Sethoxydim Risk Assessment
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- Bu səhifədəki naviqasiya:
- Worksheet C03b: Accidental Spill onto the Lower Legs for 1 Hour Based on the Assumption of First- Order Absorption [WrkDrmFrLeg]
- EXPOSURE ASSESSMENTS FOR THE GENERAL PUBLIC Worksheet D01a: Direct Spray of a Child, Assumption of First-Order Absorption [SpillFOACh01] Verbal Description
Worksheet C03a: Accidental Spill onto the Hands for 1 Hour Based on the Assumption of First-Order Absorption [WrkDrmFrHnd] Verbal Description: A worker spills a solution of the compound at a specified concentration (C) on a defined area of the skin (A). Based on the amount of liquid adhering to the skin (L), the amount of chemical absorbed (Dose) over a given period is calculated from the first order dermal absorption coefficient (k a ), the amount of time that the chemical remains on the surface of the skin before it is effectively removed by washing (T) and the body weight (W) (Durkin et al. 1995). Parameter Value Units Source Liquid adhering to skin after a spill (L) 0.008 mL/cm 2 STD.Liq Body weight (W) 70 kg STD.BW Surface Areas (A) Hands 840 cm 2 STD.Hands Duration of Exposure (T) 1 hours First-order dermal absorption rates (k a ) Central 0.00110 hour -1 DERM.ABSC Lower 0.000470 DERM.ABSL Upper 0.00250 DERM.ABSU Concentration in solution (C) Central 3.6 mg/mL APPL.TypDr Lower 0.56 APPL.LowDr Upper 9 APPL.HI_Dr Amount Deposited on Skin (Amnt): L × A × C Central 24.192 mg Lower 3.7632 Upper 60.48 Proportion absorbed over period T (Prop): 1-e -k T Central 0.0010994 unitless Lower 0.0004699 Upper 0.0024969 Absorbed Dose (D Abs ): Amnt × Prop ÷ W Central 3.80e-04 mg/kg bw Lower 2.53e-05 Upper 2.16e-03 WS-23 Worksheet C03b: Accidental Spill onto the Lower Legs for 1 Hour Based on the Assumption of First- Order Absorption [WrkDrmFrLeg] Verbal Description: A worker spills a solution of the compound at a specified concentration (C) on a defined area of the skin (A). Based on the amount of liquid adhering to the skin (L), the amount of chemical absorbed (Dose) over a given period is calculated from the first order dermal absorption coefficient (k a ), the amount of time that the chemical remains on the surface of the skin before it is effectively removed by washing (T) and the body weight (W) (Durkin et al. 1995). Parameter Value Units Source Liquid adhering to skin after a spill (L) 0.008 mL/cm 2 STD.Liq Body weight (W) 70 kg STD.BW Surface Areas (A) Legs 2070 cm 2 STD.LLegs Duration of Exposure (T) 1 hours First-order dermal absorption rates (k a ) Central 0.00110 hour -1 DERM.ABSC Lower 0.000470 DERM.ABSL Upper 0.00250 DERM.ABSU Concentration in solution (C) Central 3.6 mg/mL APPL.TypDr Lower 0.56 APPL.LowDr Upper 9 APPL.HI_Dr Amount Deposited on Skin (Amnt): L × A × C Central 59.616 mg Lower 9.2736 Upper 149.04 Proportion absorbed over period T (Prop): 1-e -k T Central 0.0010994 unitless Lower 0.0004699 Upper 0.0024969 Absorbed Dose (D Abs ): Amnt × Prop ÷ W Central 9.36e-04 mg/kg bw Lower 6.23e-05 Upper 5.32e-03 WS-24 EXPOSURE ASSESSMENTS FOR THE GENERAL PUBLIC Worksheet D01a: Direct Spray of a Child, Assumption of First-Order Absorption [SpillFOACh01] Verbal Description: A naked child is accidentally sprayed over the entire body surface (A) with a field dilution of a specified concentration (C). The child is effectively washed - i.e., all of the compound is removed - after a specified period of time (T). The absorbed dose (D) is calculated from the amount of liquid adhering to the skin (L), the first-order dermal absorption rate (k a ) and the body weight (W). Parameter Value Units Source Liquid adhering to skin after a spill (L) 0.008 mL/cm 2 STD.Liq Body weight (W) 13.3 kg PUBL.BWC Exposed surface area (A) Whole Body 6030 cm 2 PUBL.SAC Duration of Exposure (T) 1 hours First-order dermal absorption rates (k a ) Central 0.00110 hour -1 DERM.ABSC Lower 0.000470 DERM.ABSL Upper 0.00250 DERM.ABSU Concentration in solution (C) Central 3.6 mg/mL APPL.TypDr Lower 0.56 APPL.LowDr Upper 9 APPL.HI_Dr Amount Deposited on Skin (Amnt): L × A × C Central 173.664 mg Lower 27.0144 Upper 434.16 Proportion absorbed over period T (Prop): 1-e -k T Central 0.0010994 unitless Lower 0.0004699 Upper 0.0024969 Absorbed Dose (D Abs ): Amnt × Prop ÷ W Central 1.44e-02 mg/kg bw Lower 9.54e-04 Upper 8.15e-02 WS-25 Yüklə 4,8 Kb. Dostları ilə paylaş:
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