Synthetic Biology Final Report

Synthetic Biology | Annex
 
 
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•  Reengineering cellular components and machineries 
•  Engineering new biological processes for specific industrial applications 
•  Engineering a novel organism from existing and newly designed parts 
 
•  Engineering of biological systems with structures and functions not found in nature 
•  Application of engineering principles to biology, redesigning biological materials and using them as new 
substrates 
•  Application of engineering principles 
•  Engineer  novel  biological  systems  with  useful  and  predictable  functions  by  combining  modular,  well-
characterised genetic parts in a rational and systematic manner 
•  Design  and  engineer  biologically  based  parts,  novel devices  and  systems;  redesigning  existing,  natural 
biological systems 
•  Application of systematic design – using engineering principles 
•  Engineering biological systems or modules 
•  Apply engineering principles to biological studies 
•  Engineering of biological entities not found in nature 
•  Reverse engineer and redesign pre-existing biological parts and devices 
•  Engineer predicted outputs 
•  Combine knowledge and techniques of biology, chemistry, computer science, and engineering. 
•  De novo engineering of regulatory systems 
•  Engineering-driven building of increasingly  complicated biological entities  (parts, devices and systems) 
from simple and basic building blocks 
•  Engineering artificial biological systems with the ultimate goal of programming novel cell and organism 
behaviour 
•  Engineering DNA based biological circuits by using standardised biological parts; identifying the minimal 
genome;  constructing  protocells;  creating  orthogonal  biological  systems  through  chemical  synthetic 
biology 
•  Systematic  construction  of  biological  systems  with  cells  being  build  module  by  module  (bottom  up 
engineering strategy) 
•  Application of engineering principles toward the construction of novel biological systems 
•  Central goal is to transform biology into a system that can be engineered 
•  Application  of  the  principles  of  engineering  to  the  construction  of  life  with  desired  properties  in  a 
rational and systematic way 
•  Engineering novel cell activities 
•  Engineer  and  create  complex  biological  systems  for  practical  applications  from  lesser  understood  and 
unreliable basic components 
•  Engineering challenge with interchangeable parts joined to yield novel pathways 
•  Modular, well-characterised biological parts to predictably construct novel genetic devices and complex 
cell-based systems following engineering principle 
•  Engineering of biology (bottom up and top down approaches) 
•  Design and construction of biological systems guided by engineering principles 
•  De novo engineering of regulatory systems with desired behaviour 
•  Reverse-engineering the design rules governing the machinery of cells and cell circuits 
•  Synthetic biology is at the interface of engineering and biology 
•  Integration of computational analysis, biological data and the systems engineering paradigm 
•  Reverse-engineer naturally evolved systems and to build new systems 
•  Engineering of genetic molecular machines with a specific predefined function 

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Synthetic Biology | Annex
 
 
85 
•  Routine engineering of complex biological systems 
•  Newly engineered organism functions as a machine 
Construction 
•  Construct new parts, modify existing biological systems 
•  Reconstruct the decision-making networks 
•  Design  and  construction  of  new  biological  components  such  as  enzymes,  genetic  circuits,  and  cells, 
redesign of existing biological systems 
•  The  design  and  construction  of  new  biological  parts,  devices  and  systems  and  redesign  of  existing, 
natural biological systems for useful purposes 
•  Redesign and fabrication of existing biological systems, construction of new biological parts, devices and 
systems that do not occur in nature 
•  New tools that support pathway construction and optimisation. 
•  Piece together biological components from several different origins, re-design a natural or construct a 
novel pathway that the host uses to synthesise a valuable chemical 
•  Design and construction of new biological functions that are not found in nature 
•  Functional stand-alone elements, reconstructed in novel configurations 
•  Reconstruction  of  entire  cellular  genomes  from  virtual  sequence  information  and  using  chemical 
components 
•  Engineering DNA based biological circuits by using standardised biological parts; identifying the minimal 
genome;  constructing  protocells;  creating  orthogonal  biological  systems  through  chemical  synthetic 
biology 
•  Systematic  construction  of  biological  systems  with  cells  being  build  module  by  module  (bottom  up 
engineering strategy) 
•  Application of engineering principles toward the construction of novel biological systems 
•  Application  of  the  principles  of  engineering  to  the  construction  of  life  with  desired  properties  in  a 
rational and systematic way 
•  Modular, well-characterised biological parts to predictably construct novel genetic devices and complex 
cell-based systems following engineering principle 
•  Design and construction of biological systems guided by engineering principles 
 
•  Novel synthetic networks 
•  Improve biological systems 
•  Modify existing cells and organisms so that they work as cell factories 
Trans- and inter-disciplinarity 
•  Emerging transdisciplinary field 
•  Interdisciplinary attempts 
•  Mixing and matching genetic parts 
Chemistry 
•  Chemical synthetic biology – chemical and biochemical technology 
•  Bio-engineering, chemical synthetic biology 
•  Extension of synthetic chemistry – development of novel molecules 
Aims 
•  To generate industrially scalable systems with a defined purpose 
•  Exploit  the  potential  further  by  generating  novel  pathways,  novel  products,  by  combining  different 
biosynthetic steps originating from different bacteria 

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