The complex world of polysaccharides edited by Desiree Nedra Karunaratne

 

Is Chitosan a New Panacea? Areas of Application 

 

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[134] Allan G (1984) Biochemical applications of chitin and chitosan. In Zikakis J, editor. 

Chitin, Chitosan and related enzymes. Orland, FL: Academic Press. pp 119-133. ISBN 

0127809503, 9780127809502. 

[135] Ohshima Y, Nishino K, Yonekura Y, Kishimoto S and Wakabayashy S (1987). Clinical 

application of chitin non-woven fabric as a wound dreesing. Eur. J. plast. surg. 10:66-69. 

DOI: 10.1007/BF00578375. 

[136] Minami S, Okamoto Y, Tanioka S, Sashiwa H,Saimoto H, Matsuhashi A, Shigemasa Y 

(1993) Effects of chitosan on wound healing. In M. Yalpani, Carbohydrates and 

carbohydrate polymers: analysis, biotechnology, modification, antiviral, biomedical and 

other applications. pp. 141-152. Vol 1Mount Prospect: ATL Press. ISBN 1882360400, 

9781882360406. 

[137] Okamoto Y, Minami S, Matsuhashi A ,Sashiwa H, Saimoto H, Shigemasa Y, Taniagua 

T, Tanaka Y, and Tokura S (1993) Application of polymeric N-acetyl-D-glucosamine 

(chitin) to veterinary practice. J. vet. med. sci. 55, 743-747. (PMID:8286525). 

[138] Okamoto Y, Kawakami K, Miyatake K, Morimoto M, Shigemasa Y, Minami S (2002) 

Analgesic effects of chitin and chitosan. Carbohyd. Polym. 49:249-252. ISSN: 01448617. 

DOI: http://dx.doi.org/10.1016/S0144-8617(01)00316-2,. 

[139] Qin CQ, Du YM, Xiao L, Li Z and Gao XH (2002a) Enzymic preparation of water 

soluble chitosan and their antitumor activity. Int. j. biol. macromol. 31:111-117. ISSN 

0141-8130. DOI http://dx.doi.org/10.1016/S0141-8130(02)00064-8. 

[140] Jeon Y-J and Kim S-K (2002) Antitumor Activity of Chitosan Oligosaccharides 

Produced In Ultrafiltration Membrane Reactor System. J. microbiol. biotechnol. 12:503-

507. ISSN 1017-7825. 

[141] Maeda Y and Kimura Y (2004) Antitumor Effects of Various Low-Molecular-Weight 

Chitosans Are Due to Increased Natural Killer Activity of Intestinal Intraepithelia 

lymphocytes in sarcoma 180-bearing mice. J. nutr. 134:945-950. 

[142] Qin CQ, Zhou B, Zeng L, Zhang Z, Liu Y.; Du, Y.M. & Xiao, L. (2004). The 

physicochemical properties and antitumor activity of cellulose-treated chitosan. Food 

Chem., 84, 107-115, ISSN 0308-8146. doi:10.1016/S0308-8146(03)00181-X. 

[143] Qin CQ, Du YM, Xiao L, Gao XH, Zhou JL and Liu HL (2002b) Effect of Molecular 

Weight and Structure on Antitumor Activity of Oxidized Chitosan. Wuhan univ. j. nat. 

sci., 7, 231-236, ISSN 1007-1202. DOI: 10.1007/BF02830325. 

[144] Harish Prashanth KV and Tharanathan RN (2005) Depolymerized products of chitosan 

as potent inhibitors of tumor-induced angiogenesis. Biochim. Biophys. Acta, 1722, 22-

29, ISSN 0006-3002. DOI: 10.1016/j.bbagen.2004.11.009. 

[145] Wang S-L, Lin T-Y, Yen Y-H, Liao H-F and Chen Y-J (2006) Bioconversion of shellfish 

chitin wastes for the production of Bacillus subtilis W-118 chitinase. Carbohydr. res., 

341, 2507–2515, ISSN 0008-6215. DOI: 10.1016/j.carres.2006.06.027. 

[146]  Parvez S, Rahman MM, Khan MA, Khan MAH, Islam JMM, Ahmed M, Rahman MF, 

Ahmed B (2012) Preparation and characterization of artificial skin using chitosan and 

gelatin composites for potential biomedical application. Polymer Bulletin: 1-17. Article 

in Press. DOI: 10.1007/s00289-012-0761-7. 

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The Complex World of Polysaccharides 

 

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[147] Brandl F, Sommer F, Goepferich A (2007) Rational design of hydrogels for tissue 

engineering: Impact of physical factors on cell behavior. Biomaterials. 28:134–146. ISSN: 

01429612. DOI: 10.1016/j.biomaterials.2006.09.017. 

[148] Tsioptsias C, Tsivintzelis I, Papadopoulou L, Panayiotou C A.(2009) novel method for 

producing tissue engineering scaffolds from chitin, chitin-hydroxyapatite, and cellulose. 

Mater. Sci. Eng. C. 29: 159–164. ISSN: 09284931. DOI: 10.1016/j.msec.2008.06.003. 

[149] Drury JL and Mooney DJ(2003) Hydrogels for tissue engineering: scaffold design 

variables and applications. Biomaterials 24, 4337–4351. ISSN: 01429612. DOI: 

10.1016/S0142-9612(03)00340-5. 

[150] Khor E and Lim LY (2003) Implantable applications of chitin and chitosan. 

Biomaterials 24: 2339–2349. ISSN: 01429612 DOI: 10.1016/S0142-9612(03)00026-7. 

[151] Klokkevold PR, Fukayama H, Sung EC, Bertolami CN (1999) The effect of chitosan 

(poly-N-acetyl glucosamine) on lingual hemostasis in heparinized rabbits. J. oral 

maxillofac. surg. 57: 49–52. PII: S0278-2391(99)90632-8 

[152] Okamoto Y, Yano R, Miyatake K, Tomohiro I, Shigemasa Y, Minami S (2003) Effects of 

chitin and chitosan on blood coagulation. Carbohyd. polym. 53: 337-342. ISSN: 

01448617. DOI: 10.1016/S0144-8617(03)00076-6. 

[153] Freier T, Montenegro R, Shan Koh H, Shoichet S (2005) Chitin-based tubes for tissue 

engineering in the nervous system. Biomaterials. 26: 4624–4632. ISSN: 01429612. DOI: 

10.1016/j.biomaterials.2004.11.040. 

[154] Gong Y, Gong L, Gu X, Ding F (2009) Chitooligosaccharides promote peripheral nerve 

regeneration in a rabbit common peroneal nerve crush injury model. Microsurgery. 

29(8): 650–656. ISSN: 07381085 DOI: 10.1002/micr.20686 

[155] Aam B, Heggset E, Norberg A, SØrlie M, Vårum K, Eijsink V (2010)Production of 

Chitooligosaccharides and Their Potential Applications in Medicine. Mar. Drugs. 

8(5)1482–1517. ISSN: 16603397 DOI: 10.3390/md8051482 

[156] Muzzarelli RAA(2010) Chitins and chitosans as immunoadjuvants and non-allergenic 

drug carriers. Mar. Drugs, 8, 292–312. ISSN: 16603397. DOI: 10.3390/md8020292. 

[157] Jeong HJ, Koo HN, Oh EY, Chae HJ, Kim HR, Suh SB, Kim CH, Cho KH, Park BR, 

Park ST, Lee YM, Kim HM (2000)Nitric oxide production by high molecular weight 

water-soluble chitosan via nuclear factor-kappaB activation. Int. j. immunopharmacol. 

22: 923–933. http://dx.doi.org/10.1016/S0192-0561(00)00055-2. 

[158] Minami S, Suzuki H, Okamoto Y, Fujinaga T, Shigemasa Y (1998) Chitin and chitosan 

activate complement via the alternative pathway. Carbohyd. polym. 36: 151-155. ISSN: 

01448617. http://dx.doi.org/10.1016/S0144-8617(98)00015-0. 

[159] Freier T, Montenegro R, Shan Koh H, Shoichet MS (2005) Chitin-based tubes for tissue 

engineering in the nervous system. Biomaterials. 26: 4624–4632. ISSN: 01429612. DOI: 

10.1016/j.biomaterials.2004.11.040. 

[160] Razdan A and Pettersson D (1994) Effect of chitin and chitosan on nutrient 

digestibility and plasma lipid concentrations in broiler chickens. Br. j. nutr. 72: 277–288. 

ISSN: 00071145 . DOI: 10.1079/BJN19940029. 

[161] Muzzarelli RAA and Muzzarelli C (2006) Chitosan, a dietary supplement and a food 

technology commodity. In Functional Food Carbohydrates; Biliaderis, C.G., Izydorczyk, 

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