Appendix 2-5: Rejected ecotox bibliography Excluded
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Rec #: 2950 Keywords: HUMAN HEALTH Notes: Chemical of Concern: MLN Abstract: Abstract: Samples of drinking water (56), feedstuffs (73) and raw milk (56) were collected on-site from 19 dairy farms in the Province Heilongjiang, China during 2008-2009, and measured by a gas chromatographic method after extraction and purification to investigate their pollution about 7 organophosphorus pesticides (OPPs) including dimethoate, fenthion, malathion, methyl parathion, monocrotophos, phorate and trichlorphon. The survey showed that 16 drinking water, 33 feedstuffs and 16 raw milk samples contained one to four detectable OPPs with levels of 0.008-0.039, 0.010-0.140 and 0.006-0.048 mg times kg super(-1), respectively. Dimethoate, monocrotophos, phorate and trichlorphon were the most detectable while other three OPPs were the less detectable. OPPs were detected in a considerable occurrence in the raw milk but their residue level in most positive milk samples (12 out of 16) was less than 0.020 mg times kg super(-1), implying the raw milk had very low safety risk in practical.Original Abstract: Proben von Trinkwasser (56), Futtermitteln (73) und Rohmilch (56) wurden vor Ort in 19 Milcherzeugerbetrieben in der ProvinzHeilongjiang, China, im Zeitraum 2008-2009 gezogen und gaschromatografisch nach Extraktion und einer entsprechenden Reinigung auf sieben Organophosphor-Pestizide (OPPs) untersucht (Dimethoat, Fenthion, Malathion, Methylparathion, Monocrotophos, PhorateandTrichlorphon). Die Untersuchung ergab, dass 16 Trinkwasser-, 33 Futtermittel-und 16 Rohmilchproben ein bis vier nachweisbare OPP(s) in Konzentrationen von 0,008-0,039, 0,010-0,140 und 0,006-0,048 mg/kg aufwiesen. Dimethoat, Monocrotophos, PhorateandTrichlorphon waren am haeufigsten nachweisbar, waehrend die anderen drei Pestizide seltener gefunden wurden. Die OPPs wurden somit in einem betraechtlichen Anteil in der Rohmilch gefunden, wobei allerdings die Rueckstandskonzentrationen in den meisten positiven Milchproben (12 von 16) unterhalb 0,020 mg/kg lagen. Diese Werte zeigen, dass die Rohmilch nur ein sehr geringes gesundheitliches Risiko aufweist. Keywords: Milk Keywords: Residues Keywords: P 2000:FRESHWATER POLLUTION Keywords: Pesticides Keywords: Dimethoate Keywords: Drinking water Keywords: Pollution Abstracts Keywords: Malathion Keywords: Dairy farms Keywords: Parathion English. Date revised - 2012-11-01. Last updated - 2012-12-03. DOI - MD-0019271619; 17094885; 0026-3788. SubjectsTermNotLitGenreText - Milk; Residues; Pesticides; Dimethoate; Drinking water; Malathion; Dairy farms; Parathion 730. Zhao, X. H. and Wang, J. Degradation of seven organophosphorus pesticides in the fresh milk heated at 63 degrees C and two pHs. 2012; 67, 192-194. Rec #: 16810 Keywords: CHEM METHODS Notes: Chemical of Concern: MLN Abstract: Abstract: Fresh bovine milk pre-adjusted to a pH of 6.6 or 7.5 was spiked with seven organophosphorus pesticides including dimethoate, fenthion, malathion, methyl parathion, monocrotophos, phorate and trichlorphon, and then heated at 63 degrees C to investigate the degradation behaviors of these pesticides. The pesticide residues were extracted from the milk with organic solvent and analyzed by gas chromatography after purification. The degradation rate constant of the pesticides was calculated based on the degradation is a first order reaction. The calculation results show that the degradation of the pesticides except for fenthion was enhanced by the slight alkaline pH, while dimethoate, methyl parathion and trichlorphon were more susceptible to the slight alkaline pH. Totally, dimethoate and malathion (or monocrotophos) degraded faster (or slowest), indicating that they were (or it was) more instable (or most stable). Number of Volumes: 2 ISI Document Delivery No.: 927GG 731. Zhao, X. H.; Wang, J.; Li, T. J., and Zhang, Y. H. Degradation behaviors of seven organophosphorus pesticides in skimmed milk inoculated with Streptococcus thermophilus or Lactobacillus helveticus. 2012; 67, 399-401. Rec #: 16820 Keywords: CHEM METHODS Notes: Chemical of Concern: MLN Abstract: Abstract: Streptococcus (S.) thermophilus or Lactobacillus (L.) helveticus were inoculated into skimmed milk at 42 degrees C to study their impacts on the degradation behaviors of seven selected organophosphorus pesticides (OPPs) including dimethoate, fenthion, malathion, methyl parathion, monocrotophos, phorate and trichlorphon. The residual OPPs in the spiked milk were extracted with an acetone-acetonitrile solvent in proportion of 1:4 (v/v), purified with dichloromethane and quantified in a gas chromatography. The analysis results showed that during an incubation of 24 h, the residual amount of the investigated OPPs in the milk decreased gradually about 23-49% as the occurrence of OPPs degradation. The applied strains exhibited accelerating effects mainly on the degradation of methyl parathion, monocrotophos, phorate and trichlorphon. Among the OPPs investigated, both phorate and trichlorphon were more susceptive to the strains with an enhanced degradation rate about 109-114% and 61-77%, while malathion exhibited resistance to the strains with an unchanged degradation rate. The present study shows that some lactic acid bacteria might have the ability to degrade some OPPs and provide safety help to some fermented foods. Number of Volumes: 4 ISI Document Delivery No.: 044ZH 732. Zhao, Xin-Huai; Wang, Jing, and Zhao, Xin-Huai. A Brief Study on the Degradation Kinetics of Seven Organophosphorus Pesticides in Skimmed Milk Cultured With Lactobacillus Spp. At 42 Degree C. 2012 Mar 1; 131, (1): 300-304. Rec #: 2780 Keywords: CHEM METHODS Notes: Chemical of Concern: MLN Abstract: Abstract: Seven organophosphorus pesticides (OPPs) including dimethoate, fenthion, malathion, methyl parathion, monocrotophos, phorate and trichlorphon were added to skimmed milk. The milk was inoculated with one strain of Lactobacillus spp. including L. bulgaricus, L. paracasei and L. plantarum, and cultured at 42 degree C for 24 h to investigate their impacts on degradation kinetics of the OPPs. The residual OPPs in the milk were extracted by an extraction solvent and quantified in a gas chromatography after purification. Degradation rate constant and half live periods of the OPPs were calculated from a first-order reaction kinetics model. The result shows that the selected Lactobacillus spp. exhibited some acceleration on OPPs degradation totally. Dimethoate and methyl parathion were more stable but malathion was the most labile. Both L. bulgaricus and L. plantarum had stronger acceleration on the degradation of the OPPs studied. Keywords: Pesticides (organophosphorus) Keywords: Milk Keywords: phorate Keywords: Solvents Keywords: monocrotophos Keywords: Fenthion Keywords: Malathion Keywords: Lactobacillus Keywords: Gas chromatography Keywords: Kinetics Keywords: Microbiology Abstracts B: Bacteriology Keywords: Purification Keywords: Dimethoate Keywords: Methyl parathion Keywords: J 02300:Methods English. Date revised - 2011-11-01. Last updated - 2012-03-29. DOI - 68718d63-5a6a-4ba3-bc9dcsamfg201; 15910307; 0308-8146. SubjectsTermNotLitGenreText - Pesticides (organophosphorus); Milk; Gas chromatography; phorate; Kinetics; monocrotophos; Solvents; Purification; Methyl parathion; Dimethoate; Fenthion; Malathion; Lactobacillus 733. Zhou, Jiong-Lin; Lian, Yong; Peng, Shuang-Qing, and Zhou, Jiong-Lin. Induction of Micronuclei in Hepg2 Cell Line by Dichlorvos, Dimethoate and Malathion. 2010 Apr; 27, (4): 287-289. Rec #: 4250 Keywords: IN VITRO Notes: Chemical of Concern: MLN Abstract: Abstract: Objective: Micronucleus test (MNT) was used to evaluate the single and combined genotoxicity of dichlorvos (DDVP), dimethoate (DM) and malathion (Mal) in HepG2 cell line, and 2x2 factorial design was adopted to elucidate the combined genotoxic effects. Methods: In cytotoxicity test, HepG2 cells were exposed to the three OPPs (DDCP, DM, Mal) for 4 h respectively, and the doses at which cell viability above 80% were selected for the MNT, DDVP: 3.125-25 kg/ml,DM: 25-200 kg/ml, Mal: 50-400 kg/ml, the micronucleated cell (MNC) rates and the replicative index(RI) were calculated. The combined genotoxicity of them was investigated with their doses as follows: low dose (DDVP: 3.125 kg/ml, DM: 25 kg/ml, Mal: 50 (kg/ml); high dose (DDVP: 12.5 kg/ml, DM: 100 kg/ml, Mal: 200 kg/ml). Results In MNT, after treatment of HepG2 cells with DDVP, DM or Mal alone for 4 h, the MNC rates were increased in a dose-response manner (DDVP: r=0.955, P<0.01; DM: r=0.976, P<0.01; Mal: r=0.950, P < 0.01), and the MNC rates were statistically higher than solvent control at the two or three higher doses of DDVP,DM and Mal. RI of HepG2 cells decreased in a dose-dependent manner with increasing DDVP dosage. RI also decreased with increasing DM or Mal dosage,but not revealed dose-response relationships. The 2 x 2 factorial analysis revealed that at low mixed concentration, DDVP and DM, DDVP and Mal, as well as DM and Mal exhibited interactions (P < 0.05) characterized as synergistic effect; but at high mixed concentration, their interactions (P < 0.05) were characterized as antagonistic effect. Conclusion: DDVP, DM and Mal can induce micronucles both in sole way and combined way, but the combined effects is concerned with the combined dosages. Keywords: Synergistic effects Keywords: Genotoxicity Keywords: Micronuclei Keywords: Solvents Keywords: dichlorvos Keywords: Malathion Keywords: Cytotoxicity Keywords: Dose-response effects Keywords: Dimethoate Keywords: Toxicology Abstracts Keywords: dimethoate Keywords: X 24330:Agrochemicals Keywords: Dichlorvos Chinese. Date revised - 2010-06-01. Last updated - 2013-04-19. DOI - 19e300c4-9409-4398-8320csamfg201; 12939068; 1001-5914. SubjectsTermNotLitGenreText - Cytotoxicity; Dose-response effects; Micronuclei; Genotoxicity; Solvents; Dimethoate; Malathion; Dichlorvos; Synergistic effects; dichlorvos; dimethoate 734. -îolovi-ç, Mirjana B.; Krsti-ç, Danijela Z.; U+í-çumli-ç, Gordana S., and Vasi-ç, Vesna M. Single and simultaneous exposure of acetylcholinesterase to diazinon, chlorpyrifos and their photodegradation products. 2011 May; 100, (1): 16-22. Rec #: 1080 Keywords: IN VITRO Notes: Chemical of Concern: MLN Abstract: In vitro inhibition of electric eel acetylcholinesterase (AChE) by single and simultaneous exposure to organophosphorus insecticides diazinon and chlorpyrifos, and their transformation products, formed due to photoinduced degradation, was investigated. Increasing concentrations of diazinon, chlorpyrifos and their oxidation products, diazoxon and chlorpyrifos-oxon, inhibited AChE in a concentration-dependent manner. IC50 (20 min) values, obtained from the inhibition curves, were (in mol/l): (5.1 -_ 0.3) +ů 10ęĆ8, (4.3 -_ 0.2) +ů 10ęĆ6 and (3.0 -_ 0.1) +ů 10ęĆ8 for diazoxon, chlorpyrifos and chlorpyrifos-oxon, respectively, while maximal diazinon concentration was lower than its IC50 (20 min). Calculated KI values, in mol/l, of 7.9 +ů 10ęĆ7, 9.6 +ů 10ęĆ6 and 4.3 +ů 10ęĆ7 were obtained for diazoxon, chlorpyrifos and chlorpyrifos-oxon, respectively. However, 2-isopropyl-4-methyl-6-pyrimidinol (IMP) and 3,5,6-trichloro-2-pyridinol, diazinon and chlorpyrifos hydrolysis products, did not noticeably affect the enzyme activity at all investigated concentrations. Additive inhibition effect was achieved for lower concentrations of the inhibitors (diazinon/diazoxon _+1 +ů 10ęĆ4/1 +ů 10ęĆ8 mol/l i.e., chlorpyrifos/chlorpyrifos-oxon _+2 +ů 10ęĆ6/3 +ů 10ęĆ8 mol/l), while an antagonistic effect was obtained for all higher concentrations of the organophosphates. Inhibitory power of 1 +ů 10ęĆ4 mol/l diazinon irradiated samples can be attributed mostly to the formation of diazoxon, while the presence of non-inhibiting photodegradation product IMP did not affect diazinon and diazoxon inhibitory efficiencies. Diazinon/ Chlorpyrifos/ Photodegradation products/ Acetylcholinesterase/ Simultaneous exposure http://www.sciencedirect.com/science/article/pii/S0048357511000204 B5 (EC) - Yüklə 1,76 Mb. Dostları ilə paylaş:
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