Original research article ebola and zika virus

 
Table No.3 Characteristics of reported cases of congenital malformation potentially linked with
zika virus infection in Brazil (AS OF 18 JANUARY 2016) 
 
No.
Date of report location
Clinical findings
Laboratory findings
1. 
17 November 2015
Paraíba state
Foetus with microcephaly at ultrasound exams (US)
30.1 weeks’ gestation
Head circumference <2.6 SD
Observed lesions (US):
- Brain atrophy with coarse calcifications involving the white 
matter of the frontal lobes, including the caudate, lentostriatal 
vessels and cerebellum.
- Corpus callosal and vermian dysgenesis.
- Enlarged cisterna magna
Mother: symptoms compatible with Zika virus infection at week 
18-19 of gestation*
RT-PCR Zika virus positive in amniotic fluid 
(Instituto Oswaldo Cruz)
(Melo 
et al
., 2016; Ministério da Saúde, 2015) 
2. 
28 November 2015
Ceara state
Newborn
Born the 18 November 2015 (residing Tejuçuoca, Ceara State)
No measurement of head circumference at birth
Weight: 945 grams at birth
Died within 5 min after birth
Observed lesions (US, 13 Nov 2015):
-microcephaly (head circumference 190 mm)
- fetal anasarca
- polydramnios
Presence of Zika viral genome in blood and 
tissue samples of the newborn (Evandro Chagas 
Institute)
(Centro de operações de emergências em saúde 
pública sobre microcefalias 
2015; Pan American Health Organization, 2015) 
3. 
15 January 2016
Hawaii (USA)
Case: baby with congenital microcephaly who was born recently 
on Oahu island, Hawaii.
Mother had a probable exposure to Zika virus when she was 
residing in Brazil in May 2015 (no further details provided)
Laboratory confirmation of a past Zika
virus infection (no details)
(US CDC laboratory)
(Hawaii Department of health, 2016)