Therapeutic possibilities for the correction of cognitive and psychoemotional impairments in patients with post-covid syndrome
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- Bu səhifədəki naviqasiya:
- After treatment Before treatment After treatment
- MMSE (balls)
- Schulte (points)
- Test score 10 words (seconds)
- Delayed playback
Note: * - significant difference between the results before and after treatment (p<0.05). When comparing using the Wilcoxon test for conjugated samples, as well as intergroup comparison (Mann-Whitney test), the dynamics of p-significance had the following indicators: statistical significance was determined only in the A-subgroup during comparison, it was at this point in time that the most significant increase in test scores occurred. The earlier the BAC therapy is carried out, the faster the positive dynamics in the acute period is noted, the longer the drug intake contributed to a more stable positive dynamics in the future (consolidation of the achieved result). Comparison of quantitative data using the Mann-Whitney test showed an approximate to statistically significant difference between subgroups at visit 1 (p 0.068), and at subsequent visits - a significant statistical significance of differences (visit 2 p 0.02, visit 3 p 0.007, visit 4 p 0.01). The statistical significance of the differences between subgroups at visit 1 was 0.04 (Freeman-Holton). It should be noted that at visits 3 and 4 there were no patients with dementia in the main group, while in the control group the percentage of patients with severe CI increased to 18% (3 people). At the same time, among patients of the A-subgroup, over a given period of time, the performance of the neuropsychological test MMSE improved significantly (by 67%). Assessment of cognitive status with a 10-word test Interesting results were obtained when processing the 10-word memorization test (this test reflects the state of memory, the process of memorizing words and storing memorized information). The indicator of short-term memory showed intergroup statistically significant differences in delayed reproduction of information (Table 3). The indicator of delayed recall after treatment in the B-subgroup had a positive trend, and in the A-subgroup it had a more pronounced statistically significant positive trend, which confirms the effective effect of BAC therapy on mnestic functions. There was an increase in the number of reproduced words, the quality of delayed memory improved (by 25%) (p 0.02). The statistical significance of intergroup differences is determined at visit 1 and all subsequent visits by the chi-square test and at visits 1 (p 0.047), 4 (p 0.015) by the Mann-Whitney test. Intergroup differences were assessed, the criterion of the total cognitive score was applied (comparison base - CG and visit 0), significant statistically significant dynamics was observed when comparing group indicators. Schulte’s level of attention The results of data processing according to the Schulte test are quite interesting. The technique is used to study the rate of sensorimotor reactions and characteristics of attention, the level of mental performance. The average time to complete a task according to one table is normally 30–40 seconds []. As can be seen from Table 3, the descriptive statistics (mean ± standard deviation) are quite different between the study groups. The Schulte test does not involve a variable assessment of cognitive status. It seems to the researcher that precisely because of this, and also because of the small sample sizes, the processing results do not have p-significance. In a visit comparison of the two studied populations (Mann-Whitney test), close to the critical value of the quantitative indicator of the degree of distrust in the conclusion about the presence of a connection (p 0.05) was observed at visits 1 and 2, at visits 3 and 4, statistical significance increased to 0.023 and 0.016, respectively. However, the most interesting are intra-group comparisons (Wilcoxon's T-test). In the control group, no statistically significant differences were observed, both in stepwise comparison (visit 0 1 p 0.49, visit 0 2 p 0.834, visit 0 3 p 0.366, visit 0 4 p 0.257), and in pairwise comparison of the primary data of visit 0 with each subsequent one (visit 0 1 p 0.49, visit 0 2 p 0.743, visit 0 3 r 0.675, visit 0 4 r 0.224. In the main group, when comparing visit 0 in pairs with subsequent ones, the statistical significance has a pronounced tendency to stabilization (visit 0 1 р 0.026, visit 0 2 р 0.237, visit 0 3 р 0.773, visit 0 4 р 0.576), and in stepwise comparison it acquires a significant statistical value of the p indicator (visit 0 1 р 0.026, visit 0 2 р 0.008, visit 0 3 r 0.01, visit 0 4 r 0.009). Yüklə 214,17 Kb. Dostları ilə paylaş:
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