The complex world of polysaccharides edited by Desiree Nedra Karunaratne

Complexes of Polysaccharides and Glycyrrhizic Acid with Drug Molecules   

Mechanochemical Synthesis and Pharmacological Activity  601 

[48] G.A.Tolstikov, L.A.Baltina, V.P.Grankina, R.M.Kondratenko, T.G. Tolstikova (2007) 

Licorice: biodiversity, chemistry and application in medicine, Academic Publishing 

House “GEO”, Novosibirsk, 311p. (rus).  

[49] G.A.Tolstikov, Yu.I.Murinov and others (1991) Complexes of β-glycyrrhizic  acid  

with prostaglandins – new class of uterotonic agents. Pharm. Chem. J. 3: 42-44  

(rus). 

[50] A.O.Bryzgalov, T.G.Tolstikova, I.V.Sorokina and others (2005) Antiarrhythmic activity 

of alaglizin. J. Expert Clin. Pharm. 68(4): 24-28 (rus). 

[51] T.G.Tolstikova, A.O.Bryzgalov, I.V.Sorokina, M.V.Hvostov and others (2007) Increase in 

Pharmacological Activity of Drugs in their Clathrates with Plant Glycosides. Letters in 

Drug Design & Discovery. 4: 168-170. 

[52] T.G.Tolstikova, M.V.Khvostov, A.O.Bryzgalov, A.V.Dushkin, E.S.Meteleva (2009) 

Complex of Nifedipine with Glycyrrhizic Acid as a Novel Water-Soluble 

Antihypertensive and Antiarrhythmic Agent. Letters in Drug Design & Discovery. 6: 

155-158. 

[53] T.G.Tolstikova, G.I.Lifshits, M.V.Khvostov, A.O.Bryzgalov, I.V.Sorokina. (2007) 

Complexing in the development of low-dose beta-adrenoceptor antagonists 

(experimental study). Herald of the NSU. Series: biology, clinical medicine. 2(5): 70-73 

(rus). 

[54] X.Zhu,. W.G.Shin (2005) Gender Differences in Pharmacokinetics of Oral Warfarin in 

Rats. Biopharm. Drug Dispos. 26: 147-150. 

[55] D.F.Avgustinovich, I.L.Kovalenko, I.V.Sorokina, T.G.Tolstikova, A.G.Tolstikov (2004) 

Ethological study of antidepressant effect of fluaglisine in conditions of chronic social stress 

in mice. Bul. Exp. Biol. and Med. 137(1):99-103. 

[56] T.G.Tolstikova, I.V.Sorokina, I.L.Kovalenko and others (2004) Influence of clathrate 

formation to the pharmacon activity in complexes with glycyrrhizic acid. Doklady 

Akademii Nauk. 394(2):707-709. 

[57] G.T.Shishkina, N.N.Dygalo, A.M.Yudina and others (2005) Effects of Fluoxetine and Its 

Complexes with Glycyrrizhinic Acid on Behavior and Brain Monoamine Levels in Rats. 

I. P. Pavlov Journal of Higher Nervous Activity. 2: 207-212 (rus). 

[58] L.A.Baltina, Yu.I.Murinov, A.F.Ismagilova, G.A.Tolstikov and others (2003) Production 

and antineoplastic action of complex compounds of β-glycerrhizic acid with some 

antineoplastic drugs. Pharm. Chem. J. 37: 3-4 (rus). 

[59] R.M.Kondratenko, L.A.Baltina, G.A.Tolstikov and others (2003) Complex compounds of 

glycerrhizic acid with antimicrobial drugs. Pharm. Chem. J. 37: 32-35 (rus). 

[60] V.A.Vavilin, N.F.Salakhutdinov, Yu.I.Ragino and others (2008) Hypocholesteremic 

properties of complex compound of simvastatin with glycerrhizic acid (simvaglizin) in 

experimental models. Biomed. Chem. 54: 301-313. 

[61] Yu.I.Ragino, V.A.Vavilin, N.F.Salakhutdinov and others (2008) Examination of the 

hypocholesteremic effect and safety of simvaglizin on the model of 

hypercholesterolemia in rabbits. Bull. Exp. Biol. Med. 145: 285-287. 

---

 

The Complex World of Polysaccharides 

602 

[62] E. N. Medvedeva, V. A. Babkin, L. A. Ostroukhova (2003) Larch arabinogalactan - 

features and prospects, Review Chemistry of Vegetable Raw Materials [Khimiya 

rastitel'nogo syr´y], 1: 27-37 (rus). 

---

Chapter 23 

 

 

 

 

© 2012 Rodrigues et al., licensee InTech. This is an open access chapter distributed under the terms of the 

Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits 

unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 

The Chitosan as Dietary Fiber:  

An in vitro Comparative Study  

of Interactions with Drug  

and Nutritional Substances 

Máira Regina Rodrigues, Alexandre de Souza e Silva and Fábio Vieira Lacerda 

Additional information is available at the end of the chapter 

http://dx.doi.org/10.5772/48311 

1. Introduction 

Obesity is considered a disease that has grown significantly in the last two decades 

worldwide. The concern with this increase is justified because obesity develops and remains 

due to different factors, causing several other diseases and sometimes, can lead to death. 

Several strategies have been searched to control its progress usually through therapies and, 

in critical cases, surgeries. Despite all efforts, statistical studies show that obesity is still 

growing consequently generates the necessity of further studies on the subject (Dacome, 

2005). 

Epidemiological researches have studied the impact of overweight and obesity on the risk of 

chronic disease, as coronary heart disease, type 2 diabetes mellitus, hypertension, stroke, 

dyslipidemia, insulin-resistance, glucose intolerance, metabolic syndrome, and cancers of 

the breast, endometrium, prostate and colon (Aslander-van Vliet et al., 2007). Health 

consequences and compromised quality of life associated with obesity provide incentives to 

abate the obesity epidemic. However, despite recognition of these effects, the epidemic of 

obesity and overweight is not reversed (Johnson et al., 2007). 

In general, treatments for obesity are based on regular exercise, nutritional reeducation, 

pharmacological treatment, behavioral therapy and use of dietary fibers that promote the 

reduction of fat absorption (Aslander-van Vliet et al., 2007). Much research has been 

conducted on the dietary supplements that promote the reduction of body weight and fat 

mass (Saper et al., 2004). These ingredients reportedly act as a fiber to increase satiety and 

also to decrease the absorption of fat by binding to it (Kumirska et al., 2010). 

---