25921agtcctattt ctgaacatga ctaccagattggtggttata ctgaaaaatg ggaatctgga 25981 gtaaaagact gtgttgtatt acacagttacttcacttcag actattacca gctgtactca 26041 actcaattga gtacagacac tggtgttgaacatgttacct tcttcatcta caataaaatt 26101 gttgatgagc ctgaagaaca tgtccaaattcacacaatcg acggttcatc cggagttgtt 26161 aatccagtaa tggaaccaat ttatgatgaaccgacgacga ctactagcgt gcctttgtaa 26221 gcacaagctg atgagtacga acttatgtactcattcgttt cggaagagac aggtacgtta 26281 atagttaata gcgtacttct ttttcttgctttcgtggtat tcttgctagt tacactagcc 26341 atccttactg cgcttcgatt gtgtgcgtactgctgcaata ttgttaacgt gagtcttgta 26401aaaccttctt tttacgttta ctctcgtgttaaaaatctga attcttctag agttcctgat 26461 cttctggtct aaacgaacta aatattatattagtttttct gtttggaact ttaattttag 26521 ccatggcaga ttccaacggt actattaccgttgaagagct taaaaagctc cttgaacaat 26581 ggaacctagt aataggtttc ctattccttacatggatttg tcttctacaa tttgcctatg 26641 ccaacaggaa taggtttttg tatataattaagttaatttt cctctggctg ttatggccag 26701 taactttagc ttgttttgtg cttgctgctgtttacagaat aaattggatc accggtggaa 26761 ttgctatcgc aatggcttgt cttgtaggcttgatgtggct cagctacttc attgcttctt 26821 tcagactgtt tgcgcgtacg cgttccatgtggtcattcaa tccagaaact aacattcttc 26881tcaacgtgcc actccatggc actattctgaccagaccgct tctagaaagt gaactcgtaa 26941 tcggagctgt gatccttcgt ggacatcttcgtattgctgg acaccatcta ggacgctgtg 27001 acatcaagga cctgcctaaa gaaatcactgttgctacatc acgaacgctt tcttattaca 27061 aattgggagc ttcgcagcgt gtagcaggtgactcaggttt tgctgcatac agtcgctaca 27121 ggattggcaa ctataaatta aacacagaccattccagtag cagtgacaat attgctttgc 27181 ttgtacagta agtgacaaca gatgtttcatctcgttgact ttcaggttac tatagcagag 27241 atattactaa ttattatgag gacttttaaagtttccattt ggaatcttga ttacatcata 27301 aacctcataa ttaaaaattt atctaagtcactaactgaga ataaatattc tcaattagat 27361gaagagcaac caatggagat tgattaaacgaacatgaaaa ttattctttt cttggcactg 27421 ataacactcg ctacttgtga gctttatcactaccaagagt gtgttagagg tacaacagta 27481 cttttaaaag aaccttgctc ttctggaacatacgagggca attcaccatt tcatcctcta [250] 27541 gctgataaca aatttgcact gacttgctttagcactcaat ttgcttttgc ttgtcctgac 27601 ggcgtaaaac acgtctatca gttacgtgccagatcagttt cacctaaact gttcatcaga 27661 caagaggaag ttcaagaact ttactctccaatttttctta ttgttgcggc aatagtgttt 27721 ataacacttt gcttcacact caaaagaaagacagaatgat tgaactttca ttaattgact 27781 tctatttgtg ctttttagcc tttctgctattccttgtttt aattatgctt attatctttt 27841ggttctcact tgaactgcaa gatcataatgaaacttgtca cgcctaaacg aacatgaaat 27901 ttcttgtttt cttaggaatc atcacaactgtagctgcatt tcaccaagaa tgtagtttac 27961 agtcatgtac tcaacatcaa ccatatgtagttgatgaccc gtgtcctatt cacttctatt 28021 ctaaatggta tattagagta ggagctagaaaatcagcacc tttaattgaa ttgtgcgtgg 28081 atgaggctgg ttctaaatca cccattcagtacatcgatat cggtaattat acagtttcct 28141 gtttaccttt tacaattaat tgccaggaacctaaattggg tagtcttgta gtgcgttgtt 28201 cgttctatga agacttttta gagtatcatgacgttcgtgt tgttttagat ttcatctaaa 28261 cgaacaaact aaaatgtctg ataatggaccccaaaatcag cgaaatgcac cccgcattac 28321gtttggtgga ccctcagatt caactggcagtaaccagaat ggagaacgca gtggggcgcg 28381 atcaaaacaa cgtcggcccc aaggtttacccaataatact gcgtcttggt tcaccgctct 28441 cactcaacat ggcaaggaag accttaaattccctcgagga caaggcgttc caattaacac 28501 caatagcagt ccagatgacc aaattggctactaccgaaga gctaccagac gaattcgtgg 28561 tggtgacggt aaaatgaaag atctcagtccaagatggtat ttctactacc taggaactgg 28621 gccagaagct ggacttccct atggtgctaacaaagacggc atcatatggg ttgcaactga 28681 gggagccttg aatacaccaa aagatcacattggcacccgc aatcctgcta acaatgctgc 28741 aatcgtgcta caacttcctc aaggaacaacattgccaaaa ggcttctacg cagaagggag 28801cagaggcggc agtcaagcct cttctcgttcctcatcacgt agtcgcaaca gttcaagaaa 28861 ttcaactcca ggcagcagta ggggaacttctcctgctaga atggctggca atggcggtga 28921 tgctgctctt gctttgctgc tgcttgacagattgaaccag cttgagagca aaatgtctgg 28981 taaaggccaa caacaacaag gccaaactgtcactaagaaa tctgctgctg aggcttctaa 29041 gaagcctcgg caaaaacgta ctgccactaaagcatacaat gtaacacaag ctttcggcag 29101 acgtggtcca gaacaaaccc aaggaaattttggggaccag gaactaatca gacaaggaac 29161 tgattacaaa cattggccgc aaattgcacaatttgccccc agcgcttcag cgttcttcgg 29221 aatgtcgcgc attggcatgg aagtcacaccttcgggaacg tggttgacct acacaggtgc 29281catcaaattg gatgacaaag atccaaatttcaaagatcaa gtcattttgc tgaataagca 29341 tattgacgca tacaaaacat tcccaccaacagagcctaaa aaggacaaaa agaagaaggc 29401 tgatgaaact caagccttac cgcagagacagaagaaacag caaactgtga ctcttcttcc 29461 tgctgcagat ttggatgatt tctccaaacaattgcaacaa tccatgagca gtgctgactc [251] 29521 aactcaggcc taaactcatg cagaccacacaaggcagatg ggctatataa acgttttcgc 29581 ttttccgttt acgatatata gtctactcttgtgcagaatg aattctcgta actacatagc 29641 acaagtagat gtagttaact ttaatctcacatagcaatct ttaatcagtg tgtaacatta 29701 gggaggactt gaaagagcca ccacattttcaccgaggcca cgcggagtac gatcgagtgt 29761acagtgaaca atgctaggga gagctgcctatatggaagag ccctaatgtg taaaattaat 29821 tttagtagtg ctatccccat gtgattttaatagcttctta ggagaatgac aaaaaaaaaa |