Content Outline a joint Program of the Federation of State Medical Boards

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juvenile idiopathic arthritis; rheumatoid arthritis, Felty syndrome; psoriatic 

arthropathy 

inflammatory disorders: adhesive capsulitis of shoulder (frozen shoulder syndrome); 

ankylosis/spondylopathy (inflammatory); bursitis; fasciitis; osteochondritis, 

osteochondritis dissecans; tendinitis, supraspinatus syndrome, enthesopathy of spine, 

elbow, ankle; temporomandibular joint disorders; fibrositis, myofascial pain 

syndrome; synovitis; tenosynovitis; myositis 

Neoplasms: benign neoplasms (e.g., ganglion cyst); malignant neoplasms of bone (eg, 

osteosarcoma, sarcoma, leiomyosarcoma, rhabdosarcoma); metastases to bone, 

secondary malignant neoplasm of bone 

Degenerative and metabolic disorders 

degenerative/metabolic disorders of bone, tendon, and cartilage: chondromalacia; disc 

degeneration, herniated disc; Legg-Calvé-Perthes disease; Osgood-Schlatter disease; 

osteodystrophy; osteomalacia; osteonecrosis (avascular), bone infarct; osteoporosis; 

osteopenia; osteitis deformans (Paget disease of bone); pathologic fracture; 

radiculopathies; spondylolisthesis/spondylosis (degenerative) 

degenerative/metabolic disorders of joints: gout, gouty arthritis, pseudogout; joint 

effusion; osteoarthritis 

degenerative/metabolic disorders of muscles, ligaments, fascia: Dupuytren contracture; 

muscle calcification and ossification; muscle wasting and diffuse atrophy; 

rhabdomyolysis 

Traumatic and mechanical disorders: amputation and care of amputees; backache, including 

low back pain; blast injuries; compartment syndrome; contractures, hospital-acquired; 

contusions; dislocations; fractures; sprains, strains; kyphoscoliosis, scoliosis; rotator cuff 

syndrome; slipped capital femoral epiphysis; dislocation of hip 

Congenital disorders: achondroplasia/dwarfism; disorders of limb development (HOX gene 

mutation, phocomelia); developmental dysplasia of the hip; dislocation of hip in 

infantile spinal muscular atrophy; genu valgum or varum; foot deformities (flat foot, 

valgus/varus deformities); osteogenesis imperfecta; McArdle disease; mitochondrial 

myopathies

 

Adverse effects of drugs on the musculoskeletal system: drug-induced myopathy (eg, 

steroids, statins, cocaine, AZT); malignant hyperthermia 

 

Cardiovascular System

 

Normal Processes 

Embryonic development, fetal maturation, and perinatal transitional changes 

Organ structure and function 

chambers, valves 

cardiac cycle, mechanics, heart sounds, cardiac conduction  

hemodynamics, including blood volume and systemic vascular resistance 

circulation in specific vascular beds, including pulmonary and coronary 

Cell/tissue structure and function 

heart muscle, metabolism, oxygen consumption, biochemistry, and secretory function 

(eg, atrial natriuretic peptide) 

endothelium and secretory function, vascular smooth muscle, microcirculation, and 

lymph flow 

neural  and  hormonal  regulation  of  the  heart,  blood  vessels,  and  blood  volume, 

including responses to change in posture, exercise, and tissue metabolism, and 

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autonomic responses 

Repair, regeneration, and changes associated with stage of life 

Abnormal Processes: Health and Health Maintenance, Screening, Diagnosis, 

Management, Risks, Prognosis 

Infectious, immunologic, and inflammatory disorders 

infectious disorders: bacterial endocarditis, myocarditis 

immunologic and inflammatory disorders: atherosclerosis (eg, atherosclerosis of the 

aorta) 

Neoplasms: myxoma, metastases 

Dysrhythmias: premature beats (PACs, PVCs); atrial flutter/fibrillation; multifocal atrial 

tachycardia; paroxysmal tachycardias; ventricular tachycardia/fibrillation; wide complex 

tachycardia; torsades de pointes; bradycardias; atrioventricular block (first-, second-, 

third-degree); conduction disorder (LBBB, RBBB); cardiac arrest; sick sinus syndrome; 

prolonged QT syndrome; Wolff-Parkinson-White syndrome; carotid sinus hypersensitivity; 

pacemaker dysfunction, including failure to sense, capture 

Heart failure: chordae tendineae rupture; congestive heart failure; cor pulmonale; diastolic 

dysfunction; systolic dysfunction; mitral valve dysfunction; heart failure secondary to 

myocardial infarction; high-output heart failure, including thyrotoxicosis-induced, 

anemia-induced; tachycardia-induced; cardiogenic pulmonary edema 

Ischemic heart disease: acute coronary syndrome, acute myocardial infarction; angina 

pectoris, stable and unstable/coronary artery disease/coronary insufficiency; 

coronary artery spasm 

Diseases of the myocardium: cardiomyopathy, dilated, including alcoholic, viral,  takotsubo; 

cardiomyopathy, obstructive hypertrophic; cardiomyopathy, familial dilated; 

cardiomyopathy, restrictive; hypertensive heart disease, left ventricular hypertrophy, 

right ventricular hypertrophy; complications of myocardial infarction; nontraumatic 

tamponade post-myocardial infarction; papillary muscle rupture/dysfunction; ventricular 

free wall rupture; myocarditis 

Diseases of the pericardium: chronic constrictive pericarditis; pericardial effusion; pericardial 

tamponade; acute pericarditis; pericarditis, following myocardial infarction, surgery, 

trauma 

Valvular heart disease: valve disorders, mitral/aortic/tricuspid, pulmonic (eg, 

regurgitation, stenosis, prolapse, insufficiency, vegetation);  functional murmurs; 

rheumatic heart disease; complications of artificial valves 

Hypotension: orthostatic hypotension 

Hypertension: elevated blood pressure reading without diagnosis of hypertension; essential 

hypertension; malignant hypertension; secondary hypertension  

Dyslipidemia: hypercholesterolemia; hyperlipidemia; hypertriglyceridemia; 

lipoproteins/lipoprotein lipase deficiency 

Vascular disorders 

disorders  of  the  great  vessels:  aneurysm,  aortic  (abdominal/thoracic),  dissection, 

ruptured; aneurysm, iliac, other peripheral vascular, ruptured; aortoiliac disease 

peripheral arterial vascular disease: arterial embolus/thrombosis; arteriovenous 

fistula; atheroembolic disease; claudication; cholesterol emboli; hypertensive 

vascular disease; peripheral arterial disease; thromboangiitis obliterans 

diseases of the veins: deep venous thrombosis, venous thromboembolism; 

phlebitis/thrombophlebitis; varicose veins; venous insufficiency; stasis ulcers, 

stasis dermatitis 

Traumatic and mechanical disorders: ventricular puncture; myocardial contusion; 

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