Two Years Eligibility: Bachelor’s degree in Pharmacy with

SEMESTER 4

S.No		Paper		Course Title					L		T	P		Cr				% Weightage					E
		Code														A			B		C	D
1		PMC. 605		Medicinal Chemistry of Anticancer Agents					4		1	-		4		25			25		25	25	100
2		PMC. 606		Thesis Evaluation and Viva Voce					-		-	-		20		-			-		-	-	500
					04	-	4	24												600

1. 
   Continuous Assessment: Based on Objective Type Tests
   
2. 
   Pre-Scheduled Test-1: Based on Objective Type & Subjective Type Test (By Enlarged Subjective Type)
   
3. 
   Pre-Scheduled Test-2: Based on Objective Type & Subjective Type Test (By Enlarged Subjective Type)
   
4. 
   End-Term Exam (Final): Based on Objective Type Tests
   
5. 
   Total Marks
   

L: Lectures T: Tutorial P: Practical Cr: Credits

Semester 1

Course Tile: Computer Applications		L	T	P	Credits	Marks
Paper Code: PMC.501		2	0	0	2	50

Unit 1 18 hours

Fundamentals of computers: Parts of computers, Hardware, BIOS, Operating systems, Binary system, Logic gates and Boolean algebra.

Application software: Spreadsheet applications, Word-processing applications, Presentation applications, Internet browsers, Reference Management, and Image processing applications.

Unit 2 18 hours

Computer language: Basic DOS commands, AutoHotKey scripting language, HTML and basic structure of a webpage, Designing websites.

World wide web: Origin and concepts, Latency and bandwidth, Searching the internet, Advanced web-search using Boolean logic, Cloud computing.

Suggested Readings:

1. 
   Gookin, D. (2007). MS Word 2007 for Dummies. Wiley.
   
2. 
   Harvey, G. (2007). MS Excel 2007 for Dummies. Wiley.
   
3. 
   Johnson, S. (2009). Windows 7 on demand. Perspiration Inc.
   
4. 
   Norman, G. and Streiner, D. (3^rd edn) (2008). Biostatistics: The Bare Essentials. Decker Inc., Canada.
   
5. 
   Sokal, R.R. and Rohlf, F.J. (1994). Biometry: The Principles and Practices of Statistics in Biological Research, W.H. Freeman and Company, New York.
   
6. 
   Thurrott, P. and Rivera, R. (2009). Windows 7 Secrets. Wiley.
   

Course Tile: Organic Chemistry-I		L	T	P	Credits	Marks
Paper Code: PMC.502		4	1	0	4	100

Unit 1 22 hours

Stereochemistry: IUPAC nomenclature of organic molecules, Elements of symmetry, chirality, Projection formulae [Fly wedge, Fischer, Newman and Saw horse], Configurational and conformational isomerism in acyclic and cyclic compounds; stereogenicity, stereoselectivity, enantioselectivity, diastereoselectivity, racemic mixture and their resolution, configurational notations of simple molecules, DL and RS configurational notations, threo and erythro isomers, methods of resolution, optical purity, enantiotopic and diastereotopic atoms, groups and faces, stereospecific and stereoselective synthesis, Asymmetric synthesis, Optical activity in the absence of chiral carbon (biphenyls, allenes and spiranes), chirality due to helical shape, stereochemistry of the compounds containing nitrogen, sulphur and phosphorus, conformational analysis of cyclic compounds such as cyclopentane, cyclohexane, cyclohexanone derivatives, decalins, 1,2-; 1,3-, 1,4-disubstituted cyclohexane derivatives and D-Glucose, effect of conformation on the course of rate of reactions, effect of conformation on reactivity, conformation of sugars, strain due to unavoidable crowding, geometrical isomerism, cis–trans and E-Z conventions, methods of inter-conversion of E and Z isomers, determination of configuration by physical and chemical methods.

Unit 2 18 hours

Aliphatic nucleophilic subsitution reaction: The SN2, SN1, mixed SN1 and SN2 and SET mechanism, The SNi mechanism. Nucleophilic substitution at an allylic, aliphatic and vinylic carbon. Reactivity effects of substrate structure, attacking nucleophile, leaving group and reaction medium, ambident nucleophile, regioselectivity, competition between SN1 and SN2 mechanism.

Aromatic nucleophilci substitution: The SNAr, benzyne and SN1 mechanism, reactivity effect of substrate structure, leaving group and attacking nucleophile.

Aliphatic electrophilic substitution: Bimolecular mechanisms SE2 and SE1 mechanism, electrophilic substution accompanied by double bond shifts, effect of substrates, leaving groups and the solvent polarity on the reactivity.

Aromatic electrophilic substitution: The arenium ion mechanism, orientation and reactivity, energy profile diagrams, ortho/para ratio, ipso attack, orientation in other ring systems, quantitative treatment of reactivity in substrates and electrophiles, Diazonium coupling, Vilsmeir reaction, Gatterman-Koch reaction.

Unit 3 16 hours

Elimination reactions: The E2, E1 and E1cB mechanisms and their spectrum, orientation of the double bond, reactivity effects of substrate structures, attacking base, the leaving group and the medium, mechanism and orientation in pyrolytic elimination.

Addition to carbon-carbon multiple bonds: Mechanistic and stereochemical aspects of addition reactions involving electrophiles, nucleophiles and free radicals, Regio- and chemoselectivity, orientation and reactivity, hydroboration, alkylation, epoxidation and hydroxylation, addition of halogen polar reagents to alkenes.

Unit 4 16 hours

Addition to carbon-hetero multiple bonds: Reactivity of carbonyl group, homologation and dehomologation of carbonyl compounds, nucleophilic addition of hetero-atoms (N,O,S), conjugate addition reactions, acylation of carbonyl carbon, carbonyl cyclizations and cleavages, carboxylic acids and derivatives, decarboxylation reactions, addition of Grignard, organozinc and organolithium reagents to carbonyl and unsaturated carbonyl compounds, mechanism of condensation reactions involving enolates-Aldol, Knoevenagel, Claisen, Mannich, Benzoin, Perkin and Stobbe reactions, hydrolysis of esters and amides, ammonolysis of esters.

Suggested Readings:

1. 
   Finar, I.L., (2003). Organic Chemistry Vol. 1. Pearson Education, 4^th edition.
   
2. 
   Mc Murry J., Organic Chemistry, Asian Book Pvt. Ltd, 8^th edition, New Delhi
   
3. 
   Smith, M. B. (2013). March's advanced organic chemistry: reactions, mechanisms, and structure. John Wiley & Sons.
   
4. 
   Ahluwalia, V. K., and Parasar R. K., (2011). Organic Reaction Mechanism, Narosa Publishing House (P) Ltd., 4^th edition, New Delhi-110002.
   
5. 
   Bansal, R. K., (2010). A text book of Organic Chemistry, New Age Inrternational (P) Ltd., 5^th edition, New Delhi.
   
6. 
   Bansal R.K., (2010). Organic Reaction Mechanism, New Age International (P) Ltd., New Delhi.
   
7. 
   Kalsi, P.S., (2010). Organic Reactions and Their Mechanisms. New Age International Pub., 3^rd edition, New Delhi.
   
8. 
   Kalsi, P.S., (2010). Stereochemistry: Conformation and Mechanism, New Age International (p) Ltd. New Delhi.
   
9. 
   Lowry, T. H., Richardson K. S., (1998). Mechanism and Theory in Organic Chemistry, Addison-Wesley Longman Inc., 3^rd edition, New York.
   
10. 
    Morrison, R.T., Boyd, R.N. (2011). Organic Chemistry, Prentice- Hall of India, 6^th edition, New Delhi.
    
11. 
    Mukherjee, S.M. Singh, S.P., (2009). Reaction Mechanism in Organic Chemistry. Macmillan India Ltd., 3^rd edition, New Delhi.
    
12. 
    Robert and Casereo, (1977). Basic principle of Organic Chemistry, Addison-Wesley, 2^nd edition.
    
13. 
    Solomn, C.W.G, Fryble, C.B. (2009). Organic Chemistry. John Wiley and Sons, Inc., 10^th edition.
    
14. 
    Sykes, P., (1997). A Guide Book to Mechanism in Organic Chemistry, Prentice Hall, 6^th edition.
    
15. 
    Eliel, E. L., & Wilen, S. H. (2008). Stereochemistry of organic compounds. John Wiley & Sons.
    

Course Tile: Spectral Analyses		L	T	P	Credits	Marks
Paper Code: PMC.503		4	1	0	4	100

Unit 1 18 hours

UV-Visible spectroscopy: Principle of UV-Visible Spectroscopy, Chromophores and their interaction with UV-visible radiation and their utilization in structural, qualitative and quantitative analysis of drug molecules. Woodward-Fieser rule, solvent effects, stereochemical effect.

Infrared Spectroscopy: Infrared radiation and its interaction with organic molecules, vibrational mode of bonds, instrumentation and applications, effect of hydrogen bonding and conjugation on absorption bands, interpretation of IR spectra. FTIR.

Unit 2 18 hours

Nuclear magnetic resonance spectroscopy: Magnetic properties of nuclei, Field and precession, Chemical shift concept, Isotopic nuclei, Reference standards and solvents. ¹H- NMR spectra, Chemical shifts, Spin spin coupling, Coupling constants, Integration of signals, Interpretation of spectra, Decoupling, double resonance and shift reagent methods, Long range coupling, Resonance of other nuclei e.g. ¹⁹F, ¹⁵N, ³¹P.

Unit 3 18 hours

Principles of FT-NMR with reference to ¹³C NMR, Free induction decay, Average time domain and frequency domain signals, Spin-spin and spin-lattice relaxation phenomenon, Nuclear Overhauser enhanced (NOE), ¹³C NMR spectra, their interpretation and application. APT and DEPT techniques, Principle of 2-D NMR, Correlation spectroscopy (COSY) Homo COSY (¹H-¹H COSY), Hetro COSY (¹H-¹³C COSY, HMQC), long range ¹H-¹³C COSY (HMBC), NOESY, DEPT and 2D INADEQUATE experiments and their application, Solid-state NMR.

Unit 4 18 hours

Mass spectrometry: Basic principles and brief outline of instrumentation, Ion formation, molecular ion, metastable ion, Mc Lafferty rearrangement, Nitrogen rule, fragmentation process in relation to molecular structure and functional groups. Relative abundance of isotopes, chemical ionization, FAB, ESI and MALDI other recent advances in mass spectrometry.

Suggested Readings:

1. 
   Banwell, C.N.; McCash, E. M. (2000). Fundamentals of molecular spectroscopy, Tata McGraw-Hill, New Delhi.
   
2. 
   Dyer, J.R. (2009). Application of Absorption Spectroscopy of Organic Compounds, Publisher: Phi Learning.
   
3. 
   Kalsi, P.S. (2004). Spectroscopy of Organic Compounds, New Age International Ltd.
   
4. 
   Kemp, W. (1991). Organic spectroscopy, ELBS London.
   
5. 
   Khopkar, S.M. (2007). Basic Concepts of Analytical Chemistry, New Age International Pvt Ltd.
   
6. 
   Melinda J.D., (2010). Introduction to solid NMR Spectroscopy, Wiley India Pvt Ltd
   
7. 
   Mendham, J.; Denney, R.C.; Barnes, J. D.; Thomas, M. J. K. (2003). Vogel’s Textbook of Quantitative Chemical Analysis, Pearson Education Pvt. Ltd., New Delhi.
   
8. 
   Pavia, D.L.; Lampman, G. M. (2010). Introduction to Spectroscopy, G. S. Kriz, Harcourt College, NY.
   
9. 
   Popov, A.I.; Halenga, K. (1991). Modern NMR techniques and their Applications, Marcel Deckker.
   
10. 
    Silverstein, R.M. (2006). Spectrometric Identifications of Organic Compounds, John Wiley.
    
11. 
    Skoog, D.A.; West, D.M.; Holler, F.J.; Crouch, S.R. (2004). Fundamental of Analytical Chemistry, Saunders College Publishing, New York.
    
12. 
    Willard, H.H.; Merrit, L.L.; Dean, J.A.; Settle, F.A. (2001). Instrumental methods of analysis, CBS Publishers and Distributors.
    
13. 
    Williams, D.H.; Fleming, I. (2004). Spectroscopy Methods in Organic Chemistry, Tata McGraw-Hill Publishing Co. Ltd., New Delhi.
    

Course Tile: Organic Synthesis-I-Practical		L	T	P	Credits	Marks
Paper Code: PMC.504		-	-	4	2	50