Sethoxydim Risk Assessment
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- Worksheet D01b: Direct Spray of a Woman, Assumption of First-Order Absorption [SpillFOAWm01] Verbal Description
- Worksheet D02
- PropAbs ): 1 - e -ka × Te Central 2.61e-02 unitless Lower 1.12e-02 Upper 5.82e-02 Absorbed dose ( D
- Worksheet D03
- Drift ) Central 1 unitless Direct spray Lower 1 Upper 1 Proportion Removed by Washing ( Wash
Worksheet D01b: Direct Spray of a Woman, Assumption of First-Order Absorption [SpillFOAWm01] Verbal Description: A woman is sprayed over the feet and lower legs (A) with a field dilution of a specified concentration (C). The woman effectively washes - i.e., all of the compound is removed - after a specified period of time (T). The absorbed dose (D) is calculated from the amount of liquid adhering to the skin (L), the first-order dermal absorption rate (k a ) and the body weight (W). Parameter Value Units Source Liquid adhering to skin after a spill (L) 0.008 mL/cm 2 STD.Liq Body weight (W) 64 kg PUBL.BWF Exposed surface area (A) Feet and lower legs 2915 cm 2 PUBL.SAF1 Duration of Exposure (T) 1 hours First-order dermal absorption rates (k a ) Central 0.00110 hour -1 DERM.ABSC Lower 0.000470 DERM.ABSL Upper 0.00250 DERM.ABSU Concentration in solution (C) Central 3.6 mg/mL APPL.TypDr Lower 0.56 APPL.LowDr Upper 9 APPL.HI_Dr Amount Deposited on Skin (Amnt): L × A × C Central 83.952 mg Lower 13.0592 Upper 209.88 Proportion absorbed over period T (Prop): 1-e -k T Central 0.0010994 unitless Lower 0.0004699 Upper 0.0024969 Absorbed Dose (D Abs ): Amnt × Prop ÷ W Central 1.44e-03 mg/kg Lower 9.59e-05 Upper 8.19e-03 WS-26 Worksheet D02: Dermal contact with contaminated vegetation by a young woman [VegC_FOA01]. Verbal Description: A woman wearing shorts and a short sleeved shirt is in contact with contaminated vegetation for 1 hour shortly after application of the compound - i.e. no dissipation or degradation is considered. The chemical is effectively removed from the surface of the skin - i.e., washing - after 24 hours. Parameter/Assumption Value Units Source/Reference Contact time (Tc) 1 hour N/A Exposure time (Te) 24 hours N/A Body weight (W) 64 kg PUBL.BWF Exposed surface area (A) 5300 cm 2 PUBL.SAF2 Application Rates in lb/acre (Rlb) Central 0.3 lb/acre APPL.TYP Lower 0.09375 APPL.LOW Upper 0.375 APPL.HI First-order dermal absorption rate (k) Central 0.00110 hour -1 DERM.AbsC Lower 0.000470 DERM.AbsL Upper 0.00250 DERM.AbsU Application Rates in µg/cm 2 (Rµg): Rlb × Const.lbac_ugcm Central 3.363 µg/cm 2 Lower 1.0509375 Upper 4.20375 Proportion dislodgeable (PropDr) 0.1 none PUBL.DisL Dislodgeable residue (Dr): Rµg × PropDr Central 0.3363 µg/cm 2 Lower 0.10509375 Upper 0.420375 Transfer Rate (Tr): Tr = 10 (1.09 × log10(Dr) + 0.05) ÷ 1000 µg/mg Central 3.42e-04 mg/(cm 2 hr) The method of Durkin et al. (1995, p. 68, equation 4) is used to Lower 9.63e-05 calculate the transfer rate (Tr) in Upper 4.36e-04 units of µg/(cm 2 A hr)) based on the Amount Transferred to Skin Surface (Amnt): Tr × Tc × A dislodgeable residue (Dr) in units Central 1.81304 mg of : g/cm 2 . This is converted to Lower 0.51026 units of mg/(cm 2 A hr)) by dividing by 1000 µg/mg. Upper 2.31228 Proportion Absorbed (PropAbs): 1 - e -ka × Te Central 2.61e-02 unitless Lower 1.12e-02 Upper 5.82e-02 Absorbed dose (D Abs ): Amnt × PropAbs ÷ W Central 7.38e-04 mg/kg bw Lower 8.94e-05 Upper 2.10e-03 WS-27 Worksheet D03: Consumption of contaminated fruit, acute exposure scenario [VegAcHHRA01]. Verbal Description: Edible fruit is contaminated by drift (Dr). A drift of 1 (unity) indicates direct spray. The individual consumes contaminated fruit shortly after application of the chemical - i.e. no dissipation or degradation is considered. The concentration of the chemical in fruit (C) is estimated from empirical relationships relating residues on plants to application rate. Parameters/Assumptions Value Units Source/Reference Amount of fruit consumed per Unit Body Weight (A): Central 0.00168 kg fruit/kg PUBL.FrTC Lower 0.00168 bw/day PUBL.FrTL Upper 0.01244 PUBL.FrTU Application rates (R) Central 0.3 lb/acre APPL.Typ Lower 0.09375 APPL.Low Upper 0.375 APPL.Hi Residue rates (rr) Central 7 mg/kg per HK.FRT2 Lower 7 lb/acre HK.FRT2 Upper 15 HK.FRU2 Drift (Drift) Central 1 unitless Direct spray Lower 1 Upper 1 Proportion Removed by Washing (Wash) Central 0 unitless No washing is assumed for Lower 0 this scenario. Upper 0 Concentration on fruit (C): R × rr × Drift × (1-Wash) Central 2.1 mg/kg fruit Lower 0.65625 Upper 5.625 Dose estimates (D): C × A Central 3.53e-03 mg/kg bw Lower 1.10e-03 Upper 7.00e-02 WS-28 Yüklə 4,8 Kb. Dostları ilə paylaş:
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