Sağlık Bakanlığı Göztepe Eğitim ve Araştırma Hastanesi
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FASEB J 2001; 15: 2579- 85. 101) Sooy K, Schermerhorn T, Noda M. Calbindin-D(28k) control (Ca+132)(i) and insülin release. Evidence obtained from calbindin- D(28k) knockout mice beta cell lines. L Biol Chem 1999; 274: 34343- 9. 102) Gregory S, Giarratana N, Smiroldo S, Uskokovic M, Adorini L. 1 alpha, 25 dihydroxyvitamin D3 anolog enhances regulatory T-cell and arrest autoimmune diabetes in NOD mice. Diabetes 2002; 52: 1367- 74. 103) Mathiue C, Waer M, Laurey J, Rutgeers O, Bouillion R. Prevention of autoimmun diabetes in NOD mice by 1,25 dihydroxyvitamin D3. Diabetologia 1994; 37: 552- 8. 52 104) Hypponen E, Laara E, Reunanen A, Jarvelin MR, Virtanen SM. Đntake of vitamin D and risk of type 1 diabetes: a birth- cohort study. Lancet 2001; 358: 1500- 3. 105) Vitamin D supplement in early childhood and risk for type 1( insulin- dependent) diabetes mellitus. The EURODIAB Substudy 2 Study Group. Diabetologia 1999; 42: 51- 4. 106) Norman AW, Frankel JB, Heldt AM, Grodsky GM. Vitamin D deficiency inhibits pancreatic secretion of insulin. Science 1980; 209: 823- 5. 107) Chiu KC, Chiu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr 2004; 79: 820- 5. 108) Anastassios G. Pittas, Bess Dawson-Hughes, Tricia Li. Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care 2006; 29: 650- 6. 109) Ogunkolade BW, Boucher BJ, Prahl JM. Vitamin D receptor(VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretion capacity and VDR Genotype in Bangladeshia Asians. Diabetes 2002; 51: 2294- 300. 110) Oh J-Y, Berrett- Conner E. Association between vitamin D receptor polymorphism and type II diabetes or metabolic syndrome in community-dwelling older adults: the Rancho Bernardo Study. Metabolism 2002; 51: 356- 9. 111) Holic MF. Vitamin D and Sunlight: Strategies for cancer prevention and other health benefits. Clin J Am Soc Nephrol 2008 Jun 11. 112) Ustianowski A, Shaffer R, Collin S. Prevalence and associations of vitamin D deficiency in foreign-born persons with tuberculosis in London. J Infect 2005; 50: 432- 7. 113) Wejse C, Olesen R, Rabna P. Serum 25-hydroxyvitamin D in a West African population of tuberculosis patients and unmatched healthy controls. Am J Clin Nutr 2007; 86: 1376- 83. 114) Norval M. The Effect of ultraviolet radiation on human viral infections. Photochem Photobiol 2006; 82: 1495- 504. 115) Najada AS, Habashneh MS, Khader M. The frequency of nutritional rickets among hospitalized infants and its relation to respiratory diseases. J Trop Pediatr 2004; 50: 364- 8. 116) Muhe L, Lulseged S, Mason KE & Simoes EAF: Case control study of the role of nutritional rickets in the risk of developing pneumonia in Ethiopian children. Lancet 1997; 349: 1801- 4. 117) Eyles D, Brown J, Mackay-Sim A, McGrath J, Feron F. Vitamin D3 and brain development. Neuroscience 2003; 118: 641- 53. 118) McGrath JJ, Saha S, Lieberman DE. Season of birth is associated with anthropometric and neurocognitive outcomes during infancy and childhood in a general population birth cohort. Schizophr Res 2006; 81: 91- 100.
53 119) Morris GS, Zhou Q, Hegsted M. Maternal consumption of a low vitamin D diet retards metabolic and contractile development in the neonatal rat heart. J Mol Cell Cardiol 1995; 27: 1245– 50. 120) Weishaar RE, Simpson RV. Vitamin D3 and cardiovascular function in rats. J Clin Invest 1987; 79: 1706– 12. 121) Zittermann A. Vitamin D and disease prevention with special reference to cardiovascular disease. Prog Biophys Mol Biol. 2006; 92: 39- 48. 122) Ortlepp JR, Krantz C, Kimmel M. Additive effects of the chemokine receptor 2, vitamin D receptor, interleukin- 6 polymorphisms and cardiovascular risk factors on the prevalence of myocardial infarction in patients below 65 years. Int J Cardiol 2005; 105: 90- 5. 123) Hullett DA, Cantorna M, Redaelli C. Prolongation of allograft survival by 1,25- dihydroxyvitamin D3. Transplantation 1998; 66: 824- 8. 124) LaClair RE, Hellman RN, Karp SL. Prevalence of calcidiol deficiency in CKD: a cross- sectional study across latitudes in the United States. Am J Kidney Dis 2005; 45: 1026- 33. 125) Holick MF. Vitamin D: importance in the prevention of cancer, type 1 diabetes, heart disease and osteoporozis. Am J Clin Nutr 2004; 79: 362- 71. 126) Bhalla AK, Amento EP, Clemens TL. Specific high-affinity receptors for 1,25- dihydroxyvitamin D3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation. J Clin Endocrinol Metab 1983; 57:1308- 10. 127) Provvedini DM, Tsoukas CD, Deftos LJ. 1,25 Dihydroxyvitamin D3 receptors in human leukocytes. Science 1983; 221:1181- 3. 128) Manolagas, SC, Werntz DA, Tsoukas CD, Proveddini DM, Vaughan JH. 1,25- Dihydroxyvitamin D3 receptors in lymphocytes from patients with rheumatoid arthritis. J Lab Clin Med 1986; 108: 595- 600. 129) Coffman RL, Varkila K, Scott P. Role of cytokines in the differentiation of CD4+T-cell subsets in vivo. Đmmunol Rev 1991; 123: 189- 207. 130) Cantorna MT, Zhu Y, Froicu M, Wittke A. Vitamin D status, 1,25 dihydroxyvitamin D3, and the immune system. Am J Clin Nutri 2004; 80: 1717- 20. 131) Mahon BD, Wittke A, Weaver V. The targets of vitamin D depend on the differentiation and activation status of CD4-positive T cell. J Cell Biochem 2003; 89: 922- 32. 132) Bemiss CJ, Mahon BD, Henry A. Interleukin- 2 is one of the Targets of 1,25- dihydroxyvitamin D3 in the immune system. Arch Biochem Biophys 2002; 402: 249- 54. 54 133) Cantorna MT, Humpal-Winter J, DeLuca HF. In vivo upregulation of interleukin- 4 is One mechanism underlying the immunoregulatory effects of 1,25-dihydroxyvitamin D3. Arch Biochem Biophys 2000; 377: 135- 8. 134) Abe E, Miyaura C, Sakagami H. Differentiation of mouse myeloid leukemia cells induced by 1, 25- dihydroxyvitamin D3. Proc Natl Acad Sci USA 1981; 78: 4990- 4. 135) Tanaka H, Abe E, Miyaura C. 1-alpha, 25- dihydroxycholecalciferol and a human myeloid leukaemia cell line (HL- 60). Biochem J 1982; 204: 713- 9. 136) Cantorna MT. Vitamin D and its role in immunology: multiple sclerosis, and inflammatory bowel disease. Prog Biophys Mol Biol 2006; 92: 60- 4. 137) Merlino LA, Curtis J, Mikuls TR, Cerhan JR, Criswell LA, Saaq KG, et al. Vitamin D intake is inversely associated with rheumatoid arthritis: results from the lowa Women’s Health Study. Arthritis Rheum2004; 50: 72- 7. 138) Fournier C, Gepner P, Sadouk M. In vivo beneficial effects of cyclosporine A and 1,25- dihydroxyvitamin D3 on the induction of experimental autoimmune thyroiditis. Clin Immunol Immunopathol 1990; 54: 53- 63. 139) Hahn HJ, Kuttler B, Mathieu C. 1,25- Dihydroxyvitamin D3 reduced MHC antigen expression on pancreatic beta-cell in vitro. Transplant Proc 1997; 26: 2156- 7. 140) Pani MA, Regulla K, Segni M. Vitamin D 1 alpha-hydroxylase (CYP 1 alpha) polymorphism in Grave’s disease, Hashimoto’s thyroiditis and type 1 diabetes mellitus. Eur J Endocrinol 2002; 146: 777- 81. 141) Stefanic M, Papic S, Suver M. Association of vitamin D gene 3’- variants with Hashimoto’s thyroiditis in the Croatian population. Đnt J Đmmunogenet 2008; 35: 125- 31. 142) Youshiyuki Ban, Matsuo Taniyama, Yoshio Ban. Vitamin D receptor gene polymorphism in Hashimoto’s thyroiditis. Thyroid 2002; 11(6): 607- 608. 143) Kozan Ö, Oğuz A, Abacı A, ve ark. Türkiye Metabolik Sendrom Prevalans Çalışması (METSAR) Sonuçları. II. Metabolik Sendrom Sempozyumu. Đstanbul Mart 2005. 144) Altan O, Ahmet K, Ali Metin E ve ark. Analysis of all- cause mortality and coronary events in the Turkish Adult risk factory survet 2005. Türk Kardiyol Dern Arş 2006; 34: 149- 153.
145) Beus KS, Stack BC Jr. Synchronous thyroid pathology in patient presenting with primary hyperparathyroidism. Am J Otolaryngol 2004; 25: 308- 12. 146) Mellado DM, Farias- Llamas OA, Olivares- Becerra JJ. Detection of thyroid patology during surgical exploration of the neck for primary hyperthyroidism. Cir Cir 2004; 72: 89-92. 55 147) Sidhu S, Campbell P. Thyroid patology associated with primary hyperparathyroidism. Aust N Z J Surg 2000; 70: 285- 7. 148) Savli H, Sevinc A, Sari R. Occult parathyroid carcinoma in a patient with papillary thyroid carcinoma and Hashimoto’s thyroiditis. J Endocrinol Đnvest 2001; 24: 42- 4.
EK-1 HASTA BĐLGĐ FORMU : Hastanın kimlik bilgileri : Hasta : Kontrol
:
Adı- soyadı : Cinsiyeti: K E
Çalışmaya alınma tarihi: 56
Protokol no:
Doğum tarihi:
Telefon no: Hastanın risk profili:
Hipertansiyon: var yok Dislipidemi: var yok
KAH: var yok Sigara: içmemiş bırakmış içiyor
Alkol: kullanmıyor <1kez/ay 1-2kez/ay 1-2kez/hafta 3-4kez/hafta hergün
Egzersiz: yapmıyor <1kez/hafta
1-3kez/hafta >4kez/hafta Hastanın kullandığı ilaçlar:
Antihipertansif ilaç: kullanıyor kullanmıyor Antihiperlipidemik ilaç: kullanıyor kullanmıyor
Tiroid ilacı: kullanıyor kullanmıyor Diğer ilaçlar: .........
Kan basıncı : Sağ : / mmHg
Sol : / mmHg
NDS : /dakika 57 Boy : c / cm Kilo: /kg Bel çevresi: /cm Kalça çevresi: /cm
Biyokimyasal analiz:( Hastanın dosyasından kaydedilecektir) Açlık plazma glukozu: ........mg/dl Kalsiyum: .......mg/dl
Kreatinin: .........mg/dl Fosfor: ........mg/dl
Trigliserid: ........mg/dl Albümin: .......gr/dl
Kolesterol: ........mg/dl TSH: ........uIU/ml
HDL: ..........mg/dl Anti TPO: .........IU/ml
LDL: ..........mg/dl Anti Tg: ...... IU/ml
AST( SGOT): .........U/L ALT(SGPT): ..........U/L
Çalışmada bakılacak olan özel tetkikler:
PTH: .........pg/ml
25-OH D vitamini: .........ng/ml
EK-2 BĐLGĐLENDĐRĐLMĐŞ HASTA OLUR FORMU Sayın katılımcımız;
Sağlık Bakanlığı Göztepe Eğitim ve Araştırma Hastanesi Endokrinoloji ve Đç Hastalıkları polikliniklerinde yürütülmesi planlanan bu çalışmada yer almanız isteğinize bağlıdır. 58 Çalışmaya katılmayı reddetme ve çalışmanın herhangi bir aşamasında ayrılma hakkına sahipsiniz. Bu durum cezai bir yükümlülüğe veya daha sonraki tedaviniz için herhangi bir olumsuzluğa ve engele yol açmayacaktır.
Daha önce yapılan çalışmalarda, patogenezinde inflamasyonun rol aldığı kanser, multıpl skleroz, romatoid artrit, sistemik lupus eritematozus, hipertansiyon, koroner kalp hastalığı, metabolik sendrom ve diabetes mellitus gibi hastalıklarda Dvitamini yetersizliğinin sık olduğu görülmüştür. Bu çalışmada tiroidin en sık rastlanılan otoimmun hastalığı olan Hashimoto tiroiditinde PTH ve D vitamini düzeyi araştırılacaktır.
Çalışmamıza katılımınız halinde 1 kez kliniğe çağrılacaksınız. Çalışmaya katılmayı kabul eden hastalarımızın fizik muayenesinde sağ ve sol koldan kan basıncı, boy, kilo, bel çevresi ve dakika nabız sayısı ölçülecektir. Ayrıca biyokimya parametreleri, PTH ve 25- Hidroksi D vitamini düzeyleri için kan örnekleri alınacaktır. Çalışmamızda hayatı tehdit edecek herhangi bir tehlike bulunmamaktadır. Bu çalışmadan elde edilen sonuçlar, kimliğiniz açıklanmadan sadece bilimsel amaçlarla yayınlanacaktır. Elde edilen test sonuçları hakkında bilgilendirilceksiniz. Bu olur formunun bir örneği size verildikten sonra çalışmaya başlanacaktır. Çalışmamız, hastane etik kurulundan izin alınarak gerçekleştirilecektir. Çalışma Prof.Dr. Aytekin Oğuz gözetiminde Asist. Dr. Safiye Arık tarafından yürütülecektir. Herhangi bir sebeple 05547315525 numaralı telefonlara ulaşabilirsiniz. Katılımınız için teşkkür ederiz.
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